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1. 发明授权

US08062573B2 Solid micro-perforators and methods of use 有权
标题翻译：实心微穿孔机及使用方法
公开(公告)号：US08062573B2
公开(公告)日：2011-11-22
申请号：US10528059
申请日：2003-09-15
申请人： Sung-Yun Kwon
发明人： Sung-Yun Kwon
IPC分类号： B29C41/46
CPC分类号： A61K9/0021 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： Porous microperforators (210A), preferably in an array of multiple perforators are employed for delivery of a drug, where the micro-perforators may dissolve in situ. Suitable micro-perforators may include multiple layers of dissolvable materials to effect sequential drug delivery. In further aspects, contemplated micro-perforators may employ a diagnostic device in which a detector layer or detector is operationally coupled to the micro-perforators.
摘要翻译：多孔微孔穿孔器（210A），优选以多个穿孔器阵列，用于递送药物，其中微穿孔器可以原位溶解。合适的微穿孔器可以包括多层可溶解材料以实现顺序药物递送。在另外的方面，预期的微穿孔器可以采用其中检测器层或检测器可操作地耦合到微穿孔器的诊断装置。

2. 发明授权

US07182747B2 Solid solution perforator for drug delivery and other applications 有权
标题翻译：固体溶剂穿孔剂用于药物递送和其他应用
公开(公告)号：US07182747B2
公开(公告)日：2007-02-27
申请号：US11285669
申请日：2005-11-21
申请人： Sung-Yun Kwon
发明人： Sung-Yun Kwon
IPC分类号： A61B17/20
CPC分类号： A61B17/205 , A61B2017/00345 , A61K9/0021 , A61K9/7084 , A61K2039/54 , A61M31/007 , A61M37/0015 , A61M2037/0023
摘要： A solid drug solution perforator (SSP) system and an associated drug reservoir are provided for delivering therapeutic, prophylactic and/or cosmetic compounds, for nutrient delivery and for drug targeting. For drug delivery, the SSP system includes an active drug ingredient and a matrix of perforator material that biodegrades or dissolves quickly upon contact with a patient's body. The SSP system provides a skin barrier perforator and a controller for prompt initiation and cut-off of drug delivery. In a preferred method of transdermal drug delivery, an SSP system containing a selected drug penetrates into an epidermis or dermis, and the drug is promptly released from the (dissolving) SSP system perforator. An additional drug is optionally delivered from a patch reservoir through skin pores created by insertion of the perforator. Formulation and fabrication procedures for the SSP and associated reservoir are also provided. An SSP system can be fabricated with variety of shapes and dimensions.
摘要翻译：提供固体药物穿透器（SSP）系统和相关联的药物储存器用于递送治疗，预防和/或化妆品化合物，用于营养物质输送和药物靶向。对于药物递送，SSP系统包括活性药物成分和与患者身体接触时快速生物降解或溶解的穿孔剂材料基质。 SSP系统提供皮肤屏障穿孔器和用于迅速启动和切断药物递送的控制器。在透皮药物递送的优选方法中，含有选择的药物的SSP系统渗透到表皮或真皮中，药物迅速从（溶解）SSP系统穿孔器中释放出来。额外的药物可选地从补片储存器通过由穿孔器插入而产生的皮肤孔递送。还提供了SSP和相关储层的配方和制造程序。可以制造具有各种形状和尺寸的SSP系统。

3. 发明申请

US20120193840A1 METHOD OF MANUFACTURING SOLID SOLUTION PERFORATOR PATCHES 审中-公开
标题翻译：制造固体溶剂执行器贴片的方法
公开(公告)号：US20120193840A1
公开(公告)日：2012-08-02
申请号：US13364438
申请日：2012-02-02
申请人： Sung-Yun Kwon
发明人： Sung-Yun Kwon
IPC分类号： B29C33/40 , B29C37/00 , B29C51/10
CPC分类号： B29C33/42 , A61M37/0015 , A61M2037/0046 , A61M2037/0053 , B29K2995/006 , B29L2031/7544
摘要： Provided are methods for fabricating and manufacturing solid solution perforators (SSPs) using sharp metal and subsequent molding and use. The methods entail making microneedles by precision machining techniques and micromold structures from plastic materials. Various designs of patch are described.
摘要翻译：提供了使用尖锐金属制造和制造固溶体穿孔器（SSP）的方法，随后的模塑和使用。该方法需要通过精密加工技术和塑料材料的微型结构来制造微针。描述了各种贴片设计。

4. 发明申请

US20090035446A1 Solid Solution Perforator Containing Drug Particle and/or Drug-Adsorbed Particles 审中-公开
标题翻译：含有药物颗粒和/或药物吸附颗粒的固体溶液穿孔器
公开(公告)号：US20090035446A1
公开(公告)日：2009-02-05
申请号：US11991682
申请日：2006-09-05
申请人： Sung-Yun Kwon
发明人： Sung-Yun Kwon
IPC分类号： A61L33/04
CPC分类号： A61K9/0021 , A61K2039/54 , A61K2039/55555 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053
摘要： A solid drug solution perforator containing drug particles and/or drug-adsorbed or loaded particles with an associated drug reservoir (SSPP system) are provided for delivering therapeutic, prophylactic and/or cosmetic compounds, diagnostics, and for nutrient delivery and drug targeting. For drug delivery, the SSPP system includes an active drug ingredient in particulate form or drug adsorbed on the particle surface in a matrix material that dissolves upon contact with a patient's body. In a preferred method of transdermal drug delivery, an SSPP system containing a drug-adsorbed microparticle penetrates into the epidermis or dermis, and the drug is released from the (dissolving) SSPP system perforator and desorbed from the particles. An additional drug is optionally delivered from a patch reservoir through skin pores created by insertion of the perforator Formulation and fabrication procedures for the SSPP and associated reservoir are also provided. An SSPP system can be fabricated with variety of shapes and dimensions.
摘要翻译：提供含有药物颗粒和/或药物吸附或负载的颗粒与固定的药物储存器（SSPP系统）的固体药物溶液穿孔器，用于递送治疗，预防和/或化妆品化合物，诊断以及营养物质输送和药物靶向。对于药物递送，SSPP系统包括颗粒形式的活性药物成分或吸收在基质材料的颗粒表面上的药物，其在与患者身体接触时溶解。在透皮药物递送的优选方法中，含有药物吸附的微粒的SSPP系统渗透到表皮或真皮中，并且药物从（溶解）SSPP系统穿孔器释放并从颗粒中解吸。额外的药物可选地从补片储存器通过由穿孔器的插入产生的皮肤孔递送。还提供了用于SSPP和相关贮存器的制造程序。可以制造具有各种形状和尺寸的SSPP系统。

5. 发明授权

US07211062B2 Solid solution perforator for drug delivery and other applications 有权
标题翻译：固体溶剂穿孔剂用于药物递送和其他应用
公开(公告)号：US07211062B2
公开(公告)日：2007-05-01
申请号：US10767359
申请日：2004-01-28
申请人： Sung-Yun Kwon
发明人： Sung-Yun Kwon
IPC分类号： A61M37/00 , A61B17/20
CPC分类号： A61B17/205 , A61B2017/00345 , A61K9/0021 , A61K9/7084 , A61K2039/54 , A61M31/007 , A61M37/0015 , A61M2037/0023
摘要： A solid drug perforator (SSP) system and an associated drug reservoir are provided for delivering theraputic, prophylactic and/or cosmetic compounds, for nutrient delivery and for drug targeting. For drug delivery, the SSP system includes an active drug ingredient and a matrix of perforator material that biodegrades or dissolves quickly upon contact with a patient's body. The SSP system provides a skin barrier perforator and a controller for prompt initiation and cut-off of drug delivery. In a preferred method of transdermal drug delivery, an SSP system containing a selected drug penetrates into an epidermis or dermis, and the drug is promptly released from the (dissolving) SSP system perforator. An additional drug is optionally delivered from a patch reservoir through skin pores created by insertion of the perforator. Formulation and fabrication procedures for the SSP and associated reservoir are also provided. An SSP system can be fabricated with variety of shapes and dimensions.
摘要翻译：提供固体药物穿孔器（SSP）系统和相关联的药物储存器用于递送治疗，预防和/或化妆品化合物，用于营养物质输送和药物靶向。对于药物递送，SSP系统包括活性药物成分和与患者身体接触时快速生物降解或溶解的穿孔剂材料基质。 SSP系统提供皮肤屏障穿孔器和用于迅速启动和切断药物递送的控制器。在透皮药物递送的优选方法中，含有选择的药物的SSP系统渗透到表皮或真皮中，药物迅速从（溶解）SSP系统穿孔器中释放出来。额外的药物可选地从补片储存器通过由穿孔器插入而产生的皮肤孔递送。还提供了SSP和相关储层的配方和制造程序。可以制造具有各种形状和尺寸的SSP系统。

6. 发明申请

US20060074376A1 Solid solution perforator for drug delivery and other applications 有权
标题翻译：固体溶剂穿孔剂用于药物递送和其他应用
公开(公告)号：US20060074376A1
公开(公告)日：2006-04-06
申请号：US11285669
申请日：2005-11-21
申请人： Sung-Yun Kwon
发明人： Sung-Yun Kwon
IPC分类号： A61B17/20
CPC分类号： A61B17/205 , A61B2017/00345 , A61K9/0021 , A61K9/7084 , A61K2039/54 , A61M31/007 , A61M37/0015 , A61M2037/0023
摘要： A solid drug solution perforator (SSP) system and an associated drug reservoir are provided for delivering therapeutic, prophylactic and/or cosmetic compounds, for nutrient delivery and for drug targeting. For drug delivery, the SSP system includes an active drug ingredient and a matrix of perforator material that biodegrades or dissolves quickly upon contact with a patient's body. The SSP system provides a skin barrier perforator and a controller for prompt initiation and cut-off of drug delivery. In a preferred method of transdermal drug delivery, an SSP system containing a selected drug penetrates into an epidermis or dermis, and the drug is promptly released from the (dissolving) SSP system perforator. An additional drug is optionally delivered from a patch reservoir through skin pores created by insertion of the perforator. Formulation and fabrication procedures for the SSP and associated reservoir are also provided. An SSP system can be fabricated with variety of shapes and dimensions.
摘要翻译：提供固体药物穿透器（SSP）系统和相关联的药物储存器用于递送治疗，预防和/或化妆品化合物，用于营养物质输送和药物靶向。对于药物递送，SSP系统包括活性药物成分和与患者身体接触时快速生物降解或溶解的穿孔剂材料基质。 SSP系统提供皮肤屏障穿孔器和用于迅速启动和切断药物递送的控制器。在透皮药物递送的优选方法中，含有选择的药物的SSP系统渗透到表皮或真皮中，药物迅速从（溶解）SSP系统穿孔器中释放出来。额外的药物可选地从补片储存器通过由穿孔器插入而产生的皮肤孔递送。还提供了SSP和相关储层的配方和制造程序。可以制造具有各种形状和尺寸的SSP系统。

7. 发明授权

US09381680B2 Method of manufacturing solid solution perforator patches and uses thereof 有权
标题翻译：制造固溶透射片的方法及其用途
公开(公告)号：US09381680B2
公开(公告)日：2016-07-05
申请号：US12994148
申请日：2009-05-21
申请人： Sea-Jin Oh , Sung-Yun Kwon
发明人： Sea-Jin Oh , Sung-Yun Kwon
IPC分类号： B29C33/38 , A61M37/00 , B29C33/30 , B29C33/00 , A61B17/20 , A61B17/00
CPC分类号： B29C33/3885 , A61B17/205 , A61B2017/00345 , A61B2017/00761 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , A61M2037/0061 , B29C33/0027 , B29C33/0033 , B29C33/308 , B29C33/3878
摘要： Methods for fabricating and manufacturing solid solution perforators (SSPs) using sharp metal or glass needles and/or subsequent molding and use are described. The methods entail making microneedles by various precision machining techniques and micromold structures from curable materials. Various designs of patch, cartridge and applicator are described. Also described are methods for adjusting the microneedle mechanical strength using formulation and/or post-drying processes.
摘要翻译：描述了使用锋利的金属或玻璃针和/或随后的模制和使用来制造和制造固溶体穿孔器（SSP）的方法。该方法需要通过各种精密加工技术制造微针，并且可以从可固化材料制成微型结构。描述了贴片，盒和敷贴器的各种设计。还描述了使用制剂和/或后干燥方法调节微针机械强度的方法。

8. 发明申请

US20130287832A1 SOLUBLE NEEDLE ARRAYS FOR DELIVERY OF INFLUENZA VACCINES 有权
标题翻译：用于输送流感疫苗的可溶性针头阵列
公开(公告)号：US20130287832A1
公开(公告)日：2013-10-31
申请号：US13817814
申请日：2011-08-19
申请人： Derek O'Hagan , Manmohan Singh , Sung-Yun Kwon
发明人： Derek O'Hagan , Manmohan Singh , Sung-Yun Kwon
IPC分类号： A61K9/14
CPC分类号： A61K39/145 , A61B17/205 , A61B2017/00004 , A61K9/146 , A61K39/12 , A61K2039/5252 , A61K2039/54 , A61K2039/70 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2202/30 , C12N2760/16111 , C12N2760/16134 , C12N2760/16211 , C12N2760/16234 , G01N33/68 , G01N2333/11
摘要： Influenza vaccines are administered using solid biodegradable microneedles. The microneedles are fabricated from the influenza vaccine in combination with solid excipient(s) and, after penetrating the skin, they dissolve in situ and release the vaccine to the immune system. The influenza vaccine is (i) a purified influenza virus surface antigen vaccine, rather than a live vaccine or a whole-virus or split inactivated vaccine (ii) an influenza vaccine prepared from viruses grown in cell culture, not eggs, (iii) a monovalent influenza vaccine e.g. for immunizing against a pandemic strain, (iv) a bivalent vaccine, (v) a tetravalent or >4-valent vaccine, (vi) a mercury-free vaccine, or (vii) a gelatin-free vaccine.
摘要翻译：流感疫苗使用固体可生物降解的微针进行施用。微针由流感疫苗与固体赋形剂组合制成，并且在穿透皮肤后，它们原位溶解并将疫苗释放到免疫系统中。流感疫苗是（i）纯化的流感病毒表面抗原疫苗，而不是活疫苗或全病毒或分裂灭活疫苗（ii）由在细胞培养物中生长的病毒而不是鸡蛋制备的流感疫苗，（iii）单价流感疫苗，例如用于免疫大流行性毒株，（iv）二价疫苗，（v）四价或> 4价疫苗，（vi）无汞疫苗或（vii）无明胶疫苗。

9. 发明授权

US06945952B2 Solid solution perforator for drug delivery and other applications 有权
标题翻译：固体溶剂穿孔剂用于药物递送和其他应用
公开(公告)号：US06945952B2
公开(公告)日：2005-09-20
申请号：US10179749
申请日：2002-06-25
申请人： Sung-Yun Kwon
发明人： Sung-Yun Kwon
IPC分类号： A61B17/20 , A61M37/00
CPC分类号： A61B17/205 , A61B2017/00345 , A61K9/0021 , A61K9/7084 , A61K2039/54 , A61M31/007 , A61M37/0015 , A61M2037/0023
摘要： A solid drug solution perforator (SSP) system and an associated drug reservoir are provided for delivering therapeutic, prophylactic and/or cosmetic compounds, for nutrient delivery and for drug targeting. For drug delivery, the SSP system includes an active drug ingredient and a matrix of perforator material that biodegrades or dissolves quickly upon contact with a patient's body. The SSP system provides a skin barrier perforator and a controller for prompt initiation and cut-off drug delivery. In a preferred method of transdermal drug delivery, an SSP system containing a selected drug penetrates into an epidermis or dermis, and the drug is promptly released from the (dissolving) SSP system perforator. An additional drug is optionally delivered from a patch reservoir through skin pores created by insertion of the perforator. Formulation and fabrication procedures for the SSP and associated reservoir are also provided. An SSP system can be fabricated with variety of shapes and dimensions.
摘要翻译：提供固体药物穿透器（SSP）系统和相关联的药物储存器用于递送治疗，预防和/或化妆品化合物，用于营养物质输送和药物靶向。对于药物递送，SSP系统包括活性药物成分和与患者身体接触时快速生物降解或溶解的穿孔剂材料基质。 SSP系统提供皮肤屏障穿孔器和控制器，用于迅速启动和切断药物递送。在透皮药物递送的优选方法中，含有选择的药物的SSP系统渗透到表皮或真皮中，药物迅速从（溶解）SSP系统穿孔器中释放出来。额外的药物可选地从补片储存器通过由穿孔器插入而产生的皮肤孔递送。还提供了SSP和相关储层的配方和制造程序。可以制造具有各种形状和尺寸的SSP系统。

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