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1. 发明申请

US20110121486A1 METHOD OF MANUFACTURING SOLID SOLUTION PEFORATOR PATCHES AND USES THEREOF 有权
标题翻译：制造固体解决方案的方法及其用途
公开(公告)号：US20110121486A1
公开(公告)日：2011-05-26
申请号：US12994148
申请日：2009-05-21
申请人： Sea-Jin Oh , Sung-Yun Kwon
发明人： Sea-Jin Oh , Sung-Yun Kwon
IPC分类号： B29C33/42
CPC分类号： B29C33/3885 , A61B17/205 , A61B2017/00345 , A61B2017/00761 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , A61M2037/0061 , B29C33/0027 , B29C33/0033 , B29C33/308 , B29C33/3878
摘要： Methods for fabricating and manufacturing solid solution perforators (SSPs) using sharp metal or glass needles and/or subsequent molding and use are described. The methods entail making microneedles by various precision machining techniques and micromold structures from curable materials. Various designs of patch, cartridge and applicator are described. Also described are methods for adjusting the microneedle mechanical strength using formulation and/or post-drying processes.
摘要翻译：描述了使用锋利的金属或玻璃针和/或随后的模制和使用来制造和制造固溶体穿孔器（SSP）的方法。该方法需要通过各种精密加工技术制造微针，并且可以从可固化材料制成微型结构。描述了贴片，盒和敷贴器的各种设计。还描述了使用制剂和/或后干燥方法调节微针机械强度的方法。

2. 发明授权

US09381680B2 Method of manufacturing solid solution perforator patches and uses thereof 有权
标题翻译：制造固溶透射片的方法及其用途
公开(公告)号：US09381680B2
公开(公告)日：2016-07-05
申请号：US12994148
申请日：2009-05-21
申请人： Sea-Jin Oh , Sung-Yun Kwon
发明人： Sea-Jin Oh , Sung-Yun Kwon
IPC分类号： B29C33/38 , A61M37/00 , B29C33/30 , B29C33/00 , A61B17/20 , A61B17/00
CPC分类号： B29C33/3885 , A61B17/205 , A61B2017/00345 , A61B2017/00761 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , A61M2037/0061 , B29C33/0027 , B29C33/0033 , B29C33/308 , B29C33/3878
摘要： Methods for fabricating and manufacturing solid solution perforators (SSPs) using sharp metal or glass needles and/or subsequent molding and use are described. The methods entail making microneedles by various precision machining techniques and micromold structures from curable materials. Various designs of patch, cartridge and applicator are described. Also described are methods for adjusting the microneedle mechanical strength using formulation and/or post-drying processes.
摘要翻译：描述了使用锋利的金属或玻璃针和/或随后的模制和使用来制造和制造固溶体穿孔器（SSP）的方法。该方法需要通过各种精密加工技术制造微针，并且可以从可固化材料制成微型结构。描述了贴片，盒和敷贴器的各种设计。还描述了使用制剂和/或后干燥方法调节微针机械强度的方法。

3. 发明授权

US08062573B2 Solid micro-perforators and methods of use 有权
标题翻译：实心微穿孔机及使用方法
公开(公告)号：US08062573B2
公开(公告)日：2011-11-22
申请号：US10528059
申请日：2003-09-15
申请人： Sung-Yun Kwon
发明人： Sung-Yun Kwon
IPC分类号： B29C41/46
CPC分类号： A61K9/0021 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： Porous microperforators (210A), preferably in an array of multiple perforators are employed for delivery of a drug, where the micro-perforators may dissolve in situ. Suitable micro-perforators may include multiple layers of dissolvable materials to effect sequential drug delivery. In further aspects, contemplated micro-perforators may employ a diagnostic device in which a detector layer or detector is operationally coupled to the micro-perforators.
摘要翻译：多孔微孔穿孔器（210A），优选以多个穿孔器阵列，用于递送药物，其中微穿孔器可以原位溶解。合适的微穿孔器可以包括多层可溶解材料以实现顺序药物递送。在另外的方面，预期的微穿孔器可以采用其中检测器层或检测器可操作地耦合到微穿孔器的诊断装置。

4. 发明申请

US20050251088A1 Solid micro-perforators and methods of use 有权
标题翻译：实心微穿孔机及使用方法
公开(公告)号：US20050251088A1
公开(公告)日：2005-11-10
申请号：US10528059
申请日：2003-09-15
申请人： Sung-Yun Kwon
发明人： Sung-Yun Kwon
IPC分类号： A61M31/00 , A61M37/00
CPC分类号： A61K9/0021 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： Porous microperforators (210A), preferably in an array of multiple perforators are employed for delivery of a drug, where the micro-perforators may dissolve in situ. Suitable micro-perforators may include multiple layers of dissolvable materials to effect sequential drug delivery. In further aspects, contemplated micro-perforators may employ a diagnostic device in which a detector layer or detector is operationally coupled to the micro-perforators.
摘要翻译：多孔微孔穿孔器（210A），优选以多个穿孔器阵列，用于递送药物，其中微穿孔器可以原位溶解。合适的微穿孔器可以包括多层可溶解材料以实现顺序药物递送。在另外的方面，预期的微穿孔器可以采用其中检测器层或检测器可操作地耦合到微穿孔器的诊断装置。

5. 发明授权

US07182747B2 Solid solution perforator for drug delivery and other applications 有权
标题翻译：固体溶剂穿孔剂用于药物递送和其他应用
公开(公告)号：US07182747B2
公开(公告)日：2007-02-27
申请号：US11285669
申请日：2005-11-21
申请人： Sung-Yun Kwon
发明人： Sung-Yun Kwon
IPC分类号： A61B17/20
CPC分类号： A61B17/205 , A61B2017/00345 , A61K9/0021 , A61K9/7084 , A61K2039/54 , A61M31/007 , A61M37/0015 , A61M2037/0023
摘要： A solid drug solution perforator (SSP) system and an associated drug reservoir are provided for delivering therapeutic, prophylactic and/or cosmetic compounds, for nutrient delivery and for drug targeting. For drug delivery, the SSP system includes an active drug ingredient and a matrix of perforator material that biodegrades or dissolves quickly upon contact with a patient's body. The SSP system provides a skin barrier perforator and a controller for prompt initiation and cut-off of drug delivery. In a preferred method of transdermal drug delivery, an SSP system containing a selected drug penetrates into an epidermis or dermis, and the drug is promptly released from the (dissolving) SSP system perforator. An additional drug is optionally delivered from a patch reservoir through skin pores created by insertion of the perforator. Formulation and fabrication procedures for the SSP and associated reservoir are also provided. An SSP system can be fabricated with variety of shapes and dimensions.
摘要翻译：提供固体药物穿透器（SSP）系统和相关联的药物储存器用于递送治疗，预防和/或化妆品化合物，用于营养物质输送和药物靶向。对于药物递送，SSP系统包括活性药物成分和与患者身体接触时快速生物降解或溶解的穿孔剂材料基质。 SSP系统提供皮肤屏障穿孔器和用于迅速启动和切断药物递送的控制器。在透皮药物递送的优选方法中，含有选择的药物的SSP系统渗透到表皮或真皮中，药物迅速从（溶解）SSP系统穿孔器中释放出来。额外的药物可选地从补片储存器通过由穿孔器插入而产生的皮肤孔递送。还提供了SSP和相关储层的配方和制造程序。可以制造具有各种形状和尺寸的SSP系统。

6. 发明申请

US20050064528A1 Non-or minimally invasive monitoring methods 审中-公开
标题翻译：非微创监测方法
公开(公告)号：US20050064528A1
公开(公告)日：2005-03-24
申请号：US10499061
申请日：2002-12-13
申请人： Sung-Yun Kwon , Terry Burkoth
发明人： Sung-Yun Kwon , Terry Burkoth
IPC分类号： A61B5/00 , A61B10/00 , A61B17/00 , A61B17/54 , C12M1/34 , C12Q1/54 , G01N33/66
CPC分类号： A61B5/14532 , A61B5/14514 , A61B5/1486 , A61B17/545 , A61B2010/008 , A61B2017/00747 , A61B2017/00765 , G01N33/66
摘要： An apparatus for sensing an analyte is described, wherein the apparatus includes an interface contact element that is used to establish an interface with a quantity of body fluid. The interface contact element is adapted to facilitate diffusion of a target analyte across the interface essentially free of net mass fluid transport. The quantity of body fluid is exposed to the interface contact element through micro-pathways. The apparatus can also include a sensing material adapted to sense the target analyte with at least one analytical method. Methods for using the apparatus in a non- or minimally invasive monitoring technique are also described. FIG. (1) illustrates a non-limiting embodiment of the apparatus used to test the principles of the invention.
摘要翻译：描述了用于感测分析物的装置，其中所述装置包括用于建立与一定体液的界面的界面接触元件。界面接触元件适于促进目标分析物在基本上不含净质量流体输送的界面上的扩散。体液通过微通道暴露于界面接触元件。该装置还可以包括适于用至少一种分析方法感测目标分析物的感测材料。还描述了在非侵入性或微创监测技术中使用该装置的方法。图。（1）示出了用于测试本发明的原理的装置的非限制性实施例。

7. 发明申请

US20070196490A1 Method of enhancing needleless transdermal powered drug delivery 审中-公开
标题翻译：增强无针透皮动力药物递送的方法
公开(公告)号：US20070196490A1
公开(公告)日：2007-08-23
申请号：US11488192
申请日：2006-07-18
申请人： Sung-Yun Kwon , Terry Burkoth
发明人： Sung-Yun Kwon , Terry Burkoth
IPC分类号： A61K9/38 , A61K9/14
CPC分类号： A61K9/0021 , A61K38/28
摘要： A method is provided for enhancing the transdermal or intradermal delivery of a therapeutic agent using a needleless syringe drug delivery system. In one embodiment, the method entails first administering to a predetermined area of skin or mucosa particles comprising the therapeutic agent, a placebo and/or a permeation enhancing agent. A transdermal delivery device or occlusive dressing is then topically positioned over the area of skin or mucosa. In another embodiment, the method entails administering a formulation of particles wherein the formulation includes particles that contain a therapeutic agent and placebo particles.
摘要翻译：提供了一种使用无针注射器药物递送系统增强治疗剂的透皮或皮内递送的方法。在一个实施方案中，该方法需要首先给包含治疗剂，安慰剂和/或渗透促进剂的皮肤或粘膜颗粒的预定区域施用。然后将透皮递送装置或闭合敷料局部定位在皮肤或粘膜的区域上。在另一个实施方案中，该方法需要施用颗粒制剂，其中制剂包含含有治疗剂和安慰剂颗粒的颗粒。

8. 发明授权

US07211062B2 Solid solution perforator for drug delivery and other applications 有权
标题翻译：固体溶剂穿孔剂用于药物递送和其他应用
公开(公告)号：US07211062B2
公开(公告)日：2007-05-01
申请号：US10767359
申请日：2004-01-28
申请人： Sung-Yun Kwon
发明人： Sung-Yun Kwon
IPC分类号： A61M37/00 , A61B17/20
CPC分类号： A61B17/205 , A61B2017/00345 , A61K9/0021 , A61K9/7084 , A61K2039/54 , A61M31/007 , A61M37/0015 , A61M2037/0023
摘要： A solid drug perforator (SSP) system and an associated drug reservoir are provided for delivering theraputic, prophylactic and/or cosmetic compounds, for nutrient delivery and for drug targeting. For drug delivery, the SSP system includes an active drug ingredient and a matrix of perforator material that biodegrades or dissolves quickly upon contact with a patient's body. The SSP system provides a skin barrier perforator and a controller for prompt initiation and cut-off of drug delivery. In a preferred method of transdermal drug delivery, an SSP system containing a selected drug penetrates into an epidermis or dermis, and the drug is promptly released from the (dissolving) SSP system perforator. An additional drug is optionally delivered from a patch reservoir through skin pores created by insertion of the perforator. Formulation and fabrication procedures for the SSP and associated reservoir are also provided. An SSP system can be fabricated with variety of shapes and dimensions.
摘要翻译：提供固体药物穿孔器（SSP）系统和相关联的药物储存器用于递送治疗，预防和/或化妆品化合物，用于营养物质输送和药物靶向。对于药物递送，SSP系统包括活性药物成分和与患者身体接触时快速生物降解或溶解的穿孔剂材料基质。 SSP系统提供皮肤屏障穿孔器和用于迅速启动和切断药物递送的控制器。在透皮药物递送的优选方法中，含有选择的药物的SSP系统渗透到表皮或真皮中，药物迅速从（溶解）SSP系统穿孔器中释放出来。额外的药物可选地从补片储存器通过由穿孔器插入而产生的皮肤孔递送。还提供了SSP和相关储层的配方和制造程序。可以制造具有各种形状和尺寸的SSP系统。

9. 发明申请

US20060074376A1 Solid solution perforator for drug delivery and other applications 有权
标题翻译：固体溶剂穿孔剂用于药物递送和其他应用
公开(公告)号：US20060074376A1
公开(公告)日：2006-04-06
申请号：US11285669
申请日：2005-11-21
申请人： Sung-Yun Kwon
发明人： Sung-Yun Kwon
IPC分类号： A61B17/20
CPC分类号： A61B17/205 , A61B2017/00345 , A61K9/0021 , A61K9/7084 , A61K2039/54 , A61M31/007 , A61M37/0015 , A61M2037/0023
摘要： A solid drug solution perforator (SSP) system and an associated drug reservoir are provided for delivering therapeutic, prophylactic and/or cosmetic compounds, for nutrient delivery and for drug targeting. For drug delivery, the SSP system includes an active drug ingredient and a matrix of perforator material that biodegrades or dissolves quickly upon contact with a patient's body. The SSP system provides a skin barrier perforator and a controller for prompt initiation and cut-off of drug delivery. In a preferred method of transdermal drug delivery, an SSP system containing a selected drug penetrates into an epidermis or dermis, and the drug is promptly released from the (dissolving) SSP system perforator. An additional drug is optionally delivered from a patch reservoir through skin pores created by insertion of the perforator. Formulation and fabrication procedures for the SSP and associated reservoir are also provided. An SSP system can be fabricated with variety of shapes and dimensions.
摘要翻译：提供固体药物穿透器（SSP）系统和相关联的药物储存器用于递送治疗，预防和/或化妆品化合物，用于营养物质输送和药物靶向。对于药物递送，SSP系统包括活性药物成分和与患者身体接触时快速生物降解或溶解的穿孔剂材料基质。 SSP系统提供皮肤屏障穿孔器和用于迅速启动和切断药物递送的控制器。在透皮药物递送的优选方法中，含有选择的药物的SSP系统渗透到表皮或真皮中，药物迅速从（溶解）SSP系统穿孔器中释放出来。额外的药物可选地从补片储存器通过由穿孔器插入而产生的皮肤孔递送。还提供了SSP和相关储层的配方和制造程序。可以制造具有各种形状和尺寸的SSP系统。

10. 发明申请

US20140316333A1 DISSOLVING SOLID SOLUTION PERFORATOR PATCH FOR MIGRAINE TREATMENT 审中-公开
标题翻译：解决用于MIGRAINE治疗的固体溶剂执行器贴片
公开(公告)号：US20140316333A1
公开(公告)日：2014-10-23
申请号：US14354090
申请日：2012-10-29
申请人： Sung-Yun KWON
发明人： Sung-Yun Kwon
IPC分类号： A61M37/00 , A61K31/4468 , A61K31/137 , A61K31/485 , A61K38/26 , A61K31/4985 , A61K31/4535
CPC分类号： A61M37/0015 , A61K9/0021 , A61K9/006 , A61K31/137 , A61K31/4045 , A61K31/4468 , A61K31/4535 , A61K31/48 , A61K31/485 , A61K31/4985 , A61K38/26 , A61K45/06 , A61M2037/0023 , A61M2037/0046
摘要： A dissolving solid solution perforator (SSP) patch for oral cavity administration may include at least one perforator. The at least one perforator may contain a first drug and be configured to pierce an outside layer of an oral cavity for promptly delivering the first drug. The at least one perforator may penetrate an epithelium layer of the oral cavity and to deliver the antimigraine drug into blood vessels in a submucosa layer.
摘要翻译：用于口腔给药的溶解固溶体穿孔器（SSP）贴片可以包括至少一个穿孔器。所述至少一个穿孔器可以包含第一药物并且被构造成刺穿口腔的外层以迅速地输送第一药物。所述至少一个穿孔器可以穿透口腔的上皮层并将抗偏头痛药物输送到粘膜下层中的血管中。

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