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1. 发明申请

US20130023443A1 METHOD FOR DETECTING PNEUMONIA CAUSATIVE BACTERIA USING NUCLEIC ACID CHROMATOGRAPHY 有权
标题翻译：使用核酸色谱检测肺炎球菌引起的细菌的方法
公开(公告)号：US20130023443A1
公开(公告)日：2013-01-24
申请号：US13637815
申请日：2011-03-30
申请人： Mutsunori Shirai , Takayuki Ezaki , Tsukasa Hayashi , Takeshi Ujiiye , Makoto Ganaha , Shigekazu Yamamoto
发明人： Mutsunori Shirai , Takayuki Ezaki , Tsukasa Hayashi , Takeshi Ujiiye , Makoto Ganaha , Shigekazu Yamamoto
IPC分类号： C40B30/04 , C40B40/06
CPC分类号： G01N33/56933 , C12Q1/6816 , C12Q1/6865 , C12Q1/689 , C12Q2600/112 , C12Q2600/156 , G01N33/56911 , G01N33/56916 , G01N33/56938 , G01N33/56944 , Y02A50/451 , C12Q2565/137 , C12Q2525/143 , C12Q2537/125 , C12Q2537/143 , C12Q2563/149 , C12Q2565/625
摘要： Provided are a method and a kit for accurately and rapidly detecting ten types of targeting pneumonia bacteria: Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, Chlamydophila pneumoniae, Legionella pneumophila, Klebsiella pneumoniae, Pseudomonas aeruginosa, Moraxella catarrhalis, methicillin-resistant Staphylococcus aureus (MRSA), and Staphylococcus aureus. A set of primer pairs directed to their respective target regions contained in the DnaJ gene, etc., of the ten types of pneumonia causative bacteria is designed for the ten bacterial strains and used to amplify gene products. A set of bacterial strain-specific probe pairs is further designed for the ten bacterial strains such that the probe pairs hybridize with the amplification products via sequences in the respective target regions differing from the sequences hybridized by the set of primer pairs. A first probe-bound labeled high molecular carrier in which plural types of first probes for the pneumonia bacteria are bound to a labeled high molecular carrier and a solid-phase second probe-carrying developing support are used as the set of probe pairs to perform nucleic acid chromatography.
摘要翻译：提供了用于准确和快速检测十种靶向性肺炎细菌的方法和试剂盒：肺炎链球菌，流感嗜血杆菌，肺炎支原体，肺炎衣原体，嗜肺军团菌，肺炎克雷伯菌，铜绿假单胞菌，卡他莫拉菌，耐甲氧西林金黄色葡萄球菌（MRSA））和金黄色葡萄球菌（Staphylococcus aureus）。针对十种类型肺炎致病细菌的DnaJ基因等中包含的各自靶区域的一组引物对设计用于十种细菌菌株并用于扩增基因产物。针对10个细菌菌株进一步设计了一组细菌菌株特异性探针对，使得探针对通过与由该组引物对杂交的序列不同的各个靶区域中的序列与扩增产物进行杂交。使用第一探针结合标记的高分子载体，其中用于肺炎细菌的多种类型的第一探针与标记的高分子载体结合，并且使用固相第二探针携带的显影载体作为探针对的一组以进行核酸酸性色谱。

2. 发明授权

US06841265B2 Titanium alloy vacuum and vacuum part 有权
标题翻译：钛合金真空和真空部分
公开(公告)号：US06841265B2
公开(公告)日：2005-01-11
申请号：US10312701
申请日：2002-03-18
申请人： Hiroki Kurisu , Mitsuru Matsuura , Setsuo Yamamoto , Masaki Hesaka , Atsushi Takemura
发明人： Hiroki Kurisu , Mitsuru Matsuura , Setsuo Yamamoto , Masaki Hesaka , Atsushi Takemura
IPC分类号： B01J3/00 , B01J3/03 , C22C14/00 , C23C8/12 , C23C8/16 , C23C16/44 , B23P15/00
CPC分类号： C23C8/16 , C22C14/00 , Y10S428/923 , Y10T428/12993
摘要： The objective of the present invention is to provide a titanium alloy vacuum container and vacuum parts that can easily achieve an ultra-high vacuum in a short time through vacuum evacuation.The titanium alloy of the titanium alloy vacuum container and vacuum parts has a compact structure composed of fine grains, each having a size of approximately not more than 10 μm, with a surface that is exposed to at least vacuum being set to have a surface roughness of not more than 50 nm; and in this structure, preferably, the surface roughness thereof may be set to not more than 10 nm, the titanium alloy may have a hardness in a range of not less than 230 Hv to not more than 310 Hv, and the titanium alloy may have a passivity surface film made by a thin titanium oxide layer or nitride layer that is formed on the surface thereof. The titanium alloy, which is desirably used in such titanium alloy vacuum container and vacuum parts, contains 0.3 wt. % to 0.5 wt. % of iron and 0.3 wt. % to 0.5 wt. % of oxygen, and the remainder thereof is made from Ti obligatory impurities.
摘要翻译：本发明的目的是提供一种钛合金真空容器和真空部件，其可以通过真空排气在短时间内容易地实现超高真空。钛合金真空容器和真空部件的钛合金具有紧凑的结构由细颗粒组成，每个细颗粒具有大约不超过10μm的尺寸，其中至少暴露于真空的表面被设定为具有不大于50nm的表面粗糙度; 在该结构中，优选其表面粗糙度可以设定为不大于10nm，钛合金的硬度可以在230Hv以上且不高于310Hv的范围内，并且钛合金可以具有由形成在其表面上的薄氧化钛层或氮化物层制成的无源表面膜。希望用于这种钛合金真空容器和真空部件中的钛合金含有0.3wt。％至0.5wt。铁含量为0.3％％至0.5wt。的氧气，其余部分由Ti强制性杂质制成。

3. 发明授权

US09347944B2 Method for detecting pneumonia causative bacteria using nucleic acid chromatography 有权
标题翻译：使用核酸色谱法检测肺炎致病菌的方法
公开(公告)号：US09347944B2
公开(公告)日：2016-05-24
申请号：US13637815
申请日：2011-03-30
申请人： Mutsunori Shirai , Takayuki Ezaki , Tsukasa Hayashi , Takeshi Ujiiye , Makoto Ganaha , Shigekazu Yamamoto
发明人： Mutsunori Shirai , Takayuki Ezaki , Tsukasa Hayashi , Takeshi Ujiiye , Makoto Ganaha , Shigekazu Yamamoto
IPC分类号： C12Q1/68 , G01N33/569
CPC分类号： G01N33/56933 , C12Q1/6816 , C12Q1/6865 , C12Q1/689 , C12Q2600/112 , C12Q2600/156 , G01N33/56911 , G01N33/56916 , G01N33/56938 , G01N33/56944 , Y02A50/451 , C12Q2565/137 , C12Q2525/143 , C12Q2537/125 , C12Q2537/143 , C12Q2563/149 , C12Q2565/625
摘要： Provided are a method and a kit for accurately and rapidly detecting ten types of targeting pneumonia bacteria: Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, Chlamydophila pneumoniae, Legionella pneumophila, Klebsiella pneumoniae, Pseudomonas aeruginosa, Moraxella catarrhalis, methicillin-resistant Staphylococcus aureus (MRSA), and Staphylococcus aureus. A set of primer pairs directed to their respective target regions contained in the DnaJ gene, etc., of the ten types of pneumonia causative bacteria is designed for the ten bacterial strains and used to amplify gene products. A set of bacterial strain-specific probe pairs is further designed for the ten bacterial strains such that the probe pairs hybridize with the amplification products via sequences in the respective target regions differing from the sequences hybridized by the set of primer pairs. A first probe-bound labeled high molecular carrier in which plural types of first probes for the pneumonia bacteria are bound to a labeled high molecular carrier and a solid-phase second probe-carrying developing support are used as the set of probe pairs to perform nucleic acid chromatography.
摘要翻译：提供了用于准确和快速检测十种靶向性肺炎细菌的方法和试剂盒：肺炎链球菌，流感嗜血杆菌，肺炎支原体，肺炎衣原体，嗜肺军团菌，肺炎克雷伯菌，铜绿假单胞菌，卡他莫拉菌，耐甲氧西林金黄色葡萄球菌（MRSA））和金黄色葡萄球菌（Staphylococcus aureus）。针对十种类型肺炎致病细菌的DnaJ基因等中包含的各自靶区域的一组引物对设计用于十种细菌菌株并用于扩增基因产物。针对10个细菌菌株进一步设计了一组细菌菌株特异性探针对，使得探针对通过与由该组引物对杂交的序列不同的各个靶区域中的序列与扩增产物进行杂交。使用第一探针结合标记的高分子载体，其中用于肺炎细菌的多种类型的第一探针与标记的高分子载体结合，并且使用固相第二探针携带的显影载体作为探针对的一组以进行核酸酸性色谱。

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