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1. 发明授权

US09491933B2 Infected nail of animal infected with fungus 有权
标题翻译：感染真菌感染的指甲
公开(公告)号：US09491933B2
公开(公告)日：2016-11-15
申请号：US12810202
申请日：2008-12-25
申请人： Nobuo Kubota , Tsuyoshi Shimamura , Saori Nagasaka
发明人： Nobuo Kubota , Tsuyoshi Shimamura , Saori Nagasaka
IPC分类号： A61K48/00 , A01K67/00 , C12Q1/02 , C12Q1/18
CPC分类号： A01K67/00 , A01K2207/10 , A01K2227/107 , A01K2267/0337 , C12Q1/025 , C12Q1/18
摘要： The invention can produce an infected nail of an animal and an infected animal model in which the nail plate and nail bed of the nail are sufficiently infected with a superficial fungus which were difficult to be produced in the past, and provides an evaluation method useful for development of a therapeutic agent for intractable infectious diseases such as tinea unguium using the nail and the infected animal model. For producing the infected nail of an animal and the infected animal model infected with a superficial fungus, an immunosuppressive component is administered to an animal in advance to decrease immunocompetence, and then, a superficial fungus is inoculated into the animal, whereby the infected nail of an animal and the infected animal model reflecting clinical manifestation in which the nail plate and nail bed of the nail are sufficiently infected with the superficial fungus can be produced with good reproducibility in a short period of time.
摘要翻译：本发明可以产生感染的动物指甲和感染的动物模型，其中钉子的甲板和甲板被过去难以产生的浅表真菌充分感染，并且提供了用于使用指甲和感染动物模型开发难治性感染性疾病如癣菌的治疗剂。为了产生受感染的动物指甲和感染表皮真菌的受感染动物模型，预先向动物施用免疫抑制成分以降低免疫能力，然后将表面真菌接种到动物中，由此将受感染的指甲可以在短时间内以良好的再现性产生反映临床表现的动物和感染的动物模型，其中甲板的指甲板和甲床被表面真菌充分感染。

2. 发明申请

US20160243203A1 TREATMENT OF POMPE'S DISEASE 审中-公开
公开(公告)号：US20160243203A1
公开(公告)日：2016-08-25
申请号：US14863333
申请日：2015-09-23
申请人： GENZYME THERAPEUTIC PRODUCTS LIMITED PARTNERSHIP
发明人： Johannes B. M. M. van BREE , Edna H. G. VENNEKER , David P. MEEKER
IPC分类号： A61K38/47 , A61K9/00
CPC分类号： A61K38/47 , A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/107 , A01K2267/01 , A01K2267/0306 , A61K9/0019 , C12N9/2408 , C12N15/8509 , C12Y302/0102
摘要： The invention provides methods of treating Pompe's disease using human acid alpha glucosidase. A preferred treatment regime comprises administering greater than 10 mg/kg body weight per week to a patient.

3. 发明申请

US20150307595A1 HUMAN POLYCLONAL ANTIBODIES FROM GENETICALLY ENGINEERED ANIMALS 审中-公开
标题翻译：来自遗传工程动物的人多肽抗体
公开(公告)号：US20150307595A1
公开(公告)日：2015-10-29
申请号：US14791246
申请日：2015-07-02
申请人： Jens-Ulrich Buelow
发明人： Jens-Ulrich Buelow
IPC分类号： C07K16/06
CPC分类号： C07K16/06 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2227/107 , A01K2267/01 , C07K16/00 , C07K16/082 , C07K2317/21 , C07K2317/51 , C07K2317/734 , C12N15/8509 , C12N15/8777
摘要： Substantially human antisera are provided by genetically modifying a domestic animal generally weighing at least about 1 kg. The domestic animal is genetically modified by generating inactive heavy and light chain immunoglobulin loci and integrating at least functional portions of the human heavy and light chain immunoglobulin loci, whereby the human loci generate an immune response. The antisera find use in the treatment of diseases, immunocompromised patients and in case of transplantation.
摘要翻译：通过对通常重至少约1kg的家畜进行遗传修饰来提供基本上人抗血清。通过产生无活性的重链和轻链免疫球蛋白基因座并整合人重链和轻链免疫球蛋白基因座的至少功能部分来整合家畜，由此人类基因座产生免疫应答。抗血清可用于治疗疾病，免疫功能低下的患者和移植的情况。

4. 发明申请

US20140093491A1 RECOMBINANT OR TRANSGENIC FACTOR VII COMPOSITION, EACH FACTOR VII MOLECULE HAVING TWO N-GLYCOSYLATION SITES WITH DEFINED GLYCAN UNITS 审中-公开
标题翻译：重组或转基因因子VII组成，每个因子VII分子具有两个定义的糖原单位的N-糖苷化位点
公开(公告)号：US20140093491A1
公开(公告)日：2014-04-03
申请号：US13886033
申请日：2013-05-02
申请人： LFB BIOTECHNOLOGIES
发明人： Abdessatar Sami Chtourou , Emmanuel Nony , Nicolas Bihoreau
IPC分类号： C12N9/64
CPC分类号： C12N9/6437 , A01K67/0275 , A01K2217/05 , A01K2227/107 , A01K2267/01 , A61K38/00 , C12N15/8509 , C12Y304/21021
摘要： The invention is related to a composition of recombinant or transgenic Factor VII, each molecule of Factor VII of the composition exhibiting two N-glycosylation sites, wherein, among all the molecules of FVII of the composition, the rate of Galα1,3G al glycan moieties is comprised between 0 and 4%. The invention is also related to a process for preparing such a composition of FVII.
摘要翻译：本发明涉及重组或转基因因子VII的组合物，组合物的每个因子VII分子表现出两个N-糖基化位点，其中组合物中FVII的所有分子中Galα1,3G氨基糖聚糖部分的比例在0和4％之间。本发明还涉及制备这种FVII组合物的方法。

5. 发明申请

US20130203648A1 Preparation of Recombinant Human Plasma Phospholipid Transfer Protein (PLTP) From the Milk of Transgenic Animals 有权
标题翻译：从转基因动物的牛奶制备重组人血浆磷脂转移蛋白（PLTP）
公开(公告)号：US20130203648A1
公开(公告)日：2013-08-08
申请号：US13639969
申请日：2011-04-06
申请人： Pierre-Jean Ripoll , Laurent Lagrost
发明人： Pierre-Jean Ripoll , Laurent Lagrost
IPC分类号： C07K14/47 , A01K67/027
CPC分类号： C07K14/47 , A01K67/0275 , A01K67/0278 , A01K2217/052 , A01K2217/206 , A01K2227/107 , A01K2267/01 , C12N15/8509 , C12N2830/008
摘要： The invention relates to obtaining a preparation of recombinant human PLTP from the milk of a transgenic animal containing in its genome one or more copies of a transgene comprising a polynucleotide coding for human PTLP, placed under transcriptional control of a promoter permitting its specific expression in the cells of the mammary glands of said animal. The recombinant human PLTP preparation obtained can be used in the prevention or treatment of septic shock.
摘要翻译：本发明涉及从含有其基因组的转基因动物的乳中获得重组人PLTP的制备物，所述转基因动物的一个或多个拷贝的转基因包含编码人PTLP的多核苷酸，置于启动子的转录控制下，其允许其特异性表达所述动物的乳腺细胞。获得的重组人PLTP制剂可用于预防或治疗败血性休克。

6. 发明申请

US20110059510A1 TRANSGENIC RABBITS PRODUCING HUMAN FACTOR VII 审中-公开
标题翻译：生产人体因子的转基因生物
公开(公告)号：US20110059510A1
公开(公告)日：2011-03-10
申请号：US12934124
申请日：2008-03-25
申请人： Pierre-Jean Ripoll
发明人： Pierre-Jean Ripoll
IPC分类号： C12N9/48 , A01K67/027 , A23C9/00
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/107 , A01K2267/01 , C07K14/47 , C12N9/6437 , C12N9/647 , C12N15/8509 , C12N2830/008 , C12N2830/30 , C12N2830/40 , C12N2830/85 , C12Y304/21021
摘要： The invention relates to transgenic rabbits that produce human factor VII in their mammary glands. The milk of said transgenic rabbits can be used as a raw material for the production of recombinant human factor VII.
摘要翻译：本发明涉及在其乳腺中产生人因子VII的转基因家兔。所述转基因兔的乳可用作生产重组人因子VII的原料。

7. 发明申请

US20100092449A1 Treatment of Pompe's Disease 审中-公开
标题翻译：庞培病的治疗
公开(公告)号：US20100092449A1
公开(公告)日：2010-04-15
申请号：US12633932
申请日：2009-12-09
申请人： Johannes B.M.M van Bree , Edna H.G. Venneker , David P. Meeker
发明人： Johannes B.M.M van Bree , Edna H.G. Venneker , David P. Meeker
IPC分类号： A61K38/47
CPC分类号： A61K38/47 , A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/107 , A01K2267/01 , A01K2267/0306 , A61K9/0019 , C12N9/2408 , C12N15/8509 , C12Y302/0102
摘要： The invention provides methods of treating Pompe's disease using human acid alpha glucosidase. A preferred treatment regime comprises administering greater than 10 mg/kg body weight per week to a patient.
摘要翻译：本发明提供了使用人类α-糖苷酶处理庞培病的方法。优选的治疗方案包括每周施用大于10mg / kg体重的患者。

8. 发明授权

US07482506B2 Ras p27 mouse models and uses thereof 失效
标题翻译： Ras p27小鼠模型及其用途
公开(公告)号：US07482506B2
公开(公告)日：2009-01-27
申请号：US10472057
申请日：2002-03-26
申请人： W. Jack Pledger , Rosalind J. Jackson , Jalila Adnane , Said M. Sebti
发明人： W. Jack Pledger , Rosalind J. Jackson , Jalila Adnane , Said M. Sebti
IPC分类号： G01N33/00 , A01K67/00 , A01K67/033 , A01K67/027
CPC分类号： C07H1/00 , A01K67/0275 , A01K67/0276 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/107 , A01K2267/0331 , C07H3/00 , C07K14/82 , C08G77/38 , C08G77/42 , C12N15/8509 , C12P19/44
摘要： The subject invention pertains to a transgenic animal model for tumorigenesis having a genome comprising a ras transgene and which is heterozygous or homozygous for a null p27 gene, and methods of using such animal to screen compounds or evaluate treatments for oncogenic and antitumor activity. The subject invention further concerns a transgenic mouse comprising a ras transgene and which has a genome that is wild-type p27+/+, and wherein the mouse has an FVB/N and C57BL/6X 129 genetic background; and methods of using such transgenic mice to screen compounds or evaluate treatments for oncogenic or antitumor activity. Advantageously, the female animals of the subject invention are fertile and capable of nursing their young. The subject invention also pertains to in vitro systems including isolated cells or tissues of animal models for tumorigenesis, which can be used to screen compounds and treatments for oncogenic and antitumor activity.
摘要翻译：本发明涉及用于肿瘤发生的转基因动物模型，其具有包含ras转基因的基因组，并且对于无效p27基因是杂合的或纯合的，以及使用该动物筛选化合物或评价致癌和抗肿瘤活性的治疗的方法。本发明还涉及包含ras转基因并且具有野生型p27 + / +的基因组的转基因小鼠，并且其中所述小鼠具有FVB / N和C57BL / 6X 129遗传背景; 以及使用这些转基因小鼠筛选化合物或评估致癌或抗肿瘤活性的治疗方法。有利地，本发明的雌性动物是肥沃的并能够护理他们的年轻人。本发明还涉及包括用于肿瘤发生的动物模型的分离的细胞或组织的体外系统，其可用于筛选化合物和治疗癌症和抗肿瘤活性。

9. 发明申请

US20080206223A1 Treatment of pompe's disease 失效
标题翻译：治疗庞培病
公开(公告)号：US20080206223A1
公开(公告)日：2008-08-28
申请号：US12012003
申请日：2008-01-30
申请人： Johannes B.M.M. Van Bree , Edna H.G. Venneker , David P. Meeker
发明人： Johannes B.M.M. Van Bree , Edna H.G. Venneker , David P. Meeker
IPC分类号： A61K38/47 , A61P21/00
CPC分类号： A61K38/47 , A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/107 , A01K2267/01 , A01K2267/0306 , A61K9/0019 , C12N9/2408 , C12N15/8509 , C12Y302/0102
摘要： The invention provides methods of treating Pompe's disease using human acid alpha glucosidase. A preferred treatment regime comprises administering greater than 10 mg/kg body weight per week to a patient.
摘要翻译：本发明提供了使用人类α-糖苷酶处理庞培病的方法。优选的治疗方案包括每周施用大于10mg / kg体重的患者。

10. 发明申请

US20060212952A1 Methods for cloning mammals using reprogrammed donor chromatin or donor cells 审中-公开
公开(公告)号：US20060212952A1
公开(公告)日：2006-09-21
申请号：US11439788
申请日：2006-05-24
申请人： Philippe Collas , James Robl , Eddie Sullivan , P. Kasinathan
发明人： Philippe Collas , James Robl , Eddie Sullivan , P. Kasinathan
IPC分类号： A01K67/027
CPC分类号： C12N15/8771 , A01K67/0273 , A01K2227/101 , A01K2227/102 , A01K2227/103 , A01K2227/105 , A01K2227/107 , A01K2227/108 , A01K2267/02 , C12N15/873 , C12N2501/999 , C12N2517/10
摘要： The invention provides methods for cloning mammals that allow the donor chromosomes or donor cells to be reprogrammed prior to insertion into an enucleated oocyte. The invention also features methods of inserting chromosomes or nuclei into recipient cells.

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