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1. 发明申请

US20180263238A1 CELL ENCAPSULATION DEVICE 审中-公开
公开(公告)号：US20180263238A1
公开(公告)日：2018-09-20
申请号：US15922251
申请日：2018-03-15
申请人： Boston Scientific Limited
发明人： Aiden Flanagan , Matthew McEvaddy , Martin L. Fawdry , Gary Duffy , Eamonn J. Tuohy
IPC分类号： A01N1/02 , C12N5/071
CPC分类号： A01N1/021 , A61F2/022 , A61K9/0024 , A61K35/22 , A61L2300/62 , A61L2300/64 , A61M2205/04 , C12N5/0677 , G01N2800/042
摘要： An implantable device for encapsulating cells includes one or more cell encapsulation layers. Each of the cell encapsulation layers includes a first membrane that is semipermeable, a second membrane that is semipermeable, and a first plurality of weld lines. The second membrane is attached to the first membrane by the first plurality of weld lines. The first membrane, the second membrane, and the first plurality of weld lines define at least one cell channel for encapsulating cells. The cell encapsulation device is configurable between a collapsed configuration and an inflated configuration.

2. 发明申请

US20180098867A1 IMPLANTABLE SYSTEMS AND STENTS CONTAINING CELLS FOR THERAPEUTIC USES 审中-公开
公开(公告)号：US20180098867A1
公开(公告)日：2018-04-12
申请号：US15785035
申请日：2017-10-16
申请人： Patrica G. Rojo
发明人： Nicholas A. Rojo
IPC分类号： A61F2/82 , A61M5/165 , A61F2/02
CPC分类号： A61F2/82 , A61F2/022 , A61F2250/0067 , A61M2005/1652
摘要： An implantable system includes cells that produce and release a therapeutic agent, or agents, to a host in need. The system can include cells capable of eluting therapeutic agents in response to changing physiological conditions within a host. The system may comprise naked cells, encapsulated cells, or a mixture of non-encapsulating and encapsulated cells. The system may also comprise cells, and/or cell groups, of different origins. The implantable device may be placed intra-vascular, within bone marrow, within soft tissue, in the peritoneal cavity, or intra-hepatic, etc. The system can be comprised of a stent, or like devices. Such stents and like devices may optionally include port(s), catheter(s), and containment envelope systems for holding the above cells.

3. 发明申请

US20170354760A1 ENCAPSULATION OF PANCREATIC CELLS DERIVED FROM HUMAN PLURIPOTENT STEM CELLS 审中-公开
公开(公告)号：US20170354760A1
公开(公告)日：2017-12-14
申请号：US15679002
申请日：2017-08-16
申请人： ViaCyte, Inc.
发明人： Laura Martinson , Chad Green , Evert Kroon , Emmanuel Edward Baetge
IPC分类号： A61L27/38 , A61L27/14 , A61M5/00 , A61M31/00 , A61F2/02 , A61L27/54 , A61L27/50 , C12N5/071 , A01N1/02 , A61K38/28 , A61K35/39 , A61L27/56 , A61K35/12
CPC分类号： A61L27/3804 , A01N1/0221 , A61F2/022 , A61K35/39 , A61K38/28 , A61K2035/126 , A61L27/14 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/62 , A61L2300/64 , A61M5/00 , A61M31/00 , A61M31/002 , A61M2202/07 , A61M2205/04 , C12N5/0676 , C12N5/0678 , C12N2501/115 , C12N2501/117 , C12N2501/119 , C12N2501/16 , C12N2501/19 , C12N2501/385 , C12N2501/41 , C12N2501/415 , C12N2506/02
摘要： The present invention relates to methods for encapsulating pancreatic progenitors in a biocompatible semi-permeable encapsulating device. The present invention also relates to production of human insulin in a mammal in response to glucose stimulation.

4. 发明授权

US09777259B2 Somatic stem cells 有权
公开(公告)号：US09777259B2
公开(公告)日：2017-10-03
申请号：US14877585
申请日：2015-10-07
申请人： StemBios Technologies, Inc.
发明人： James Wang
IPC分类号： C12N5/071 , A61M1/36 , A61K35/545 , C12N5/074 , A61F2/02
CPC分类号： C12N5/067 , A61F2/022 , A61K35/545 , A61M1/36 , C12N5/0607 , C12N2501/04 , C12N2501/11 , C12N2501/115 , C12N2501/12 , C12N2501/125 , C12N2501/135 , C12N2501/155 , C12N2501/16 , C12N2501/22 , C12N2501/237 , C12N2501/415
摘要： A somatic stem cell that is CD10+, CXCR4+, and CD31+ and another somatic stem cell that is CD105+, CD44+, and nestin+. Also disclosed are both a method of preparing these stem cells and a method of using them to treat degenerative diseases, e.g., a muscle-degenerative disease. The invention further includes making and using liver cells derived from the somatic cell that is CD105+, CD44+, and nestin+.

5. 发明申请

US20170252500A1 INTEGRATED HYBRID BIO-ARTIFICIAL LIVER BIOREACTOR DESIGN AND METHOD THEREOF 审中-公开
公开(公告)号：US20170252500A1
公开(公告)日：2017-09-07
申请号：US15224055
申请日：2016-07-29
申请人： Indian Institute of Technology, Kanpur
发明人： Ashok Kumar , Apeksha Damania
IPC分类号： A61M1/34 , C12M1/00 , A61M1/16 , A01N1/02
CPC分类号： A61M1/3489 , A01N1/0221 , A01N1/0236 , A01N1/0247 , A61F2/022 , A61M1/16 , C12M23/34 , C12M29/04 , C12M29/10
摘要： The present invention relates to the field of bio-artificial liver technology. Particularly, the invention provides an integrated hybrid bio-artificial liver support system that provides the features of artificial liver assist devices with that of bio-artificial liver support systems.

6. 发明申请

US20170232186A1 Implantable Cell Device with Supportive and Radial Diffusive Scaffolding 审中-公开
公开(公告)号：US20170232186A1
公开(公告)日：2017-08-17
申请号：US15582761
申请日：2017-04-30
申请人： Lars Ulrik Wahlberg , Jens Tornøe
发明人： Lars Ulrik Wahlberg , Jens Tornøe
IPC分类号： A61M5/14 , C12N5/00 , A61K35/12 , A61L31/04 , A61L31/00 , A61F2/02 , A61L31/16
CPC分类号： A61M5/14 , A61F2/02 , A61F2/022 , A61F2240/001 , A61K35/12 , A61K2035/126 , A61K2035/128 , A61L31/005 , A61L31/04 , A61L31/16 , A61L2300/62 , A61L2300/64 , A61M5/00 , C12N5/0012 , Y10T29/49826
摘要： The invention features an implantable cell device that includes a membrane defining and enclosing a chamber; a distance body within the chamber for reducing the diffusion distance for a biological active factor to or across the membrane; and a support scaffold within the chamber for increasing the cell support surface area per unit volume of the chamber for distributing cells.

7. 发明授权

US09669154B2 Implantable cell device with supportive and radial diffusive scaffolding 有权
公开(公告)号：US09669154B2
公开(公告)日：2017-06-06
申请号：US13876088
申请日：2011-09-27
申请人： Lars Ulrik Wahlberg , Jens Tornøe
发明人： Lars Ulrik Wahlberg , Jens Tornøe
IPC分类号： A61M5/00 , C12M1/12 , A61F2/02 , C12N5/00 , A61K35/12
CPC分类号： A61M5/14 , A61F2/02 , A61F2/022 , A61F2240/001 , A61K35/12 , A61K2035/126 , A61K2035/128 , A61L31/005 , A61L31/04 , A61L31/16 , A61L2300/62 , A61L2300/64 , A61M5/00 , C12N5/0012 , Y10T29/49826
摘要： The invention features an implantable cell device. The device includes a membrane defining and enclosing a chamber; a distance body, within the chamber, for reducing the diffusion distance for a biological active factor to or across the membrane; and a support scaffold, within the chamber, for increasing the cell support surface area per unit volume of the chamber for distributing cells.

8. 发明授权

US09463083B2 Air gap for supporting cells 有权
标题翻译：支撑细胞气隙
公开(公告)号：US09463083B2
公开(公告)日：2016-10-11
申请号：US14473127
申请日：2014-08-29
申请人： Beta O2 Technologies Ltd.
发明人： Yaki Stern , Yoram Rozy
IPC分类号： A61M37/00 , C12M1/00 , A61F2/02 , C12M1/04 , C12M1/12
CPC分类号： A61F2/022 , C12M21/02 , C12M21/08 , C12M23/24 , C12M25/06 , C12M31/10
摘要： Apparatus is provided, including a housing configured for insertion into a body of a subject; at least one oxygen reservoir disposed within the housing; and at least one layer of transplanted cells, disposed within the housing; and gaseous oxygen disposed within the at least one oxygen reservoir. Other embodiments are also described.
摘要翻译：提供了一种装置，包括被构造用于插入到被检体的身体中的壳体; 设置在所述壳体内的至少一个氧储存器; 以及设置在所述壳体内的至少一层移植细胞; 和设置在所述至少一个氧气储存器内的气态氧。还描述了其它实施例。

9. 发明申请

US20150217109A1 Multi-Layered Micro-Channel Electrode Array with Regenerative Selectivity 有权
标题翻译：具有再生选择性的多层微通道电极阵列
公开(公告)号：US20150217109A1
公开(公告)日：2015-08-06
申请号：US14605148
申请日：2015-01-26
申请人： The Charles Stark Draper Laboratory, Inc.
发明人： Anilkumar H. Achyuta , Bryan L. McLaughlin , James Hsiao
IPC分类号： A61N1/05 , A61F2/02
CPC分类号： A61N1/0551 , A61B5/04001 , A61B5/4893 , A61B5/6877 , A61F2/022 , A61F2250/0001 , A61F2250/0067 , A61N1/36003 , A61N1/36103
摘要： A scaffold defines a plurality of channels, into which axons of a severed nerve may regenerate, such as after limb amputation. Each channel includes a corresponding electrode. Regenerating axons may make electrical contact with the electrodes. Each channel is at least partially filled with a growth factor selected to selectively stimulate axon regeneration. Adjacent channels may include different growth factors, so as to attract different types of axons, for example efferent axons and afferent axons, to each of the adjacent channels. The growth factors may be distributed in the channels so as to present a gradient across a geometry of each channel. This gradient provides enhanced differentiated geometric guidance to the axons, thereby yielding better specificity, in terms of which axons regenerate into which channels. Topography, such as geometric patterns in walls, ceilings and floors of the channels, may also be used to selectively encourage axon regeneration into the channels.
摘要翻译：支架限定多个通道，切断的神经的轴突可以再生，例如肢体截肢后。每个通道包括相应的电极。再生轴突可能与电极电接触。每个通道至少部分地填充有选择性刺激轴突再生的生长因子。相邻的通道可以包括不同的生长因子，以便吸引不同类型的轴突，例如传出轴突和传入轴突到每个相邻通道。生长因子可以分布在通道中，以便在每个通道的几何形状上呈现梯度。该梯度提供对轴突的增强的差异几何指导，从而产生更好的特异性，其中轴突再生成哪些通道。还可以使用地形，例如墙壁，天花板和通道的地板中的几何图案，以选择性地鼓励轴突再生进入通道。

10. 发明授权

US08834979B2 Bag for forming an implantable artificial organ 有权
标题翻译：用于形成植入式人造器官的袋子
公开(公告)号：US08834979B2
公开(公告)日：2014-09-16
申请号：US13811601
申请日：2011-07-06
申请人： Serge Piranda
发明人： Serge Piranda
IPC分类号： A61F2/04 , A61F2/00 , A61F2/02 , C12M3/00 , C12M1/00
CPC分类号： A61F2/04 , A61F2/00 , A61F2/02 , A61F2/022 , A61F2002/0081 , A61F2002/0086 , C12M21/08 , C12M23/14 , Y10T428/1334 , Y10T428/24273 , Y10T428/24281
摘要： A pouch for forming an implantable artificial organ, including a closed shell provided in a semi-pervious membrane. The pouch further includes a sheet contained within the shell, the sheet including projections on the surface thereof for maintaining a space for cells between the sheet and the shell.
摘要翻译：一种用于形成植入式人造器官的袋，包括设置在半透膜中的封闭壳。袋还包括容纳在壳体内的片材，片材在其表面上包括突起，用于保持片材与壳体之间的细胞空间。

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