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1. 发明授权

US09526913B2 Non-invasive energy upconversion methods and systems 有权
标题翻译：非侵入式能量上转换方法和系统
公开(公告)号：US09526913B2
公开(公告)日：2016-12-27
申请号：US14168795
申请日：2014-01-30
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人： Tuan Vo-Dinh , Jonathan P. Scaffidi , Venkata Gopal Reddy Chada , Benoit Lauly , Yan Zhang , Molly K. Gregas , Ian Nicholas Stanton , Joshua T. Stecher , Michael J. Therien , Frederic A. Bourke, Jr. , Harold Walder , Zak Fathi , Jennifer A. Ayres , Zhenyuan Zhang , Joseph H. Simmons , Stephen John Norton
IPC分类号： A61N5/06 , A61K49/00 , A61L2/08 , A61N1/40 , A61N5/02
CPC分类号： A61N5/062 , A61B5/0059 , A61B5/0071 , A61B5/055 , A61B5/4848 , A61B6/481 , A61K41/0042 , A61K41/0052 , A61K41/0061 , A61K49/0039 , A61L2/0047 , A61L2/08 , A61L2202/21 , A61L2202/22 , A61M5/007 , A61N1/406 , A61N5/02 , A61N5/0601 , A61N5/0618 , A61N5/0622 , A61N5/0624 , A61N5/10 , A61N2005/063 , A61N2005/0656 , A61N2005/0659 , A61N2005/0662 , A61N2005/067 , A61N2005/1098
摘要： A nanoparticle-based system for enhancement of emitted light inside a medium. The nanoparticle-based system includes a phosphorescent material which, upon activation, produces the emitted light, and a metallic structure attached to the phosphorescent material. The metallic structure has a surface plasmon resonance which resonates at a frequency which spectrally overlaps with one or more frequencies of the emitted light.
摘要翻译：一种用于增强介质内发射光的基于纳米颗粒的系统。基于纳米颗粒的系统包括磷光材料，其在激活时产生发射的光，以及附着到磷光材料的金属结构。金属结构具有表面等离子体共振，其以与所发射的光的一个或多个频率光谱重叠的频率谐振。

2. 发明申请

US20160325111A1 NON-INVASIVE SYSTEMS AND METHODS FOR IN-SITU PHOTOBIOMODULATION 审中-公开
标题翻译：非入侵系统和用于现场光电转换的方法
公开(公告)号：US20160325111A1
公开(公告)日：2016-11-10
申请号：US15151642
申请日：2016-05-11
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人： Frederic A. BOURKE, JR. , Tuan VO-DINH , Harold WALDER
IPC分类号： A61N5/06 , A61N5/02 , A61N5/10 , A61K41/00 , A61K47/48
CPC分类号： A61N5/062 , A61K41/0057 , A61K41/0061 , A61K47/6923 , A61N5/022 , A61N5/0618 , A61N5/0622 , A61N5/10 , A61N2005/0642 , A61N2005/0659 , A61N2005/0661 , A61N2005/0662 , A61N2005/1098
摘要： Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.
摘要翻译：用于修饰介导或与生物活性相关的靶结构的产物，组合物，系统和方法，包括治疗由病毒，细胞，亚细胞结构介导或与靶结构相关的疾病，病症或疾病或胞外结构。所述方法可以通过向受试者施加起始能量以非侵入性方式原位进行，从而直接或经由调节剂产生对靶结构的作用或改变。所述方法还可以通过向受试者原位施加引发能量来直接或经由能量调节剂活化药剂，任选地在存在一种或多种等离子体激元活性剂的情况下进行，从而产生效果或改变目标结构。包含配制或配置的产品或组合的套件以及用于实施这些方法的系统。

3. 发明授权

US09371275B2 5-aminolevulinic acid prodrugs for use in photodynamic therapy and photodynamic diagnosis 有权
标题翻译：用于光动力学治疗和光动力学诊断的5-氨基乙酰丙酸前药
公开(公告)号：US09371275B2
公开(公告)日：2016-06-21
申请号：US14077469
申请日：2013-11-12
申请人： Swedish Pharma AB
发明人： Leif A. Eriksson , Lennart Löfgren
IPC分类号： C07C271/22 , C07D317/30 , A61K45/06 , A61K31/22 , A61K31/357 , C07C251/00 , A61K31/27 , A61K31/325 , A61K41/00 , C07C251/06 , C07C251/38
CPC分类号： C07C271/22 , A61K31/22 , A61K31/27 , A61K31/325 , A61K31/357 , A61K41/0061 , A61K45/06 , C07C251/00 , C07C251/06 , C07C251/38 , C07D317/30
摘要： There is provided a compound of Formula (I) and salts thereof, where R1 is an oxime or an alkylated oxime; the alkylated oxime comprises a linear or branched alkyl group of length C1 to C5; and R2 are each independently (a) an unsubstituted or substituted linear or branched alkyl group of chain length C1-7, (b) an aryl substituted alkyl group, where the aryl group is substituted, (c) an alkoxy substituted alkyl group, where the alkoxy group is substituted by a methoxy group or an alkoxy group substituted with an alkoxy group, or (d) an H atom, where the substituents in (a) and (b) are hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, nitro, oxo or fluoro groups. The compounds may be used as a medicament.
摘要翻译：提供式（I）的化合物及其盐，其中R 1是肟或烷基化的肟; 烷基化肟包含长度为C1至C5的直链或支链烷基; 和（R 2）各自独立地为（a）未取代或取代的链长C 1-7的直链或支链烷基，（b）芳基取代的烷基，其中芳基被取代，（c）烷氧基取代的烷基，其中烷氧基被甲氧基或被烷氧基取代的烷氧基取代，或（d）H原子，其中（a）和（b）中的取代基是羟基，烷氧基，酰氧基，烷氧基羰氧基，氨基，芳基，硝基，氧代或氟基团。这些化合物可以用作药物。

4. 发明授权

US09326964B2 Semi-solid compositions and pharmaceutical products 有权
标题翻译：半固体组合物和药物产品
公开(公告)号：US09326964B2
公开(公告)日：2016-05-03
申请号：US14707639
申请日：2015-05-08
申请人： PHOTOCURE ASA
发明人： Gry Stensrud
IPC分类号： A61K31/195 , A61K31/221 , A61K9/00 , A61K9/06 , A61K41/00 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/24 , A61K47/26
CPC分类号： A61K31/221 , A61K9/0031 , A61K9/0034 , A61K9/06 , A61K31/195 , A61K41/0061 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/24 , A61K47/26
摘要： This invention relates to semi-solid compositions and semi-solid pharmaceutical products for use in the photodynamic treatment (PDT) of cancer, pre-cancerous conditions and non-cancerous conditions in the female reproductive system, the anus and the penis, preferably for use in PDT of endometrial, cervical, vulvar, vaginal, anal and penile dysplasia and HPV infections of the uterus, cervix, the vulva, the vagina, the anus and the penis. The semi-solid compositions and pharmaceutical products comprise an active ingredient which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative of 5-ALA or pharmaceutically acceptable salts thereof. The invention relates further to methods of PDT of cancer, pre-cancerous conditions and non-cancerous conditions in the female reproductive system, the anus and the penis, wherein said semi-solid compositions and pharmaceutical products are used.
摘要翻译：本发明涉及用于癌症的光动力学治疗（PDT），女性生殖系统，肛门和阴茎中的癌前病症和非癌症状态的半固体组合物和半固体药物产品，优选用于在子宫内膜，子宫颈，外阴，阴道，肛门和阴茎发育异常和子宫，子宫颈，外阴，阴道，肛门和阴茎的HPV感染的PDT中。半固体组合物和药物产品包含5-氨基乙酰丙酸（5-ALA）或5-ALA的前体或衍生物的活性成分或其药学上可接受的盐。本发明还涉及在雌性生殖系统，肛门和阴茎中的癌症的PDT，癌前病症和非癌症病症的方法，其中使用所述半固体组合物和药物产品。

5. 发明申请

US20160045757A1 IRRADIATION DEVICE 有权
标题翻译：辐射装置
公开(公告)号：US20160045757A1
公开(公告)日：2016-02-18
申请号：US14783240
申请日：2014-04-09
申请人： PHOTOCURE ASA
发明人： Morten GROSETH
IPC分类号： A61N5/06 , A61K41/00
CPC分类号： A61N5/062 , A61K41/0061 , A61N5/0603 , A61N2005/0605 , A61N2005/0607 , A61N2005/0608 , A61N2005/0611 , A61N2005/0632 , A61N2005/0645 , A61N2005/0651 , A61N2005/0652
摘要： An irradiation device for insertion into an orifice of the body to provide photodynamic therapy comprises: a housing moulded from a resilient material and adapted to be fully inserted and secured in the orifice, the housing enclosing an LED lamp system 22 and a power source 41 for powering the LED lamp system 22; wherein the device is independently operational while located in the orifice; characterised in that: the housing comprises a first housing part 2 for holding the power source 41 and a second housing part 4 for holding the LED lamp system 22, the first and second housing parts 2, 4 being separable and being preferably formed separately from the LED lamp system 22; and in that the first housing part 2 consists of a chamber 6 for holding the power source 41 and an opening 26 into the chamber 6 is provided through a resilient opening part 8, wherein the chamber 6 is closed when the first housing part 2 is joined to the second housing part 4.
摘要翻译：一种用于插入身体的孔中以提供光动力疗法的照射装置包括：由弹性材料模制的并适于完全插入并固定在孔中的壳体，壳体包围LED灯系统22和用于为LED灯系统22供电; 其中所述装置在位于所述孔中时独立地操作; 其特征在于：壳体包括用于保持电源41的第一壳体部分2和用于保持LED灯泡系统22的第二壳体部分4，第一和第二壳体部分2,4可分离并优选地与 LED灯系统22; 并且第一壳体部分2包括用于保持动力源41的腔室6和通过弹性开口部分8设置在腔室6中的开口26，其中当第一壳体部分2接合时腔室6关闭到第二壳体部分4。

6. 发明申请

US20160030565A1 USE OF AMINOLEVULINIC ACID AND DERIVATIVES THEREOF 审中-公开
公开(公告)号：US20160030565A1
公开(公告)日：2016-02-04
申请号：US14873566
申请日：2015-10-02
申请人： Photocure ASA
发明人： Hans Christian Wulf , Aslak Godal , Jo Klaveness , Per Harald Fuglerud
IPC分类号： A61K41/00 , A61N5/06 , A61K31/221
CPC分类号： A61K41/0061 , A61K31/221 , A61N5/0616 , A61N5/062 , A61N2005/0652 , A61N2005/0662 , A61N2005/0663
摘要： The invention provides the use of a photosensitiser which is a derivative (e.g. an ester) of 5-aminolevulinic acid (5-ALA), or a pharmaceutically acceptable salt thereof, in the manufacture of a composition for use in methods of photodynamic therapy (PDT) on an animal, wherein said PDT comprises: (a) administering to said animal a composition comprising said photosensitiser; and (b) photoactivating said photosensitiser, and side-effects (e.g. pain and/or erythema) of said PDT are prevented or reduced by use of one or more of (i)-(iv): (i) said composition comprises said photosensitiser in a concentration of less than 10% wt (e.g. 0.5 to 8% wt), (ii) said composition is administered for less than 2 hours (e.g. 30 minutes to 90 minutes) prior to said photoactivation, (iii) said photoactivation is carried out with a light source having a fluence rate of less than 50 mW/cm2 (e.g. 5 to 40 mW/cm2), (iv) said photoactivation is carried out with sunlight. Preferably, side effects of PDT are prevented or reduced by using (ii) or (iv) in combination with (i) and/or (ii).

7. 发明申请

US20160016000A1 METHODS AND COMPOSITIONS FOR TREATING OCULAR GLAUCOMA 审中-公开
标题翻译：用于治疗眼睑炎的方法和组合物
公开(公告)号：US20160016000A1
公开(公告)日：2016-01-21
申请号：US14665575
申请日：2015-03-23
申请人： Massachusetts Eye and Ear Infirmary
发明人： Joan W. Miller , Akihisa Matsubara , Deeba Husain , Evangelos S. Gragoudas
IPC分类号： A61N5/06 , A61K41/00
CPC分类号： A61N5/062 , A61F9/00781 , A61F9/0079 , A61F9/008 , A61F2009/00868 , A61F2009/00891 , A61K41/0057 , A61K41/0061 , A61K41/0071 , A61K41/0076 , A61N2005/0662 , A61N2005/067
摘要： The invention provides a photodynamic therapy-based method for treating ocular glaucoma. A photosensitizer, for example, a benzoporphyrin derivative photosensitizer, is administered to a mammal either having or at risk of developing ocular glaucoma. The photosensitizer, when present in the ciliary body, is activated by light, for example, light from a laser. The treatment results in a reduction of intraocular pressure within the treated eye, which can persist for a prolonged period of time.
摘要翻译：本发明提供一种治疗眼部青光眼的基于光动力疗法的方法。将具有苯并卟啉衍生物光敏剂的光敏剂给予具有或具有发生眼睛青光眼风险的哺乳动物。光敏剂当存在于睫状体中时，被光激发，例如来自激光的光。该治疗导致治疗眼睛内的眼压降低，其可以持续较长时间。

8. 发明申请

US20150224211A1 LEUKOCYTES AS DELIVERY CELLS FOR IMAGING AND DISEASE THERAPY 审中-公开
标题翻译：作为成像和疾病治疗的递送细胞的白细胞介素
公开(公告)号：US20150224211A1
公开(公告)日：2015-08-13
申请号：US14694511
申请日：2015-04-23
申请人： Deryl L. Troyer , Stefan H. Bossmann
发明人： Deryl L. Troyer , Stefan H. Bossmann , Hongwang Wang , Matthew T. Basel , Tej B. Shrestha , Sebastian Wendel
IPC分类号： A61K49/00 , A61K9/127 , A61K47/46 , A61K41/00 , A61K31/65
CPC分类号： A61K49/0013 , A61K9/1271 , A61K31/65 , A61K41/0061 , A61K47/46 , A61K49/0021 , A61K49/0041 , A61K49/0084 , Y02A50/473
摘要： Theranostic methods are described herein, which are useful in diagnosing and/or treating infection, inflammation, and/or cancer. The methods utilize naturally-occurring leukocytes for in situ photodynamic therapy and imaging, and for the delivery of targeted therapies to the infection, inflammation, and/or cancer.
摘要翻译：治疗方法在本文中描述，其可用于诊断和/或治疗感染，炎症和/或癌症。该方法利用天然存在的白细胞用于原位光动力治疗和成像，并且用于将感染，炎症和/或癌症的靶向治疗递送。

9. 发明申请

US20150216830A1 5-AMINOLEVULINIC ACID DERIVATIVES, METHODS FOR THEIR PREPARATION AND USES THEREOF 审中-公开
标题翻译： 5-氨基酸衍生物，其制备方法及其用途
公开(公告)号：US20150216830A1
公开(公告)日：2015-08-06
申请号：US14663767
申请日：2015-03-20
申请人： BAR ILAN UNIVERSITY , RAMOT AT TEL AVIV UNIVERSITY LTD.
发明人： Ada REPHAELI , Nataly TARASENKO , Zvi MALIK , Abraham NUDELMAN , Gili BERKOVITCH-LURIA , Dvir DORON
IPC分类号： A61K31/221 , A61K45/06
CPC分类号： A61K31/221 , A61K31/197 , A61K31/225 , A61K41/0061 , A61K45/06 , A61K47/54 , A61K47/55 , A61K2300/00 , A61N5/062 , C07C229/22
摘要： There are provided conjugates comprising 5-aminolevulinic acid (5-ALA), an aldehyde and a carboxylic acid (e.g., a histone deacetylase inhibitor), compositions comprising same, methods for their preparation and uses thereof for treatment of cancer and anemia, and for inducing erythropoiesis.
摘要翻译：提供了包含5-氨基乙酰丙酸（5-ALA），醛和羧酸（例如组蛋白脱乙酰酶抑制剂）的组合物，包含其的组合物，其制备方法及其用于治疗癌症和贫血，以及用于诱导红细胞生成。

10. 发明申请

US20150031761A1 USE OF 5-AMINOLEVULINIC ACID AND DERIVATIVES IN A SOLID FORM FOR PHOTODYNAMIC TREATMENT AND DIAGNOSIS 审中-公开
标题翻译：用于光化学治疗和诊断的固体形式中的5-氨基酸和衍生物的使用
公开(公告)号：US20150031761A1
公开(公告)日：2015-01-29
申请号：US14333979
申请日：2014-07-17
申请人： Photocure ASA
发明人： Jo Klaveness , Gry Stensrud , Aslak Godal , Jon Erik Braenden , Bjorn Klem
IPC分类号： A61K9/02 , A61K41/00 , A61K31/221 , A61K9/48 , A61K9/28 , A61K9/14 , A61K9/20 , A61K49/00 , A61K31/197
CPC分类号： A61K9/02 , A61K9/0031 , A61K9/0034 , A61K9/0075 , A61K9/14 , A61K9/1635 , A61K9/1652 , A61K9/20 , A61K9/2013 , A61K9/205 , A61K9/2054 , A61K9/2077 , A61K9/28 , A61K9/284 , A61K9/2846 , A61K9/2866 , A61K9/2886 , A61K9/48 , A61K9/4858 , A61K9/4891 , A61K9/5042 , A61K9/5073 , A61K31/197 , A61K31/221 , A61K41/0057 , A61K41/0061 , A61K49/00 , A61K49/0021
摘要： The present invention relates to the use of a photosensitiser which is 5-ALA or a precursor or derivative thereof (e.g. an ALA ester), in the manufacture of a pharmaceutical product for use in the photodynamic treatment or diagnosis of cancer, an infection associated with cancer, or in the treatment or diagnosis of a non-cancerous condition, wherein said pharmaceutical product is in the form of a solid. The invention also relates to solid pharmaceutical products for use in such methods, e.g. suppositories, pessaries, tablets, pellets and capsules which comprise 5-ALA or a precursor or derivative thereof (e.g. an ALA ester) and at least one pharmaceutically acceptable carrier or excipient. Such products are particularly suitable for use in the photodynamic treatment or diagnosis of cancerous or non-cancerous conditions in the lower part of the gastrointestinal system or in the female reproductive system, e.g. in the treatment or diagnosis of colorectal cancer or cervical cancer.
摘要翻译：本发明涉及使用5-ALA或其前体或衍生物（例如ALA酯）的光敏剂在制造用于癌症的光动力学治疗或诊断的药物产品中，与癌症或治疗或诊断非癌症状况，其中所述药物产品为固体形式。本发明还涉及用于这些方法的固体药物产品，例如。栓剂，阴道栓剂，片剂，丸剂和胶囊，其包含5-ALA或其前体或衍生物（例如ALA酯）和至少一种药学上可接受的载体或赋形剂。这些产品特别适用于光动力学治疗或诊断胃肠系统下部或女性生殖系统中的癌性或非癌性病症。在结直肠癌或宫颈癌的治疗或诊断中。

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