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1. 发明申请

US20190184145A1 Implants for Localized Drug Delivery and Methods of Use Thereof 审中-公开
公开(公告)号：US20190184145A1
公开(公告)日：2019-06-20
申请号：US16273760
申请日：2019-02-12
申请人： The Regents of the University of California
发明人： Pamela MUNSTER , Jim KIRIAKIS , Hani SBITANY , Scott THOMAS
IPC分类号： A61M31/00 , A61L27/54 , A61L27/18 , A61K31/565 , A61K9/00 , A61K31/56
CPC分类号： A61M31/002 , A61K9/0004 , A61K9/0024 , A61K9/0041 , A61K9/0092 , A61K31/56 , A61K31/565 , A61L27/18 , A61L27/54 , C08L83/04
摘要： Provided herein is an implant for delivering a hydrophobic active agent to a target tissue. The implant may include a scaffold defining a first surface and a second surface opposite the first surface, wherein the scaffold is substantially impermeable to a hydrophobic active agent, and a silicone tubing having a wall permeable to the active agent, wherein a first length of the silicone tubing is affixed to the first surface of the scaffold, wherein the two ends of the silicone tubing extend from the first surface, and wherein a path outlined by a second length of the tubing within the first length is circuitous. Also provided is a method of using the implant to locally deliver a hydrophobic active agent to a target tissue, and kits that find use in performing the present method.

2. 发明授权

US09730865B2 Application and uses of PRG4 and therapeutic modulation thereof 有权
公开(公告)号：US09730865B2
公开(公告)日：2017-08-15
申请号：US13321532
申请日：2010-05-24
申请人： Benjamin Sullivan , Edward R. Truitt , David Sullivan
发明人： Benjamin Sullivan , Edward R. Truitt , David Sullivan
IPC分类号： A61B17/24 , A61K8/02 , A61L27/50 , A61K8/64 , A61K8/73 , A61K9/00 , A61K31/728 , A61Q11/00 , A61Q19/00 , A61K36/886 , A61K38/17 , C07K14/47 , C07K14/435 , A61K9/68
CPC分类号： A61K8/02 , A61K8/64 , A61K8/735 , A61K9/0014 , A61K9/0041 , A61K9/0048 , A61K9/0056 , A61K9/0058 , A61K9/0063 , A61K31/728 , A61K36/886 , A61K38/1709 , A61L27/50 , A61Q11/00 , A61Q19/00 , C07K14/435 , C07K14/47 , C07K14/4725 , C07K2317/41 , A61K2300/00
摘要： The present invention relates to the uses of the protein PRG4 and therapeutic modulation thereof. In particular, the present invention relates compositions and methods utilizing PRG4 and therapeutic modulation thereof, including, use as a surgical lubricant, use in a treatment for prevention or reduction of post-surgical adhesions, use in a treatment for oral ulcerations, use as an athletic lubricating patch, use as a dermal filler, use in a treatment for dry mouth, use in a drug delivery method or composition, and use in nursing lubrication.

3. 发明申请

US20170112863A1 NEW COMPOSITION 审中-公开
公开(公告)号：US20170112863A1
公开(公告)日：2017-04-27
申请号：US15400356
申请日：2017-01-06
申请人： Phosphagenics Limited
发明人： Roksan Libinaki , Robert Lee Neely
IPC分类号： A61K31/665 , A61K9/00 , A61K31/015 , A61K31/355 , A23K20/174 , A61K33/34 , A61K33/30 , A61K9/06 , A23K50/10 , A61K47/44 , A61K33/04
CPC分类号： A61K31/665 , A23K20/174 , A23K50/10 , A61K9/0014 , A61K9/0019 , A61K9/0041 , A61K9/0053 , A61K9/0095 , A61K9/06 , A61K31/015 , A61K31/07 , A61K31/355 , A61K31/66 , A61K33/04 , A61K33/30 , A61K33/34 , A61K45/06 , A61K47/44 , A61K2300/00
摘要： Compositions and formulations comprising a non-neutralised tocol phosphate and a vitamin A compound, which are suitable for the treatment of inflammation and/or infection in breast or udder tissue, more particularly in a mammary gland, reducing the somatic cell count in a lactating subject and supplementing vitamin E levels in a subject.

4. 发明申请

US20160263062A1 ANTIMICROBIAL COMPOSITIONS 审中-公开
标题翻译：抗微生物组合物
公开(公告)号：US20160263062A1
公开(公告)日：2016-09-15
申请号：US15031036
申请日：2014-10-22
申请人： DELAVAL HOLDING AB
发明人： Sarah Liebowitz , N. Camelia Traistaru
IPC分类号： A61K31/19 , A61K47/10 , A61K9/00 , A61K47/20
CPC分类号： A61K31/19 , A01N37/36 , A61K9/0041 , A61K47/10 , A61K47/20 , A01N25/30 , A01N2300/00
摘要： Antimicrobial compositions and related methods are disclosed. The antimicrobial compositions include glycolic acid, an anionic surfactant, and at least one additional surfactant selected from anionic and nonionic surfactants.
摘要翻译：公开了抗微生物组合物和相关方法。抗微生物组合物包括乙醇酸，阴离子表面活性剂和至少一种选自阴离子和非离子表面活性剂的另外的表面活性剂。

5. 发明授权

US09314472B2 Treatment and prevention of mastitis 有权
标题翻译：治疗和预防乳腺炎
公开(公告)号：US09314472B2
公开(公告)日：2016-04-19
申请号：US14056122
申请日：2013-10-17
申请人： Chad S. Beus , Paul B. Savage
发明人： Chad S. Beus , Paul B. Savage
IPC分类号： A61K31/56 , A61K31/575
CPC分类号： A61K31/575 , A61K9/0041
摘要： Treating and Preventing mastitis employing cationic steroidal antimicrobials (CSAs). Treating or preventing clinical mastitis in a mammal includes administering a cationic steroidal anti-microbial compound (CSA) formulation to the intra-mammary organ of a mammal (e.g., a dairy cow), such as by injection into the mammary organ (e.g., through the teat of the mammary organ), and/or topical application. The dairy cow can be lactating and have a somatic cell count (SCC) less than or equal to 500,000 cells/mL at the time of administering the CSA formulation. Alternatively, the dairy cow can be lactating and have a somatic cell count (SCC) greater than 500,000 cells/mL at the time of administering the CSA formulation. The dairy cow can be taken out of production during the administration of the CSA formulation for a period of time of about 3 days or less, 2 days or less, or 1 day or less.
摘要翻译：使用阳离子甾体抗菌药（CSA）治疗和预防乳腺炎。治疗或预防哺乳动物的临床乳腺炎包括向哺乳动物（例如，奶牛）的乳腺内器官施用阳离子甾族抗微生物化合物（CSA）制剂，例如通过注射入乳腺器官（例如，通过乳房器官的乳头）和/或局部应用。在施用CSA制剂时，奶牛可以是泌乳的并且具有小于或等于500,000细胞/ mL的体细胞计数（SCC）。或者，在施用CSA制剂时，奶牛可以是泌乳的并且具有大于500,000个细胞/ mL的体细胞计数（SCC）。在CSA制剂的给药期间，奶牛可以在约3天或更少，2天或更少或1天或更少的时间内被取出生产。

6. 发明授权

US09173836B2 Pharmaceutical preparations for treatments of diseases and disorders of the breast 有权
标题翻译：用于治疗乳腺疾病和疾病的药物制剂
公开(公告)号：US09173836B2
公开(公告)日：2015-11-03
申请号：US12871678
申请日：2010-08-30
申请人： Gerianne Tringali DiPiano , Peter Kevin Mays , John Ziemniak
发明人： Gerianne Tringali DiPiano , Peter Kevin Mays , John Ziemniak
IPC分类号： A61K31/58 , A61P15/00 , A61P21/00 , A61K38/09 , A61K31/137 , A61K9/00 , A61K9/06 , A61K31/445 , A61K47/10 , A61K47/22
CPC分类号： A61K9/0014 , A61K9/0041 , A61K9/06 , A61K31/445 , A61K47/10 , A61K47/22
摘要： Formulations for topical or local administration of drugs directly to the breast or chest to produce a regional or local effect with lower systemic drug levels than when an effective amount is administered systemically are disclosed herein. In a preferred embodiment, the drug is administered to the surface of the breast, areola, or directly to the nipple. The formulations provide increased patient comfort, increased bioavailability and relatively high blood levels in the region to be treated with a reduction of side effects compared to those administered systemically. The preferred formulations contain drugs in the form of micro or nanoparticles, which may be formed of drug alone or in combination with an excipient or carrier. The excipient or carrier may modify the release rates or enhance absorption into the affected area. The drug formulation may be in the form of a cream, lotion or foam.
摘要翻译：在本文中公开了用于局部或局部施用药物的制剂直接进入乳房或胸部以产生具有比全身施用有效量的更低的全身药物水平的区域或局部作用。在优选的实施方案中，将药物施用于乳房，乳晕或者乳头的表面。与全身施用的那些相比，该制剂提供了增加的患者舒适度，增加的生物利用度和待治疗的区域中相对较高的血液水平，同时减少副作用。优选的制剂含有微量或纳米颗粒形式的药物，其可以单独使用药物或与赋形剂或载体组合形成。赋形剂或载体可以改变释放速率或增强对受影响区域的吸收。药物制剂可以是霜剂，洗剂或泡沫剂的形式。

7. 发明申请

US20150250816A1 METHOD OF TREATING A MAMMALIAN TEAT AND RELATED COMPOSITIONS 审中-公开
标题翻译：一种麦芽糖胺和相关组合物的处理方法
公开(公告)号：US20150250816A1
公开(公告)日：2015-09-10
申请号：US14720368
申请日：2015-05-22
申请人： Zurex PharmAgra, Inc.
发明人： Carmine J. Durham , Michael C. Pawlak , Randal D. Stevenson
IPC分类号： A61K31/765 , A61K31/194 , A61K47/10 , A61K31/235 , A61K31/5415 , A61K9/70
CPC分类号： A61K31/765 , A61K9/0041 , A61K9/06 , A61K9/08 , A61K9/7015 , A61K31/194 , A61K31/235 , A61K31/5415 , A61K47/02 , A61K47/10 , A61K47/32 , A61K47/36 , A61K47/38 , A61K2800/42 , A61K2300/00
摘要： A method of treating or protecting a mammalian teat by applying a topical composition to the teat, wherein the topical conditioning composition comprises (a) citrate; (b) methylene blue; and (c) an alkyl para-hydroxybenzoate; as well as related methods and compositions.
摘要翻译：一种通过将局部组合物施用于乳头来治疗或保护哺乳动物奶头的方法，其中所述局部调理组合物包含（a）柠檬酸盐; （b）亚甲基蓝; 和（c）对羟基苯甲酸烷基酯; 以及相关方法和组成。

8. 发明申请

US20150051300A1 ANTIINFECTIVE FREE INTRAMAMMARY VETERINARY COMPOSITION 审中-公开
标题翻译：抗生素免费内分泌兽药组合物
公开(公告)号：US20150051300A1
公开(公告)日：2015-02-19
申请号：US14184100
申请日：2014-02-19
申请人： Bimeda Research & Development Limited
发明人： Vincent McNally , James Patrick Morgan
IPC分类号： A61K47/02 , A61K47/06
CPC分类号： A61K33/245 , A01J7/04 , A23K50/10 , A61K9/0041 , A61K9/06 , A61K31/20 , A61K47/02 , A61K47/06
摘要： An antiinfective-free formulation for prophylactic treatment of mastitis in dry cows comprises a seal formulation, having approximately 65% by weight of bismuth sub-nitrate in a gel based on aluminum stearate. The seal formulation is prepared by adding the bismuth sub-nitrate to the gel base in at least two separate stages.
摘要翻译：用于在干牛中预防乳腺炎的抗感冒制剂包括密封制剂，其在基于硬脂酸铝的凝胶中具有约65重量％的亚硝酸铋。通过在至少两个分开的阶段向凝胶基质中加入亚硝酸铋制备密封制剂。

9. 发明授权

US08442629B2 Iontophoresis preparation for treating breast cancer and/or mastitis 失效
标题翻译：用于治疗乳腺癌和/或乳腺炎的离子电渗疗法
公开(公告)号：US08442629B2
公开(公告)日：2013-05-14
申请号：US12988047
申请日：2009-04-17
申请人： Kenichi Suzuki , Makoto Kanebako , Toshio Inagi
发明人： Kenichi Suzuki , Makoto Kanebako , Toshio Inagi
IPC分类号： A61N1/30 , A61K33/00
CPC分类号： A61K45/06 , A61K9/0009 , A61K9/0041 , A61K31/555 , A61K31/675 , A61K33/24 , A61N1/044 , A61N1/0448 , A61K2300/00
摘要： Provided is to enhance the therapeutic effect of an iontophoretic preparation for treatment of breast cancer or mastitis.An iontophoretic preparation for treatment of breast cancer and/or mastitis containing, as an active ingredient, a nonsteroidal anti-inflammatory analgesic agent and/or an anticancer agent, wherein an electrolyte is topically administered through the nipple part into the mammary gland; subsequently, a donor is applied to the nipple part; and the active ingredient is topically administered through the nipple part into the mammary gland by application of current.
摘要翻译：提供用于治疗乳腺癌或乳腺炎的离子电渗疗法的治疗效果。一种用于治疗乳腺癌和/或乳腺炎的离子电渗疗法制剂，其包含作为活性成分的非甾体抗炎止痛剂和/或抗癌剂，其中电解质通过乳头部分局部施用到乳腺中; 随后，将供体施加到乳头部分; 并且活性成分通过施加电流通过乳头部分局部施用到乳腺中。

10. 发明申请

US20130085137A1 Topical antimicrobial compositions and methods of using same 审中-公开
标题翻译：局部抗微生物组合物及其使用方法
公开(公告)号：US20130085137A1
公开(公告)日：2013-04-04
申请号：US13573544
申请日：2012-09-21
申请人： Hydromer, Inc.
发明人： Irina Grigorian , Manfred F. Dyck , Rainer Gruening
IPC分类号： A61K31/5415 , A61K31/15
CPC分类号： A61K31/5415 , A61K9/0017 , A61K9/0041 , A61K9/08 , A61K31/136 , A61K31/15
摘要： The invention includes a method of treating a mammal comprising topically applying an aqueous composition to a target site on the mammal, wherein the aqueous composition comprises: active ingredients comprising i) a cosmetic dye selected from a violet, blue or green dye, or combinations thereof, and ii) an enhancing ingredient, wherein the relative weight percentage of the cosmetic dye to the enhancing ingredient is about 1:2 to about 40:1, wherein the cosmetic dye interacts with keratinous material thereby i) substantially staining the target site and ii) inhibiting the active ingredients from significantly leaching from the target site.
摘要翻译：本发明包括治疗哺乳动物的方法，其包括将水性组合物局部施用于哺乳动物的靶位点，其中所述水性组合物包含：活性成分，其包含i）选自紫色，蓝色或绿色染料的化妆品染料或其组合，和ii）增强成分，其中化妆品染料与增强成分的相对重量百分比为约1:2至约40:1，其中化妆品染料与角质材料相互作用，从而i）基本上染色靶位点和ii ）抑制活性成分从目标部位显着浸出。

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