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1. 发明申请

US20170368222A1 SOLUTION FOR TREATING CONTACT LENS AND CONTACT LENS PACKAGING SYSTEM 审中-公开
公开(公告)号：US20170368222A1
公开(公告)日：2017-12-28
申请号：US15343229
申请日：2016-11-04
申请人： PEGAVISION CORPORATION
发明人： Yu-Chin LAI , Min-Tzong YEH , Han-Yi CHANG , Ya-Hui CHANG
IPC分类号： A61L12/14 , A61L12/08
CPC分类号： A61L12/14 , A61L12/08 , A61L12/086 , C11D3/0078 , C11D3/227 , C11D3/3784
摘要： A solution for treating a contact lens and a contact lens packaging system are provided. The solution includes about 0.01 to about 1.0 parts by weight (pbw) of a polymer having phosphorylcholine groups, about 0.005 to about 0.05 pbw of a hydrophilic molecule, about 0.01 to about 1.0 pbw of an inorganic salt, and about 100 pbw of water. A number-average molecular weight of the polymer is about 4,000 to about 1,000,000 daltons. The polymer has a structure of formula (I): wherein, in formula (I), m is a positive integer, n is zero or a positive integer, and R is C2-C12 alkyl group, or C2-C12 hydroxyalkyl group. When n is a positive integer, m/n is greater than 1. Moreover, a number-average molecular weight of the hydrophilic molecule is about 10,000 to about 5,000,000 daltons. The hydrophilic molecule is hyaluronic acid (HA) or hyaluronate salt.

2. 发明申请

US20170368221A1 SOLUTION FOR TREATING CONTACT LENS 有权
公开(公告)号：US20170368221A1
公开(公告)日：2017-12-28
申请号：US15256637
申请日：2016-09-05
申请人： PEGAVISION CORPORATION
发明人： Han-Yi CHANG , Ya-Hsuan LIAO , Shu-Chen LU , Ya-Hui CHANG , Yu-Chin LAI
IPC分类号： A61L12/14 , C11D3/36 , C11D3/00 , C08F130/02 , C11D3/04 , C11D3/37 , C11D3/16
CPC分类号： A61L12/14 , A61K9/0048 , A61K9/08 , A61K47/32 , C08F130/02 , C11D3/0078 , C11D3/042 , C11D3/046 , C11D3/168 , C11D3/365 , C11D3/3784 , C11D7/10
摘要： A solution for treating contact lens is provided. The solution includes about 0.01-1.0 parts by weight (pbw) of a polymer having phosphorylcholine groups, about 0.01-1 pbw of an inorganic salt, and about 100 pbw of water. The polymer has a number-average molecular weight of about 4,000 to about 1,000,000 daltons and has a structure of formula (I): wherein, in formula (I), m is a positive integer, n is zero or a positive integer, and R is C2-C12 alkyl group or C2-C12 hydroxyalkyl group. When n is a positive integer, m/n is greater than 1.

3. 发明申请

US20170298296A1 CONTACT LENS CARE SOLUTION 有权
公开(公告)号：US20170298296A1
公开(公告)日：2017-10-19
申请号：US15397642
申请日：2017-01-03
申请人： BenQ Materials Corporation
发明人： Fan-Dan Jan , Bo-Ching Lin , Min-Chun Chung
IPC分类号： C11D3/00 , C11D3/20 , A61L12/14 , C11D3/37
CPC分类号： C11D3/0078 , A61L12/14 , A61L12/141 , C11D3/06 , C11D3/2065 , C11D3/2082 , C11D3/2086 , C11D3/222 , C11D3/33 , C11D3/3773
摘要： The invention is related to a contact lens care solution comprising a buffer solution, a chelating agent, a surfactant and a wetting agent, wherein the wetting agent comprises 100 parts by weight of glycerol, 0.5 to 40 parts by weight of vinylacetamide-containing polymer and 5 to 40 parts by weight of alginic acid.

4. 发明申请

US20160330962A1 COMPOSITIONS COMPRISING A BIOCIDAL POLYAMINE 有权
标题翻译：包含生物聚酰胺的组合物
公开(公告)号：US20160330962A1
公开(公告)日：2016-11-17
申请号：US15222576
申请日：2016-07-28
申请人： Curza Global, LLC , University of Utah Research Foundation
发明人： Ryan Looper , Dustin Williams , Sujeevini Jeyapalina , Travis Haussener , Paul R. Sebahar , Hariprasada R. Kanna Reddy
IPC分类号： A01N47/28 , A01N33/10 , A01N33/08 , A01N47/12 , A01N37/18 , A01N43/30 , A01N43/84 , A01N43/10 , A01N43/40 , A01N43/54 , A01N43/56 , A61L31/14 , A61L29/14 , A61K8/41 , A61K8/42 , A61K8/49 , A61Q5/02 , A61Q19/10 , A61Q19/00 , A61Q15/00 , A61L2/232 , C09D5/14 , A01N33/04
CPC分类号： A01N47/28 , A01N33/04 , A01N33/08 , A01N33/10 , A01N37/18 , A01N37/30 , A01N37/40 , A01N43/10 , A01N43/30 , A01N43/40 , A01N43/54 , A01N43/56 , A01N43/84 , A01N47/12 , A61K8/41 , A61K8/42 , A61K8/49 , A61K8/4926 , A61K8/494 , A61K8/4953 , A61K8/4973 , A61K8/4986 , A61K31/135 , A61K31/166 , A61L2/18 , A61L2/22 , A61L2/232 , A61L2/235 , A61L12/14 , A61L29/14 , A61L31/14 , A61L2202/21 , A61L2202/24 , A61Q5/02 , A61Q15/00 , A61Q19/007 , A61Q19/10 , C07C211/27 , C07C211/29 , C07C217/58 , C07C233/78 , C07C271/20 , C07C275/14 , C07C2601/14 , C07D295/135 , C07D317/58 , C08K5/17 , C09D5/14
摘要： Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.
摘要翻译：描述了包含多胺化合物的化合物，组合物和方法，其可用于杀死，分散，治疗或减少生物膜，或抑制或基本上防止生物膜形成。在某些方面，本发明涉及包含对能够形成生物膜的各种细菌菌株具有抗微生物或分散活性的多胺化合物的化合物，组合物和方法。

5. 发明授权

US09439433B2 Compositions and methods comprising a biocidal polyamine 有权
标题翻译：包含杀生物多胺的组合物和方法
公开(公告)号：US09439433B2
公开(公告)日：2016-09-13
申请号：US14507701
申请日：2014-10-06
申请人： Curza Global, LLC , University of Utah Research Foundation
发明人： Ryan Looper , Dustin Williams , Sujeevini Jeyapalina , Travis Haussener , Paul R. Sebahar , Hariprasada R. Kanna Reddy
IPC分类号： A01N43/84 , A61K31/166 , A01N47/12 , A01N43/56 , A01N47/28 , A01N33/10 , A01N37/40 , A01N37/30 , A01N43/54 , C07C217/58 , C07C275/14 , C07C271/20 , C07C211/29 , A61K31/135 , C07C211/27 , A01N43/40 , A01N43/10 , A01N33/04 , C07C233/78 , A01N37/18 , C07D317/58 , A01N43/30 , C07D295/135 , A61L2/18 , A61L2/22 , A61L2/235 , A61L12/14
CPC分类号： A01N47/28 , A01N33/04 , A01N33/08 , A01N33/10 , A01N37/18 , A01N37/30 , A01N37/40 , A01N43/10 , A01N43/30 , A01N43/40 , A01N43/54 , A01N43/56 , A01N43/84 , A01N47/12 , A61K8/41 , A61K8/42 , A61K8/49 , A61K8/4926 , A61K8/494 , A61K8/4953 , A61K8/4973 , A61K8/4986 , A61K31/135 , A61K31/166 , A61L2/18 , A61L2/22 , A61L2/232 , A61L2/235 , A61L12/14 , A61L29/14 , A61L31/14 , A61L2202/21 , A61L2202/24 , A61Q5/02 , A61Q15/00 , A61Q19/007 , A61Q19/10 , C07C211/27 , C07C211/29 , C07C217/58 , C07C233/78 , C07C271/20 , C07C275/14 , C07C2601/14 , C07D295/135 , C07D317/58 , C08K5/17 , C09D5/14
摘要： Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.
摘要翻译：描述了包含多胺化合物的化合物，组合物和方法，其可用于杀死，分散，治疗或减少生物膜，或抑制或基本上防止生物膜形成。在某些方面，本发明涉及包含对能够形成生物膜的各种细菌菌株具有抗微生物或分散活性的多胺化合物的化合物，组合物和方法。

6. 发明申请

US20160199526A1 OPHTHALMIC SOLUTION 审中-公开
标题翻译： OPHTHALMIC解决方案
公开(公告)号：US20160199526A1
公开(公告)日：2016-07-14
申请号：US14914066
申请日：2014-08-05
申请人： NOF CORPORATION
发明人： Shunsuke SAKURAI , Koji MIYAMOTO , Yohei TAKADA , Yoshihisa SHIMAMURA , Mao MARUHASHI , Nobuyuki SAKAMOTO
IPC分类号： A61L12/10 , A61L12/14
CPC分类号： A61L12/10 , A61K9/0048 , A61K31/155 , A61K47/02 , A61K47/32 , A61K47/34 , A61K47/38 , A61L12/14 , A61L12/141 , A61L12/142
摘要： Provided is an ophthalmic solution of which preservative component, hexamethylene biguanide, contained therein is inhibited from being adsorbed on soft contact lenses and eye droppers. The ophthalmic solution contains, at a specific ratio, (A) hydroxypropyl methylcellulose having 28.0 to 30.0 mass % methoxy groups and 7.0 to 12.0 mass % hydroxypropoxy groups, both with respect to the total amount of the hydroxypropyl methylcellulose, at a methoxy group/hydroxypropoxy group ratio of 2.5 to 4.0 by mass, wherein a 2 mass % aqueous solution of the hydroxypropyl methylcellulose at 20° C. has a viscosity of 50 to 4000 mPa·s; (B) sodium chloride or potassium chloride; (C) hexamethylene biguanide or a salt thereof; (D) 2-methacryloyloxyethyl phosphorylcholine/butyl methacrylate copolymer; and (E) water.
摘要翻译：本发明提供了防止其中含有六亚甲基双胍的防止组分被吸收在软性隐形眼镜和滴眼剂上的眼用溶液。该眼用溶液在甲氧基/羟丙氧基上以特定比例含有（A）具有28.0〜30.0质量％甲氧基的羟丙基甲基纤维素和7.0〜12.0质量％羟丙氧基，相对于羟丙基甲基纤维素的总量组合比为2.5〜4.0质量％，其中羟丙基甲基纤维素在20℃下的2质量％水溶液的粘度为50〜4000mPa·s; （B）氯化钠或氯化钾; （C）六亚甲基双胍或其盐; （D）2-甲基丙烯酰氧基乙基磷酸胆碱/甲基丙烯酸丁酯共聚物; 和（E）水。

7. 发明授权

US09321890B2 Macroinitiator containing hydrophobic segment 有权
标题翻译：含有疏水部分的大分子引发剂
公开(公告)号：US09321890B2
公开(公告)日：2016-04-26
申请号：US14301584
申请日：2014-06-11
申请人： Johnson & Johnson Vision Care, Inc.
发明人： Ryuta Tamiya , Kazuhiko Fujisawa , Masataka Nakamura
IPC分类号： G02B1/10 , C08G77/452 , C08G77/26 , C08G77/388 , C08L83/08 , G02B1/04 , A61L27/18 , A61L12/14
CPC分类号： C08L83/10 , A61L12/14 , A61L27/18 , A61L2430/16 , C08G77/26 , C08G77/388 , C08G77/452 , C08L83/08 , C08L2201/10 , C08L2201/54 , C08L2203/02 , G02B1/043 , G02B1/18 , C08L101/14 , C08L83/04
摘要： The present invention relates to macroinitiators comprising at least one hydrophobic segments in a molecule, wherein a molecular weight of the hydrophobic segment is 300 to 1800. The present invention further relates to block copolymers, wetting agent and polymeric materials having the block copolymers of the present invention associated with, which is suitable for medical devices, particularly for ophthalmic devices, including contact lenses, ophthalmic lenses, punctal plugs and artificial corneas.
摘要翻译：本发明涉及包含分子中至少一个疏水链段的大分子引发剂，其中疏水链段的分子量为300至1800.本发明还涉及嵌段共聚物，润湿剂和具有本发明的嵌段共聚物的聚合物材料其适用于医疗装置，特别是用于眼科装置，包括隐形眼镜，眼用透镜，泪点塞和人造角膜。

8. 发明申请

US20150038512A1 COMPOSITIONS AND METHODS COMPRISING A BIOCIDAL POLYAMINE 有权
标题翻译：包含生物聚酰胺的组合物和方法
公开(公告)号：US20150038512A1
公开(公告)日：2015-02-05
申请号：US14507701
申请日：2014-10-06
申请人： Curza Global, LLC , The University of Utah
发明人： Ryan Looper , Dustin Williams , Sujeevini Jeyapalina , Travis Haussener , Paul R. Sebahar , Hariprasada R. Kanna Reddy
IPC分类号： A01N43/84 , A01N33/04 , C07D295/135 , A01N37/18 , C07D317/58 , A01N43/30 , C07C211/09 , C07C233/78
CPC分类号： A01N47/28 , A01N33/04 , A01N33/08 , A01N33/10 , A01N37/18 , A01N37/30 , A01N37/40 , A01N43/10 , A01N43/30 , A01N43/40 , A01N43/54 , A01N43/56 , A01N43/84 , A01N47/12 , A61K8/41 , A61K8/42 , A61K8/49 , A61K8/4926 , A61K8/494 , A61K8/4953 , A61K8/4973 , A61K8/4986 , A61K31/135 , A61K31/166 , A61L2/18 , A61L2/22 , A61L2/232 , A61L2/235 , A61L12/14 , A61L29/14 , A61L31/14 , A61L2202/21 , A61L2202/24 , A61Q5/02 , A61Q15/00 , A61Q19/007 , A61Q19/10 , C07C211/27 , C07C211/29 , C07C217/58 , C07C233/78 , C07C271/20 , C07C275/14 , C07C2601/14 , C07D295/135 , C07D317/58 , C08K5/17 , C09D5/14
摘要： Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.
摘要翻译：描述了包含多胺化合物的化合物，组合物和方法，其可用于杀死，分散，治疗或减少生物膜，或抑制或基本上防止生物膜形成。在某些方面，本发明涉及包含对能够形成生物膜的各种细菌菌株具有抗微生物或分散活性的多胺化合物的化合物，组合物和方法。

9. 发明申请

US20120016102A1 NON-TOXIC BIOFILM INHIBITOR 有权
标题翻译：非毒性生物膜抑制剂
公开(公告)号：US20120016102A1
公开(公告)日：2012-01-19
申请号：US13179058
申请日：2011-07-08
申请人： Robert S. Hodges , Randall T. Irvin , Carmen Giltner , Erin Van Schaik
发明人： Robert S. Hodges , Randall T. Irvin , Carmen Giltner , Erin Van Schaik
IPC分类号： C07K7/08 , C07K14/00
CPC分类号： A61K38/164 , A61L12/14 , A61L27/227 , A61L27/54 , A61L29/048 , A61L29/16
摘要： The present invention relates to a composition, device and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of Pseudomonas aeruginosa type IV pilin, which binds to an abiotic surface (e.g., steel, plastic) with high affinity and prevents binding of a variety of P. aeruginosa strains to the surface. The inventive composition represents a non-toxic inhibitor for biofilm formation, particularly on an abiotic surface, which is responsible for a large number of problematic diseases and massive economic losses. The inventive method is useful as a safe and environmentally friendly means of modifying a surface of a variety of biomedical, nanotechnological, and biotechnological devices or articles.
摘要翻译：本发明涉及在生物或非生物表面上预防或抑制生物膜形成的组合物，装置和方法。组合物包含基于铜绿假单胞菌IV型皮林的C-末端受体结合结构域的肽，其以高亲和力结合非生物表面（例如，钢，塑料），并防止多种铜绿假单胞菌菌株与表面。本发明的组合物代表用于生物膜形成的无毒性抑制剂，特别是在非生物表面上，其负责大量有问题的疾病和巨大的经济损失。本发明的方法可用作改变各种生物医学，纳米技术和生物技术装置或制品的表面的安全和环境友好的手段。

10. 发明申请

US20090304811A1 Pharmaceutical Formulations Comprising Stabilized Polysaccharides and Source of Hydrogen Peroxide 有权
标题翻译：包含稳定多糖和过氧化氢源的药物制剂
公开(公告)号：US20090304811A1
公开(公告)日：2009-12-10
申请号：US12468136
申请日：2009-05-19
申请人： Erning Xia , Michael E. Allen , Steven K. MacLeod , Tammy J. Kleiber , Graig M. Cody
发明人： Erning Xia , Michael E. Allen , Steven K. MacLeod , Tammy J. Kleiber , Graig M. Cody
IPC分类号： A61K33/40 , A61K33/22 , C11D3/04
CPC分类号： C11D3/0078 , A61K9/0048 , A61K9/08 , A61K31/715 , A61K31/726 , A61K31/728 , A61K31/734 , A61K33/40 , A61K47/08 , A61K47/10 , A61K47/36 , A61L12/124 , A61L12/14 , A61L12/145 , C11D3/222 , C11D3/3947 , A61K2300/00
摘要： A pharmaceutical formulation that is effective in adversely affecting the viability of microorganisms or in inhibiting their growth and that provides better safety and/or comfort to the users comprises a polysaccharide, a source of hydrogen peroxide, and an anti-oxidant. The formulation can further comprise a chelating agent and/or an ophthalmically active agent for treating or controlling a disease or disorder of the eye. The formulation may be used to treat, clean, disinfect, store, wet, or rewet contact lenses.
摘要翻译：有效地不利地影响微生物活力或抑制其生长并为使用者提供更好的安全性和/或舒适性的药物制剂包括多糖，过氧化氢源和抗氧化剂。制剂还可以包含用于治疗或控制眼疾病或病症的螯合剂和/或眼用活性剂。该制剂可用于治疗，清洁，消毒，储存，湿润或再湿润隐形眼镜。

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