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1. 发明申请

US20190192735A1 Biomolecular Patterning of Three Dimensional Tissue Scaffolds 审中-公开
公开(公告)号：US20190192735A1
公开(公告)日：2019-06-27
申请号：US14001327
申请日：2012-02-27
申请人： Ryan C. Bailey , Brendan A. Harley , Teresa A. Martin , Steven R. Caliari
发明人： Ryan C. Bailey , Brendan A. Harley , Teresa A. Martin , Steven R. Caliari
IPC分类号： A61L27/38 , C12N5/00 , C08B37/00 , C12N5/077
CPC分类号： A61L27/38 , A61K35/12 , A61K35/32 , A61K38/1858 , A61K38/30 , A61L27/26 , A61L27/48 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2430/02 , A61L2430/06 , A61L2430/20 , A61L2430/28 , A61L2430/30 , A61L2430/32 , A61L2430/40 , C08B37/0063 , C12N5/0062 , C12N5/0654 , C12N5/0655 , C12N5/0657 , C12N5/0658 , C12N2533/54 , C08L89/06
摘要： The invention provides methods and compositions for making and using collagen-glycosaminoglycan three-dimensional scaffolds immobilized with biomolecules that are spatially and temporally patterned. The method comprises adding benzophenone to a collagen-glycosaminoglycan three dimensional scaffold in the dark; adding one or more biomolecules to one or more areas of the collagen-glycosaminoglycan three-dimensional scaffold (which can be done optionally in the dark or in the light); and exposing the collagen-2glycosaminoglycan three-dimensional scaffold to light at a wavelength of about 350 to about 365 nm.

2. 发明申请

US20190117855A1 PROTEIN BIOMATERIAL AND BIOCOACERVATE VESSEL GRAFT SYSTEMS AND METHODS OF MAKING AND USING THEREOF 审中-公开
公开(公告)号：US20190117855A1
公开(公告)日：2019-04-25
申请号：US15987827
申请日：2018-05-23
申请人： Gel-Del Technologies, Inc.
发明人： David B. Masters
IPC分类号： A61L31/16 , A61L27/50 , A61L31/04 , A61L27/54 , A61L24/00 , A61L27/26 , A61L24/10 , A61L24/04
CPC分类号： A61L31/16 , A61L24/0015 , A61L24/043 , A61L24/108 , A61L27/26 , A61L27/507 , A61L27/54 , A61L31/041 , A61L31/047 , A61L2300/802 , C08L89/06
摘要： The present invention relates to protein biocoacervates and biomaterials vessel graft systems used in cardiovascular applications and other medical applications, the components utilized in the vessel graft systems and the methods of making and using such systems. More specifically the present invention relates to protein biocoacervates and biomaterials vessel graft systems used in various medical applications and/or the devices used in such vessel graft systems including, but not limited to, vessel grafts as drug delivery devices for the controlled release of pharmacologically active agents, tubular grafts, vascular grafts, protein biomaterial sutures and biomeshes, protein biomaterial adhesives and glues, and other biocompatible biocoacervate or biomaterial devices used in the vessel graft systems of the present invention.

3. 发明申请

US20190030213A1 BIOLOGICAL AGENTS FOR THE INDUCTION OF BIOMINERALIZATION 审中-公开
公开(公告)号：US20190030213A1
公开(公告)日：2019-01-31
申请号：US15988914
申请日：2018-05-24
申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
发明人： Bernhard GANSS , Yuichi IKEDA
IPC分类号： A61L27/54 , A61L27/26 , A61L27/56 , A61L27/52
CPC分类号： A61L27/54 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/52 , A61L27/56 , A61L2300/252 , A61L2430/02 , A61L2430/12 , C08L89/06
摘要： This disclosure provides a product comprised of a collagen gel to which recombinant human Amelotin (AMTN) protein is added. This AMTN-collagen gel is applied to one side of a physiologically acceptable scaffold that has first been impregnated with AMTN-free collagen gel. The resulting two-layer collagen membrane (layer 1 comprised of scaffold surrounded by collagen gel; layer 2 comprised of collagen gel containing AMTN) is applied to a mineralized tissue surface such as dentin and bone with the collagen gel containing AMTN of layer 2 facing this mineral surface. Upon immersion in simulated body fluid (SBF), the presence of AMTN in layer 2 triggers the formation of hydroxyapatite mineral deposits that intimately connect with the existing mineral surface and thus provide physical attachment. A similar product is disclosed but in addition to AMTN, it contains the Odontogenic, Ameloblast-Associated (ODAM) protein as well with both proteins exhibiting a synergistic effect.

4. 发明申请

US20190001018A1 CROSSLINKED GELS COMPRISING POLYALKYLENEIMINES, AND THEIR USES AS MEDICAL DEVICES 审中-公开
公开(公告)号：US20190001018A1
公开(公告)日：2019-01-03
申请号：US15882244
申请日：2018-01-29
申请人： HyperBranch Medical Technology, Inc.
发明人： Kenneth E. Stockman , Michael A. Carnahan , Keith R. D'Alessio , Mark W. Grinstaff
IPC分类号： A61L26/00
CPC分类号： A61L26/0019 , A61B2017/0065 , A61B2017/00951 , A61K31/785 , A61K31/787 , A61K51/1279 , A61L24/0031 , A61L24/0036 , A61L24/043 , A61L24/046 , A61L26/0052 , A61L26/008 , A61L26/0085 , A61L27/18 , A61L27/26 , A61L27/52 , A61L27/56 , C08L79/02
摘要： One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer. In certain instances, the polyethyleneimine is mixed with a second polymer, such as a polyethylene glycol containing nucleophilic groups. In certain instances, the compositions used to seal the wound or tissue plane are formed by reacting a polyalkyleneimine bearing electrophilic groups with a cross-linking reagent containing nucleophilic groups. In certain instances, the electrophilic groups on the polyalkyleneimine are activated esters, such as N-hydroxy succinimide ester. In certain instances, the compositions used to seal the wound or tissue plane are formed by reacting a polyalkyleneimine bearing photopolymerizable groups with ultraviolet or visible light. Compositions used to seal the wound which contain PEI or a derivative of PEI are found to adhere tightly to the tissue. Other aspects of the present invention relate to methods of filling a void of a patient or adhering tissue. In certain instances, the methods use a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Another aspect of the present invention relates to a polymeric composition formed by exposing a polyalkyleneimine to an activated polyalkylene glycol. In certain instances, the composition is attached to mammalian tissue.

5. 发明申请

US20180353655A1 READY TO USE BIODEGRADABLE AND BIOCOMPATIBLE ARTIFICIAL SKIN SUBSTITUTE AND A METHOD OF PREPARATION THEREOF 审中-公开
公开(公告)号：US20180353655A1
公开(公告)日：2018-12-13
申请号：US16108155
申请日：2018-08-22
申请人： DATT MEDIPRODUCTS LIMITED , DATT LIFE SCIENCE PVT. LTD.
发明人： Rajan Datt , Siddharth Pandey , Pallavi Shrivastava , Supriya Srivastava
IPC分类号： A61L27/60 , A61L27/36 , A61L27/26 , A61L27/48 , A61L27/38 , A61L27/56 , A61L27/54
CPC分类号： A61L27/60 , A61L27/26 , A61L27/3633 , A61L27/3834 , A61L27/48 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/414 , C08L5/08 , C08L89/06
摘要： The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells (Human mesenchymal stem cells, Human fibroblast, Keratinocytes, fibroblast differentiated form mesenchymal stem cells in vitro and keratinocytes differentiated form mesenchymal stem cells in vitro) in vitro for continued periods of time. In the present invention, mesenchymal stem cells (MSCs) derived from bone marrow or umbilical cord are inoculated and grown on a pre-established scaffold or matrix made up of chitosan and gelatin. The developed tissue constructs contain cells, growth factors, cytokines and other regulatory factors secreted by cells. The developed bioengineered tissue constructs provide the support, growth factors and essential cytokines for wound healing. Developed tissue construct useful in the treatment of burns wound, diabetic foot ulcer wound and type of chronic skin wounds. It is helpful in healing and regeneration of skin tissue.

6. 发明申请

US20180272033A1 COMPOSITIONS COMPRISING SILK FIBROIN PARTICLES AND USES THEREOF 审中-公开
公开(公告)号：US20180272033A1
公开(公告)日：2018-09-27
申请号：US15799455
申请日：2017-10-31
申请人： Sofregen Medical, Inc.
发明人： Anh Hoang , Christopher P. Gulka , Jodie E.M. Giordano , Joseph E. Brown , Thomas L. Carroll
IPC分类号： A61L27/26 , A61L27/56 , A61L27/50
CPC分类号： A61L27/227 , A61L27/26 , A61L27/502 , A61L27/56 , A61L2400/06 , A61L2430/34 , C08K5/053 , C08K7/22 , C08L5/08 , C08L89/00
摘要： Various aspects described herein relate to compositions comprising silk fibroin particles and methods of using the same, as well as devices and methods of delivering such compositions. The compositions described herein are suitable for injection into a site of defect in a soft tissue to provide bulking and/or augmentation effect to the soft tissue.

7. 发明授权

US10070948B2 Biosynthetic implant for soft tissue repair 有权
公开(公告)号：US10070948B2
公开(公告)日：2018-09-11
申请号：US14970655
申请日：2015-12-16
申请人： Sofradim Production
发明人： Yves Bayon , Philippe Gravagna , Alfredo Meneghin
IPC分类号： A61F2/00 , A61L27/24 , A61L27/26 , A61L27/54 , A61L27/56 , D04B21/12
CPC分类号： A61F2/0063 , A61F2/0077 , A61F2002/0068 , A61F2002/0081 , A61L27/24 , A61L27/26 , A61L27/54 , A61L27/56 , A61L2300/404 , A61L2300/602 , D04B21/12 , D10B2401/12 , D10B2403/0112 , D10B2403/0122 , D10B2509/08 , C08L5/08
摘要： An implant and a process for preparing such an implant are disclosed. The implant includes a porous layer including collagen, a non-porous layer including a collagenic constituent, and a reinforcement component. The non-porous layer is joined to the porous layer and the reinforcement member is embedded into the non-porous layer. The porous layer has a three dimensional density ranging from about 20 mg collagen/cm3 to about 200 mg collagen/cm3.

8. 发明授权

US10052350B2 Fabrication of gelatin hydrogel sheet for the transplantation of corneal endothelium 有权
公开(公告)号：US10052350B2
公开(公告)日：2018-08-21
申请号：US14344011
申请日：2012-09-17
申请人： WAKE FOREST UNIVERSITY HEALTH SCIENCES
发明人： GuoGuang Niu , Shay Soker
IPC分类号： A61K35/30 , A61L27/22 , A61L27/26 , A61L27/38 , A61L27/50 , A61L27/52 , A61L27/54 , A61L27/56 , A61F2/14
CPC分类号： A61K35/30 , A61F2/142 , A61L27/222 , A61L27/26 , A61L27/3808 , A61L27/50 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/236 , A61L2430/16 , C08L89/06 , C08L5/08 , C08L71/02
摘要： The invention provides a corneal endothelial composition comprising a transparent hydrogel scaffold and a single layer of cultured corneal endothelial cells on the surface of the scaffold. The hydrogel scaffold I comprised of at least one biopolymer, preferably gelatin. Also provided are methods of making a corneal endothelial scaffold.

9. 发明申请

US20180207095A1 CELL TISSUE GEL CONTAINING COLLAGEN AND HYALURONAN 审中-公开
公开(公告)号：US20180207095A1
公开(公告)日：2018-07-26
申请号：US15935768
申请日：2018-03-26
申请人： National Cheng Kung University
发明人： Lynn L.H. Huang
IPC分类号： A61K9/06 , C08L5/08 , A61K35/50 , A61L27/26 , A61L27/38 , C12N5/0775 , C12N5/073 , C08L89/06 , A61K35/28 , A61L27/54 , A61L27/52
CPC分类号： A61K9/06 , A61K35/28 , A61K35/50 , A61L27/26 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L2300/414 , C08L5/08 , C08L89/06 , C12N5/0068 , C12N5/0605 , C12N5/0668 , C12N2533/54 , C12N2533/76 , C12N2533/80
摘要： Described herein is a cell tissue gel containing collagen and hyaluronan at a weight ratio of 0.01-100:1.

10. 发明申请

US20180203161A1 BIOMEDICAL DEVICES CONTAINING INTERNAL WETTING AGENTS 审中-公开
公开(公告)号：US20180203161A1
公开(公告)日：2018-07-19
申请号：US15917924
申请日：2018-03-12
申请人： Johnson & Johnson Vision Care, Inc.
发明人： Kevin P. McCabe , Frank F. Molock, JR. , Gregory A. Hill , Azaam Alli , Robert B. Steffen , Douglas G. Vanderlaan , James D. Ford
IPC分类号： G02B1/04 , A61L27/26 , G02C7/02 , C08F291/00 , A61L27/18 , A61L27/52 , C08F251/00 , C08F265/04 , C08F271/00 , C08F271/02 , C08F283/06 , C08F283/12 , C08F290/06 , C08L83/04
CPC分类号： G02B1/043 , A61L27/18 , A61L27/26 , A61L27/52 , C08F251/00 , C08F265/04 , C08F271/00 , C08F271/02 , C08F283/06 , C08F283/12 , C08F290/06 , C08F291/00 , G02C7/022 , C08L83/04
摘要： This invention includes a wettable biomedical device containing a high molecular weight hydrophilic polymer and a hydroxyl-functionalized silicone-containing monomer.

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