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1. 发明公开

US20240269482A1 MEDICAL DEVICES, SYSTEMS, AND RELATED METHODS 审中-公开
公开(公告)号：US20240269482A1
公开(公告)日：2024-08-15
申请号：US18437356
申请日：2024-02-09
申请人： Boston Scientific Scimed, Inc.
发明人： Evan BENNETT , Aldo MORA ALVARADO , Ricardo Andres ESQUIVEL DAVANZO , Timothy Lawrence RUBESCH , Peter FADLOVICH , Lawrence ABOYER , Paige O'REILLY
IPC分类号： A61N5/10 , A61M25/10
CPC分类号： A61N5/10 , A61M25/1011 , A61M25/10182 , A61M2025/1061 , A61M2025/1079 , A61M2210/1053 , A61M2210/1096 , A61M2210/167 , A61N2005/1094 , A61N2005/1096
摘要： A medical device for use during radiation therapy may include a longitudinal body configured to be positioned within a urethra. The longitudinal body may include a lumen, a distal end, and a proximal end. A first balloon may be coupled to a distal portion of the longitudinal body and fluidly connected to a first port at the proximal end of the longitudinal body. A second balloon may be positioned between the first balloon and the proximal end of the longitudinal body and fluidly connected to a second port at the proximal end of the longitudinal body.

2. 发明申请

US20160256709A1 SYSTEM AND METHOD FOR MANUFACTURING BOLUS FOR RADIOTHERAPY USING A THREE-DIMENSIONAL PRINTER 审中-公开
标题翻译：使用三维打印机制造放射治疗玻璃体的系统和方法
公开(公告)号：US20160256709A1
公开(公告)日：2016-09-08
申请号：US15157029
申请日：2016-05-17
申请人： Dalhousie University
发明人： James Robar , Shiqin Su
IPC分类号： A61N5/10 , B29C67/00
CPC分类号： A61N5/1031 , A61B6/032 , A61B6/5217 , A61N5/1048 , A61N5/1075 , A61N2005/1034 , A61N2005/1076 , A61N2005/1087 , A61N2005/1089 , A61N2005/1096 , A61N2005/1097 , B29C64/106 , B29C64/386 , B29K2067/046 , B29K2995/0056 , B29L2031/753 , B33Y50/02 , B33Y80/00
摘要： Disclosed herein are systems, methods, and computer-readable storage devices for manufacturing patient-specific bolus for use in targeted radiotherapy treatment. Based on dose calculations without a bolus and based on three-dimensional scan data of a patient, the example system generates a model of a bolus for targeting radiotherapy treatment to a planning target volume or target region within the patient. The system can perform several iterations to generate a resulting model for the bolus. Then, the system can generate instructions for controlling a three-dimensional printer to generate the bolus that conforms to the patient's skin surface while also specifically targeting the planning target volume for the radiotherapy treatment. In this way, the amount of radiotherapy treatment administered to other tissue is reduced, while the costs, time, and human involvement in creating the bolus are significantly reduced.
摘要翻译：本文公开了用于制造用于靶向放射治疗治疗的患者特异性推注的系统，方法和计算机可读存储装置。基于没有大剂量并且基于患者的三维扫描数据的剂量计算，该实施例系统产生用于靶向放射疗法治疗的药丸模型，以用于患者体内的规划目标体积或目标区域。该系统可以执行多次迭代以产生推注的结果模型。然后，系统可以产生用于控制三维打印机以产生符合患者皮肤表面的推注的指令，同时还专门针对放射疗法治疗的规划目标体积。以这种方式，减少了施用于其他组织的放射治疗的量，而显着减少了在造成大剂量时的成本，时间和人参与。

3. 发明授权

US09381379B2 Radiation therapy techniques using targeted wave superposition, magnetic field direction and real-time sensory feedback 有权
标题翻译：使用靶向波叠加，磁场方向和实时感觉反馈的放射治疗技术
公开(公告)号：US09381379B2
公开(公告)日：2016-07-05
申请号：US14612285
申请日：2015-02-02
申请人： Christopher V. Beckman
发明人： Christopher V. Beckman
IPC分类号： A61N5/10
CPC分类号： A61N5/1084 , A61B2090/0481 , A61N5/1077 , A61N2005/1094 , A61N2005/1096
摘要： New techniques for radiotherapy and radiosurgery are provided. In some aspects of the invention, multiple sources of radiation with characteristics that are projected to constructively interfere at a treatment target are provided. In other aspects, hardware directs multiple radiation sources from the same side of a treatment target, and focuses the initiation of substantial interference on a leading structure in the target. In other aspects, refractive models updated by live feedback are used to improve dosage distribution by, among other things, optimizing the number, length, superposition, overlap, angle and nature of radiation beams. In additional aspects, interstitial beacons and radiation path diversion structures are inserted to improve dosage distribution to a target and avoid critical neighboring structures. In particle therapy, regionally actuable external magnetic fields are also provided, to improve dosage accuracy and avoid collateral damage.
摘要翻译：提供放射治疗和放射外科的新技术。在本发明的一些方面，提供了具有预期在治疗目标上建设性干扰的特征的多个辐射源。在其他方面，硬件从治疗目标的同一侧引导多个辐射源，并且将目标上的引导结构的实质性干扰集中起来。在其他方面，通过实时反馈更新的折射模型用于通过优化辐射束的数量，长度，叠加，重叠，角度和性质来改善剂量分布。在另外的方面，插入间质信标和辐射路径转移结构以改善对目标的剂量分布并避免关键的相邻结构。在颗粒治疗中，还提供了区域可致动的外部磁场，以提高剂量准确度并避免附带损伤。

4. 发明授权

US09119873B2 Use of a composition comprising a poly-organosiloxane 有权
标题翻译：包含聚有机硅氧烷的组合物的用途
公开(公告)号：US09119873B2
公开(公告)日：2015-09-01
申请号：US14361164
申请日：2012-10-11
申请人： SERVICIO ANDALUZ DE SALUD
发明人： Santiago Velázquez Miranda
IPC分类号： A61K41/00 , A61L31/06 , A61N5/10 , A61K31/80
CPC分类号： A61K41/0038 , A61K31/80 , A61L31/06 , A61N5/10 , A61N5/103 , A61N2005/1087 , A61N2005/1096 , A61N2005/1097 , C08L83/04
摘要： A composition based on a poly-organosiloxane which is suitable for its use as a bolus in radiotherapy treatments. Other possible uses of this composition are the production of an immobilizing mask for radio surgery or cranial stereotaxy treatments and the production of an intraoral depressor.
摘要翻译：基于聚有机硅氧烷的组合物，其适用于放射疗法治疗中的推注。该组合物的其它可能用途是生产用于放射外科手术或颅骨立体定向治疗的固定掩模和口腔内抑制剂的生产。

5. 发明申请

US20150133713A1 Method For Compensating The Deviation Of A Hadron Beam Produced By A Hadron-Therapy Installation 审中-公开
标题翻译：用于补偿由Hadron-Therapy安装产生的强子束的偏差的方法
公开(公告)号：US20150133713A1
公开(公告)日：2015-05-14
申请号：US14399477
申请日：2013-05-10
申请人： Ion Beam Applications S.A.
发明人： Olivier Vierlinck , Michel Closset , David Wikler
IPC分类号： A61N5/10
CPC分类号： A61N5/1067 , A61N5/1043 , A61N5/1045 , A61N5/1065 , A61N5/1075 , A61N5/1081 , A61N2005/1057 , A61N2005/1087 , A61N2005/1096
摘要： The present invention relates to a method for compensating the deviation of an energetic beam of hadrons delivered by an irradiation unit of a hadron-therapy installation, with respect to an isocentre of a rotatable gantry supporting said irradiation unit, said irradiation unit comprising a collimator comprising an opening for the passage of said beam. The present invention also relates to a program comprising an algorithm for calculation of a correction to be applied to the position of an opening of a collimator of an irradiation unit of a hadron-therapy installation. The invention finally also relates to a hadron therapy installation.
摘要翻译：本发明涉及一种用于补偿由强子治疗装置的照射单元输送的强子的能量束相对于支撑所述照射单元的可旋转机架的等中心的偏离的方法，所述照射单元包括准直器，该准直器包括：用于通过所述梁的开口。本发明还涉及包括用于计算要应用于强子治疗装置的照射单元的准直器的开口的位置的校正的算法的程序。本发明最终还涉及强子治疗装置。

6. 发明申请

US20150112194A1 IMPLANT FOR TARGETING THERAPEUTIC PROCEDURE 审中-公开
标题翻译：用于治疗手术的植入物
公开(公告)号：US20150112194A1
公开(公告)日：2015-04-23
申请号：US14581807
申请日：2014-12-23
申请人： Focal Therapeutics, Inc.
发明人： James B. STUBBS
IPC分类号： A61N5/10
CPC分类号： A61B90/39 , A61B17/22 , A61B2017/00004 , A61B2090/363 , A61B2090/3908 , A61B2090/3925 , A61B2090/3966 , A61B2090/3995 , A61F2/12 , A61L31/044 , A61L31/148 , A61M31/002 , A61N5/02 , A61N5/1039 , A61N5/1042 , A61N5/1045 , A61N5/1049 , A61N5/1067 , A61N5/1069 , A61N5/107 , A61N5/1077 , A61N7/02 , A61N2005/1051 , A61N2005/1089 , A61N2005/1091 , A61N2005/1096
摘要： An implantable device has a body that is substantially rigid and has a predetermined shape. The body is further bioabsorbable and has a density less than or equal to about 1.03 g/cc. When the device is implanted in a resected cavity in soft tissue, it causes the cavity to conform to the predetermined shape. The implantable device is further imageable due to its density being less than that of soft tissue such that the boundaries of the tissue corresponding to the predetermined shape can be determined.
摘要翻译：可植入装置具有基本上刚性且具有预定形状的主体。身体是进一步的生物可吸收的并且具有小于或等于约1.03g / cc的密度。当将该装置植入软组织中的切除的腔中时，其使空腔符合预定形状。可植入装置由于其密度小于软组织的密度而进一步可成像，使得可以确定对应于预定形状的组织的边界。

7. 发明申请

US20150041685A1 PROTECTIVE BODY FOR INSERTION INTO BODY CAVITY 有权
标题翻译：保护身体进入体内
公开(公告)号：US20150041685A1
公开(公告)日：2015-02-12
申请号：US14386928
申请日：2012-12-21
申请人： Franz Karl Bohler , Gunar Koller , Christian Lechner
发明人： Gunar Koller
IPC分类号： A61N5/10 , G21F3/00
CPC分类号： A61N5/10 , A61B2090/0445 , A61B2090/3966 , A61N5/1014 , A61N5/1015 , A61N5/1016 , A61N5/1071 , A61N2005/1018 , A61N2005/1094 , A61N2005/1096 , G21F3/00
摘要： A protective body for insertion into a body cavity of a human or animal body for the protection of tissue and/or organs that are not to be irradiated when carrying out radiation therapy, wherein the protective body (1) includes at least one absorber body (2) designed to absorb radiation and having at least one curved surface (3) that delimits the absorber body, and the absorber body (2) has a density at 20° C. of at least 5 gram per cubic centimetre, preferably of at least 10 gram per cubic centimeter.
摘要翻译：一种用于插入到人或动物体的体腔中用于保护在进行放射治疗时不被照射的组织和/或器官的保护体，其中所述保护体（1）包括至少一个吸收体（ 2）设计成吸收辐射并且具有限定吸收体的至少一个弯曲表面（3），并且吸收体（2）的密度在20℃为至少5克/立方厘米，优选至少为 10克/立方厘米。

8. 发明授权

US08890097B2 Multi-leaf collimator, particle beam therapy system, and treatment planning apparatus 有权
标题翻译：多叶准直器，粒子束治疗系统和治疗计划装置
公开(公告)号：US08890097B2
公开(公告)日：2014-11-18
申请号：US14263594
申请日：2014-04-28
申请人： Mitsubishi Electric Corporation
发明人： Takaaki Iwata
IPC分类号： A61N5/10
CPC分类号： A61N5/1045 , A61N5/103 , A61N5/1042 , A61N5/1043 , A61N2005/1087 , A61N2005/1095 , A61N2005/1096 , G21K1/046
摘要： There are provided a leaf row in which a plurality of leaf plates are arranged in the thickness direction of the row in such a way that the respective one end faces of the leaf plates are trued up and a leaf plate drive mechanism that drives each of the plurality of leaf plates in such a way that the one end face approaches or departs from a beam axis. In each of the leaf plates, a facing side facing a leaf plate that is adjacent to that leaf plate in the thickness direction is formed of a plane including a first axis on the beam axis; the leaf plate drive mechanism drives the leaf plate along a circumferential orbit around the second axis, on the beam axis, that is perpendicular to the beam axis and the first axis.
摘要翻译：提供了一种叶片排，其中多个叶板沿着该排的厚度方向布置，使得叶板的相应的一个端面被修整，并且叶板驱动机构驱动每个叶板多个叶板以一端面接近或离开梁轴的方式。在每个叶板中，在厚度方向上与叶板相邻的面对侧的面对侧由在轴线上包括第一轴线的平面形成; 叶板驱动机构沿垂直于梁轴和第一轴的梁轴上的第二轴的圆周轨道驱动叶板。

9. 发明申请

US20140249406A1 COMPENSATOR-BASED BRACHYTHERAPY 审中-公开
标题翻译：基于补偿器的BRACHYTHERAPY
公开(公告)号：US20140249406A1
公开(公告)日：2014-09-04
申请号：US14072270
申请日：2013-11-05
申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION
发明人： Ryan Flynn , Yusung Kim , Xing Li , Kee-Ho Yuen
IPC分类号： A61N5/10
CPC分类号： A61N5/1001 , A61N5/1014 , A61N2005/1012 , A61N2005/1096
摘要： Compensator-based brachytherapy (CBT) for treatment of cancerous tumors or other pathologic tissues. CBT permits, in one aspect, increased dosage conformity for non-radially symmetric tumors by utilizing a device that can shield radiation emanated from an electronic brachytherapy (BT) source or non-electronic BT source. The device can comprise, in one aspect, a radiation compensator having a treated surface that comprises a position-dependent thickness based at least on a radiation therapy plan specific to a patient and geometry of a patient region to be treated. In an additional or alternative aspect, the device can comprise a source of radiation movably inserted into an enclosure coupled to the radiation compensator. As part of CBT, in one implementation, the radiation source can reside at a plurality of locations within the radiator compensator during a respective plurality of dwell times based on the radiation therapy plan.
摘要翻译：用于治疗癌性肿瘤或其他病理组织的基于补偿剂的近距离放射治疗（CBT）。 CBT允许在一个方面通过利用可以屏蔽从电子近距离放射治疗（BT）源或非电子BT源发出的辐射的装置来增加非径向对称肿瘤的剂量一致性。在一个方面，该装置可以包括具有经处理的表面的辐射补偿器，该处理的表面至少基于患者特有的放射治疗计划和待治疗的患者区域的几何形状包括位置依赖性厚度。在附加或替代方面，该装置可以包括可移动地插入耦合到辐射补偿器的外壳中的辐射源。作为CBT的一部分，在一个实施方案中，辐射源可以在基于辐射治疗计划的相应的多个停留时间期间驻留在辐射器补偿器内的多个位置处。

10. 发明授权

US08754386B2 Multi-leaf collimator, particle beam therapy system, and treatment planning apparatus 有权
标题翻译：多叶准直器，粒子束治疗系统和治疗计划装置
公开(公告)号：US08754386B2
公开(公告)日：2014-06-17
申请号：US13696931
申请日：2010-08-17
申请人： Takaaki Iwata
发明人： Takaaki Iwata
IPC分类号： A61N5/10 , G21K1/02
CPC分类号： A61N5/1045 , A61N5/103 , A61N5/1042 , A61N5/1043 , A61N2005/1087 , A61N2005/1095 , A61N2005/1096 , G21K1/046
摘要： There are provided a leaf row (5C) in which a plurality of leaf plates (5L) are arranged in the thickness direction of the row (5C) in such a way that respective end faces (EL) of the leaf plates (5L) are trued up, and a leaf plate drive mechanism (5D) that drives each of the plurality of leaf plates (5L) in such a way that the end face (EL) approaches or departs from a beam axis (XB). In each of the leaf plates (5L), a facing side (PL) facing a leaf plate that is adjacent to that leaf plate in the thickness direction is formed of a plane (Psa) including a first axis (Asa) on the beam axis (XB); the leaf plate drive mechanism (5D) drives the leaf plate (5L) along a circumferential orbit (OL) around the second axis (Asb), on the beam axis (XB), that is perpendicular to the beam axis (XB) and the first axis (Asa).
摘要翻译：设置有叶片（5C），其中多个叶板（5L）沿着行（5C）的厚度方向布置成使叶板（5L）的各个端面（EL）为以及以端面（EL）接近或离开光束轴线（XB）的方式驱动多个叶板（5L）中的每一个的叶板驱动机构（5D）。在每个叶板（5L）中，在厚度方向上与该板板相邻的面板（PL）的面对侧（PL）由在轴线上包括第一轴线（Asa）的平面（Psa）形成（XB）; 叶板驱动机构（5D）沿垂直于梁轴（XB）的梁轴（XB）上沿第二轴线（Asb）的圆周轨道（OL）驱动叶板（5L），并且第一轴（Asa）。

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