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1. 发明申请

US20190184371A1 MATERIAL FOR BLOOD PURIFICATION 审中-公开
公开(公告)号：US20190184371A1
公开(公告)日：2019-06-20
申请号：US16327188
申请日：2017-09-08
申请人： TORAY INDUSTRIES, INC.
发明人： Shungo KANDA , Hiroshi TAKAHASHI , Naotoshi TOMITA
IPC分类号： B01J20/26 , B01J20/28 , B01J20/32 , B01D15/38
CPC分类号： B01J20/265 , A61M1/36 , B01D15/3828 , B01J20/22 , B01J20/28 , B01J20/28016 , B01J20/28023 , B01J20/28038 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3251 , B01J20/3293 , B01J20/3295
摘要： An object of the present invention is to provide a material for blood purification having the capability to remove cytokines and activated leukocyte-activated platelet complexes. The present invention provides a material for blood purification, the material containing a water-insoluble material in which a ligand having an amide group(s) and an amino group(s) is bound to a substrate, wherein the content of the amide group(s) is 3.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material; and wherein the content of the amino group(s) is 1.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material.

2. 发明授权

US10036004B1 Production of high purity chondroitinase ABC 有权
公开(公告)号：US10036004B1
公开(公告)日：2018-07-31
申请号：US15788824
申请日：2017-10-20
申请人： Advantek Serum Laboratories Ltd.
发明人： Bing Lou Wong , Wai Hong Chung
IPC分类号： C12N9/88 , B01D15/38
CPC分类号： C12N9/88 , B01D15/3804 , B01D15/3828 , C12Y402/02004 , C12Y402/0202
摘要： The present invention provides a method for purifying Chondroitinase ABC (ChABC). The present method includes using a heparin-immobilized affinity chromatography column, and through chromatography method obtaining a purified ChABC from a matrix containing said ChABC. The present method is capable of obtaining ChABC in high purity with the advantages of simplicity in preparation and high yield.

3. 发明申请

US20160375378A1 PROCESS FOR PURIFICATION AND ISOLATION OF ESTROGENS 审中-公开
标题翻译：雌激素的纯化和分离过程
公开(公告)号：US20160375378A1
公开(公告)日：2016-12-29
申请号：US15262570
申请日：2016-09-12
申请人： Dr. Reddy's Laboratories Ltd.
发明人： Chandrashaker Akula , John Lomans , Madhukiran Tummidi , Prashant Anil Tatake
IPC分类号： B01D15/36 , B01J20/26 , B01D15/38 , A61K31/566
CPC分类号： B01D15/362 , A61K31/565 , A61K31/566 , B01D15/361 , B01D15/363 , B01D15/3828 , B01J20/261 , A61K2300/00
摘要： The present application relates to a method for obtaining a mixture of estrogens from the pregnant mare's urine.
摘要翻译：本申请涉及一种从怀孕母猪尿中获得雌激素混合物的方法。

4. 发明申请

US20160332142A1 Affinity Chromatography Media and Chromatography Devices 审中-公开
标题翻译：亲和色谱介质和色谱仪
公开(公告)号：US20160332142A1
公开(公告)日：2016-11-17
申请号：US15111672
申请日：2015-01-15
申请人： W. R. GRACE & CO.-CONN. , REPLIGEN CORPORATION
发明人： Feng Gu , Surya Kiran Chodavarapu , James Bogdanor , Dennis McCreay , James Neil Pryor , James Rusche , James Peyser , Thomas Pauly
IPC分类号： B01J20/286 , B01J20/28 , B01J20/32 , B01D15/38
CPC分类号： B01J20/286 , B01D15/3809 , B01D15/3828 , B01J20/28004 , B01J20/28059 , B01J20/28061 , B01J20/28073 , B01J20/28085 , B01J20/28088 , B01J20/289 , B01J20/3204 , B01J20/3219 , B01J20/3274
摘要： Chromatography media and devices containing chromatography media are disclosed. Methods of making chromatography devices and methods of using chromatography devices containing the chromatography media are also disclosed.
摘要翻译：公开了含有色谱介质的色谱介质和装置。还公开了制备色谱装置的方法和使用含有色谱介质的色谱装置的方法。

5. 发明申请

US20160318980A1 Chemically Modified Graphene 审中-公开
标题翻译：化学改性石墨烯
公开(公告)号：US20160318980A1
公开(公告)日：2016-11-03
申请号：US15155695
申请日：2016-05-16
申请人： Research Foundation of The City University of New York , Rutgers, The State University of New Jersey
发明人： Michele Vittadello , Kamil Woronowicz , Manish Chhowalla , Paul G. Falkowski , John W. Harrold, JR.
IPC分类号： C07K14/315 , B01J20/289 , B01J20/30 , C07D303/46 , C25B11/04 , C12P7/06 , C25B1/00 , C25B1/04 , C25B9/16 , B01J20/22 , C07K14/31
CPC分类号： C07K14/315 , B01D15/325 , B01D15/3809 , B01D15/3828 , B01J20/205 , B01J20/223 , B01J20/289 , B01J20/3085 , B01J20/3204 , B01J20/3206 , B01J20/3219 , B01J20/3236 , B01J20/3251 , B01J20/3265 , B01J20/3274 , B01J20/3289 , B01J39/26 , B01J45/00 , B01J2220/52 , B01J2220/58 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C01B32/194 , C01B32/23 , C07D303/46 , C07K1/20 , C07K1/22 , C07K14/31 , C07K2319/20 , C07K2319/21 , C12N11/02 , C12N11/14 , C12P3/00 , C12P7/06 , C25B1/003 , C25B1/04 , C25B9/16 , C25B11/0405 , C25B11/0415 , C25B11/0489 , G01N30/482 , G01N33/551 , Y02E50/17 , Y02E60/366 , Y10S977/734 , Y10S977/847 , Y10S977/914
摘要： This disclosure relates to graphene derivatives, as well as related devices including graphene derivatives and methods of using graphene derivatives.
摘要翻译：本公开涉及石墨烯衍生物，以及包括石墨烯衍生物和使用石墨烯衍生物的方法的相关装置。

6. 发明申请

US20160228849A1 Multifunctional Sorbent Materials and Uses Thereof 审中-公开
标题翻译：多功能吸附材料及其用途
公开(公告)号：US20160228849A1
公开(公告)日：2016-08-11
申请号：US15022998
申请日：2014-09-19
申请人： MEDISOTEC
发明人： Van So Le , Minh Khoi Le
IPC分类号： B01J20/22 , C07F7/28 , C07F7/21 , B01J20/30
CPC分类号： B01J20/22 , B01D15/3828 , B01J20/28004 , B01J20/28042 , B01J20/28057 , B01J20/28078 , B01J20/28092 , B01J20/3085 , B01J20/3204 , B01J20/3257 , B01J20/3425 , B01J20/3475 , B01J41/08 , C07F7/21 , C07F7/28 , G21F9/12
摘要： The invention relates to a method for producing a sorbent material, comprising firstly providing a porous silica substrate, said substrate comprising a plurality of silanol groups on a surface thereof then reacting said silanol groups with either a silicon compound of formula RnSi(OR′)4-n, where R is an alkyl group and n is 0 or 1, or an aminoalkyl silane of formula R″mRnSi(OR′)4-n-m having at least two hydrolysable groups attached to silicon, where R″ is an aminoalkyl group, m is 1 or 2 and n is 0 or 1s or a compound of formula M(OR′)4, or a mixture of any two or more of the preceding compounds, hydrolysing the product, men reacting hydroxyl groups formed with one or more reagents, wherein each reagent is independently selected from the group consisting of an aminoalkyl silane having at least two hydrolysable groups attached to the silicon and a compound of formula M(OR′)4, and finally hydrolysing the product, wherein each OR′ independently is a hydrolysable group and each M independently is Zr, Ti, Hf, Sn, Th, Pb or Ge. There is also described a sorbent material and use of a sorbent material for purifying, separating and concentrating processes.
摘要翻译：本发明涉及一种用于生产吸附剂材料的方法，其包括首先提供多孔二氧化硅基质，所述基材在其表面上包含多个硅烷醇基团，然后使所述硅烷醇基团与式R n Si（OR'）4的硅化合物 -n，其中R为烷基且n为0或1，或式R“mRnSi（OR'）4-nm的氨基烷基硅烷具有至少两个与硅连接的可水解基团，其中R”为氨基烷基， m为1或2，n为0或1或式M（OR'）4的化合物或任何两种或多种前述化合物的混合物水解产物，使与形成的一个或多个试剂的羟基反应其中每个试剂独立地选自具有至少两个与硅结合的可水解基团的氨基烷基硅烷和式M（OR'）4化合物，最后水解产物，其中每个OR'独立地为可水解组和ea ch M独立地是Zr，Ti，Hf，Sn，Th，Pb或Ge。还描述了吸附剂材料和用于净化，分离和浓缩过程的吸附剂材料。

7. 发明申请

US20160025699A1 DETERMINATION OF THE DISTRIBUTION OF REACTIVE AND NON-REACTIVE SULFUR IN PETROLEUM AND ITS FRACTIONS 审中-公开
标题翻译：确定石油及其分类中反应性和非反应性硫的分布情况
公开(公告)号：US20160025699A1
公开(公告)日：2016-01-28
申请号：US14776077
申请日：2014-03-13
申请人： FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
发明人： Ryan P. RODGERS , Winston K. ROBBINS , Vladislav V. LOBODIN
IPC分类号： G01N33/28
CPC分类号： G01N33/287 , B01D15/362 , B01D15/3828 , B01J45/00 , G01N30/96 , G01N2030/8854
摘要： A method to determine the distribution of non-reactive sulfur compounds and reactive sulfur compounds in petroleum samples by separating non-reactive sulfur compounds from reactive sulfur compounds in a petroleum composition includes the step of contacting the petroleum composition with a Ag-containing cation exchange media. The petroleum composition and the Ag-containing cation exchange media are contacted with a non-reactive sulfur compound solvent capable of eluting the non-reactive sulfur compounds in the presence of the Ag-containing cation exchange media and incapable of eluting the reactive sulfur compounds in the presence of the Ag-containing cation exchange media at the conditions of the exchange. The non-reactive sulfur compounds are eluted from the media with the non-reactive sulfur compound solvent to provide a first fraction. The amount of non-reactive sulfur compounds in the first fraction is then determined.
摘要翻译：通过在石油组合物中分离反应性硫化合物的非反应性硫化合物来确定石油样品中非反应性硫化合物和反应性硫化合物的分布的方法包括使石油组合物与含Ag阳离子交换介质接触的步骤。将石油组合物和含Ag阳离子交换介质与能够在含Ag阳离子交换介质存在下洗脱非反应性硫化合物的非反应性硫化合物溶剂接触，并且不能将反应性硫化合物洗脱在交换条件下存在含Ag的阳离子交换介质。非反应性硫化合物用非反应性硫化合物溶剂从介质中洗脱以提供第一级分。然后确定第一级分中的非反应性硫化合物的量。

8. 发明申请

US20150368354A1 METHODS FOR REDUCING AGGREGATE CONTENT IN PROTEIN PREPARATIONS 有权
标题翻译：降低蛋白质制剂中聚集体含量的方法
公开(公告)号：US20150368354A1
公开(公告)日：2015-12-24
申请号：US14766129
申请日：2014-02-05
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： Peter Stanley GAGNON
IPC分类号： C07K16/30 , B01D15/36 , B01D15/34 , C07K16/00 , C07K1/20
CPC分类号： C07K1/14 , B01D15/327 , B01D15/34 , B01D15/363 , B01D15/3828 , C07K1/165 , C07K1/20 , C07K16/00 , C07K16/3015
摘要： A method of reducing aggregate and product-contaminant complex content in a protein preparation including a desired protein includes (i) contacting the protein preparation with at least one solid surface comprising at least one surface-bound ligand capable of binding a metal, the surface-bound ligand being capable of binding a metal is initially substantially devoid of a metal, the operating conditions are selected to substantially prevent the binding of the desired protein to the at least one solid surface and (ii) separating the protein preparation from the surface-bound ligand, such that when more than one surface-bound ligand is present, each surface-bound ligand is independently either of the same net charge or charge neutral.
摘要翻译：一种降低包含所需蛋白质的蛋白质制剂中的聚集体和产物 - 污染物复合物含量的方法包括（i）使蛋白质制剂与至少一个固体表面接触，所述至少一个固体表面包含至少一个能够结合金属的表面结合配体，能够结合金属的结合配体最初基本上不含金属，选择操作条件以基本上防止所需蛋白质与至少一种固体表面的结合，和（ii）将蛋白质制剂与表面结合配体，使得当存在多于一个表面结合的配体时，每个表面结合的配体独立地是相同的净电荷或电荷中性。

9. 发明授权

US09193760B2 Dissociation of product-complexed contaminants in chromatography 有权
标题翻译：色谱中产物复合污染物的分离
公开(公告)号：US09193760B2
公开(公告)日：2015-11-24
申请号：US13237294
申请日：2011-09-20
申请人： Peter S. Gagnon
发明人： Peter S. Gagnon
IPC分类号： C07K1/00 , C07K1/18 , B01D15/38 , C07K1/22 , B01D15/36
CPC分类号： C07K1/18 , B01D15/362 , B01D15/3828 , C07K1/22
摘要： The invention provides methods and materials for using apatite chromatography supports to dissociate and remove contaminants that are complexed to biological products. The invention further provides materials and methods for dissociating aggregations of target biological molecules or improperly folded target molecules to improve purification of the target molecule.
摘要翻译：本发明提供了使用磷灰石层析载体来分离和去除与生物制品复合的污染物的方法和材料。本发明还提供用于解离靶生物分子的聚集体或不正确折叠的靶分子以提高靶分子纯化的材料和方法。

10. 发明授权

US09187588B2 Elution of metal ions from chelating resin using amino acid eluant 有权
标题翻译：使用氨基酸洗脱液从螯合树脂中洗脱金属离子
公开(公告)号：US09187588B2
公开(公告)日：2015-11-17
申请号：US14414815
申请日：2013-08-13
申请人： Dow Global Technologies LLC , Rohm and Haas Company , Stephen M. Smith
发明人： Charles R. Marston , Stephen M. Smith , Matthew L. Rodgers , Karen S. Eastman
IPC分类号： C08G6/00 , C08F212/36 , B01J45/00 , B01J49/00 , C22B3/42 , B01D15/38 , C08F212/08
CPC分类号： C08F212/36 , B01D15/3828 , B01J45/00 , B01J49/50 , C08F212/08 , C22B3/42 , Y02P10/234
摘要： A method of eluting metal ions from a bed of metal-loaded chelating resin wherein the resin includes a crosslinked styrene-divinylbenzene copolymer matrix with pendent methyleneaminopyridine or phosphonic acid groups and the method includes the step of passing an eluant through the bed to at least partially remove the metal ions from the chelating resin and create a metal-rich eluate, wherein the eluant includes an aqueous solution comprising an amino acid compound having a molecular weight less than 500 Daltons.
摘要翻译：一种从金属负载的螯合树脂床中洗脱金属离子的方法，其中树脂包括具有侧链亚甲基氨基吡啶或膦酸基团的交联的苯乙烯 - 二乙烯基苯共聚物基质，并且该方法包括使洗脱剂通过床至少部分地从螯合树脂中除去金属离子并产生富含金属的洗脱液，其中洗脱剂包括含有分子量小于500道尔顿的氨基酸化合物的水溶液。

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