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1. 发明申请

US20180093030A1 Dialysate free artificial kidney device 审中-公开
公开(公告)号：US20180093030A1
公开(公告)日：2018-04-05
申请号：US15732169
申请日：2017-09-27
申请人： Curion Research Corporation
发明人： Jamie Allen Hestekin , Christa Noel Hestekin , Grace Ann C. Morrison , Sadia Ali Paracha
IPC分类号： A61M1/16 , A61M1/10
CPC分类号： A61M1/1696 , A61M1/1006 , A61M1/12 , A61M1/1605 , A61M1/1649 , A61M1/165 , A61M1/1654 , A61M1/1678 , A61M1/28 , A61M1/3472 , A61M1/3482 , A61M1/3639 , A61M2205/3331 , A61M2209/088 , A61N1/00 , B01D61/022 , B01D61/12 , B01D61/145 , B01D61/246 , B01D61/28 , B01D61/32 , B01D61/44 , B01D61/445 , B01D61/48 , B01D61/485 , B01D61/50 , B01D61/54 , B01D61/58 , B01D2311/243 , B01D2311/2684 , B01D2313/40 , B01D2317/02 , B01D2325/42 , C02F1/441 , C02F1/442 , C02F1/444 , C02F1/4695 , C02F9/00
摘要： A device and method are described for the treatment of blood, which device may be used in conjunction with or in place of a failed Kidney. The device includes an ultrafiltration unit to remove proteins, red and white blood cells and other high molecular weight components, a nanofiltration unit to remove glucose, at least one electrodeionization unit to transport ions from the blood stream, and a reverse osmosis unit to modulate the flow of water, to both the blood and urine streams. In one embodiment, a specialized electrodeionization unit is provided having multiple chambers defining multiple dilute fluid channels, each channel filled with an ion specific resin wafer, and electrodes at the extremity of the device and proximate each of the resin filled dilute channels. By selective application of voltages to these electrodes, the ion transport functionality of a given dilute channel can be turned on or off.

2. 发明授权

US09636447B2 Filtering of a time-dependent pressure signal 有权
公开(公告)号：US09636447B2
公开(公告)日：2017-05-02
申请号：US14234527
申请日：2012-06-20
申请人： Bo Olde , Kristian Solem , Mattias Holmer , Jan Sternby
发明人： Bo Olde , Kristian Solem , Mattias Holmer , Jan Sternby
IPC分类号： A61B5/02 , A61M1/36 , B01D61/30 , B01D61/32 , G01L19/00 , A61B5/021 , A61B5/00
CPC分类号： A61M1/3607 , A61B5/02108 , A61B5/6866 , A61B5/7217 , A61M1/34 , A61M1/3403 , A61M1/3621 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M2205/3331 , A61M2205/3368 , A61M2205/50 , B01D61/30 , B01D61/32 , G01L19/00
摘要： A device removes first pulses in a pressure signal of a pressure sensor which is arranged in a fluid containing system to detect the first pulses, which originate from a first pulse generator, and second pulses, which originate from a second pulse generator. The first pulse generator operates in a sequence of pulse cycles, each pulse cycle resulting in at least one first pulse. The device repetitively obtains a current data sample, calculates a corresponding reference value and subtracts the reference value from the current data sample. The reference value is calculated as a function of other data sample(s) in the same pressure signal. The fluid containing system may include an extracorporeal blood flow circuit, e.g. as part of a dialysis machine, and a cardiovascular system of a human patient.

3. 发明申请

US20170065760A1 APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT 审中-公开
标题翻译：用于提取血液治疗的装置
公开(公告)号：US20170065760A1
公开(公告)日：2017-03-09
申请号：US15353883
申请日：2016-11-17
申请人： GAMBRO LUNDIA AB
发明人： Mauro Suffritti , Michela Carpani
IPC分类号： A61M1/34 , B01D61/32 , B01D61/22
CPC分类号： A61M1/341 , A61M1/1603 , A61M1/1615 , A61M1/3434 , A61M1/3437 , A61M1/3441 , A61M1/3639 , A61M2205/3331 , A61M2205/502 , A61M2205/52 , B01D61/22 , B01D61/32 , B01D2311/14
摘要： An apparatus for extracorporeal blood treatment, comprising a treatment unit (2) having a first chamber (3) and a second chamber (4) separated from one another by a semipermeable membrane (5), a blood removal line (6) connected in inlet with the first chamber (3) and a blood return line (7) connected in outlet with the first chamber; an infusion line (9; 9a, 9b) of a replacement fluid and a fluid evacuation line (10) connected in outlet from the second chamber. A regulating device (20) of a transmembrane pressure is active on at least one of the lines and a control unit (15) is configured to: command the regulating device (20) by setting a first increase (δTMP1), determine a value of a control parameter (φ1) corresponding to the first increase, compare the value of the control parameter (φ1) with a reference value (φref) and, if the value of the control parameter is greater than the reference value, command the regulating device (20) by setting a second increase (δTMP2) which is greater than the first increase (δTMP1).
摘要翻译：一种用于体外血液处理的装置，包括具有通过半透膜（5）彼此分离的第一室（3）和第二室（4）的处理单元（2），连接在入口与第一腔室（3）和血液回流管线（7）连接在出口与第一腔室; 更换流体的输液管线（9; 9a，9b）和连接在第二室的出口处的排液管线（10）。跨膜压力的调节装置（20）在至少一条线路上有效，并且控制单元（15）被配置为：通过设定第一增加（δTMP1）来指示调节装置（20），确定对应于第一增加的控制参数（φ1），将控制参数（φ1）的值与参考值（φref）进行比较，并且如果控制参数的值大于参考值，则命令调节装置 20）通过设定大于第一增加（δTMP1）的第二增加（δTMP2）。

4. 发明申请

US20170021088A1 Manifold Diaphragms 审中-公开
标题翻译：歧管隔膜
公开(公告)号：US20170021088A1
公开(公告)日：2017-01-26
申请号：US15055857
申请日：2016-02-29
申请人： Fresenius Medical Care Holdings, Inc.
发明人： Barry Neil Fulkerson , Alec Huang , Brian Thomas Kelly
IPC分类号： A61M1/36 , A61M1/16
CPC分类号： A61M1/3656 , A61M1/16 , A61M1/1609 , A61M1/1645 , A61M1/166 , A61M1/1692 , A61M1/1696 , A61M1/3626 , A61M1/3639 , A61M1/3641 , A61M1/3646 , A61M2205/126 , A61M2205/13 , A61M2205/14 , A61M2205/15 , A61M2205/18 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2205/3375 , A61M2205/3393 , A61M2205/3553 , A61M2205/3584 , A61M2205/502 , A61M2205/505 , A61M2205/52 , B01D61/18 , B01D61/30 , B01D61/32 , B01D2313/10 , B01D2313/105 , B01D2313/12 , B01D2313/125 , B01D2313/243
摘要： The specification discloses a portable dialysis machine having a detachable controller unit and base unit. The controller unit includes a door having an interior face, a housing with a panel, where the housing and panel define a recessed region configured to receive the interior face of the door, and a manifold receiver fixedly attached to the panel. The manifold includes diaphragms adapted to minimize the dead space between the dialysis machine pins and improve responsivity. The base unit has a planar surface for receiving a container of fluid, a scale integrated with the planar surface and a heater in thermal communication with the container. Embodiments of the disclosed portable dialysis system have improved structural and functional features, including improved modularity, ease of use, and safety features.
摘要翻译：本说明书公开了一种具有可拆卸控制器单元和基座单元的便携式透析机。控制器单元包括具有内表面的门，具有面板的壳体，其中壳体和面板限定了构造成接收门的内表面的凹陷区域，以及固定地连接到面板的歧管接收器。歧管包括适于最小化透析机针之间的死空间并提高响应性的膜片。基座单元具有用于接收流体容器的平坦表面，与平坦表面一体化的刻度和与容器热连通的加热器。所公开的便携式透析系统的实施例具有改进的结构和功能特征，包括改进的模块性，易用性和安全特征。

5. 发明申请

US20160303304A1 "SYSTEM AND METHOD FOR PAIRING A DIALYSIS MACHINE WITH PERIPHERAL DEVICES" 审中-公开
标题翻译： “用于与外围设备配对的DIALYSIS机器的系统和方法”
公开(公告)号：US20160303304A1
公开(公告)日：2016-10-20
申请号：US15192062
申请日：2016-06-24
申请人： BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE SA
发明人： Alex Anping Yu , Robert W. Childers , Peter A. Hopping
IPC分类号： A61M1/16 , A61M1/28
CPC分类号： A61M1/1611 , A61M1/28 , A61M2205/12 , A61M2205/3553 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2230/005 , A61M2230/201 , A61M2230/30 , A61M2230/50 , A61M2230/65 , B01D61/30 , B01D61/32 , G06F19/00 , G06F19/3418 , G16H10/65
摘要： A system and method for pairing a dialysis machine with peripheral devices are disclosed. An example system includes first and second memory devices, a first dialysis machine including a first memory device port configured to be connectable to the first memory device, and a second dialysis machine including a second memory device port configured to be connectable to the second memory device. The system also includes an intermediate data transfer unit including a port configured to connect to the first and the second memory devices to enable data transfer with the respective dialysis machines. The intermediate data transfer unit is configured to receive data from a weight sensor, a blood pressure sensor, or a remote exchange device for a patient and store the data to the first or second memory device to communicate the data to the respective first or second dialysis machine.
摘要翻译：公开了一种用于将透析机与外围设备配对的系统和方法。示例性系统包括第一和第二存储器设备，第一透析机器，其包括被配置为可连接到第一存储器设备的第一存储器设备端口，以及第二透析机器，其包括配置为可连接到第二存储器设备的第二存储器设备端口。该系统还包括中间数据传送单元，其包括被配置为连接到第一和第二存储器设备的端口，以使得能够与相应的透析机进行数据传输。中间数据传送单元被配置为从重量传感器，血压传感器或用于患者的远程交换设备接收数据，并将数据存储到第一或第二存储器设备，以将数据传送到相应的第一或第二透析机。

6. 发明申请

US20160206801A1 BLOOD FLUID REMOVAL SYSTEM PERFORMANCE MONITORING 审中-公开
标题翻译：血液流体清除系统性能监测
公开(公告)号：US20160206801A1
公开(公告)日：2016-07-21
申请号：US15067559
申请日：2016-03-11
申请人： Medtronic, Inc.
发明人： Martin Gerber , Suping Lyu , Bryant Pudil
IPC分类号： A61M1/16 , B01D65/02 , B01D61/32 , A61M1/36
CPC分类号： A61M1/1603 , A61B5/0031 , A61B5/026 , A61B5/0295 , A61B5/053 , A61B5/0537 , A61B5/145 , A61B5/14503 , A61B5/14535 , A61B5/14539 , A61B5/14546 , A61B5/4836 , A61B5/4848 , A61B5/6866 , A61B2560/0223 , A61M1/00 , A61M1/14 , A61M1/16 , A61M1/1601 , A61M1/1605 , A61M1/1607 , A61M1/1613 , A61M1/28 , A61M1/34 , A61M1/3403 , A61M1/342 , A61M1/3607 , A61M1/3609 , A61M1/361 , A61M1/3612 , A61M2205/04 , A61M2205/18 , A61M2205/33 , A61M2205/3303 , A61M2205/3306 , A61M2205/3313 , A61M2205/3331 , A61M2205/3334 , A61M2205/3375 , A61M2205/3523 , A61M2205/50 , A61M2205/52 , A61M2205/60 , A61M2205/70 , A61M2230/00 , A61M2230/005 , A61M2230/20 , A61M2230/207 , A61M2230/208 , A61M2230/65 , B01D61/00 , B01D61/32 , B01D65/02 , B01D2321/12 , B01D2321/40 , G06F19/00
摘要： Monitoring of the performance of a blood fluid removal medium of a blood fluid removal device includes monitoring of condition, such as fluid flow rate or concentration of blood waste product, downstream of the medium. Upstream monitoring of the condition may also be performed to enhance the ability to determine whether the blood fluid removal medium is performing within predetermined ranges.
摘要翻译：监测血液流体去除装置的血液流体去除介质的性能包括在介质下游监测诸如流体流动速率或血液废物产物浓度的状况。还可以进行条件的上游监视，以增强确定血液流体去除介质是否在预定范围内执行的能力。

7. 发明申请

US20160051927A1 MEMBRANE-BASED EXHAUST GAS SCRUBBING METHOD AND SYSTEM 审中-公开
公开(公告)号：US20160051927A1
公开(公告)日：2016-02-25
申请号：US14928923
申请日：2015-10-30
申请人： IONADA INCORPORATED
发明人： Edoardo PANZIERA
IPC分类号： B01D53/22 , B01D53/30 , B01D63/04
CPC分类号： F01N3/0821 , B01D53/1425 , B01D53/1443 , B01D53/1475 , B01D53/1481 , B01D53/1493 , B01D53/22 , B01D53/228 , B01D53/229 , B01D53/30 , B01D53/504 , B01D53/96 , B01D61/246 , B01D61/28 , B01D61/32 , B01D63/02 , B01D63/04 , B01D63/043 , B01D65/06 , B01D71/024 , B01D2053/224 , B01D2251/304 , B01D2251/604 , B01D2252/103 , B01D2252/1035 , B01D2252/30 , B01D2257/302 , B01D2257/404 , B01D2257/50 , B01D2257/504 , B01D2258/012 , B01D2259/4566 , B01D2311/106 , B01D2311/18 , B01D2317/04 , B01D2321/162 , B01D2321/164 , F01N3/085 , F01N3/0885 , F01N9/00 , F01N13/004 , F01N13/011 , Y02C10/06 , Y02C10/10
摘要： Various exemplary embodiments relate to a method and apparatus to reduce emissions of target emission gasses such as sulfur oxides, nitrogen oxides, and carbon oxides from combustion exhaust such as marine engine exhaust by gas membrane separation and liquid carrier chemical absorption. The membrane separation system consists of an absorption system containing semi-permeable hollow fiber membranes through which is circulated a liquid absorbent. Exhaust gases contact the exterior surface of the membranes and the target gasses selectively permeate the membrane wall and are absorbed by the liquid carrier(s) within the bore and thereby are removed from the exhaust stream.

8. 发明授权

US09227004B2 Customizable personal dialysis device having ease of use and therapy enhancement features 有权
标题翻译：可定制的个人透析装置具有易用性和治疗增强功能
公开(公告)号：US09227004B2
公开(公告)日：2016-01-05
申请号：US13650794
申请日：2012-10-12
申请人： Baxter International Inc. , Baxter Healthcare S.A.
发明人： John A. Biewer , Andrey Kopychev , Merrick F. Kossack , Philip J. D'Almada Remedios
IPC分类号： A61M1/16 , B01D61/32 , A61M1/28
CPC分类号： A61M1/28 , A61M1/16 , A61M1/282 , A61M2205/18 , A61M2205/3334 , A61M2205/3368 , A61M2205/3393 , A61M2205/50 , A61M2205/502 , A61M2205/505 , A61M2205/581 , A61M2205/582 , A61M2205/583 , B01D61/32 , G06F19/00
摘要： A peritoneal dialysis machine includes an enclosure; dialysate pump located within the enclosure; a graphical user interface allowing a patient to program a treatment including at least one patient fill performed by the dialysate pump, at least one dwell, and at least one drain performed by the dialysate pump; and the GUI further programmed to provide an alert when it is time to begin the treatment so as to complete the at least one patient fill, dwell and drain by a prescribed time.
摘要翻译：腹膜透析机包括外壳; 位于外壳内的透析泵; 图形用户界面，允许患者编程治疗，包括由透析泵执行的至少一个患者填充，至少一个停留和由透析泵执行的至少一个排水; 并且GUI进一步被编程为在开始治疗的时候提供警报，以便在规定的时间内完成至少一个患者填充，停留和排泄。

9. 发明申请

US20150335808A1 TOTAL CHLORINE WATER DETECTION SYSTEM AND METHOD FOR MEDICAL FLUID TREATMENTS 有权
标题翻译：全氯液检测系统及医用流体处理方法
公开(公告)号：US20150335808A1
公开(公告)日：2015-11-26
申请号：US14819033
申请日：2015-08-05
申请人： Baxter International Inc. , Baxter Healthcare S.A.
发明人： Jeff White , Ye Chen , Yuanpang Samuel Ding , Joel Titus , Justin Rohde , Shincy Maliekkal , Kevin Cooper
IPC分类号： A61M1/16 , C02F1/467 , B01D61/24 , B01D61/32 , G01N33/18 , C02F1/44
CPC分类号： A61M1/14 , A61M1/1656 , A61M1/1666 , A61M1/1668 , A61M1/1674 , B01D61/243 , B01D61/32 , B01D2311/2684 , C02F1/44 , C02F1/4674 , C02F2209/29 , C02F2305/02 , G01N27/4168 , G01N33/182 , Y02W10/33 , Y10T436/193333
摘要： A system and method for determining a concentration of total chlorine in dialysis water are provided. The system comprises a main unit housing a KI/water sample chamber and a sodium sulfate chamber. A first electrode pair bridges the two chambers and generates tri-iodide proportional to the amount of total chlorine in the water sample. A second electrode pair in contact with fluid in the KI/water sample detects an amount of tri-iodide generated by the first electrode pair. The system is suitable for use in connection with, or for incorporation into, a water purification system for generating dialysis fluid, and may include a display that alerts the user to stop or prevent a hemodialysis treatment if the total chlorine level exceeds a predetermined level.
摘要翻译：提供了一种用于测定透析水中总氯浓度的系统和方法。该系统包括容纳KI /水样品室和硫酸钠室的主单元。第一电极对桥接两个室，并产生与水样品中总氯量成比例的三碘化物。与KI /水样品中的流体接触的第二电极对检测由第一电极对产生的三碘化物的量。该系统适用于与用于生成透析液体的水净化系统相关联或用于并入用于产生透析液体的水净化系统，并且可以包括如果总氯含量超过预定水平则警告用户停止或防止血液透析治疗的显示器。

10. 发明授权

US09155823B2 Determining dialysis treatment effectiveness 有权
标题翻译：确定透析治疗有效性
公开(公告)号：US09155823B2
公开(公告)日：2015-10-13
申请号：US13214519
申请日：2011-08-22
申请人： Jeffrey Tarn , Fei Wang , Aiyuan Wang
发明人： Jeffrey Tarn , Fei Wang , Aiyuan Wang
IPC分类号： A61M1/16 , B01D61/30 , B01D61/32 , A61M1/28
CPC分类号： A61M1/16 , A61M1/1601 , A61M1/1603 , A61M1/1611 , A61M1/28 , A61M2202/0498 , A61M2205/15 , A61M2205/50 , A61M2205/502 , A61M2205/505 , A61M2205/52 , B01D61/30 , B01D61/32
摘要： A method performed on a dialysis machine includes receiving a first value that represents a pre-dialysis body weight of a patient and receiving a second value that represents a volume of liquid (V) inside a body of the patient. The method also includes administering dialysis to the patient, calculating an instantaneous body weight (W) of the patient based at least in part on the first value, determining a length of time (t) for which the dialysis was administered to the patient, determining a dialyzer clearance (K) associated with the dialysis, and calculating, based at least in part on the length of time, the instantaneous body weight, the volume, and the dialyzer clearance, a urea reduction ratio (URR) associated with the dialysis.
摘要翻译：在透析机上执行的方法包括接收表示患者的透析前体重的第一值，并接收表示患者体内的液体体积（V）的第二值。该方法还包括对患者进行透析，至少部分地基于第一值计算患者的瞬时体重（W），确定向患者施用透析的时间长度（t），确定与透析相关联的透析器间隙（K），并且至少部分地基于时间长度计算瞬时体重，体积和透析器间隙，与透析相关联的尿素减少率（URR）。

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