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1. 发明申请

US20190192524A1 Modulators of Caspase-6 审中-公开
公开(公告)号：US20190192524A1
公开(公告)日：2019-06-27
申请号：US15118452
申请日：2015-02-14
申请人： The University of British Columbia , University of Hamburg
发明人： Mehdi Mike Khankischpur , Olga Petina , Detief Gettken , Dabmar Ehmhoefer , Michael Hayden
IPC分类号： A61K31/535 , A61P25/28 , A61K31/55 , A61K31/4375 , A61K31/27 , A61K31/445 , A61K31/13 , A61K31/135 , A61K31/198
CPC分类号： A61K31/535 , A61K31/13 , A61K31/135 , A61K31/165 , A61K31/198 , A61K31/27 , A61K31/4375 , A61K31/445 , A61K31/55 , A61K45/06 , A61P25/28 , C07C251/28 , A61K2300/00
摘要： Modulators of caspase-6 activity are provided for use in the treatment of neurodegenerative diseases.

2. 发明申请

US20140018576A1 Method for Preparing Formamide Compounds 有权
标题翻译：甲酰胺化合物的制备方法
公开(公告)号：US20140018576A1
公开(公告)日：2014-01-16
申请号：US13805899
申请日：2012-04-04
申请人： Thibault Cantat , Christophe Gomes , Olivier Jacquet
发明人： Thibault Cantat , Christophe Gomes , Olivier Jacquet
IPC分类号： C07C231/10
CPC分类号： C07C231/10 , B01J31/0244 , B01J31/0245 , B01J31/0251 , B01J31/122 , B01J31/2409 , B01J2231/625 , B01J2531/0247 , B01J2531/842 , C07B59/00 , C07B2200/05 , C07C241/04 , C07C249/02 , C07C249/16 , C07D231/12 , C07D233/06 , C07D233/58 , C07D241/04 , C07D243/28 , C07D249/02 , C07D249/08 , C07D249/16 , C07D251/28 , C07D295/185 , C07C233/03 , C07C243/28 , C07C251/28 , C07C251/86
摘要： The present invention relates to a method for preparing formamide compounds using carbon dioxide, and to the use of said method for manufacturing vitamins, pharmaceutical products, adhesives, acrylic fibres, synthetic leathers, pesticides and fertilisers. The invention also relates to a method for manufacturing vitamins, pharmaceutical products, adhesives, acrylic fibres, synthetic leathers, pesticides and fertilisers which includes a step of preparing formamide compounds by the method according to the invention.
摘要翻译：本发明涉及使用二氧化碳制备甲酰胺化合物的方法，以及所述使用所述制造维生素，药物产品，粘合剂，丙烯酸纤维，合成革，农药和肥料的方法。本发明还涉及一种制造维生素，药物产品，粘合剂，丙烯酸纤维，合成皮革，农药和肥料的方法，其包括通过本发明的方法制备甲酰胺化合物的步骤。

3. 发明授权

US08476411B2 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides 有权
标题翻译：含有，涉及非天然氨基酸和多肽的方法和使用的组合物
公开(公告)号：US08476411B2
公开(公告)日：2013-07-02
申请号：US13178189
申请日：2011-07-07
申请人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
发明人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
IPC分类号： C07K16/00
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , A61K47/60 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02A50/473 , Y02P20/55
摘要： Non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides, are disclosed. The non-natural amino acids, by themselves or as a part of a polypeptide, can include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Methods for making, modifying, and purifying the non-natural amino acid polypeptides are also disclosed. Further, methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses, are disclosed.
摘要翻译：公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括至少一个肟，羰基，二羰基和/或羟胺基团。还公开了制备，修饰和纯化非天然氨基酸多肽的方法。此外，公开了使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

4. 发明授权

US07696312B2 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides 有权
标题翻译：含有，涉及非天然氨基酸和多肽的方法和使用的组合物
公开(公告)号：US07696312B2
公开(公告)日：2010-04-13
申请号：US11874060
申请日：2007-10-17
申请人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
发明人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
IPC分类号： C07K2/00 , C07K4/00 , C07C251/00 , C07C251/32
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , A61K47/60 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02A50/473 , Y02P20/55
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括广泛的可能的官能团，但典型的具有至少一个肟，羰基，二羰基和/或羟胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个肟，羰基，二羰基和/或羟胺基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

5. 发明授权

US07638491B2 Therapies using non-natural amino acids and polypeptides 有权
标题翻译：使用非天然氨基酸和多肽的疗法
公开(公告)号：US07638491B2
公开(公告)日：2009-12-29
申请号：US11313305
申请日：2005-12-21
申请人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
发明人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
IPC分类号： A61K38/27 , A61K38/00 , A61K38/16 , C07K2/00 , C07K4/00 , C07C251/00 , C07C251/32
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , A61K47/60 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02A50/473 , Y02P20/55
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括广泛的可能的官能团，但典型的具有至少一个肟，羰基，二羰基和/或羟胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个肟，羰基，二羰基和/或羟胺基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

6. 发明申请

US20080268518A1 Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acids and Polypeptides 审中-公开
公开(公告)号：US20080268518A1
公开(公告)日：2008-10-30
申请号：US11925662
申请日：2007-10-26
申请人： Zhenwei MIAO , Junjie LIU , Thea NORMAN , Russell DRIVER
发明人： Zhenwei MIAO , Junjie LIU , Thea NORMAN , Russell DRIVER
IPC分类号： C12N9/04 , C07C229/00 , C07D209/04 , C07D317/10 , C07D307/77 , C07K2/00 , C07K14/00 , C12N9/14 , C07K16/00 , C12N9/00 , C07H21/00 , C12N1/00 , C12N7/00
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , A61K47/60 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02A50/473 , Y02P20/55
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.

7. 发明申请

US20080177038A1 Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acids and Polypeptides 审中-公开
公开(公告)号：US20080177038A1
公开(公告)日：2008-07-24
申请号：US11874094
申请日：2007-10-17
申请人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
发明人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
IPC分类号： C07K1/00 , C12P21/00 , C07K1/107
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , A61K47/60 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02A50/473 , Y02P20/55
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.

8. 发明申请

US20070112072A1 Quinoneimines of malonic acid diamides 有权
标题翻译：丙二酸二酰胺喹啉酮
公开(公告)号：US20070112072A1
公开(公告)日：2007-05-17
申请号：US10565506
申请日：2004-07-23
申请人： David Dekkers , Lucien Aarden , Janna Ten Brinke
发明人： David Dekkers , Lucien Aarden , Janna Ten Brinke
IPC分类号： A61K31/16 , C07C251/22
CPC分类号： C07C251/28 , A23L33/10 , C07C235/16 , C07C323/41 , Y02P20/55
摘要： The present invention provides optionally substituted compounds of the formula I or salts thereof; wherein R1 is O or S when double bonded to the ring or is OH, SH, or a protected equivalent, when single bonded to the ring, R2 is hydrogen or more preferably an C1-C10 organic group attached by a carbon atom, X is H, O, OO, S or SS R3 is absent where X═H, is hydrogen or is a hydroxyl or thiol protecting group, R4 is a hetero- or preferably homo-cyclic aryl group, optionally substituted with a further group R5 and groups T1 are each, independently, absent, hydrogen or an S—R6 group, where any/each R6 is independently an organic group of molecular weight up to around 500 amu. The invention further provides a method for the synthesis of such compounds and a method of treatment comprising administering such compounds to a mammalian subject.
摘要翻译：本发明提供任选取代的式I化合物或其盐; 当双键键合到环上时，R 1是O或S，或者是OH，SH或被保护的等价物，当单键与环结合时，R 2是氢或更优选由碳原子连接的C 1 -C 10 - 有机基团，X是H，O，OO，S或SS R 3 在其中XH为氢或为羟基或硫醇保护基团时不存在，R 4为异或优选的高环芳基，任选被另外的基团R 5取代，和基团T 1 1各自独立地不存在氢或SR 6 - 基团，其中任何/每个R 6独立地为有机基团的分子量可达500 amu左右。本发明进一步提供了一种合成这些化合物的方法和一种治疗方法，包括向哺乳动物受试者施用此类化合物。

9. 发明授权

US09924717B2 Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto 有权
公开(公告)号：US09924717B2
公开(公告)日：2018-03-27
申请号：US15408634
申请日：2017-01-18
申请人： Dow AgroSciences LLC
发明人： Thomas Barton , Xin Gao , Jim Hunter , Paul R. LePlae, Jr. , Lori K. Lawler , William C. Lo , Jeff Petkus , Joshodeep Boruwa , Raghuram Tangirala , Gerald B. Watson , John Herbert
IPC分类号： A01N37/20 , A01N37/18 , C07D207/06 , C07D331/04 , C07D213/61 , A01N43/40 , C07D213/75 , A01N43/20 , C07C233/65 , A01N43/36
CPC分类号： A01N37/20 , A01N29/12 , A01N31/04 , A01N33/04 , A01N35/04 , A01N37/10 , A01N37/18 , A01N37/26 , A01N43/20 , A01N43/36 , A01N43/40 , A01N53/00 , C07C233/65 , C07C233/66 , C07C233/73 , C07C233/78 , C07C251/28 , C07C251/38 , C07C255/46 , C07C257/20 , C07C259/14 , C07C327/48 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07D207/06 , C07D213/61 , C07D213/75 , C07D331/04
摘要： This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing such molecules, and processes of using such molecules and compositions against such pests. These molecules and compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

10. 发明授权

US08877971B2 Method for preparing formamide compounds 有权
标题翻译：甲酰胺化合物的制备方法
公开(公告)号：US08877971B2
公开(公告)日：2014-11-04
申请号：US13805899
申请日：2012-04-04
申请人： Thibault Cantat , Christophe Gomes , Olivier Jacquet
发明人： Thibault Cantat , Christophe Gomes , Olivier Jacquet
IPC分类号： C07C231/10 , C07D265/30 , C07C249/02 , C07D231/12 , C07D233/58 , C07D251/28 , C07C249/16 , C07D243/28 , C07D233/06 , C07D249/16 , C07D249/08 , C07D249/02 , C07D241/04 , C07D295/185 , C07C241/04
CPC分类号： C07C231/10 , B01J31/0244 , B01J31/0245 , B01J31/0251 , B01J31/122 , B01J31/2409 , B01J2231/625 , B01J2531/0247 , B01J2531/842 , C07B59/00 , C07B2200/05 , C07C241/04 , C07C249/02 , C07C249/16 , C07D231/12 , C07D233/06 , C07D233/58 , C07D241/04 , C07D243/28 , C07D249/02 , C07D249/08 , C07D249/16 , C07D251/28 , C07D295/185 , C07C233/03 , C07C243/28 , C07C251/28 , C07C251/86
摘要： The present invention relates to a method for preparing formamide compounds using carbon dioxide, and to the use of said method for manufacturing vitamins, pharmaceutical products, adhesives, acrylic fibers, synthetic leathers, pesticides and fertilizers. The invention also relates to a method for manufacturing vitamins, pharmaceutical products, adhesives, acrylic fibers, synthetic leathers, pesticides and fertilizers which includes a step of preparing formamide compounds by the method according to the invention.
摘要翻译：本发明涉及使用二氧化碳制备甲酰胺化合物的方法，以及所述使用所述制造维生素，药物产品，粘合剂，丙烯酸纤维，合成革，农药和肥料的方法。本发明还涉及一种制造维生素，药物产品，粘合剂，丙烯酸纤维，合成皮革，农药和肥料的方法，其包括通过本发明的方法制备甲酰胺化合物的步骤。

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