专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20180127370A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF 有权
公开(公告)号：US20180127370A1
公开(公告)日：2018-05-10
申请号：US15807293
申请日：2017-11-08
申请人： Navitor Pharmaceuticals, Inc.
发明人： David John O'Neill , Eddine Saiah , Seong Woo Anthony Kang , Andrew Brearley , Jonathan Bentley
IPC分类号： C07D211/58 , A61P11/00 , C07D401/12 , C07D401/14 , C07D471/04 , C07D205/04 , C07D209/52 , C07D207/14 , C07D223/12 , C07D413/14
CPC分类号： C07D211/58 , A61P11/00 , C07D205/04 , C07D207/14 , C07D209/52 , C07D223/12 , C07D401/12 , C07D401/14 , C07D413/14 , C07D471/04
摘要： The present invention provides compounds, compositions thereof, and methods of using the same.

2. 发明授权

US09751885B2 Cyclopropanamine compound and use thereof 有权
公开(公告)号：US09751885B2
公开(公告)日：2017-09-05
申请号：US14435085
申请日：2013-10-11
申请人： Takeda Pharmaceutical Company Limited
发明人： Naoki Tomita , Daisuke Tomita , Yusuke Tominari , Shinichi Imamura , Shinji Morimoto , Takuto Kojima , Masashi Toyofuku , Yasushi Hattori , Tomohiro Kaku , Mitsuhiro Ito
IPC分类号： C07D487/04 , C07C255/58 , C07C255/60 , C07D231/40 , C07C317/40 , C07C237/30 , C07C237/38 , C07C237/40 , C07C255/29 , A61K45/06 , C07D309/14 , C07D319/18 , C07D413/12 , C07D241/12 , C07D417/12 , C07D261/14 , C07D207/12 , C07D285/135 , C07D211/58 , C07D295/135 , C07D213/40 , C07D207/46 , C07D213/36 , C07D223/12 , C07D231/38 , C07D241/18 , C07D265/36 , C07D277/38 , C07D333/20 , C07D405/12 , C07D471/04 , C07D513/04
CPC分类号： C07D487/04 , A61K45/06 , C07C237/30 , C07C237/38 , C07C237/40 , C07C255/29 , C07C255/58 , C07C255/60 , C07C317/40 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D207/12 , C07D207/46 , C07D211/58 , C07D213/36 , C07D213/40 , C07D223/12 , C07D231/38 , C07D231/40 , C07D241/12 , C07D241/18 , C07D261/14 , C07D265/36 , C07D277/38 , C07D285/135 , C07D295/135 , C07D309/14 , C07D319/18 , C07D333/20 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D513/04
摘要： The present invention provides a compound having a lysine specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for schizophrenia, Alzheimer's disease, Parkinson's disease or Huntington's disease, and the like. The present invention relates to a compound represented by the formula wherein A is a hydrocarbon group optionally having substituent(s), or a heterocyclic group optionally having substituent(s); B is a benzene ring optionally having further substituent(s); R1, R2 and R3 are each independently a hydrogen atom, a hydrocarbon group optionally having substituent(s), or a heterocyclic group optionally having substituent(s); A and R1 are optionally bonded to each other to form, together with the adjacent nitrogen atom, a cyclic group optionally having substituent(s); and R2 and R3 are optionally bonded to each other to form, together with the adjacent nitrogen atom, a cyclic group optionally having substituent(s), or a salt thereof.

3. 发明授权

US09676686B2 Liquid crystal composition containing nitrogen-containing cyclic compound and liquid crystal display device 有权
公开(公告)号：US09676686B2
公开(公告)日：2017-06-13
申请号：US14994150
申请日：2016-01-13
申请人： JNC CORPORATION , JNC PETROCHEMICAL CORPORATION
发明人： Yasuyuki Gotoh , Kazuo Okumura
IPC分类号： G02F1/1333 , C07C13/28 , C09K19/34 , C09K19/30 , C07D207/12 , C07D223/08 , C07D207/14 , C07D223/12 , C07D403/12 , C07D405/14 , C07D403/14 , C09K19/32 , C09K19/04 , C09K19/18
CPC分类号： C07C13/28 , C07D207/12 , C07D207/14 , C07D223/08 , C07D223/12 , C07D403/12 , C07D403/14 , C07D405/14 , C09K19/3003 , C09K19/3066 , C09K19/3068 , C09K19/32 , C09K19/3402 , C09K19/3483 , C09K2019/0466 , C09K2019/181 , C09K2019/3009 , C09K2019/301 , C09K2019/3016 , C09K2019/3019 , C09K2019/3021 , C09K2019/3042 , C09K2019/3077 , C09K2019/3083 , C09K2019/3422 , C09K2019/3425
摘要： The disclosure shows a liquid crystal composition that contains a compound having an effect of preventing photolysis of the liquid crystal composition and having high solubility in the liquid crystal composition, and that satisfies at least one of characteristics such as high maximum temperature, low minimum temperature, small viscosity, suitable optical anisotropy, large positive or negative dielectric anisotropy, large specific resistance, high stability to ultraviolet light or heat, and a suitable elastic constant, etc. and so on.The disclosure shows a liquid crystal composition that contains a compound having the following azolidine ring (Q-1) or azepane ring (Q-2), a liquid crystal display device and so on.

4. 发明授权

US09562042B2 α-oxoacyl amino-caprolactam 有权
标题翻译： α-氧代酰基氨基 - 己内酰胺
公开(公告)号：US09562042B2
公开(公告)日：2017-02-07
申请号：US14898249
申请日：2014-06-13
申请人： Seikagaku Corporation
发明人： Nobuo Kobayashi , Tsuneo Koji , Hisatomo Kunii , Mizuho Ishikawa , Daisuke Morita
IPC分类号： C07D417/12 , C07D223/12 , C07D405/12 , A61K31/55
CPC分类号： C07D417/12 , A61K31/55 , C07D223/12 , C07D405/12
摘要： The purpose of the present invention is to provide a pharmaceutical composition that is useful for the treatment of diseases that are caused by an increase in bone resorption and that does not cause serious side effects even when used in combination with another drug. The present invention relates to: an α-oxoacyl amino-caprolactam that is represented by formula (I) (in formula (I), X represents N or CH, Y represents O or CH2, and Z represents S or CH2); and a bone resorption inhibitor containing the α-oxoacyl amino-caprolactam.
摘要翻译：本发明的目的是提供一种药物组合物，其可用于治疗由骨吸收增加引起的疾病，并且即使与另一种药物组合使用也不引起严重的副作用。本发明涉及：式（I）（式（I）中X表示N或CH，Y表示O或CH 2，Z表示S或CH 2）的由式（I）表示的正 - 酰基酰基 - 己内酰胺体， ; 和含有---酰基酰基氨基己内酰胺的骨吸收抑制剂。

5. 发明授权

US09233362B2 Molybdenum and tungsten metal complexes and use thereof as precatalysts for olefin metathesis 有权
标题翻译：钼和钨金属络合物及其作为烯烃复分解的预催化剂的用途
公开(公告)号：US09233362B2
公开(公告)日：2016-01-12
申请号：US14001811
申请日：2012-02-23
申请人： Alois Furstner , Johannes Heppekausen
发明人： Alois Furstner , Johannes Heppekausen
IPC分类号： B01J31/12 , C07F11/00 , C07C67/347 , C07D223/12 , C07D307/79 , C07F7/18 , B01J31/18 , B01J31/22
CPC分类号： B01J31/12 , B01J31/1805 , B01J31/1815 , B01J31/2265 , B01J2231/543 , B01J2531/64 , B01J2531/66 , C07C67/347 , C07D223/12 , C07D307/79 , C07F7/1804 , C07F11/00
摘要： The invention relates to metal complexes of general formula (I) and to a method for the production thereof, in which M, R1, R2, R3, X and Y in addition to Ra, Rb, Rc, Rd, Re, Rf, Rg, Rh can have the meanings defined in the claims. Said metal complexes form air-stable compounds and are suitable as pre-catalysts in the olefin metathesis.
摘要翻译：本发明涉及通式（I）的金属络合物及其制备方法，其中除了Ra，Rb，Rc，Rd，Re，Rf，Rg之外的M，R 1，R 2，R 3，X和Y ，Rh可以具有权利要求中定义的含义。所述金属络合物形成空气稳定化合物，并且适合作为烯烃复分解中的预催化剂。

6. 发明授权

US08853200B2 Treatment of rheumatoid arthritis with 3-amino lactam compounds 有权
标题翻译：用3-氨基内酰胺类化合物治疗类风湿关节炎
公开(公告)号：US08853200B2
公开(公告)日：2014-10-07
申请号：US12671785
申请日：2008-08-01
申请人： David John Grainger , David Fox
发明人： David John Grainger , David Fox
IPC分类号： A61K31/55 , C07D223/10 , A61P29/00 , A61P19/10 , C07D211/76 , C07D223/12 , A61K31/45
CPC分类号： A61K31/45 , C07D211/76 , C07D223/12 , Y02A50/411
摘要： The invention relates to 3-(2′,2′-dimethylpropanoylamino)-tetrahydropyridin-2-one, and its pharmaceutical compositions and its use for preparing a medicament intended to prevent or treat inflammatory disorders.
摘要翻译：本发明涉及3-（2'，2'-二甲基丙酰基氨基） - 四氢吡啶-2-酮及其药物组合物及其用于制备旨在预防或治疗炎症性疾病的药物的用途。

7. 发明申请

US20140005175A1 Substituted Aromatic Sulfur Compounds and Methods of Their Use 有权
标题翻译：取代芳香族硫化合物及其使用方法
公开(公告)号：US20140005175A1
公开(公告)日：2014-01-02
申请号：US13975483
申请日：2013-08-26
申请人： Cephalon, Inc. , University of Utah Research Foundation , University of Hawaii
发明人： Bruce D. Dorsey , Scott K. Kuwada , Jay P. Theroff , Craig A. Zificsak
IPC分类号： C07C317/32 , C07D213/40 , C07D223/10 , C07D295/192
CPC分类号： C07C317/32 , C07C317/14 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07D213/40 , C07D213/57 , C07D213/70 , C07D213/71 , C07D215/36 , C07D217/06 , C07D223/10 , C07D223/12 , C07D231/12 , C07D235/06 , C07D235/16 , C07D263/32 , C07D263/56 , C07D263/57 , C07D271/07 , C07D271/10 , C07D295/18 , C07D295/185 , C07D295/192 , C07D309/08 , C07D309/14 , C07D333/20 , C07D333/24
摘要： Compounds of formula II are described: wherein D, n, Ra, Rb, and Rc are as herein defined, along with pharmaceutical compositions and methods of using compounds of formula II for treating or reducing the risk of peritoneal carcinomatosis in a patient.
摘要翻译：描述了式II化合物：其中D，n，Ra，Rb和Rc如本文所定义，以及使用式II化合物治疗或降低患者腹膜癌病风险的药物组合物和方法。

8. 发明申请

US20130172318A1 ANTI-INFLAMMATORY AGENTS 审中-公开
标题翻译：抗炎药物
公开(公告)号：US20130172318A1
公开(公告)日：2013-07-04
申请号：US13702898
申请日：2011-06-08
申请人： David John Grainger , David John Fox
发明人： David John Grainger , David John Fox
IPC分类号： C07D223/12 , C07D211/76
CPC分类号： C07D223/12 , C07D211/74 , C07D211/76 , C07D401/12
摘要： Disclosed herein are methods of preventing or treating inflammatory diseases using 3-aminolactam compounds, each with aromatic “tail groups”. Compounds as defined by formulae (I) and (I′), and the medical uses of the compounds, are described herein.
摘要翻译：本文公开了使用具有芳族“尾组”的3-氨基内酰胺化合物预防或治疗炎性疾病的方法。本文描述了式（I）和（I'）所定义的化合物以及化合物的医学用途。

9. 发明授权

US08389279B2 α-aminocyclolactam ligands for G-protein coupled receptors, and methods of using same 失效
标题翻译： G蛋白偶联受体的α-氨基环内酰胺配体及其使用方法
公开(公告)号：US08389279B2
公开(公告)日：2013-03-05
申请号：US13193274
申请日：2011-07-28
申请人： David J. Grainger , David John Fox
发明人： David J. Grainger , David John Fox
IPC分类号： A61K31/55 , A61K31/439 , A61P9/12 , A61P9/10 , A61P11/06 , A61P3/04 , A61P37/06 , C12N5/07
CPC分类号： C07D225/02 , C07D207/273 , C07D211/76 , C07D223/12 , C07D487/08
摘要： The invention relates to the generation of a library of compounds enriched in agonist and antagonists for members of the G-protein coupled class of receptors (GPCRs).The library contains compounds of general formula (I) wherein y is any integer from 1 to 8; z is any integer from 0 to 8 with the proviso that y and z cannot simultaneously be 1; X is —CO—(Y)k—(R1)n or SO2—(Y)k—(R1)n; k is 0 or 1 Y is a cycloalkyl or polycyloalkyl group (such as an adamantyl, adamantanemethyl, bicyclooctyl, cyclohexyl, cyclopropyl group); or Y is a cycloalkenyl or polycycloalkenyl group; each R1 is independently selected from hydrogen or an alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl, alkylamino, alkylaminoalkyl, alkylaminodialkyl, charged alkylaminotrialkyl or charged alkylcarboxylate radical of 1 to 20 carbon atoms; or each R1 is independently selected from fluoro, chloro, bromo, iodo, hydroxy, oxyalkyl, amino, aminoalkyl, aminodialkyl, charged aminotrialkyl, or carboxylate radical; and n is any integer from 1 to m, where m is the maximum number of substitutions permissible on the cyclo-group Y; or alternatively R1 may be selected from a peptido radical, for example having from 1 to 4 peptidic moieties linked together by peptide bonds (for example a peptido radical of 1 to 4 amino acid residues).
摘要翻译：本发明涉及产生富含G-蛋白偶联受体类（GPCR）成员的激动剂和拮抗剂的化合物文库。该文库含有通式（I）的化合物，其中y为1至8的整数; z是0至8的任何整数，条件是y和z不能同时为1; X是-CO-（Y）k-（R1）n或SO2-（Y）k-（R1）n; k是0或1，Y是环烷基或聚环烷基（例如金刚烷基，金刚烷甲基，双环辛基，环己基，环丙基）; 或Y是环烯基或多环烯基; 每个R 1独立地选自氢或具有1至20个碳原子的烷基，卤代烷基，烷氧基，卤代烷氧基，烯基，炔基，烷基氨基，烷基氨基烷基，烷基氨基二烷基，带电荷的烷基氨基三烷基或带电荷的烷基羧酸根。或每个R 1独立地选自氟，氯，溴，碘，羟基，氧烷基，氨基，氨基烷基，氨基二烷基，带电荷的氨基三烷基或羧酸根; n为1〜m的整数，m为环基Y上允许的最大取代数; 或者R1可以选自肽基，例如具有通过肽键连接在一起的1至4个肽部分（例如1至4个氨基酸残基的肽基）。

10. 发明申请

US20120029188A1 Substituted Aniline Derivatives 失效
标题翻译：取代苯胺衍生物
公开(公告)号：US20120029188A1
公开(公告)日：2012-02-02
申请号：US13269321
申请日：2011-10-07
申请人： Andrew David Carr , Judi Charlotte Neuss , Michael Glen Orchard , David William Porter
发明人： Andrew David Carr , Judi Charlotte Neuss , Michael Glen Orchard , David William Porter
IPC分类号： C07D281/06 , C07D403/12 , C07D223/04 , C07C237/06 , C07D401/12 , C07D211/98 , C07D207/16 , C07C229/28 , C07D267/10 , C07D241/04
CPC分类号： C07D207/14 , C07D211/72 , C07D223/12 , C07D267/10 , C07D281/06 , C07D401/12 , C07D403/12 , C07D417/12
摘要： The present invention relates to novel aniline derivatives and their use in therapy, in particular their use in the treatment of fungal infections.
摘要翻译：本发明涉及新型苯胺衍生物及其在治疗中的用途，特别是其用于治疗真菌感染。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式