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    • 3. 发明申请
    • Process for the preparation of bis-benzazolyl compounds
    • 制备双 - 苯并唑基化合物的方法
    • US20070249840A1
    • 2007-10-25
    • US11821009
    • 2007-06-21
    • Victor EliuJulia Hauser
    • Victor EliuJulia Hauser
    • C07D263/64C07D403/10C07D417/10
    • C07D263/62C07D235/20C07D263/64C07D277/66C07D405/14C07D413/14
    • The present invention provides a process for the preparation of a compound of the formula wherein Y represents —O—, —S— or —N(R2)—, R2 being hydrogen, C1-C10alkyl or aralkyl; Z represents a 2,5-furanyl, 2,5-thiophenyl, 4,4′-stilbenyl or a 1,2-ethylenyl residue and R1 represents hydrogen, halogen, C1-C10alkyl, C1-C10alkoxyl, cyano, COOM or SO3M, M being hydrogen or an alkaline or alkaline earth metal, characterized by reacting a compound of the formula with a dicarboxylic acid of the formula HOOC-Z-COOH   (3) or an ester thereof, Y, Z and R1 being as previously defined, in N-methylpyrrolidone or N,N-dimethylacetamide, in the presence of an acidic catalyst and, optionally, in the presence of a secondary solvent capable of removing water from the reaction mixture, which are useful as optical whitening agents for natural and synthetic materials.
    • 本发明提供了制备下式化合物的方法,其中Y表示-O - , - S-或-N(R 2) - ,R 2' 是氢,C 1 -C 10烷基或芳烷基; Z表示2,5-呋喃基,2,5-噻吩基,4,4'-茋基或1,2-亚乙烯基,R 1表示氢,卤素,C 1, C 1 -C 10烷基,C 1 -C 10烷氧基,氰基,COOM或SO 3 M M是氢或碱土金属或碱土金属,其特征在于使下式的化合物与式(Ⅳ)的二羧酸反应式描述=“In-line formula”end =“lead”→> HOOC -Z-COOH(3)<?in-line-formula description =“In-line Formulas”end =“tail”?>或其酯,Y,Z和R 1如前所述 在N-甲基吡咯烷酮或N,N-二甲基乙酰胺中,在酸性催化剂的存在下,任选地,在能够从反应混合物中除去水的第二溶剂存在下,其可用作天然的光学增白剂和 合成材料。