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1. 发明申请

US20170342018A1 PROCEDURE FOR THE PREPARATION OF 4-PHENYL BUTYRATE AND USES THEREOF 有权
公开(公告)号：US20170342018A1
公开(公告)日：2017-11-30
申请号：US15164126
申请日：2016-05-25
申请人： Horizon Therapeutics, LLC
发明人： Huai-Chueh Chang , Steven S. Pfeiffer , Vasilios H. Iskos , Maki Uragami , Steven Weissman , Andrew Thompson
IPC分类号： C07C69/616 , C07C51/29 , C07C57/30 , C07C67/14
CPC分类号： C07C69/616 , C07C51/29 , C07C51/60 , C07C57/30 , C07C67/14 , C07C57/72
摘要： Provided is a process for preparing 4-phenyl-1-butyric acid, comprising: reacting 4-phenyl-1-butanol with sodium chlorite, a nitroxyl radical catalyst and sodium hypochlorite in an organic solvent and a phosphate buffer; and quenching the reaction with sodium sulfite to produce 4-phenyl-1-butyric. Also provided is 4-phenyl-1-butyric acid prepared by such a process.

2. 发明申请

US20170313650A1 SYNTHETIC BUILDING BLOCKS FOR THE PRODUCTION OF MATERIALS FOR ORGANIC ELECTROLUMINESCENCE DEVICES 审中-公开
公开(公告)号：US20170313650A1
公开(公告)日：2017-11-02
申请号：US15634746
申请日：2017-06-27
申请人： Merck Patent GmbH
发明人： Philipp STOESSEL , Amir Hossain Parham , Anja JATSCH
IPC分类号： C07C253/20 , C07D403/10 , C07C253/14 , C07C253/30 , C07D209/80 , C07D209/86 , C07D333/76 , C07D307/91 , C07D251/24 , C07D239/26 , C07D235/18 , C07D209/88 , C07D487/04 , C07C2603/18 , C07C2603/26 , C07C2603/42 , C07C2603/97 , C07C2603/24
CPC分类号： C07C253/20 , C07C51/16 , C07C51/60 , C07C231/02 , C07C253/14 , C07C253/30 , C07C255/51 , C07C2601/16 , C07C2602/10 , C07C2603/18 , C07C2603/24 , C07C2603/26 , C07C2603/42 , C07C2603/97 , C07D209/80 , C07D209/86 , C07D209/88 , C07D235/18 , C07D239/26 , C07D251/24 , C07D307/91 , C07D333/76 , C07D403/10 , C07D487/04
摘要： The present invention relates to compounds which are suitable as synthesis precursors for the production of electronically active materials for use in organic electroluminescence devices.

3. 发明申请

US20150232406A1 METATHESIS DEPOLYMERIZATION USING ACRYLATES 有权
标题翻译：使用丙烯酸酯的甲基脱氮化
公开(公告)号：US20150232406A1
公开(公告)日：2015-08-20
申请号：US14422740
申请日：2013-08-20
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
发明人： Kenneth Boone Wagener , Michael Schulz
IPC分类号： C07C51/60 , C08F236/02
CPC分类号： C07C51/60 , B01J31/2265 , B01J31/2273 , B01J31/2278 , B01J31/24 , B01J2231/54 , B01J2531/821 , C07C4/22 , C07C51/62 , C07C67/475 , C08F236/02 , C07C69/602 , C07C57/66 , C07C69/593
摘要： Olefin metathesis between an acrylate monomer and a polyene comprising molecule or polymer is employed as a method of cross-metathesizing or depolymerizing the molecule. The metathesis reaction forms a telechelic acrylate molecule that is a monomer, oligomer or polymer. The telechelic acrylate molecule can be employed as a monomer for condensation polymerization.
摘要翻译：使用丙烯酸酯单体和含多烯的分子或聚合物之间的烯烃复分解作为分子的交叉分解或解聚的方法。复分解反应形成作为单体，低聚物或聚合物的遥爪丙烯酸酯分子。丙烯酸遥爪分子可用作缩聚单体。

4. 发明申请

US20150141682A1 Method to Produce N-Acyl Amino Acid Surfactants Using N-Acyl Amino Acid Surfactants or the Corresponding Anhydrides as Catalysts 有权
标题翻译：使用N-酰基氨基酸表面活性剂或相应的酸酐作为催化剂生产N-酰基氨基酸表面活性剂的方法
公开(公告)号：US20150141682A1
公开(公告)日：2015-05-21
申请号：US14409540
申请日：2012-09-28
申请人： GALAXY SURFACTANTS LTD.
发明人： Nirmal Koshti , Bharat Bhikaji Parab , Rajendra Subhash Powale , Archana Kishor Desai , Kamlesh Keshwar Barai , Pradnya Mandar Katdare , Bhagyesh Jagannath Sawant , Santosh Vishnu Kadam , Srinivas Uppalaswamy Pilli
IPC分类号： C07C231/02
CPC分类号： C07C231/02 , C07C51/60 , C07C303/22 , C07C303/26 , C07C233/47 , C07C309/15 , C07C309/00 , C07C53/38
摘要： A process of producing N-acyl amino acid based surfactants of Formula I, wherein, R is selected from C6 to C22 alkyl group, R1 is selected from H, C1 to C4 alkyl, R2 is selected from all groups on α carbon of natural amino acids, R3 is selected from COOX, CH2—SO3X, X is selected from Li+, Na+ or K+. The process comprising steps of: A) preparing fatty acid chlorides by halogenating fatty acids with either phosgene or thionyl chloride in the presence of catalytic amount of same or other N-acyl amino acid surfactant of Formula I or anhydrides of same surfactant; and B) reacting fatty acid chloride of step (A) with an amino acid in the presence of a base.
摘要翻译：制备式I的N-酰基氨基酸的表面活性剂的方法，其中R选自C 6至C 22烷基，R 1选自H，C 1至C 4烷基，R 2选自天然氨基的α碳上的所有基团酸，R3选自COOX，CH2-SO3X，X选自Li +，Na +或K +。该方法包括以下步骤：A）通过在催化量相同的式I或其它N-酰基氨基酸表面活性剂或相同表面活性剂的酸酐存在下，用光气或亚硫酰氯卤化脂肪酸来制备脂肪酰氯; 和B）使步骤（A）的脂肪酰氯与碱的存在下的氨基酸反应。

5. 发明申请

US20140336403A1 PROCESS 审中-公开
标题翻译：处理
公开(公告)号：US20140336403A1
公开(公告)日：2014-11-13
申请号：US14340939
申请日：2014-07-25
申请人： Hoffmann-La Roche Inc.
发明人： Gerard John Harnett , John Hayes , Reinhard Reents , Dennis A. Smith , Andrew Walsh
IPC分类号： C07C231/12 , C07C231/02 , C07C51/60 , C07C253/30 , C07C51/08
CPC分类号： C07C253/30 , C07C51/06 , C07C51/08 , C07C51/60 , C07C231/02 , C07C231/06 , C07C231/12 , C07C319/06 , C07C319/22 , C07C327/30 , C07C2601/14 , C07C255/46 , C07C323/40 , C07C61/08
摘要： A process for the preparation of a compound of formula (I): which is useful as an intermediate in the preparation of pharmaceutically active compounds.
摘要翻译：制备式（I）化合物的方法：其可用作药物活性化合物的制备中的中间体。

6. 发明申请

US20140163257A1 METHOD FOR REDUCING HALOGENOBENZOIC ACID ESTER USING RUTHENIUM CARBONYL COMPLEX 有权
标题翻译：使用碳酸氢钠复合物降低卤代苯甲酸酯的方法
公开(公告)号：US20140163257A1
公开(公告)日：2014-06-12
申请号：US14100163
申请日：2013-12-09
申请人： TAKASAGO INTERNATIONAL CORPORATION
发明人： Kiyoto HORI , Osamu OGATA , Wataru KURIYAMA
IPC分类号： C07C51/60
CPC分类号： C07C51/60 , C07C29/149 , C07C33/46
摘要： An object of the present invention is to provide a method for reducing a halogenobenzoic acid ester, in which dehalogenation is inhibited, by using a readily available catalyst. The method comprises reducing an ester with hydrogen gas by using an aromatic hydrocarbon as a solvent in the presence of a ruthenium complex represented by the following general formula (1): RuXY(CO)(L) (1) where X and Y represent monovalent anionic ligands, and L represents a tridentate aminodiphosphine ligand represented by the following general formula (2): where RZ1 represents an alkyl group having 1 to 4 carbon atoms, each RZ2 represents an alkyl group having 1 to 4 carbon atoms or a halogen atom, any adjacent two RZ2s may form a ring, Hal represents a halogen atom, and n represents 0 to 4.
摘要翻译：本发明的目的是提供一种通过使用容易获得的催化剂来还原其中脱卤被抑制的卤代苯甲酸酯的方法。该方法包括在由以下通式（1）表示的钌络合物存在下，通过使用芳族烃作为溶剂，用氢气还原酯：RuXY（CO）（L）（1）其中X和Y表示一价阴离子配位体，L表示由以下通式（2）表示的三齿氨基二膦配体：其中RZ1表示碳原子数1〜4的烷基，各RZ2表示碳原子数为1〜4的烷基或卤素原子，任何相邻的两个RZ2可以形成环，Hal表示卤素原子，n表示0至4。

7. 发明申请

US20120108801A1 DISUBSTITUTED-AMINODIFLUOROSULFINIUM SALTS, PROCESS FOR PREPARING SAME AND METHOD OF USE AS DEOXOFLUORINATION REAGENTS 有权
标题翻译：分离的氨基磺酸盐钠盐，其制备方法和用作脱氧试剂的方法
公开(公告)号：US20120108801A1
公开(公告)日：2012-05-03
申请号：US13379176
申请日：2010-06-18
申请人： Michel A. Couturier , Alexandre L'Heureux
发明人： Michel A. Couturier , Alexandre L'Heureux
IPC分类号： C07F5/02 , C07C51/60 , C07H1/00 , C07C17/16 , C07C67/307
CPC分类号： C07D213/76 , C07B39/00 , C07B2200/13 , C07C17/16 , C07C17/18 , C07C51/60 , C07C67/307 , C07C381/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D207/06 , C07D207/48 , C07D295/22 , C07D295/26 , C07C22/08 , C07C23/16 , C07C23/10 , C07C57/72 , C07C63/10 , C07C69/75
摘要： The invention relates to disubstituted-aminodifluorosulfinium salts represented by the formula (I). Processes for preparing same and methods of use as deoxofluorinating reagent is also provided.
摘要翻译：本发明涉及由式（I）表示的二取代 - 氨基二氟亚磺酸盐。还提供了制备方法和脱氧氟试剂的使用方法。

8. 发明授权

US07906662B2 Process for the preparation of cyclopropyl carboxylic acid esters and derivatives 有权
标题翻译：制备环丙基羧酸酯和衍生物的方法
公开(公告)号：US07906662B2
公开(公告)日：2011-03-15
申请号：US11487457
申请日：2006-07-17
申请人： Adrian Clark , Elfyn Jones , Ulf Larsson , Anna Minidis
发明人： Adrian Clark , Elfyn Jones , Ulf Larsson , Anna Minidis
IPC分类号： C07C65/17 , C07C247/22
CPC分类号： C07C61/40 , C07B2200/07 , C07C51/09 , C07C51/38 , C07C51/60 , C07C57/60 , C07C57/66 , C07C67/347 , C07C69/753 , C07C211/40 , C07C247/22 , C07C2601/02 , C07C2601/14 , C07D487/04
摘要： The compounds trans-(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarbonyl azide and trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropanaminium (2R)-2-hydroxy-2-phenylethanoate.
摘要翻译：反式 - （1R，2R）-2-（3,4-二氟苯基）环丙烷羰基叠氮化物和反式 - （1R，2S）-2-（3,4-二氟苯基）环丙烷基（2R）-2-羟基-2- 苯乙酸乙酯。

9. 再颁专利

USRE41357E1 Process for producing a fluorine atom-containing sulfonyl fluoride compound 有权
标题翻译：含氟原子的磺酰氟化合物的制造方法
公开(公告)号：USRE41357E1
公开(公告)日：2010-05-25
申请号：US12234140
申请日：2008-09-19
申请人： Masahiro Ito , Kunio Watanabe , Takashi Okazoe , Isamu Kaneko , Daisuke Shirakawa
发明人： Masahiro Ito , Kunio Watanabe , Takashi Okazoe , Isamu Kaneko , Daisuke Shirakawa
IPC分类号： C07C69/66 , C07C309/00
CPC分类号： C07C309/82 , C07C51/60 , C07C303/22 , C07C59/135
摘要： The present invention provides a process whereby fluorine atom-containing sulfonyl fluoride compound(s) useful as e.g. materials for ion-exchange membranes, can be produced efficiently and at low cost without structural limitations while solving the difficulties in production. Namely, the present invention provides a process which comprises reacting XSO2RA-E1 (1) with RB-E2 (2) to form XSO2RA-E-RB (3), then reacting (3) with fluorine in a liquid phase to form FSO2RAF-EF-RBF (4), and further, decomposing the compound to obtain FSO2RAF-EF1 (5), wherein RA is a bivalent organic group, E1 is a monovalent reactive group, RB is a monovalent organic group, E2 is a monovalent reactive group which is reactive with E1, E is a bivalent connecting group formed by the reaction of E1 with E2, RAF is a bivalent organic group formed by the fluorination of RA, etc., RBF is the same group as RB, etc., EF is a bivalent connecting group formed by the fluorination of E, etc., EF1 is a monovalent group formed by the decomposition of EF, and X is a halogen atom.
摘要翻译：本发明提供了一种可用于例如氟原子的磺酰氟化合物的方法。用于离子交换膜的材料可以在没有结构限制的情况下有效且低成本地生产，同时解决生产上的困难。即，本发明提供了使XSO 2RA-E1（1）与RB-E2（2）反应形成XSO 2RA -E-RB（3），然后使（3）与氟在液相中反应形成FSO 2RAF- EF-RBF（4），进一步分解化合物，得到FSO2RAF-EF1（5），其中RA为二价有机基团，E1为单价反应性基团，RB为一价有机基团，E2为单价反应性基团 E是与E1反应的二价连接基团，E是通过E1与E2的反应形成的二价连接基团，RAF是通过RA的氟化形成的二价有机基团等，RBF与RB等同，EF是通过E的氟化形成的二价连接基团等，EF1是通过EF的分解形成的一价基团，X是卤素原子。

10. 再颁专利

USRE41184E1 Process for producing a fluorine atom-containing sulfonyl fluoride compound 有权
公开(公告)号：USRE41184E1
公开(公告)日：2010-03-30
申请号：US12234109
申请日：2008-09-19
申请人： Masahiro Ito , Kunio Watanabe , Takashi Okazoe , Isamu Kaneko , Daisuke Shirakawa
发明人： Masahiro Ito , Kunio Watanabe , Takashi Okazoe , Isamu Kaneko , Daisuke Shirakawa
IPC分类号： C07C69/66 , C07C69/63 , C07C309/00
CPC分类号： C07C309/82 , C07C51/60 , C07C303/22 , C07C59/135
摘要： The present invention provides a process whereby fluorine atom-containing sulfonyl fluoride compound(s) useful as e.g. materials for ion-exchange membranes, can be produced efficiently and at low cost without structural limitations while solving the difficulties in production. Namely, the present invention provides a process which comprises reacting XSO2RA-E1 (1) with RB-E2 (2) to form XSO2RA-E-RB (3), then reacting (3) with fluorine in a liquid phase to form FSO2RAF-EF-RBF (4), and further, decomposing the compound to obtain FSO2RAF-EF1 (5), wherein RA is a bivalent organic group, E1 is a monovalent reactive group, RB is a monovalent organic group, E2 is a monovalent reactive group which is reactive with E1, E is a bivalent connecting group formed by the reaction of E1 with E2, RAF is a bivalent organic group formed by the fluorination of RA, etc., RBF is the same group as RB, etc., EF is a bivalent connecting group formed by the fluorination of E, etc., EF1 is a monovalent group formed by the decomposition of EF, and X is a halogen atom.

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