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1. 发明授权

US09546186B2 Non-invasive diagnostic agents of cancer and methods of diagnosing cancer, especially leukemia and lymphoma 有权
标题翻译：癌症的非侵入性诊断剂和诊断癌症的方法，特别是白血病和淋巴瘤
公开(公告)号：US09546186B2
公开(公告)日：2017-01-17
申请号：US14451916
申请日：2014-08-05
申请人： STC.UNM
发明人： Jeffrey P. Norenberg , Richard S. Larson
IPC分类号： A61K51/00 , A61M36/14 , C07F5/00 , C07F9/94 , A61K49/10 , A61K51/04
CPC分类号： C07F5/003 , A61K47/22 , A61K49/106 , A61K51/0474 , A61K51/0482 , A61K51/0485 , A61K51/0497 , C07F9/94
摘要： The present invention is directed to novel non-invasive diagnostic tools to image cancers, especially, leukemia and non-Hodgkin's lymphomas (NHL) with minimal toxicity in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probe is capable of detecting precancerous cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and staging of NHL using non-invasively molecular imaging techniques. This novel probe will also be useful to monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of NHL. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.
摘要翻译：本发明涉及用于对癌症特别是白血病和非霍奇金淋巴瘤（NHL）进行成像的新型非侵入性诊断工具，其体内毒性最小。本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。该新型成像探针能够检测癌前细胞，以及它们在组织中的转移扩散。这代表了使用非侵入性分子成像技术在NHL的诊断和分期中向前推进的量子进程。该新型探针也可用于监测患者对化疗治疗的反应和用于治疗NHL的其他干预措施或疗法。根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

2. 发明授权

US09085594B2 Organometallic compound purification 有权
标题翻译：有机金属化合物净化
公开(公告)号：US09085594B2
公开(公告)日：2015-07-21
申请号：US13549407
申请日：2012-07-13
申请人： Curtis D. Modtland , Chet D. Davidson
发明人： Curtis D. Modtland , Chet D. Davidson
IPC分类号： C07F9/00 , C07F5/00 , C07F3/00 , B01D3/02 , C07F9/90 , C07F5/06 , C07F3/06 , C07F9/94 , C07F9/72 , B01D3/14
CPC分类号： C07F9/94 , B01D3/143 , C07F3/06 , C07F5/00 , C07F5/062 , C07F9/72 , C07F9/90
摘要： A method of purifying crude organometallic compounds using a plurality of distillation columns is provided. This method effectively removes both relatively more volatile impurities and relatively less volatile impurities as compared to the organometallic compound.
摘要翻译：提供了使用多个蒸馏塔纯化粗有机金属化合物的方法。与有机金属化合物相比，该方法有效地除去相对更易挥发的杂质和相对较少的挥发性杂质。

3. 发明申请

US20140341806A1 NON-INVASIVE DIAGNOSTIC AGENTS OF CANCER AND METHODS OF DIAGNOSING CANCER, ESPECIALLY LEUKEMIA AND LYMPHOMA 有权
标题翻译：癌症非侵入性诊断试剂和诊断癌症的方法，特别是白喉和淋巴瘤
公开(公告)号：US20140341806A1
公开(公告)日：2014-11-20
申请号：US14451916
申请日：2014-08-05
申请人： STC.UNM
发明人： Jeffrey P. Norenberg , Richard S. Larson
IPC分类号： C07F5/00
CPC分类号： C07F5/003 , A61K47/22 , A61K49/106 , A61K51/0474 , A61K51/0482 , A61K51/0485 , A61K51/0497 , C07F9/94
摘要： The present invention is directed to novel non-invasive diagnostic tools to image cancers, especially, leukemia and non-Hodgkin's lymphomas (NHL) with minimal toxicity in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probe is capable of detecting precancerous cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and staging of NHL using non-invasively molecular imaging techniques. This novel probe will also be useful to monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of NHL. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.
摘要翻译：本发明涉及用于对癌症特别是白血病和非霍奇金淋巴瘤（NHL）进行成像的新型非侵入性诊断工具，其体内毒性最小。本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。该新型成像探针能够检测癌前细胞，以及它们在组织中的转移扩散。这代表了使用非侵入性分子成像技术在NHL的诊断和分期中向前推进的量子进程。该新型探针也可用于监测患者对化疗治疗的反应和用于治疗NHL的其他干预措施或疗法。根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

4. 发明申请

US20140303321A1 METAL COMPLEX COMPOUNDS AS CATALYSTS FOR POLYURETHANE COMPOSITIONS 有权
标题翻译：金属复合化合物作为聚氨酯组合物的催化剂
公开(公告)号：US20140303321A1
公开(公告)日：2014-10-09
申请号：US14359772
申请日：2012-12-12
申请人： SIKA TECHNOLOGY AG
发明人： Urs Burckhardt , Rita Cannas
IPC分类号： C08G18/22 , C08G18/76 , C08G18/32 , C09D175/08
CPC分类号： C08G18/222 , C07F1/005 , C07F1/08 , C07F1/10 , C07F1/12 , C07F3/003 , C07F3/06 , C07F5/003 , C07F5/069 , C07F7/003 , C07F7/2224 , C07F7/24 , C07F7/28 , C07F7/30 , C07F9/005 , C07F9/90 , C07F9/902 , C07F9/94 , C07F11/005 , C07F13/005 , C07F15/00 , C07F15/0006 , C07F15/0013 , C07F15/0026 , C07F15/0053 , C07F15/0066 , C07F15/0093 , C07F15/02 , C07F15/025 , C07F15/045 , C07F15/065 , C08G18/227 , C08G18/24 , C08G18/26 , C08G18/3206 , C08G18/7664 , C08G65/328 , C08G65/337 , C09D175/08
摘要： The invention relates to metal complex compounds of the formula Mk(L)x(Y)kz-nx, where the ligand L has the formula (I), and to metal complex compounds which include the reaction product of at least one salt or a complex of a transition metal or a main group metal element of the groups 13 to 15 and at least one 1,3-ketoamide. Such complex compounds are suitable in particular as catalysts for polyurethane compositions. The invention also relates to two-component polyurethane compositions including at least one polyisocyanate as the first component, at least one polyol as the second component, and at least one such metal complex compound as the catalyst. The invention additionally relates to different uses of the two-component polyurethane compositions.
摘要翻译：本发明涉及式Mk（L）x（Y）kz-nx的金属络合物，其中配体L具有式（I），以及金属络合物，其包括至少一种盐或第13至15族的过渡金属或主族金属元素的复合物和至少一种1,3-酮酰胺。这种络合物特别适用于聚氨酯组合物的催化剂。本发明还涉及包含作为第一组分的至少一种多异氰酸酯，作为第二组分的至少一种多元醇和作为催化剂的至少一种这样的金属络合物的双组分聚氨酯组合物。本发明还涉及双组分聚氨酯组合物的不同用途。

5. 发明申请

US20140142287A1 SYNTHESIS OF CARBOHYDRATE-BASED SURFACTANTS 有权
标题翻译：基于碳酸氢盐的表面活性剂的合成
公开(公告)号：US20140142287A1
公开(公告)日：2014-05-22
申请号：US14041251
申请日：2013-09-30
申请人： THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人： Jeanne E. Pemberton , Robin L. Polt , Raina M. Maier , Clifford S. Coss
IPC分类号： C07H15/06 , C07H15/14
CPC分类号： C07H15/14 , C07F3/003 , C07F9/94 , C07H1/00 , C07H15/04 , C07H15/06
摘要： The present invention provides carbohydrate-based surfactants and methods for producing the same. Methods for producing carbohydrate-based surfactants include using a glycosylation promoter to link a carbohydrate or its derivative to a hydrophobic compound.
摘要翻译：本发明提供了基于碳水化合物的表面活性剂及其制备方法。制备碳水化合物基表面活性剂的方法包括使用糖基化启动子将碳水化合物或其衍生物与疏水性化合物连接。

6. 发明申请

US20120070372A1 NON-INVASIVE DIAGNOSTIC AGENTS OF CANCER AND METHODS OF DIAGNOSING CANCER, ESPECIALLY LEUKEMIA AND LYMPHOMA 有权
标题翻译：癌症非侵入性诊断试剂和诊断癌症的方法，特别是白喉和淋巴瘤
公开(公告)号：US20120070372A1
公开(公告)日：2012-03-22
申请号：US13309972
申请日：2011-12-02
申请人： Jeffrey P. Norenberg , Richard S. Larson
发明人： Jeffrey P. Norenberg , Richard S. Larson
IPC分类号： A61K51/04 , C07F9/94 , A61P29/00 , A61P37/00 , A61P9/10 , A61P9/00 , A61P13/12 , A61P19/02 , A61P17/00 , A61P7/00 , A61P1/00 , A61P37/06 , A61P35/00 , A61P35/04 , A61P11/00 , A61P25/00 , A61P3/10 , A61P27/02 , A61P17/06 , A61P17/12 , A61P35/02 , C07F5/00
CPC分类号： C07F5/003 , A61K47/22 , A61K49/106 , A61K51/0474 , A61K51/0482 , A61K51/0485 , A61K51/0497 , C07F9/94
摘要： The present invention is directed to novel non-invasive diagnostic tools to image cancers, especially, leukemia and non-Hodgkin's lymphomas (NHL) with minimal toxicity in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probe is capable of detecting precancerous cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and staging of NHL using non-invasively molecular imaging techniques. This novel probe will also be useful to monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of NHL. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.
摘要翻译：本发明涉及用于对癌症特别是白血病和非霍奇金淋巴瘤（NHL）进行成像的新型非侵入性诊断工具，其体内毒性最小。本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。该新型成像探针能够检测癌前细胞，以及它们在组织中的转移扩散。这代表了使用非侵入性分子成像技术在NHL的诊断和分期中向前推进的量子进程。该新型探针也可用于监测患者对化疗治疗的反应和用于治疗NHL的其他干预措施或疗法。根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

7. 发明申请

US20110021654A1 NOVEL CATIONIC PHOTOPOLYMERIZATION INITIATOR 失效
标题翻译：新型阳离子光电聚合反应器
公开(公告)号：US20110021654A1
公开(公告)日：2011-01-27
申请号：US12922278
申请日：2008-12-11
申请人： Yoshihiro Matano , Hiroshi Imahori
发明人： Yoshihiro Matano , Hiroshi Imahori
IPC分类号： C08F2/46 , C07F9/94
CPC分类号： C08F2/50 , C07F9/94 , C08G59/68 , C08L63/00
摘要： An object of the present invention is to provide a novel cationic photopolymerization initiator that efficiently absorbs light and generates protons. As a means of achieving the object above, a preferred cationic photopolymerization initiator of the present invention includes an initiator comprising a bismuthonium salt represented by the following general formula (II): Wherein R11, R12, and R13 may be the same or different and are each an optionally substituted monocyclic aryl group or an optionally substituted monocyclic heteroaryl group, R14 is an optionally substituted fused polycyclic aromatic group or an optionally substituted fused polycyclic heterocyclic group, and X− is an anion associated with a cation.
摘要翻译：本发明的目的是提供一种有效吸收光并产生质子的新型阳离子光聚合引发剂。作为实现上述目的的方法，本发明优选的阳离子光聚合引发剂包括由以下通式（II）表示的铋鎓盐的引发剂：其中R11，R12和R13可以相同或不同，并且为每个是任选取代的单环芳基或任选取代的单环杂芳基，R 14是任选取代的稠合多环芳基或任选取代的稠合多环杂环基，X-是与阳离子相关的阴离子。

8. 发明申请

US20070048216A1 Non-invasive diagnostic agents of cancer and methods of diagnosing cancer, especially leukemia and lymphoma 有权
标题翻译：癌症的非侵入性诊断剂和诊断癌症的方法，特别是白血病和淋巴瘤
公开(公告)号：US20070048216A1
公开(公告)日：2007-03-01
申请号：US11507846
申请日：2006-08-22
申请人： Jeffrey Norenberg
发明人： Jeffrey Norenberg
IPC分类号： A61K51/00 , C07F5/00 , C07F13/00
CPC分类号： C07F5/003 , A61K47/22 , A61K49/106 , A61K51/0474 , A61K51/0482 , A61K51/0485 , A61K51/0497 , C07F9/94
摘要： The present invention is directed to novel non-invasive diagnostic tools to image cancers, especially, leukemia and non-Hodgkin's lymphomas (NHL) with minimal toxicity in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probe is capable of detecting precancerous cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and staging of NHL using non-invasively molecular imaging techniques. This novel probe will also be useful to monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of NHL. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.
摘要翻译：本发明涉及用于对癌症特别是白血病和非霍奇金淋巴瘤（NHL）进行成像的新型非侵入性诊断工具，其体内毒性最小。本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。该新型成像探针能够检测癌前细胞，以及它们在组织中的转移扩散。这代表了使用非侵入性分子成像技术在NHL的诊断和分期中向前推进的量子进程。该新型探针也可用于监测患者对化疗治疗的反应和用于治疗NHL的其他干预措施或疗法。根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

9. 发明授权

US06916944B2 Bismuth compound, process of producing the same, and process of producing a film 有权
标题翻译：铋化合物，其制造方法以及膜的制造方法
公开(公告)号：US06916944B2
公开(公告)日：2005-07-12
申请号：US10819120
申请日：2004-04-07
申请人： Taishi Furukawa , Noriaki Oshima , Kenichi Sekimoto
发明人： Taishi Furukawa , Noriaki Oshima , Kenichi Sekimoto
IPC分类号： C07F9/94 , C23C16/18 , C23C16/40 , C23C16/00
CPC分类号： C07F9/94 , C23C16/18 , C23C16/40
摘要： A novel bismuth compound having excellent vaporization characteristic and/or thermal stability, a process of producing the same and a process of producing a film in the film formation by the CVD process are disclosed. Bismuth compounds each represented by the following formula 1, 5 and 9, processes of producing the same, and processes of producing a film. In the formulae, R1 and R7 each represents a lower alkyl group; R2, R8, R12, and R13 each represents a lower alkyl group, a lower alkoxy group, or the like; m represents the number of the substituent R12 in the range of 0-5; n1, n2, and n3 respectively represent the number of the substituent R2, the number of the substituent R8, and the number of the substituent R13 each in the range of 0-4; and R3 to R6, R9 to R11, R14, and R15 each represents hydrogen, a lower alkyl group, or the like, provided that specific combinations of the substituents are excluded.
摘要翻译：公开了一种具有优异的蒸发特性和/或热稳定性的新型铋化合物，其制备方法以及通过CVD工艺在膜形成中制备膜的方法。铋化合物各自由下式1,5和9表示，其制备方法和制备薄膜的方法。式中，R 1和R 7各自表示低级烷基; R 2，R 8，R 12和R 13各自表示低级烷基，低级烷氧基组等; m表示0-5的取代基R 12的数目; n 1，n 2，n 2和n 3分别表示取代基R 2的数目，取代基R 8，取代基R 13的数目各自在0-4的范围内; 和R 3至R 6，R 9至R 11，R 14，R 14，，并且R 15各自表示氢，低级烷基等，条件是排除取代基的特定组合。

10. 发明申请

US20050035177A1 Method for preparing colloidal solution of bismuth sodium tartrate 审中-公开
标题翻译：酒石酸铋钠胶体溶液的制备方法
公开(公告)号：US20050035177A1
公开(公告)日：2005-02-17
申请号：US10832084
申请日：2004-04-26
申请人： Fernando Palafox
发明人： Fernando Palafox
IPC分类号： A61K9/00 , A61K31/191 , A61K31/29 , A61K33/24 , C07F9/94 , B23K1/00
CPC分类号： A61K9/0095 , A61K31/191 , A61K31/29 , A61K33/245 , C07F9/94 , Y10S514/819
摘要： A method for preparation of a semitransparent colloidal solution of bismuth sodium tartrate generally comprises producing an aqueous solution of bismuth sodium tartrate; extracting a magma of bismuth sodium tartrate from the aqueous solution at a pH of approximately 2.2; and then dissolving the magma into a salting-in mixture. After addition of preservative and strength testing, the base solution is diluted to elixir strength. The elixir is then buffered to a pH range of about 7.2 to about 7.3 in order to maintain for an extended duration the semitransparent nature of the elixir.
摘要翻译：酒石酸铋钠半透明胶体溶液的制备方法一般包括制备酒石酸铋钠水溶液; 在大约2.2的pH下从水溶液中提取酒石酸铋钠的岩浆; 然后将岩浆溶解成盐析混合物。加入防腐剂和强度试验后，将碱溶液稀释至酏剂强度。然后将酏剂缓冲至约7.2至约7.3的pH范围，以便延长持续时间，以保持酏剂的半透明性质。

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