专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20180086691A9 SYNTHESIS OF A SUBSTITUTED INDENE DERIVATIVE 审中-公开
公开(公告)号：US20180086691A9
公开(公告)日：2018-03-29
申请号：US15411863
申请日：2017-01-20
申请人： AQUINOX PHARMACEUTICALS (CANADA) INC.
发明人： Curtis Harwig , Jeyaprakashnarayanan Seenisamy , Mahesh Narayan Keregadde , Lakshindra Chetia
IPC分类号： C07C209/30
CPC分类号： C07C209/30 , C07B2200/07 , C07C213/00 , C07C249/12 , C07C2101/14 , C07C2102/02 , C07C2601/14 , C07C2602/02 , C07C2602/24 , C07D307/77 , C07D317/70 , C07D317/72 , C07J1/0011 , C07J1/0022 , C07J13/007 , C07J21/008 , C07J31/006 , C07J51/00 , C07J71/0026 , C07J73/003 , C07J73/005 , C07C215/42
摘要： This invention is directed to methods of preparing AQX-1125 having the formula: This invention is also directed to intermediates utilized in the methods of preparing AQX-1125.

2. 发明授权

US09834578B2 Enhanced sensitivity for analysis of ketosteroid compounds using mass spectrometry 有权
公开(公告)号：US09834578B2
公开(公告)日：2017-12-05
申请号：US13114885
申请日：2011-05-24
申请人： Bingfang Yue , Alan L. Rockwood , Mark M. Kushnir
发明人： Bingfang Yue , Alan L. Rockwood , Mark M. Kushnir
IPC分类号： C07J1/00 , C07J41/00
CPC分类号： C07J1/0022 , C07J41/0016
摘要： The present disclosure provides methods and composition involving increased sensitivity of compounds using mass spectrometry. In one embodiment, a method of increasing the sensitivity for detection of a carbonyl group-containing compound by mass spectrometry can comprise derivatizing the carbonyl group-containing compound with an O-substituted hydroxylamine thereby producing an oxime, resulting in enhanced sensitivity of detection by mass spectrometry, as compared to the underivatized carbonyl group-containing compound.Additionally, a method for assaying a carbonyl group-containing compound can comprise reacting the carbonyl group-containing compound in a sample with an O-substituted hydroxylamine to produce an oxime and performing analysis with mass spectrometric detection of the oxime by a mass spectrometry instrument.Further, an assay for a ketosteroid can comprise a derivatized ketosteroid produced by reacting the ketosteroid with an O-substituted hydroxylamine to produce an oxime and a mass spectrometry instrument for performing mass spectrometric analysis on the derivatized ketosteroid.

3. 发明申请

US20160022701A1 NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF 审中-公开
标题翻译：神经性STEROIDS，组合物及其用途
公开(公告)号：US20160022701A1
公开(公告)日：2016-01-28
申请号：US14775401
申请日：2014-03-13
申请人： SAGE THERAPEUTICS, INC.
发明人： Kiran Reddy , James Doherty
IPC分类号： A61K31/575 , G01N33/68 , G01N33/92 , G01N24/08 , A61K31/568 , A61K31/56
CPC分类号： A61K31/575 , A61K31/56 , A61K31/568 , C07J1/0011 , C07J1/0022 , C07J1/0029 , C07J3/00 , C07J7/002 , C07J7/007 , C07J9/00 , C07J9/005 , C07J13/005 , C07J13/007 , C07J17/00 , C07J21/00 , C07J21/008 , C07J31/006 , C07J41/0005 , C07J41/0055 , C07J41/0061 , C07J41/0088 , C07J43/003 , C07J51/00 , G01N24/08 , G01N33/5008 , G01N33/6896 , G01N33/92
摘要： Provided are methods of evaluating or treating a patient, e.g., a patient having a disorder described herein, comprising: a) optionally, acquiring a patient sample; b) acquiring an evaluation of and/or evaluating the sample for an alteration in the level S24(S)-hydroxycholesterol compared to a reference standard.
摘要翻译：提供评估或治疗患者，例如患有本文所述障碍的患者的方法，包括：a）任选地获取患者样品; b）与参考标准相比，获得对S24（S） - 羟基胆固醇水平的改变的评估和/或评估样品。

4. 发明申请

US20140135397A1 HALOGENATED PHENOLS FOR DIAGNOSTICS, ANTIOXIDANT PROTECTION AND DRUG DELIVERY 审中-公开
标题翻译：用于诊断，抗氧化剂保护和药物输送的氢化酚
公开(公告)号：US20140135397A1
公开(公告)日：2014-05-15
申请号：US14159893
申请日：2014-01-21
申请人： Keith R. Latham
发明人： Keith R. Latham
IPC分类号： A61K47/48
CPC分类号： A61K47/48023 , A61K49/006 , A61K49/0438 , A61K51/0446 , C07C43/295 , C07C217/60 , C07C229/36 , C07C233/25 , C07C323/52 , C07D209/36 , C07D475/08 , C07D489/02 , C07D499/897 , C07J1/0022 , C07J5/0053 , G01N33/52 , Y10T436/145555
摘要： The present invention provides compositions and methods for the targeted delivery, release and/or formation of a drug compound at a target site(s) within the body of an individual, such as a diseased and/or inflamed tissue in the body of the individual. These compositions may comprise a halogenated phenol ring cleavably linked to a core structure of a drug compound. Due to the variety of substituents that may be utilized in forming the different types of linkages, numerous examples of drug compounds linked to a halogenated phenol ring are proposed. The present invention further provides compositions comprising halogenated phenol starting compounds that do not undergo cleavage during a dehalogenation reaction to form a drug compound in a targeted tissue when administered to an individual. Methods of administering these non-cleaving compounds are further provided.
摘要翻译：本发明提供用于在个体体内的目标部位（例如个体体内的患病和/或发炎的组织）靶向递送，释放和/或形成药物化合物的组合物和方法。这些组合物可以包含与药物化合物的核心结构可分离连接的卤代苯酚环。由于可用于形成不同类型的键的多种取代基，提出了与卤代酚环连接的药物化合物的许多实例。本发明进一步提供包含卤代苯酚起始化合物的组合物，其在给予个体时在脱卤反应期间不会在靶组织中形成药物化合物时进行裂解。还提供了施用这些非切割化合物的方法。

5. 发明授权

US08367646B2 Steroid compounds and treatment methods 失效
标题翻译：类固醇化合物和治疗方法
公开(公告)号：US08367646B2
公开(公告)日：2013-02-05
申请号：US13306141
申请日：2011-11-29
申请人： James M. Frincke
发明人： James M. Frincke
IPC分类号： A61K31/56 , C07J1/00
CPC分类号： A61K31/568 , A61K31/565 , A61K31/567 , A61K31/5685 , A61K45/06 , C07J1/00 , C07J1/0011 , C07J1/0022 , C07J1/0025 , C07J1/0048 , C07J31/00 , C07J41/00
摘要： The invention provides methods to treating conditions such as prostate cancer, or for ameliorating one or more symptoms associated with prostate cancer, or for agents that modulate the biological activity of the androgen receptor. The invention also provides methods and compositions suitable for therapeutic applications.
摘要翻译：本发明提供了治疗诸如前列腺癌或改善与前列腺癌相关的一种或多种症状的病症或调节雄激素受体生物学活性的药物的方法。本发明还提供适用于治疗应用的方法和组合物。

6. 发明申请

US20120214987A1 METHODS AND COMPOUNDS FOR PREPARING 3ALPHA-OXYGEN SUBSTITUTED STEROIDS 审中-公开
标题翻译：制备3ALPHA-氧气取代的甾体的方法和化合物
公开(公告)号：US20120214987A1
公开(公告)日：2012-08-23
申请号：US13327701
申请日：2011-12-15
申请人： Yu Ge , Steven K. White , Yujin Huang
发明人： Yu Ge , Steven K. White , Yujin Huang
IPC分类号： C07J71/00 , C07J3/00
CPC分类号： C07J11/00 , C07J1/0011 , C07J1/0022 , C07J1/0025 , C07J1/0048 , C07J21/003 , C07J41/0038 , C07J51/00 , C07J71/001
摘要： The invention relates to processes for preparing 3α-O-linked steroids including 3α-O-linked-androst-5-ene steroids and 3α-O-linked-5a-androstane steroids. In one process a 3α,4α-epoxy androst-5-en-17-one is predominately reduced at the epoxy moiety wherein reduction of the 3α,4α epoxy functional group occurs preferentially at position C4 with retention of configuration at position C3 to provide a 3α-O-linked-androst-5-ene steroid. In another process, conditions are provided for inversion of configuration of a 3β-hydroxy-androst-5-ene steroid by the Mitsunobu reaction to provide a 3α-O-linked-androst-5-ene steroid with reduced amounts of 3α,5α-cycloandrostane side-product impurities.
摘要翻译：本发明涉及制备包括3α-O-连接的雄甾-5-烯类固醇和3α-O-连接的-5α-雄甾烷类固醇的3α-O-连接的类固醇的方法。在一个方法中，3α，4α-环氧雄甾-5-烯-17-酮在环氧部分主要降低，其中3α，4α环氧官能团的还原优先在位置C4处发生，并保留C3位置上的构型，以提供 3α-O-连接 - 雄甾-5-烯类固醇。在另一种方法中，通过Mitsunobu反应提供3β-羟基 - 雄甾-5-烯类固醇的构型的反转条件，以提供3α-5连接的雄甾-5-烯类固醇，减少量的3α，5α - 环二雄甾烷副产物杂质。

7. 发明申请

US20120126107A1 Enhanced Sensitivity for Analysis of Carbonyl Containing Compounds Using Mass Spectrometry 有权
标题翻译：使用质谱分析含羰基化合物的增强灵敏度
公开(公告)号：US20120126107A1
公开(公告)日：2012-05-24
申请号：US13114885
申请日：2011-05-24
申请人： Bingfang Yue , Alan L. Rockwood , Mark M. Kushnir
发明人： Bingfang Yue , Alan L. Rockwood , Mark M. Kushnir
IPC分类号： C07J41/00 , H01J49/26
CPC分类号： C07J1/0022 , C07J41/0016
摘要： The present disclosure provides methods and composition involving increased sensitivity of compounds using mass spectrometry. In one embodiment, a method of increasing the sensitivity for detection of a carbonyl group-containing compound by mass spectrometry can comprise derivatizing the carbonyl group-containing compound with an O-substituted hydroxylamine thereby producing an oxime, resulting in enhanced sensitivity of detection by mass spectrometry, as compared to the underivatized carbonyl group-containing compound.Additionally, a method for assaying a carbonyl group-containing compound can comprise reacting the carbonyl group-containing compound in a sample with an O-substituted hydroxylamine to produce an oxime and performing analysis with mass spectrometric detection of the oxime by a mass spectrometry instrument.Further, an assay for a ketosteroid can comprise a derivatized ketosteroid produced by reacting the ketosteroid with an O-substituted hydroxylamine to produce an oxime and a mass spectrometry instrument for performing mass spectrometric analysis on the derivatized ketosteroid.
摘要翻译：本公开提供涉及使用质谱法的化合物增加的灵敏度的方法和组合。在一个实施方案中，通过质谱法提高检测含羰基化合物的灵敏度的方法可以包括用O-取代的羟胺衍生含羰基化合物，从而产生肟，从而提高质量检测的灵敏度与未衍生的含羰基化合物相比较。此外，用于测定含羰基化合物的方法可以包括将样品中的含羰基化合物与O-取代的羟胺反应以产生肟，并通过质谱仪对肟的质谱检测进行分析。此外，酮甾类的测定可以包括通过使酮类固醇与O-取代的羟胺反应以产生肟而产生的衍生的酮类固醇，以及用于对衍生的酮类固醇进行质谱分析的质谱仪。

8. 发明授权

US08076316B2 Steroid compounds and formulations 失效
标题翻译：类固醇化合物和制剂
公开(公告)号：US08076316B2
公开(公告)日：2011-12-13
申请号：US12957661
申请日：2010-12-01
申请人： James M. Frincke
发明人： James M. Frincke
IPC分类号： A61K31/56 , C07J1/00
CPC分类号： A61K31/568 , A61K31/565 , A61K31/567 , A61K31/5685 , A61K45/06 , C07J1/00 , C07J1/0011 , C07J1/0022 , C07J1/0025 , C07J1/0048 , C07J31/00 , C07J41/00
摘要： The invention provides methods to treating conditions such as prostate cancer, or for ameliorating one or more symptoms associated with prostate cancer, or for agents that modulate the biological activity of the androgen receptor. The invention also provides methods and compositions suitable for therapeutic applications.
摘要翻译：本发明提供了治疗诸如前列腺癌或改善与前列腺癌相关的一种或多种症状的病症或调节雄激素受体生物学活性的药物的方法。本发明还提供适用于治疗应用的方法和组合物。

9. 发明申请

US20090093638A1 Allylic Oxidations Catalyzed by Dirhodium Catalysts under Aqueous Conditions 失效
标题翻译：在水性条件下由铑催化剂催化的烯丙氧基
公开(公告)号：US20090093638A1
公开(公告)日：2009-04-09
申请号：US12246324
申请日：2008-10-06
申请人： Michael P. Doyle , Arthur J. Catino , Hojae Choi , Jason M. Nichols
发明人： Michael P. Doyle , Arthur J. Catino , Hojae Choi , Jason M. Nichols
IPC分类号： C07D213/68 , C07C51/25 , C07C45/27 , C07C67/313 , C07D307/58 , C07J9/00 , C07J5/00
CPC分类号： C07C45/28 , B01J31/2217 , B01J31/2243 , B01J2231/70 , B01J2531/0219 , B01J2531/822 , C07B41/00 , C07C45/36 , C07C45/517 , C07C51/373 , C07C67/313 , C07C201/12 , C07C213/00 , C07C231/12 , C07C249/02 , C07C303/40 , C07C2601/10 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/40 , C07D213/68 , C07D307/58 , C07J1/0011 , C07J1/0022 , C07J1/0025 , C07J9/00 , C07C49/433 , C07C49/597 , C07C49/203 , C07C49/755 , C07C49/76 , C07C49/627 , C07C49/607 , C07C49/603 , C07C49/67 , C07C49/683 , C07C49/647 , C07C49/78 , C07C59/80 , C07C69/757 , C07C69/738 , C07C69/60 , C07C311/16 , C07C205/45 , C07C235/76 , C07C251/24 , C07C217/08
摘要： The present invention relates to compositions and methods for achieving the efficient allylic oxidation of organic molecules, especially olefins and steroids, under aqueous conditions. The invention concerns the use of dirhodium (II,II) “paddlewheel complexes, and in particular, dirhodium carboximate and tert-butyl hydroperoxide as catalysts for the reaction. The use of aqueous conditions is particularly advantageous in the allylic oxidation of 7-keto steroids, which could not be effectively oxidized using anhydrous methods, and in extending allylic oxidation to enamides and enol ethers.
摘要翻译：本发明涉及在水性条件下实现有机分子，特别是烯烃和类固醇的有效烯丙基氧化的组合物和方法。本发明涉及二铑（II，II）“水轮配合物的使用，特别是甲肟酸二叔丁酯和叔丁基过氧化氢作为反应的催化剂。使用水性条件在7-酮类固醇的烯丙氧基中是特别有利的，其不能用无水方法有效地氧化，并且将烯丙氧基延伸至烯酰胺和烯醇醚。

10. 发明授权

US06797834B2 Phosphoric acid isomerization of A 5 (10), 9 (11)—diene steroid to the corresponding 4, 9-diene steroid 失效
标题翻译：将A 5（10），9（11） - 二烯类固醇的磷酸异构化转化为相应的4,9-二烯类固醇
公开(公告)号：US06797834B2
公开(公告)日：2004-09-28
申请号：US10315273
申请日：2002-12-10
申请人： Rajappa Vaidyanathan
发明人： Rajappa Vaidyanathan
IPC分类号： C07J100
CPC分类号： C07J1/0022
摘要： The invention is a process for the preparation of a &Dgr;4,9-steroid of formula (II) which comprises contacting a &Dgr;5(10),9(11)-steroid of formula (I) with a phosphorous containing acid.
摘要翻译：本发明是一种制备式（II）的Delta4,9-类固醇的方法，其包括使式（I）的Delta5（10），9（11） - 类固醇与含有酸。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式