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1. 发明申请

US20170196890A1 TGR5 AGONIST COMPLEXES FOR TREATING DIABETES AND CANCER 审中-公开
公开(公告)号：US20170196890A1
公开(公告)日：2017-07-13
申请号：US15312157
申请日：2015-05-26
申请人： City of Hope
发明人： Donna Yu , James Lester Figarola , Donald David
IPC分类号： A61K31/575 , A61K31/155 , C07J41/00 , C07C279/26 , C07J9/00
CPC分类号： A61K31/575 , A61K31/155 , A61K31/19 , C07C279/26 , C07J9/005 , C07J41/0061 , C07J63/008 , A61K2300/00
摘要： Provided herein are complexes of metformin or metformin analogues and a TGR5 ligand that are useful in treating diseases including diabetes, cardiovascular disease, and cancer.

2. 发明申请

US20170073331A1 GUANIDINE COMPOUNDS AND USE THEREOF 审中-公开
标题翻译：胍基化合物及其用途
公开(公告)号：US20170073331A1
公开(公告)日：2017-03-16
申请号：US15304798
申请日：2015-04-17
申请人： IMMUNOMET THERAPEUTICS INC.
发明人： Sung Wuk Kim , Hong Woo Kim , Sang Hee Yoo , Ji Sun Lee , Hye Jin Heo , Hong Bum Lee , Ji Ae Kook , Young Woo Lee , Mi Jeong Kim , Woong Cho
IPC分类号： C07D403/12 , C07C311/47 , C07D295/13 , C07D211/14 , C07D319/18 , C07D333/20 , C07D251/18 , C07D249/14 , C07D211/54 , C07C279/04 , C07C279/08 , C07D209/44 , C07C279/16 , C07C279/06 , C07D233/91 , C07D213/38 , C07C279/12 , C07D239/42 , C07C279/24 , C07D207/16 , C07D277/46 , C07D263/48 , C07C279/26
CPC分类号： C07D403/12 , C07C279/04 , C07C279/06 , C07C279/08 , C07C279/12 , C07C279/16 , C07C279/24 , C07C279/26 , C07C311/47 , C07C311/49 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2603/74 , C07D207/16 , C07D209/40 , C07D209/44 , C07D211/14 , C07D211/54 , C07D213/38 , C07D213/40 , C07D233/88 , C07D233/91 , C07D239/42 , C07D249/14 , C07D251/18 , C07D251/48 , C07D263/48 , C07D277/46 , C07D295/13 , C07D317/58 , C07D319/18 , C07D333/16 , C07D333/20
摘要： The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating a OXPHOS-related disease, particularly cancer, by inhibiting mitochondrial oxidative phosphorylation and reprogramming cellular metabolism.
摘要翻译：本发明涉及用于抑制线粒体氧化磷酸化（OXPHOS）的胍化合物及其应用。更具体地，本发明涉及通过抑制线粒体氧化磷酸化和重新编程细胞代谢来预防或治疗OXPHOS相关疾病，特别是癌症的药物组合物。

3. 发明申请

US20170050924A1 INHIBITORS OF CREATINE TRANSPORT AND USES THEREOF 审中-公开
标题翻译：运输运输的抑制剂及其用途
公开(公告)号：US20170050924A1
公开(公告)日：2017-02-23
申请号：US15307178
申请日：2015-04-30
申请人： Rgenix, Inc.
发明人： Eduardo J. MARTINEZ , Sohail F. TAVAZONE
IPC分类号： C07C279/14 , C07D233/46 , A61K31/4168 , C07D239/14 , A61K31/505 , C07D233/52 , C07D253/06 , A61K31/53 , A61K31/155 , C07D213/74 , A61K31/4402 , C07C275/70 , C07D207/16 , A61K31/40 , C07D205/08 , A61K31/397 , C07D401/04 , A61K31/4427 , C07H19/06 , A61K31/7068 , A61K45/06
CPC分类号： C07C279/14 , A61K31/00 , A61K31/155 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/4168 , A61K31/4402 , A61K31/4427 , A61K31/505 , A61K31/53 , A61K31/704 , A61K31/7068 , A61K31/7105 , A61K45/06 , C07B2200/05 , C07C257/14 , C07C259/14 , C07C275/70 , C07C279/16 , C07C279/26 , C07C279/36 , C07C281/16 , C07C281/18 , C07C309/15 , C07C313/34 , C07C2601/02 , C07C2601/04 , C07D205/04 , C07D205/08 , C07D207/16 , C07D207/22 , C07D213/74 , C07D213/76 , C07D231/12 , C07D233/26 , C07D233/46 , C07D233/52 , C07D233/64 , C07D233/88 , C07D239/06 , C07D239/14 , C07D249/08 , C07D249/14 , C07D253/06 , C07D257/08 , C07D295/32 , C07D401/04 , C07D405/04 , C07D487/04 , C07F9/097 , C07F9/2458 , C07F9/3808 , C07F9/4006 , C07F9/48 , C07F9/568 , C07F9/572 , C07F9/6506 , C07H19/06 , A61K2300/00
摘要： This invention relates to compounds that inhibit creatine transport and/or creatine kinase, pharmaceutical compositions including such compounds, and methods of utilizing such compounds and compositions for the treatment of cancer.
摘要翻译：本发明涉及抑制肌酸转运和/或肌酸激酶的化合物，包括这些化合物的药物组合物，以及利用这些化合物和组合物治疗癌症的方法。

4. 发明授权

US09549558B2 Herbicidal azines 有权
标题翻译：除草吖嗪
公开(公告)号：US09549558B2
公开(公告)日：2017-01-24
申请号：US14437981
申请日：2013-10-22
申请人： BASF SE
发明人： Trevor William Newton , Florian Vogt , Julia Major , Kristin Hanzlik , Liliana Parra Rapado , Markus Kordes , Thomas Seitz , Matthias Witschel , Klaus Kreuz , Johannes Hutzler , Richard Roger Evans , Jens Lerchl
IPC分类号： C07D251/48 , A01N43/66 , A01N43/68 , C07C279/18 , C07D251/42 , C07C279/26 , C07D251/22
CPC分类号： A01N43/68 , C07C279/26 , C07D251/22 , C07D251/42 , C07D251/48
摘要： The present invention relates to azines of formula (I) wherein the variables are defined according to the description, processes and intermediated for preparing them, compositions comprising them and their use as herbicides, i.e. for controlling harmful plants and a method for controlling unwanted vegetation which comprises allowing a herbicidal effective amount of at least one azine of the formula I to act on plants, their seed and/or their habitat.
摘要翻译：本发明涉及式（I）的吖嗪，其中根据描述，方法和制备它们的中间体来定义变量，其包含它们的组合物及其作为除草剂的用途，即用于控制有害植物和控制不需要的植物的方法包括允许除草有效量的至少一种式I的吖嗪作用于植物，其种子和/或其栖息地。

5. 发明申请

US20160340374A1 BORATE-BASED BASE GENERATOR, AND BASE-REACTIVE COMPOSITION COMPRISING SUCH BASE GENERATOR 审中-公开
标题翻译：基于硼酸盐的基因发生器和包含这种基因发生器的基础反应性组合物
公开(公告)号：US20160340374A1
公开(公告)日：2016-11-24
申请号：US15114048
申请日：2015-01-22
申请人： WAKO PURE CHEMICAL INDUSTRIES, LTD.
发明人： Nobuhiko SAKAI , Kosuke YANABA
IPC分类号： C07F9/22 , G03F7/004 , C07F5/02 , C07D487/04 , C07C279/26 , C07D233/50
CPC分类号： C07F9/22 , C07C229/26 , C07C279/02 , C07C279/04 , C07C279/16 , C07C279/18 , C07C279/26 , C07C2601/14 , C07D233/50 , C07D487/04 , C07F5/027 , C07F9/065 , C07F9/5337 , C07F9/572 , C07F9/6584 , C07F9/65848 , G03F7/0045
摘要： An object of the present invention is to provide a compound which is capable of attaining a composition having high storage stability without reacting with a base-reactive compound, even in the case of storage for a long period of time in a mixed state with the base-reactive compound, such as an epoxy-based compound, as well as capable of generating a strong base (guanidines, biguanides, phosphazenes or phosphoniums) by irradiation of light (active energy rays) or heating; a base generator comprising the compound; and a base-reactive composition comprising the base generator and the base-reactive compound.The present invention relates to the compound represented by the general formula (A); the base generator comprising the compound; and the base-reactive composition comprising the base generator and the base-reactive compound. (wherein R1 represents an alkyl group; an arylalkynyl group which may be substituted with a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group; an alkenyl group; a 2-furylethynyl group; a 2-thiophenylethynyl group; or a 2,6-dithianyl group; R2 to R4 each independently represent an alkyl group; an arylalkynyl group which may be substituted with a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group; the aryl group which may be substituted with a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group; a furanyl group; a thienyl group; or an N-alkyl-substituted pyrrolyl group; Z+ represents an ammonium cation having a guanidinium group, a biguanidium group or a phosphazenium group, or a phosphonium cation.)
摘要翻译：（其中R1表示烷基;可被卤素原子，烷基，烷氧基或烷硫基取代的芳基炔基;烯基; 2-糠基乙炔基; 2-噻吩基乙炔基;或 2,6-二噻吩基; R 2〜R 4各自独立地表示烷基;可被卤素原子，烷基，烷氧基或烷硫基取代的芳基炔基;可被取代的芳基具有卤素原子，烷基，烷氧基或烷硫基;呋喃基;噻吩基或N-烷基取代的吡咯基; Z +表示具有胍基的铵阳离子，双胍基或磷腈鎓基或磷鎓阳离子）

6. 发明授权

US09216951B2 Lipid-lowering antidiabetic agent 有权
标题翻译：降脂抗糖尿病药
公开(公告)号：US09216951B2
公开(公告)日：2015-12-22
申请号：US14524721
申请日：2014-10-27
申请人： Thetis Pharmaceuticals LLC
发明人： Banavara L. Mylari , Frank C. Sciavolino
IPC分类号： A61K31/665 , A61K31/35 , A01N57/00 , A01N43/16 , C07C279/04 , A61K31/202 , C07C279/26 , A61K31/155 , C07C57/03
CPC分类号： C07C279/04 , A61K31/155 , A61K31/202 , C07C57/03 , C07C279/26
摘要： A composition which includes a salt of metformin and the use of the composition for treatment of or use in prediabetes, diabetes, lowering triglycerides and/or other conditions in mammals.
摘要翻译：包含二甲双胍盐的组合物和该组合物用于治疗或用于哺乳动物中的糖尿病前期，糖尿病，降低甘油三酸酯和/或其它病症的用途。

7. 发明申请

US20150344402A1 Omefibrates for Treating Dyslipidemia and Cardiovascular Disease 审中-公开
标题翻译：用于治疗血脂异常和心血管疾病的Omefibrates
公开(公告)号：US20150344402A1
公开(公告)日：2015-12-03
申请号：US14721258
申请日：2015-05-26
申请人： Jiva Pharma, Inc.
发明人： Om P. Goel
IPC分类号： C07C69/587 , C07C57/03 , C07C279/26
CPC分类号： C07C69/587 , C07C57/03 , C07C279/26
摘要： The present invention relates to the fibric acid derivatives of omega-3 fatty acids and their use in treating Type2 diabetes, obesity, hypertriglyceridemia, cardiovascular diseases, metabolic syndrome, cancer, Alzheimer's disease; and their use for modulating activity of peroxisome proliferator-activated receptors (PPARs).
摘要翻译：本发明涉及ω-3脂肪酸的纤维酸衍生物及其在治疗2型糖尿病，肥胖症，高甘油三酯血症，心血管疾病，代谢综合征，癌症，阿尔茨海默氏病中的用途; 及其用于调节过氧化物酶体增殖物激活受体（PPAR）活性的用途。

8. 发明授权

US08901107B2 Lipid-lowering antidiabetic agent 有权
标题翻译：降脂抗糖尿病药
公开(公告)号：US08901107B2
公开(公告)日：2014-12-02
申请号：US13923829
申请日：2013-06-21
申请人： Thetis Pharmaceuticals LLC
发明人： Banavara L. Mylari , Frank C. Sciavolino
IPC分类号： A01N57/00 , A61K31/665 , A01N43/16 , A61K31/35 , C07C279/04 , A61K31/202 , C07C279/26 , A61K31/155 , C07C57/03
CPC分类号： C07C279/04 , A61K31/155 , A61K31/202 , C07C57/03 , C07C279/26
摘要： A composition which includes a salt of metformin and the use of the composition for treatment of or use in prediabetes, diabetes, lowering triglycerides and/or other conditions in mammals.
摘要翻译：包含二甲双胍盐的组合物和该组合物用于治疗或用于哺乳动物中的糖尿病前期，糖尿病，降低甘油三酸酯和/或其它病症的用途。

9. 发明授权

US08329710B2 Metformin folate and preparation of the same 失效
标题翻译：二甲双胍叶酸及其制备方法相同
公开(公告)号：US08329710B2
公开(公告)日：2012-12-11
申请号：US12515657
申请日：2007-05-11
申请人： Hongping Yie , Meg M. Sun , Zuolin Zhu
发明人： Hongping Yie , Meg M. Sun , Zuolin Zhu
IPC分类号： A61K31/519
CPC分类号： C07D475/08 , C07C279/26
摘要： This disclosure is directed to compound having the formula (A) and a method of treatment using the compound. Compared with metformin, the disclosed compound has the same clinic curative effect, such as lowering blood sugar, curing poly-cystic ovary syndrome (PCOS), losing weight and so on, without resulting in the increase of homocysteine concentration, even with a little decrease of homocysteine concentration in some cases.
摘要翻译：本公开涉及具有式（A）的化合物和使用该化合物的方法。与二甲双胍相比，所公开的化合物具有降低血糖，治愈多囊卵巢综合征（PCOS），减轻体重等临床疗效，而不会导致高半胱氨酸浓度升高，甚至略有下降的同型半胱氨酸浓度。

10. 发明申请

US20120277305A1 FATTY ACID GUANIDINE AND SALICYLATE GUANIDINE DERIVATIVES AND THEIR USES 有权
标题翻译：脂肪酸和盐酸酯类衍生物及其用途
公开(公告)号：US20120277305A1
公开(公告)日：2012-11-01
申请号：US13458494
申请日：2012-04-27
申请人： Jill C. Milne , Michael R. Jirousek , Jean E. Bemis , Chi B. Vu , Amal Ting
发明人： Jill C. Milne , Michael R. Jirousek , Jean E. Bemis , Chi B. Vu , Amal Ting
IPC分类号： A61K31/164 , C07C279/14 , A61K31/166 , A61K31/27 , A61P3/00 , A61P13/12 , A61P9/10 , A61P3/04 , A61P15/00 , A61P9/00 , A61P27/02 , C07C279/26 , A61P3/06
CPC分类号： C07C279/26 , C07C279/14
摘要： The invention relates to fatty acid guanidine or salicylate guanidine derivatives; compositions comprising an effective amount of a fatty acid guanidine or salicylate guanidine derivative; and methods for treating or preventing a metabolic disease comprising the administration of an effective amount of a fatty acid guanidine or salicylate guanidine derivative.
摘要翻译：本发明涉及脂肪酸胍或水杨酸胍衍生物; 包含有效量的脂肪酸胍或水杨酸胍衍生物的组合物; 以及用于治疗或预防代谢疾病的方法，包括施用有效量的脂肪酸胍或水杨酸胍衍生物。

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