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1. 发明申请

US20180141896A1 REACTION PRODUCTS CONTAINING AMIDOAMINE GROUPS 审中-公开
公开(公告)号：US20180141896A1
公开(公告)日：2018-05-24
申请号：US15575128
申请日：2016-06-03
申请人： BYK-Chemie, GmbH
发明人： Andreas OKKEL , Bernd GÖBELT , Jürgen OMEIS , Jörg BÖMER , Monika ROCH , Sabine STELZ
IPC分类号： C07C237/04 , C07C269/02 , C07C271/28 , C08G18/28 , C08G18/71 , C08G18/76 , C09D5/00
CPC分类号： C07C237/04 , C07C269/02 , C07C271/26 , C07C271/28 , C08G18/2815 , C08G18/2825 , C08G18/283 , C08G18/2835 , C08G18/284 , C08G18/289 , C08G18/71 , C08G18/711 , C08G18/718 , C08G18/7621 , C09D5/00 , C09D7/45 , C09D7/65 , C09D17/00 , C09D133/00
摘要： A reaction product containing amido amine groups, comprising one or more species of the general formula (I) (R1—X)p—Z1—(XH)y (I) where p+y=w and w is an integer from 1 to 10, p is an integer from 1 to 10, y is an integer from 0 to 9, and X is independently O, NH and/or NZ2 and XH is independently a hydroxyl group OH, a primary amino group NH2 and/or a secondary amino group NHZ2 where Z2 is independently a branched or unbranched, saturated or unsaturated organic radical G(U)a where U is independently a hydroxyl group, a primary amino group or a secondary amino group and a is an integer from 0 to 9, where p+y+a≤s 10, and G is a branched or unbranched, saturated or unsaturated organic radical, the p R1 radicals are independently a radical of the general formula (II) Y—O—CO—NH—R2—NH—CO (II) in which the p Y radicals are independently a branched or unbranched, saturated or unsaturated organic radical which has 1 to 1000 carbon atoms and does not contain any hydroxyl groups, any primary amino groups or any secondary amino groups, the p R2 radicals are independently a branched or unbranched, saturated or unsaturated organic radical having 6 to 20 carbon atoms, Z1 is a branched or unbranched, saturated or unsaturated organic radical containing at least two carbon atoms, having at least one amide group and at least one tertiary amino group.

2. 发明申请

US20170081460A1 POLYURETHANE MATERIALS FORMED FROM EPOXIDIZED PLANT OILS 有权
公开(公告)号：US20170081460A1
公开(公告)日：2017-03-23
申请号：US14862847
申请日：2015-09-23
申请人： International Business Machines Corporation
发明人： Brandon M. Kobilka , Joseph Kuczynski , Timothy C. Mauldin , Jason T. Wertz
IPC分类号： C08G18/02 , E04B1/82
CPC分类号： C08G18/02 , C08G18/3819 , C08G18/3836 , C08G18/711 , C08G71/04 , C08G2350/00 , E04B1/82
摘要： In an example, a process of forming a polyurethane material is disclosed. The process includes forming carboxylic acid-terminated aliphatic polyol molecules from an epoxidized plant oil. The process also includes chemically reacting the carboxylic acid-terminated aliphatic polyol molecules with an azide material to form monoisocyanate-functionalized aliphatic polyol molecules. The process further includes polymerizing the monoisocyanate-functionalized aliphatic polyol molecules to form a first polyurethane material.

3. 发明申请

US20150182672A1 COATINGS FOR IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：可植入医疗器械的涂层
公开(公告)号：US20150182672A1
公开(公告)日：2015-07-02
申请号：US14643576
申请日：2015-03-10
申请人： Abbott Cardiovascular Systems Inc.
发明人： Eugene T. Michal , Syed F.A. Hossainy , Ashok Shah
IPC分类号： A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61K31/337 , A61K31/4745 , A61K31/56 , A61L31/16 , A61L2300/416 , A61L2300/43 , A61L2300/606 , C08F8/00 , C08F8/30 , C08F8/32 , C08F2800/10 , C08F2810/50 , C08G18/6212 , C08G18/711 , C09D151/003 , C09D151/06 , C09D151/08 , C09D175/04 , C08L2666/02 , C08L2666/04 , C08L2666/14 , C08F216/06 , C08F8/34 , C08F210/02 , C08F8/14
摘要： The present application teaches a coating having a biologically compatible compound conjugated to, or blended with, a polymer, wherein the polymer includes at least one olefin-derived unit and at least one unit derived from a vinyl alcohol, an allyl alcohol, or derivatives thereof.
摘要翻译：本申请教导了具有与聚合物缀合或混合的生物相容性化合物的涂层，其中所述聚合物包括至少一种烯烃衍生单元和至少一种衍生自乙烯醇，烯丙醇或其衍生物的单元。

4. 发明申请

US20120158127A1 BIOABSORBABLE AND BIOCOMPATIBLE POLYURETHANES AND POLYAMIDES FOR MEDICAL DEVICES 有权
标题翻译：可生物降解的生物成分聚氨酯和医用器件的聚酰胺
公开(公告)号：US20120158127A1
公开(公告)日：2012-06-21
申请号：US13402391
申请日：2012-02-22
申请人： Rao S. Bezwada
发明人： Rao S. Bezwada
IPC分类号： A61F2/06 , C07C233/75 , C07C219/34 , C07C265/12 , B32B15/08 , C07C205/37 , C08G69/40 , C08G18/71 , C08G69/12 , A61K47/34 , C07C271/28
CPC分类号： A61K47/34 , A61F2/442 , A61L15/64 , A61L17/06 , A61L17/105 , A61L24/043 , A61L24/046 , A61L27/18 , A61L27/58 , A61L31/10 , A61L31/148 , C08G18/10 , C08G18/711 , C08G18/771 , C08G69/26 , C08G69/40 , C08G69/44 , C08G2230/00 , C09J175/06 , Y10T428/31681 , C08L67/04 , C08L77/00 , C08L75/04
摘要： Absorbable polyurethanes, polyamides and polyester urethanes prepared from at least one compound selected from: or the corresponding diamines or diisocyanates thereof, wherein each X independently represents —CH2COO—, —CH(CH3)COO—, —CH2CH2OCH2COO—, —CH2CH2CH2CH2CH2COO—, —(CH2)yCOO— where y is 2 to 4 or 6 to 24, or —(CH2CH2O)z′CH2COO— where z′ is 2 to 24; each Y represents —COCH2O—, —COCH(CH3)O—, —COCH2OCH2CH2O—, —COCH2CH2CH2CH2CH2O—, —CO(CH2)mO— where m is 2 to 4 or 6 to 24, or —COCH2O(CH2CH2O)n— where n is 2 to 24; R′ is hydrogen, benzyl or straight-chained or branched alkyl; p is 1 to 4; and Rn represents one or more members selected from H, alkoxy, benzyloxy, aldehyde, halogen, carboxylic acid and —NO2, which is attached directly to an aromatic ring or attached through an aliphatic chain. Absorbable polymers prepared from these compounds are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention and other implantable medical devices.
摘要翻译：由选自以下的至少一种化合物或其相应的二胺或二异氰酸酯制备的可吸收的聚氨酯，聚酰胺和聚酯聚氨酯，其中每个X独立地表示-CH 2 COO-， - CH（CH 3）COO-， - CH 2 CH 2 OCH 2 COO-， - CH 2 CH 2 CH 2 CH 2 COO-， - （CH2）yCOO-，其中y为2至4或6至24，或 - （CH2CH2O）z'CH2COO-，其中z'为2至24; 每个Y表示-COCH 2 O-，-COCH（CH 3）O - ， - COCH 2 CH 2 CH 2 CH 2 - ， - COCH 2 CH 2 CH 2 CH 2 CH 2 O - ， - CO（CH 2）m O-，其中m为2至4或6至24，或-COCH 2 O（CH 2 CH 2 O） n为2〜24; R'是氢，苄基或直链或支链烷基; p为1〜4; 并且R n表示选自H，烷氧基，苄氧基，醛，卤素，羧酸和-NO 2中的一种或多种，其直接连接到芳环上或通过脂族链连接。由这些化合物制备的可吸收聚合物可用于药物递送，组织工程，组织粘合剂，防止粘附和其他可植入医疗器械。

5. 发明授权

US07772352B2 Bioabsorbable and biocompatible polyurethanes and polyamides for medical devices 有权
标题翻译：用于医疗器械的生物可吸收和生物相容性聚氨酯和聚酰胺
公开(公告)号：US07772352B2
公开(公告)日：2010-08-10
申请号：US11255050
申请日：2005-10-20
申请人： Rao S. Bezwada
发明人： Rao S. Bezwada
IPC分类号： C08G18/77 , C08G18/78 , C08L75/04 , A61K31/00 , A61K47/14
CPC分类号： A61L27/18 , A61K47/34 , A61L17/105 , A61L24/043 , A61L24/046 , A61L31/10 , C08G18/10 , C08G18/711 , C08G18/771 , C08G69/26 , C08G69/44 , C08G2230/00 , C09J175/06 , C08L67/04 , C08L77/00 , C08L75/04
摘要： Absorbable polyurethanes, polyamides and polyester urethanes prepared from at least one compound selected from: or the diamines and diisocyanates thereof, wherein each X represents a member independently selected from —CH2COO— (glycolic acid moiety), —CH(CH3)COO— (lactic acid moiety), —CH2CH2OCH2COO— (dioxanone), —CH2CH2CH2CH2CH2COO— (caprolactone moiety), —(CH2)yCOO— where y is one of the numbers 2, 3, 4 or 6-24 inclusive, and —(CH2CH2O)z′CH2COO— where z′ is an integer between 2 and 24, inclusive; each Y represents a member independently selected from —COCH2O— (glycolic ester moiety), —COCH(CH3)O— (lactic ester moiety), —COCH2OCH2CH2O— (dioxanone ester), —COCH2CH2CH2CH2CH2O— (caprolactone ester), —CO(CH2)mO— where m is an integer between 2, 3, 4 or 6-24 inclusive, —COCH2O(CH2CH2O)n— where n is an integer between 2 and 24, inclusive; R′ is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched; p is an integer between 1 and 4, inclusive; and Rn represents one or more members selected from H, alkoxy, benzyloxy, aldehyde, halogen, carboxylic acid and —NO2, which is attached directly to an aromatic ring or attached through an aliphatic chain. Absorbable polymers prepared from these compounds are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention and other implantable medical devices.
摘要翻译：由选自以下的至少一种化合物或其二胺和二异氰酸酯制备的可吸收聚氨酯，聚酰胺和聚酯聚氨酯，其中每个X表示独立地选自-CH 2 COO-（乙醇酸部分），-CH（CH 3）COO-（乳酸酸性部分），-CH 2 CH 2 OCH 2 COO-（二氧杂环己烷酮），-CH 2 CH 2 CH 2 CH 2 CH 2 COO-（己内酯部分）， - （CH 2）y COO-，其中y是数字2,3,4或6-24的含义之一，和 - （CH 2 CH 2 O） CH2COO-，其中z'是2和24之间的整数，包括端值; 每个Y表示独立地选自-COCH 2 O-（乙醇酸酯部分），-COCH（CH 3）O-（乳酸酯部分），-COCH 2 OCH 2 CH 2 O - （二恶烷酮酯），-COCH 2 CH 2 CH 2 CH 2 CH 2 O-（己内酯酯），-CO ）mO-，其中m是包含2,3,4或6-24的整数，-COCH 2 O（CH 2 CH 2 O）n - ，其中n是2和24之间的整数，包括端值; R'是氢，苄基或烷基，烷基是直链或支链的; p是1到4之间的整数，包括1和4; 并且R n表示选自H，烷氧基，苄氧基，醛，卤素，羧酸和-NO 2中的一种或多种，其直接连接到芳环上或通过脂族链连接。由这些化合物制备的可吸收聚合物可用于药物递送，组织工程，组织粘合剂，防止粘附和其他可植入医疗器械。

6. 发明申请

US20100105946A1 Hydrolytically Degradable Carbamate Derivatives of Poly(Ethylene Glycol) 有权
标题翻译：聚（乙二醇）的水解可降解的氨基甲酸酯衍生物
公开(公告)号：US20100105946A1
公开(公告)日：2010-04-29
申请号：US12559320
申请日：2009-09-14
申请人： Michael David Bentley , Xuan Zhao
发明人： Michael David Bentley , Xuan Zhao
IPC分类号： C07C69/63
CPC分类号： C08G65/33344 , A61K31/765 , A61K47/60 , C08G18/711 , C08G65/329 , C08G65/331 , C08G65/333 , C08G2210/00 , Y10S435/82
摘要： Poly(ethylene glycol) carbamate derivatives useful as water-soluble pro-drugs are disclosed. These degradable poly(ethylene glycol) carbamate derivatives also have potential applications in controlled hydrolytic degradation of hydrogels. In such degradable hydrogels, drugs may be either trapped in the gel and released by diffusion as the gel degrades, or they may be covalently bound through hydrolyzable carbamate linkages. Hydrolysis of these carbamate linkages releases the amine drug at a controllable rate as the gel degrades.
摘要翻译：公开了可用作水溶性前体药物的聚（乙二醇）氨基甲酸酯衍生物。这些可降解的聚（乙二醇）氨基甲酸酯衍生物在水凝胶的可控水解降解中也具有潜在的应用。在这种可降解的水凝胶中，当凝胶降解时，药物可以被捕获在凝胶中并通过扩散释放，或者它们可以通过可水解的氨基甲酸酯键共价结合。当凝胶降解时，这些氨基甲酸酯键的水解以可控的速率释放胺药物。

7. 发明授权

US07691364B2 Functionalized drugs and polymers derived therefrom 有权
标题翻译：功能化药物和衍生自其的聚合物
公开(公告)号：US07691364B2
公开(公告)日：2010-04-06
申请号：US11233876
申请日：2005-09-23
申请人： Rao S. Bezwada
发明人： Rao S. Bezwada
IPC分类号： A61K31/74
CPC分类号： A61K9/1647 , A61K9/0058 , A61K31/00 , A61K31/05 , A61K31/185 , A61K31/192 , A61K31/343 , A61K31/352 , A61K31/353 , A61K31/381 , A61K31/403 , A61K31/404 , A61K31/405 , A61K31/4164 , A61K31/428 , A61K31/439 , A61K31/445 , A61K31/47 , A61K31/485 , A61K31/535 , A61K31/7135 , A61K47/51 , A61L31/10 , C07C69/734 , C07C69/92 , C08G18/3206 , C08G18/711 , C08G18/771 , C08G18/797 , C08L67/04
摘要： Compounds selected from: where DRUG-OH, DRUG-COOH and DRUG-NH2 are biologically active compounds; each X is independently selected from —CH2COO-(glycolic acid moiety), —CH(CH3)COO-(lactic acid moiety), —CH2CH2OCH2COO-(dioxanone moiety), —CH2CH2CH2CH2CH2COO-(caprolactone moiety), —(CH2)yCOO—, where y is 2-4 or 6-24 and —(CH2CH2O)zCH2COO—, where z is 2-24; each Y is independently selected from —COCH2O-(glycolic ester moiety), —COCH(CH3)O-(lactic ester moiety), —COCH2OCH2CH2O-(dioxanone ester moiety), —COCH2CH2CH2CH2CH2O-(caprolactone ester moiety), —CO(CH2)mO—, where m is 2-4 or 6-24 and —COCH2O(CH2CH2O)n-where n is between 2-24; R′ is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched; and p is 1-6. Multi-functional compounds and drug dimers, oligomers and polymers are also disclosed.
摘要翻译：选自：其中DRUG-OH，DRUG-COOH和DRUG-NH 2是生物活性化合物的化合物; 每个X独立地选自-CH 2 COO-（乙醇酸部分），-CH（CH 3）COO-（乳酸部分），-CH 2 CH 2 OCH 2 COO-（二恶烷酮部分），-CH 2 CH 2 CH 2 CH 2 CH 2 COO-（己内酯部分）， - （CH 2）y COO- 其中y为2-4或6-24和 - （CH2CH2O）zCH2COO-，其中z为2-24; 每个Y独立地选自-COCH2O-（乙醇酸酯部分），-COCH（CH3）O-（乳酸酯部分），-COCH2OCH2CH2O-（二恶烷酮酯部分），-COCH2CH2CH2CH2CH2O-（己内酯酯部分），-CO ）mO-，其中m为2-4或6-24，-COCH 2 O（CH 2 CH 2 O）n - ，其中n为2-24; R'是氢，苄基或烷基，烷基是直链或支链的; p为1-6。还公开了多功能化合物和药物二聚体，低聚物和聚合物。

8. 发明申请

US20010046481A1 Hydrolytically degradable carbamate derivatives of poly(ethylene glycol) 有权
公开(公告)号：US20010046481A1
公开(公告)日：2001-11-29
申请号：US09842514
申请日：2001-04-21
申请人： Shearwater Corporation
发明人： Michael David Bentley , Xuan Zhao
IPC分类号： A61K031/74 , A61K031/665 , C08L071/02
CPC分类号： C08G65/33344 , A61K31/765 , A61K47/60 , C08G18/711 , C08G65/329 , C08G65/331 , C08G65/333 , C08G2210/00 , Y10S435/82
摘要： Poly(ethylene glycol) carbamate derivatives useful as water-soluble pro-drugs are disclosed. These degradable poly(ethylene glycol) carbamate derivatives also have potential applications in controlled hydrolytic degradation of hydrogels. In such degradable hydrogels, drugs may be either trapped in the gel and released by diffusion as the gel degrades, or they may be covalently bound through hydrolyzable carbamate linkages. Hydrolysis of these carbamate linkages releases the amine drug at a controllable rate as the gel degrades.

9. 发明授权

US5904974A PVA-base thermoplastic copolymer and its production process and use 失效
标题翻译： PVA基热塑性共聚物及其制备方法和用途
公开(公告)号：US5904974A
公开(公告)日：1999-05-18
申请号：US882151
申请日：1997-06-25
申请人： Kazuyuki Hanada , Katsumi Kuriyama
发明人： Kazuyuki Hanada , Katsumi Kuriyama
IPC分类号： B41M5/00 , B41M5/52 , C08G18/42 , C08G18/71 , C08G63/00 , C08G63/91 , C09D129/04 , C08L29/04
CPC分类号： C08G63/00 , B41M5/5254 , C08G18/4266 , C08G18/711 , C08G63/912 , Y10T428/1379 , Y10T428/24901 , Y10T428/31786 , Y10T428/3179 , Y10T428/31794 , Y10T428/31797 , Y10T428/31895 , Y10T428/31906 , Y10T428/31928
摘要： A PVA-base copolymer is obtained by subjecting a lactone, whose ring is formed of 3 to 10 carbon atoms, to ring-opening polymerization in the presence of polyvinyl alcohol (PVA). The copolymer comprises a PVA chain and an aliphatic polyester grafted as a ring-opened polymer of the lactone on the PVA chain. Further, the copolymer has a PVA content of 2 to 98 wt. %, a polyester content of 98 to 2 wt. %, and a number average molecular weight of 10,000 to 500,000.
摘要翻译： PVA基共聚物是通过在环氧聚乙烯醇（PVA）的存在下，使环形成3〜10个碳原子的内酯进行开环聚合而得到的。共聚物包含PVA链和脂肪族聚酯，作为PVA链上内酯的开环聚合物接枝。此外，共聚物的PVA含量为2〜98重量％。％，聚酯含量为98〜2wt。％，数均分子量为10,000〜500,000。

10. 发明授权

US4600752A Easy-flowing impact-resistant polyamide modified with oxycarbonyl isocyanate 失效
标题翻译：用氧羰基异氰酸酯改性的易流动抗冲击聚酰胺
公开(公告)号：US4600752A
公开(公告)日：1986-07-15
申请号：US711675
申请日：1985-03-14
申请人： Rolf-Volker Meyer , Rolf Dhein , Bert Brassat , Hermann Hagemann
发明人： Rolf-Volker Meyer , Rolf Dhein , Bert Brassat , Hermann Hagemann
IPC分类号： C08L77/00 , C08G18/60 , C08G18/71 , C08G18/77 , C08G69/48 , C08K5/22 , C08G69/46
CPC分类号： C08G18/603 , C08G18/711 , C08G18/771 , C08G69/48
摘要： Easy-flowing impact resistant polyamides are obtained by incorporating (poly)oxycarbonylisocyanates into the polyamides.
摘要翻译：通过将（聚）氧羰基异氰酸酯掺入聚酰胺中，可获得易流动的耐冲击聚酰胺。

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