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1. 发明申请

US20150141665A1 METHODS FOR PREPARING POLYMERIC REAGENTS 有权
标题翻译：制备聚合物试剂的方法
公开(公告)号：US20150141665A1
公开(公告)日：2015-05-21
申请号：US14570705
申请日：2014-12-15
申请人： Nektar Therapeutics
发明人： Michael D. Bentley , Sean M. Culbertson , Samuel P. McManus
IPC分类号： C08G65/338 , C07D207/46
CPC分类号： A61K47/60 , A61K31/765 , A61K38/26 , A61K38/28 , C07C235/68 , C07D207/46 , C07K14/575 , C08G61/02 , C08G65/33396 , C08G65/3348 , C08G65/338 , C08G65/48 , C08K5/13 , C08K2201/012
摘要： The present invention provides among other things methods for preparing polymeric reagents, wherein the method comprises (a) providing an aromatic moiety bearing a hydroxy group, a first amino group and a second amino group; (b) reacting a functional group reagent with the hydroxy group to result in a hydroxy group bearing a functional group capable of reacting with an amino group of an active agent and resulting in a hydolyzable carbamate; and (c) reacting a plurality of poly(alkylene glycol) water-soluble polymers bearing a reactive group with the first amino group and second amino group to result in (i) a first amino group bearing a water-soluble polymer through a spacer moiety, and (ii) a second amino group bearing a second water-soluble polymer through a spacer moiety.
摘要翻译：本发明提供制备聚合物试剂的方法，其中所述方法包括（a）提供带有羟基，第一氨基和第二氨基的芳族部分; （b）使官能团试剂与羟基反应以产生具有能够与活性剂的氨基反应的官能团的羟基，得到可水解的氨基甲酸酯; 和（c）使具有反应性基团的多个聚（亚烷基二醇）水溶性聚合物与第一氨基和第二氨基反应，以产生（i）通过间隔基部分含有水溶性聚合物的第一个氨基，和（ii）通过间隔基部分带有第二水溶性聚合物的第二个氨基。

2. 发明申请

US20140107349A1 Methods for Preparing Polymeric Reagents 有权
标题翻译：聚合物试剂的制备方法
公开(公告)号：US20140107349A1
公开(公告)日：2014-04-17
申请号：US14109302
申请日：2013-12-17
申请人： Nektar Therapeutics
发明人： Michael D. Bentley , Sean M. Culbertson , Samuel P. McManus
IPC分类号： C08G65/48
CPC分类号： A61K47/60 , A61K31/765 , A61K38/26 , A61K38/28 , C07C235/68 , C07D207/46 , C07K14/575 , C08G61/02 , C08G65/33396 , C08G65/3348 , C08G65/338 , C08G65/48 , C08K5/13 , C08K2201/012
摘要： The present invention provides among other things methods for preparing polymeric reagents, wherein the method comprises (a) providing an aromatic moiety bearing a hydroxy group, a first amino group and a second amino group; (b) reacting a functional group reagent with the hydroxy group to result in a hydroxy group bearing a functional group capable of reacting with an amino group of an active agent and resulting in a hydrolyzable carbamate; and (c) reacting a plurality of poly(alkylene glycol) water-soluble polymers bearing a reactive group with the first amino group and second amino group to result in (i) a first amino group bearing a water-soluble polymer through a spacer moiety, and (ii) a second amino group bearing a second water-soluble polymer through a spacer moiety.
摘要翻译：本发明提供制备聚合物试剂的方法，其中所述方法包括（a）提供带有羟基，第一氨基和第二氨基的芳族部分; （b）使官能团试剂与羟基反应，得到具有能够与活性剂的氨基反应的官能团的羟基，得到可水解的氨基甲酸酯; 和（c）使具有反应性基团的多个聚（亚烷基二醇）水溶性聚合物与第一氨基和第二氨基反应，以产生（i）通过间隔基部分含有水溶性聚合物的第一个氨基，和（ii）通过间隔基部分带有第二水溶性聚合物的第二个氨基。

3. 发明授权

US08252275B2 Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates 有权
标题翻译：具有可降解键的缀合物和可用于制备这种缀合物的聚合物试剂
公开(公告)号：US08252275B2
公开(公告)日：2012-08-28
申请号：US11454971
申请日：2006-06-16
申请人： Michael D. Bentley , Sean Culbertson , Samuel P. McManus
发明人： Michael D. Bentley , Sean Culbertson , Samuel P. McManus
IPC分类号： A61K31/74 , A61K47/00
CPC分类号： A61K47/60 , A61K31/765 , A61K38/26 , A61K38/28 , C07C235/68 , C07D207/46 , C07K14/575 , C08G61/02 , C08G65/33396 , C08G65/3348 , C08G65/338 , C08G65/48 , C08K5/13 , C08K2201/012
摘要： The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. The conjugates as well as the polymeric reagents used to form the conjugates include at least one of each the following: an aromatic moiety comprising an ionizable hydrogen atom, a spacer moiety, and a water-soluble polymer. Methods of making polymeric reagents and conjugates, as well as methods for administering conjugates and compositions, are also provided.
摘要翻译：本发明提供具有可降解键的缀合物和可用于制备这种缀合物的聚合物试剂。用于形成共轭物的共轭物以及聚合物试剂包括以下各项中的至少一种：包含可电离氢原子的芳族部分，间隔基部分和水溶性聚合物。还提供了制备聚合物试剂和缀合物的方法，以及用于施用共轭物和组合物的方法。

4. 发明申请

US20040053137A1 Solid polymeric electrolytes for lithium batteries 有权
标题翻译：用于锂电池的固体高分子电解质
公开(公告)号：US20040053137A1
公开(公告)日：2004-03-18
申请号：US10311644
申请日：2003-09-19
发明人： Charles A. Angell , Wu Xu , Xiaoguang Sun
IPC分类号： H01M010/40 , C08J005/22 , C08G079/08 , C08G079/10
CPC分类号： C08G79/10 , C08G65/328 , C08G65/338 , C08G79/08 , H01M10/052 , H01M10/0565 , H01M2300/0082 , H01M2300/0085 , Y02T10/7011
摘要： Novel conductive polyanionic polymers and methods for their preparion are provided. The polyanionic polymers comprise repeating units of weakly-coordinating anionic groups chemically linked to polymer chains. The polymer chains in turn comprise repeating spacer groups. Spacer groups can be chosen to be of length and structure to impart desired electrochemical and physical properties to the polymers. Preferred embodiments are prepared from precursor polymers comprising the Lewis acid borate tri-coordinated to a selected ligand and repeating spacer groups to form repeating polymer chain units. These precursor polymers are reacted with a chosen Lewis base to form a polyanionic polymer comprising weakly coordinating anionic groups spaced at chosen intervals along the polymer chain. The polyanionic polymers exhibit high conductivity and physical properties which make them suitable as solid polymeric electrolytes in lithium batteries, especially secondary lithium batteries.
摘要翻译：提供了新的导电聚阴离子聚合物及其制备方法。聚阴离子聚合物包含与聚合物链化学连接的弱配位阴离子基团的重复单元。聚合物链依次包含重复的间隔基团。间隔基团可以选择为长度和结构以赋予聚合物所需的电化学和物理性质。优选实施方案由包含与选定配体三配位的路易斯酸硼酸盐的前体聚合物制备，并重复间隔基以形成重复的聚合物链单元。这些前体聚合物与选择的路易斯碱反应以形成聚阴离子聚合物，其包含沿着聚合物链以选定间隔间隔的弱配位阴离子基团。聚阴离子聚合物表现出高导电性和物理性能，使其适用于锂电池，特别是二次锂电池中的固体聚合物电解质。

5. 发明授权

US5605976A Method of preparing polyalkylene oxide carboxylic acids 失效
标题翻译：聚环氧烷羧酸的制备方法
公开(公告)号：US5605976A
公开(公告)日：1997-02-25
申请号：US440732
申请日：1995-05-15
申请人： Anthony J. Martinez , Richard B. Greenwald
发明人： Anthony J. Martinez , Richard B. Greenwald
IPC分类号： A61K47/48 , C08G65/32 , C08G65/329 , C08G65/332 , C08G65/333 , C08G65/337 , C08G65/338
CPC分类号： A61K47/48215 , C08G65/329 , C08G65/3322 , C08G65/33396 , C08G65/337 , C08G65/338
摘要： The present invention is directed to methods of preparing high purity polyalkylene oxide carboxylic acids. The methods include reacting a polyalkylene oxide such as polyethylene glycol with a t-butyl haloacetate in the presence of a base followed by treatment with an acid such as trifluoroacetic acid. The resultant polymer carboxylic acids are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.
摘要翻译：本发明涉及制备高纯度聚环氧烷羧酸的方法。所述方法包括在碱的存在下使聚环氧烷如聚乙二醇与卤代乙酸叔丁酯反应，然后用酸如三氟乙酸处理。得到的聚合物羧酸具有足够的纯度，因此避免了医药级聚合物所需的昂贵且耗时的纯化步骤。

6. 发明授权

US5250202A Phenyalkyl glycidyl ether addition products 失效
标题翻译：苯基缩水甘油醚加成产物
公开(公告)号：US5250202A
公开(公告)日：1993-10-05
申请号：US811380
申请日：1991-12-20
申请人： Dieter Reinehr , Rosemarie Topfl
发明人： Dieter Reinehr , Rosemarie Topfl
IPC分类号： C08G65/04 , C08G65/26 , C08G65/331 , C08G65/338 , C09B67/46 , C11D1/06 , C11D1/12 , C11D1/29 , C11D1/34 , C11D1/72 , C11D3/37 , D06L1/14 , D06P1/613 , D06M13/175
CPC分类号： C08G65/04 , C08G65/2609 , C08G65/331 , C08G65/338 , C09B67/0085 , C11D1/06 , C11D1/123 , C11D1/29 , C11D1/345 , C11D1/72 , C11D3/3707 , D06L1/14 , D06P1/6133 , D06P1/6135 , Y10S516/01
摘要： Addition products of phenylalkyl glycidyl ethers to polyalkylene glycol ethers of the formula ##STR1## their acid esters and salts thereof, wherein R is an aliphatic radical having at least 4 carbon atoms, "Alkylene" is an alkylene radical of 2 or 3 carbon atoms, and m is a number from 2 to 100.These products represent a novel class of non-ionic or anionic surfactants that are used as textile finishing agents, especially as emulsifiers, wetting agents, foaminhibitors or dyeing auxiliaries.
摘要翻译：（1）苯基烷基缩水甘油醚与下式的聚亚烷基二醇醚的加成产物（1）它们的酸酯及其盐，其中R是具有至少4个碳原子的脂族基团，“亚烷基”是2或3的亚烷基碳原子，m为2至100的数。这些产物代表一类新型的非离子或阴离子表面活性剂，其用作纺织整理剂，特别是作为乳化剂，润湿剂，阻垢剂或染色助剂。

7. 发明授权

US5157099A Activated polymers and conjugates thereof 失效
标题翻译：活性聚合物及其共轭物
公开(公告)号：US5157099A
公开(公告)日：1992-10-20
申请号：US806690
申请日：1991-12-12
申请人： Dayton T. Reardan , Dane A. Goff
发明人： Dayton T. Reardan , Dane A. Goff
IPC分类号： C07C229/60 , C07C237/32 , C07C271/28 , C08G65/322 , C08G65/333 , C08G65/338 , C12N11/08
CPC分类号： C07C229/60 , C07C237/32 , C07C271/28 , C08G65/322 , C08G65/33389 , C08G65/338 , C12N11/08
摘要： Macromolecular species such as enzymes, proteins, drugs, and solid supports which contain reactive carbonyl, groups or groups which are readily converted to reactive carbonyl groups are modified by reaction with a compound of the formula ##STR1## in which R.sup.1 is H, C.sub.1 -C.sub.20 alkyl, phenyl, (C.sub.1 -C.sub.10 alkyl)-substituted phenyl, or phenyl-substituted C.sub.1 -C.sub.10 alkyl; R.sup.2 is C.sub.2 -C.sub.5 alkylene or (C.sub.1 -C.sub.4 alkoxy)-substituted C.sub.2 -C.sub.5 alkylene; R.sup.3 is ##STR2## R.sup.4 is H or C.sub.1 -C.sub.4 alkyl; n is at least 5; and m is zero or 1.
摘要翻译：含有反应性羰基，容易转化成反应性羰基的基团或基团的酶，蛋白质，药物和固体支持物的大分子物质通过与式（III）化合物反应而被修饰，其中R1是H，C1- C20烷基，苯基，（C1-C10烷基）取代的苯基或苯基取代的C1-C10烷基; R2是C2-C5亚烷基或（C1-C4烷氧基） - 取代C2-C5亚烷基; R 3是H或C 1 -C 4烷基; n至少为5; m为零或1。

8. 发明授权

US5122547A Production of elastic, compact or cellular moldings based on elastomers containing N-benzylurea groups in bound form, elastomers of this type, and N-benzylpolyoxyalkylene-polyamines which are suitable for this purpose 失效
标题翻译：生产弹性，紧凑型或细密模型的弹性体，其包含在本体中的N-苄氧基组合的弹性体，该类型的弹性体和适用于本发明目的的N-苯甲酰基聚甲基丙烯酰胺
公开(公告)号：US5122547A
公开(公告)日：1992-06-16
申请号：US628298
申请日：1990-12-17
申请人： Johannes Becker , Guenther Matzke , Hans U. Schmidt , Willibald Schoenleben
发明人： Johannes Becker , Guenther Matzke , Hans U. Schmidt , Willibald Schoenleben
IPC分类号： C08J9/14 , C08G18/10 , C08G18/30 , C08G18/50 , C08G18/66 , C08G18/76 , C08G18/79 , C08G18/80 , C08G65/32 , C08G65/331 , C08G65/338
CPC分类号： C08G65/338 , C08G18/10 , C08G18/5024 , C08G18/6685 , C08G18/7671 , C08G18/797 , C08G18/8035 , C08G65/331 , C08G2101/0008 , C08G2120/00
摘要： The present invention relates to a process for the production of elastic, compact or cellular moldings based on elastomers containing N-benzylurea groups in bound form, by reactinga) one or more organic and/or modified organic polyisocyanates withb) N-benzylpolyoxyalkylene-polyamines or mixtures of N-benzylpolyoxyalkylene-polyamines and polyoxyalkylene-polyamines containing from 2 to 4 primary amino groups andc) one or more alkyl-substituted aromatic polyamines having a molecular weight of up to 500,in the presence or absence ofd) catalystsand, if desired,e) blowing agents,f) auxiliaries and/org) additives,and to the N-benzylpolyoxyalkylene-polyamines and mixtures of N-benzylpolyoxyalkylene-polyamines and polyoxyalkylene-polyamines containing from 2 to 4 primary amino groups which can be used for this purpose, and to the elastomers prepared.
摘要翻译：本发明涉及一种通过使a）一种或多种有机和/或改性的有机多异氰酸酯与b）N-苄基聚氧化烯 - 甲基丙烯酸酯反应生产基于含有结合形式的N-苄基脲的弹性体的弹性，紧密或多孔模塑制品的方法，多胺或N-苄基聚氧化烯 - 多胺和含有2至4个伯氨基的聚氧化烯 - 多胺的混合物，以及c）一种或多种分子量高达500的烷基取代的芳族多胺，在d）催化剂存在或不存在的情况下并且如果需要，e）发泡剂，f）助剂和/或g）添加剂，以及N-苄基聚氧化烯 - 多胺和N-苄基聚氧化烯 - 多胺和含有2-4个伯氨基的聚氧化烯 - 多胺的混合物，其可以用于此目的，并用于制备的弹性体。

9. 发明授权

US5090914A Activated polymers and conjugates thereof 失效
标题翻译：活性聚合物及其共轭物
公开(公告)号：US5090914A
公开(公告)日：1992-02-25
申请号：US572726
申请日：1990-08-24
申请人： Dayton T. Reardan , Dane A. Goff
发明人： Dayton T. Reardan , Dane A. Goff
IPC分类号： C07C229/60 , C07C237/32 , C07C271/28 , C08G65/322 , C08G65/333 , C08G65/338 , C12N11/08
CPC分类号： C07C271/28 , C07C229/60 , C07C237/32 , C08G65/322 , C08G65/33389 , C08G65/338 , C12N11/08
摘要： Macromolecular species such as enzymes, proteins, drugs, and solid supports which contain reactive carbonyl groups or groups which are readily converted to reactive carbonyl groups are modified by reaction with a compound of the formula ##STR1## in which R.sup.1 is H, C.sub.1 -C.sub.20 alkyl, phenyl, (C.sub.1 -C.sub.10 alkyl)-substituted phenyl, or phenyl-substituted C.sub.1 -C.sub.10 alkyl; R.sup.2 is C.sub.2 -C.sub.5 alkylene or (C.sub.1 -C.sub.4 alkoxy)-substituted C.sub.2 -C.sub.5 alkylene; R.sup.3 is ##STR2## R.sup.4 is H or C.sub.1 -C.sub.4 alkyl; n is at least 5; and m is zero or 1.
摘要翻译：含有反应性羰基或易于转化成反应性羰基的基团的酶，蛋白质，药物和固体载体的大分子物质通过与下式化合物的反应来进行修饰：其中R1是H，C1-C20 烷基，苯基，（C 1 -C 10烷基）取代的苯基或苯基取代的C 1 -C 10烷基; R2是C2-C5亚烷基或（C1-C4烷氧基） - 取代C2-C5亚烷基; R 3是H或C 1 -C 4烷基; n至少为5; m为零或1。

10. 发明授权

US4933485A Lubricating oil compositions containing very long chain alkylphenyl poly (oxyalkylene) aminocarbamates 失效
标题翻译：含有非常长链烷基苯基聚（氧化烯）氨基氨基甲酸酯的润滑油组合物
公开(公告)号：US4933485A
公开(公告)日：1990-06-12
申请号：US112902
申请日：1987-10-23
申请人： Thomas F. Buckley, III
发明人： Thomas F. Buckley, III
IPC分类号： C07C271/20 , C08G65/333 , C08G65/338 , C10M133/18 , C10M149/12
CPC分类号： C10M133/18 , C07C271/20 , C08G65/33306 , C08G65/338 , C10M149/12 , C10M2207/027 , C10M2207/028 , C10M2215/04 , C10M2215/042 , C10M2215/10 , C10M2215/26 , C10M2217/046 , C10M2217/06 , C10M2219/044 , C10M2219/046 , C10M2219/087 , C10M2219/088 , C10M2219/089 , C10M2223/045 , C10N2210/02 , C10N2240/10 , C10N2240/101 , C10N2240/104 , C10N2240/106 , C10N2270/02
摘要： Disclosed are alkylphenyl poly(oxyalkylene) aminocarbamates having at least one basic nitrogen and an average molecular weight of about 800 to 6,000 and wherein the alkyl group contains at least 40 carbon atoms. Also disclosed are lubricating oil compositions and concentrates containing said alkylphenyl poly(oxyalkylene) aminocarbamates.
摘要翻译：公开了具有至少一个碱性氮和平均分子量为约800至6000的烷基苯基聚（氧化烯）氨基氨基甲酸酯，并且其中烷基含有至少40个碳原子。还公开了含有所述烷基苯基聚（氧化烯）氨基氨基甲酸酯的润滑油组合物和浓缩物。

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