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1. 发明申请

US20180371394A1 Automatic Multi-tray and Multi-plate Bioreactor Systems for Adherent Cultures 审中-公开
公开(公告)号：US20180371394A1
公开(公告)日：2018-12-27
申请号：US15954595
申请日：2018-04-17
申请人： Timothy Ray Ho , Lewis Ho
发明人： Timothy Ray Ho , Lewis Ho
IPC分类号： C12M1/12 , C12M1/00 , C12M1/36
CPC分类号： C12M25/06 , C12M23/04 , C12M23/06 , C12M23/50 , C12M27/16 , C12M29/06 , C12M29/24 , C12M29/26 , C12M41/48
摘要： Disclosed herein is an improved automatic bioreactor system utilizing a multi-tray or multi-plate cell culture vessel for cultivating adherent cells.

2. 发明授权

US10012662B2 Incubator, schedule management method, and program 有权
公开(公告)号：US10012662B2
公开(公告)日：2018-07-03
申请号：US14966447
申请日：2015-12-11
申请人： NIKON CORPORATION
发明人： Yoichi Wada
IPC分类号： G01N35/00 , C12M1/34 , C12M1/00 , C12M1/36 , G01N35/02
CPC分类号： G01N35/0092 , C12M23/50 , C12M41/14 , C12M41/36 , C12M41/48 , G01N35/028 , G01N2035/00356 , G01N2035/0094 , G01N2035/0096 , G01N2035/0097
摘要： An input section of an incubator accepts, from a user, a first input selecting a specified incubation container which registers an observing schedule, and a second input specifying an imaging condition of the specified incubation container in an observing sequence. A calculating section calculates, according to the above-mentioned imaging condition, an observing duration of the specified incubation container from a first data relating to a carrying period of an incubation container and a second data with regard to an imaging duration. A schedule management section extracts, based on a schedule data, a registrable time zone in which an observing sequence of the specified incubation container can be executed without overlapping with previously registered observing schedules, and outputs to display the registrable time zone for presentation to the user.

3. 发明授权

US09983308B2 Method and apparatus for locating the surface of solid growth culture media in a plate 有权
公开(公告)号：US09983308B2
公开(公告)日：2018-05-29
申请号：US14169630
申请日：2014-01-31
申请人： LBT Innovations Limited
发明人： Chong Kean Ooi , Michael John Tomlinson , Leon Raj , Graeme John Cross
IPC分类号： C12M1/36 , G01S15/02 , C12M1/00 , C12M1/26 , G01B21/16 , G01N35/04
CPC分类号： G01S15/02 , C12M23/10 , C12M23/50 , C12M33/04 , G01B21/16 , G01N2035/0491
摘要： A method for locating the surface of a solid growth culture medium in a plate in a plate work position, the plate work position including a sensor and having a datum level fixed in one dimension (z), the method including: placing the plate in the plate work position; using the sensor to sense the medium surface for the positioned plate and measuring the distance to the medium surface; and referencing the measured distance to the datum level to determine a surface positional reference, relative to the datum level, in one dimension (z) for the surface of the medium in the positioned plate.

4. 发明申请

US20180112164A1 Device for Observation, Imaging and Uninterrupted Culturing of Embryos and Cells 审中-公开
公开(公告)号：US20180112164A1
公开(公告)日：2018-04-26
申请号：US15334953
申请日：2016-10-26
申请人： Michael D. Cecchi , Timothy Schimmel , Jacques Cohen , Monica Mezezi , Michael Ryan Cecchi
发明人： Michael D. Cecchi , Timothy Schimmel , Jacques Cohen , Monica Mezezi , Michael Ryan Cecchi
IPC分类号： C12M1/00 , C12M3/00 , C12M1/34 , G01N21/84
CPC分类号： G01N21/84 , C12M23/22 , C12M23/48 , C12M23/50 , C12M31/02 , C12M41/14 , C12M41/34 , C12M41/36
摘要： A device for the observation, imaging and uninterrupted culturing of embryos and cells, the device comprising: an incubator; a mixing box located above the incubator; gas sensors located in the mixing box; solenoid valves attached to the mixing box; a first clear panel located on the top of the incubator, and configured to allow one to see into the incubator; a first light source located above the first clear panel, and the first light source configured to provide light into the incubator; a door attached to the incubator, the door configured to provide access to the inside of the incubator, and the door located below the access door; a rotatable platter located below the incubator, the rotatable platter comprising: a first insert configured to removably sit on the platter; a first culture dish configured to removably sit in the first insert; a second insert configured to removably sit on the platter; a second culture dish configured to removably sit in the second insert; a first moveable camera located under the rotatable platter, and configured to view a culture dish located generally directly above the first moveable camera, and the first moveable camera generally in alignment with the first light source; a computer in communication with the first moveable camera, rotatable platter, sensors, solenoid valves, touchscreen display, and light source. A device for the observation, imaging and uninterrupted culturing of embryos and cells, the device comprising: a top portion, the top portion comprising: a housing; a horizontal surface on the housing; an angled surface abutting the horizontal surface; an access door located generally on the housing; a first heating surface located on the horizontal surface; a touch screen display located on the angled surface; a middle portion abutting the top portion; the middle portion comprising: an incubator; a mixing box located above the incubator; gas sensors located in the mixing box; solenoid valves attached to the mixing box; a first clear panel located on the top of the incubator, and configured to allow one to see into the incubator; a first light source located above the first clear panel, and the first light source configured to provide light into the incubator; a door attached to the incubator, the door configured to provide access to the inside of the incubator, and the door located below the access door; a bottom portion abutting the middle portion, the bottom portion comprising: a rotatable platter, the rotatable platter comprising: a first insert configured to removably sit on the platter; a first culture dish configured to removably sit in the first insert; a second insert configured to removably sit on the platter; a second culture dish configured to removably sit in the second insert; a first moveable camera located under the rotatable platter, and configured to view a culture dish located generally directly above the first moveable camera, and the first moveable camera generally in alignment with the first light source; a computer in communication with the camera, rotatable platter, sensors, solenoid valves, touchscreen display, and light source.

5. 发明申请

US20180104697A1 INCUBATOR STAND AND INCUBATOR DOCKING SYSTEM 审中-公开
公开(公告)号：US20180104697A1
公开(公告)日：2018-04-19
申请号：US15711677
申请日：2017-09-21
申请人： Planer Plc
发明人： Stephen James Butler , Stephen Mark Joseph Wilkins
IPC分类号： B01L9/00
CPC分类号： B01L9/52 , B01L2200/025 , B01L2300/0809 , C12M23/44 , C12M23/48 , C12M23/50
摘要： An incubator stand for holding a plurality of incubators in a stacked arrangement, the incubator stand comprising: a stand base; a shaft element upstanding from the stand base; and a plurality of incubator bases rotatably received on the shaft element, each incubator base forming a support for or forming part of an incubator. A stop element is also provided which prevents or limits angular displacement of each incubator base, so that each incubator base can be pivoted out from a stack of said incubator bases to in use access an incubator associated therewith without causing the stack to topple. An incubator docking system and incubator system for transferring incubators between different environmental conditions are also provided.

6. 发明申请

US20180045746A1 DISH ROTATION DIRECTLY DRIVEN FROM TRANSPORT BELT 审中-公开
公开(公告)号：US20180045746A1
公开(公告)日：2018-02-15
申请号：US15547978
申请日：2016-02-04
申请人： BD KIESTRA B.V
发明人： Jurjen Sinnema , Roger Petri , Martijn Xander Berntsen , Martijn Kleefstra
IPC分类号： G01N35/00 , G01N35/02 , G01N35/04
CPC分类号： G01N35/00732 , C12M23/10 , C12M23/50 , G01N35/021 , G01N35/04 , G01N2035/00752 , G01N2035/0484
摘要： An apparatus for conveying a plurality of articles (10) includes a transport belt (6), a bumper stopper (14), and a rotator (12). A motor moves the transport belt which is adapted to rotate the rotator as the belt conveys the plurality of articles. The stopper can move between first and second positions relative to the transport belt wherein the bumper stopper guides one article toward the rotator when the bumper stopper is in the first position. The bumper stopper allows the article to be conveyed to another location when the bumper stopper is in the second position. The transport belt can continue to convey other articles while the one article is temporarily held in place by the bumper stopper. The rotator is configured to rotate the article conveyed by the transport belt. The article can remain in contact with the transport belt while the rotator is rotating the article.

7. 发明授权

US09752139B2 Magnetic three-dimensional cell culture apparatus and method 有权
公开(公告)号：US09752139B2
公开(公告)日：2017-09-05
申请号：US14096791
申请日：2013-12-04
申请人： University of South Florida
发明人： Jeanne L. Becker , Susan B. Coffin
IPC分类号： C12M1/00 , C12M3/00 , C12N13/00 , B82Y25/00 , C12M1/04 , C12M1/12 , C12N5/00 , H01F1/00 , H01F7/02
CPC分类号： C12N13/00 , B82Y25/00 , C12M23/24 , C12M23/50 , C12M25/16 , C12N5/0062 , H01F1/0045 , H01F7/0273
摘要： A culture apparatus and method for growing cells and tissue in a three-dimensional configuration harnesses magnetic, paramagnetic, ferromagnetic and diamagnetic forces. The cells or tissue are grown with magnetized core particles and are suspended via magnetic forces in a native, non-restricted, three-dimensional configuration while being maintained in a normal gravity (1 g) growth environment in the absence of rotational alteration of the gravity vector.

8. 发明申请

US20170198247A1 FLUID LINE ARRANGEMENT COMPRISING A PLURALITY OF FLUID LINE ELEMENTS, VALVE LINE ARRANGEMENT COMPRISING A FLUID LINE ARRANGEMENT AND A SWITCHING ARRANGEMENT, AND HANDLING ARRANGEMENT HAVING A VALVE LINE ARRANGEMENT 审中-公开
公开(公告)号：US20170198247A1
公开(公告)日：2017-07-13
申请号：US15326833
申请日：2015-06-03
申请人： Hamilton Bonaduz AG
发明人： Tobias Seiler , Oliver Kühne , Carsten Etzold
IPC分类号： C12M1/00 , F16M11/18 , C12M1/24 , B01L3/00 , B01L9/00 , F16M11/10 , F16M11/22
CPC分类号： C12M29/00 , A61M39/10 , B01L3/567 , B01L9/00 , B01L9/50 , B01L2200/025 , B01L2200/026 , B01L2300/0864 , B01L2400/06 , C12M23/08 , C12M23/38 , C12M23/40 , C12M23/50 , F16M11/10 , F16M11/18 , F16M11/22
摘要： A fluid line element for building a fluid line section comprising a plurality of identical fluid line elements, wherein the fluid line element comprises: an element body, a first throughflow opening provided on the element body and a second throughflow opening, different from the first, and a flow channel provided in the element body, which fluidically connects the first and the second throughflow openings for throughflow along a channel path. In a first region of the fluid line element, located closer to the first than to the second throughflow opening, a throughflow body formed separately from the element body is provided, which forms a part of the flow channel, is formed from a material having a lower elasticity modulus than the material of the element body, and on the longitudinal end thereof facing into the interior of the element body, comprises a valve seat formation surrounding the channel path.

9. 发明申请

US20170191021A1 CELL CULTURE DEVICE AND METHOD 审中-公开
公开(公告)号：US20170191021A1
公开(公告)日：2017-07-06
申请号：US15462295
申请日：2017-03-17
申请人： FUJIFILM Corporation
发明人： Takashi WAKUI
IPC分类号： C12M1/34 , C12N5/071 , G06K9/00 , C12M1/00
CPC分类号： C12M41/46 , C12M21/08 , C12M23/12 , C12M23/50 , C12N5/0602 , C12N5/10 , G06K9/00134 , G06K9/00147
摘要： A cell culture device and a cell culture method that enable living tissues for transplantation having constant qualities to be stably supplied as products are provided. A plurality of cell culture portions that respectively culture a plurality of cell culture units; a maturity evaluation portion that respectively evaluates maturity of the respective cell culture units in the respective cell culture portions and a movement target cell determining portion that determines a cell culture unit that does not satisfy a predetermined condition as a target to be moved to another cell culture portion in a case where the cell culture unit of which maturity does not satisfy the predetermined condition among a plurality of cell culture units cultured in any one cell culture portion of the plurality of cell culture portions exists are provided.

10. 发明申请

US20170130189A1 AUTOMATIC CULTURING DEVICE 审中-公开
公开(公告)号：US20170130189A1
公开(公告)日：2017-05-11
申请号：US15322643
申请日：2015-06-12
申请人： SHIBUYA CORPORATION
发明人： Masahiro SAKAMOTO , Noriaki NISHIMURA
IPC分类号： C12M1/36 , C12M1/26 , C12M1/00 , C12M1/12 , C12M1/24
CPC分类号： C12M41/48 , C12M23/08 , C12M23/50 , C12M33/10 , C12M37/00 , C12M41/14
摘要： An automatic culturing device configured such that, in a work chamber 2a maintained in a sterile state, first and second robots 6 and 7 are arranged so that the movable ranges thereof partially overlap each other, and such that liquid supply means 10 which supplies liquids, containing a culture medium and liquid medicine, to containers held by the robots, and temporary placement sections (handing-over table 42, centrifuge tube holder 43, and heated room 44), each of which hands over the containers between the first and second robots, are provided in the movable ranges of the first and second robots, which ranges overlap each other.The first robot takes out the containers housed in housing means (rotary stocker 8), and the second robot holds and transports the containers handed over from the first robot via the temporary placement section.The cultivating operation can be efficiently performed.

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