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1. 发明授权

US09977136B2 Beta and alpha emission tomography for three-dimensional autoradiography 有权
公开(公告)号：US09977136B2
公开(公告)日：2018-05-22
申请号：US15729428
申请日：2017-10-10
申请人： Arizona Board of Regents on Behalf of The University of Arizona , inviCRO, LLC
发明人： Harrison H. Barrett , Brian Miller , Yijun Ding , Liying Chen , John William Hoppin , Luca Caucci
IPC分类号： G01T1/29 , G01T5/08 , A61B6/03 , G01T1/161 , A61B6/00
CPC分类号： G01T1/2942 , A61B6/037 , A61B6/4258 , A61B6/5205 , G01T1/161 , G01T1/2985 , G01T5/08
摘要： The present invention provides methods and systems for 3D imaging of in vivo and ex vivo tissues. The disclosed systems and methods employ an autoradiographic approach where particles emitted by a radioactive composition within the tissue are detected. Once detected, a 3D representation of the source of particles within the tissue is reconstructed for viewing and analysis.

2. 发明申请

US20160327658A1 DEVICE FOR DETECTING THERAPEUTIC PROTON BEAM EMITTED IN PENCIL BEAM SCANNING MODE 有权
标题翻译：用于检测在光束扫描模式中发出的治疗原子束的装置
公开(公告)号：US20160327658A1
公开(公告)日：2016-11-10
申请号：US15108852
申请日：2014-12-10
申请人： National Cancer Center
发明人： Dong Ho SHIN , Me Young KIM , Joo Young KIM , Jae Man SON , Se Byeong LEE , Young Kyung LIM , Ui Jung HWANG
IPC分类号： G01T5/08 , G01T1/29 , A61N5/10 , G01T1/22
CPC分类号： G01T5/08 , A61N5/1043 , A61N5/1075 , A61N2005/1087 , G01T1/22 , G01T1/29
摘要： The disclosed device for detecting the position and dose distribution of a therapeutic proton beam emitted in a pencil beam scanning mode comprises: a proton beam progressing position detection unit comprising a plurality of first optical fibers arranged along the first direction and a plurality of second optical fibers arranged along the second direction which is different from the first direction; and a proton beam dose distribution detection unit comprising a plurality of optical wavelength converter, each of which comprises an optical wavelength conversion disk and an optical wavelength-converting optical fibers arranged along the outer circumference of the optical wavelength conversion disk. The proton beam progressing position detection unit detects a proton beam progressing position through the arrangement of the first and second optical fibers, and the proton beam dose distribution detection unit detects a dose distribution of the proton beam progressing direction through a plurality of optical wavelength conversion disks.
摘要翻译：用于检测以笔形射束扫描模式发射的治疗质子束的位置和剂量分布的所公开的装置包括：质子束进行位置检测单元，包括沿着第一方向布置的多个第一光纤和多个第二光纤沿着与第一方向不同的第二方向布置; 以及质子束剂量分布检测单元，其包括多个光波长转换器，每个光波长转换器包括沿着所述光波长转换盘的外圆周布置的光波长转换盘和光波长转换光纤。质子束进行位置检测部通过第一和第二光纤的配置来检测质子束的前进位置，质子束剂量分布检测部通过多个光波长转换盘检测质子束的行进方向的剂量分布。

3. 发明申请

US20150105603A1 MICROFABRICATED SCINTILLATION DETECTOR 有权
标题翻译：微波扫描检测器
公开(公告)号：US20150105603A1
公开(公告)日：2015-04-16
申请号：US14399907
申请日：2012-05-08
申请人： CERN-EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH
发明人： Alessandro Mapelli , Pietro Maoddi , Philippe Renaud
IPC分类号： G01T1/20 , A61N5/10 , G01T1/29
CPC分类号： G01T1/2006 , A61N5/1048 , G01T1/201 , G01T1/29 , G01T5/08 , Y10T29/49002
摘要： The present invention discloses a microfabricated scintillation detector, comprising a channel structure (26) for containing a liquid scintillator material therein and flowing said liquid scintillator material therethrough. The channel structure (26) comprises first and second sets (30, 36) of adjacent channel portions (32, 38) arranged in first and second layers (34, 40) and in fluid communication with each other. The second set (36) of adjacent channel portions (38) is directed at right angles with respect to the first set (30) of adjacent channel portions (32). The first and second layers (34, 40) are stacked on top of each other with a separation layer (42) in between, integrally connecting said first and second layers (34, 40). The channel structure (26) simultaneously forms a light guiding structure for guiding scintillation light (52) towards a longitudinal end of the corresponding channel portion (32, 38). The scintillation detector (24) further comprises a plurality of photo detectors (54), arranged such as to receive said scintillation light (50).
摘要翻译：本发明公开了一种微制造的闪烁检测器，其包括用于在其中容纳液体闪烁体材料并使所述液体闪烁体材料流过其中的通道结构（26）。通道结构（26）包括布置在第一和第二层（34,40）中并且彼此流体连通的相邻通道部分（32,38）的第一组和第二组（30,36）。相邻通道部分（38）的第二组（36）相对于相邻通道部分（32）的第一组（30）成直角。第一和第二层（34,40）在其之间彼此堆叠，其间具有分离层（42），整体地连接所述第一和第二层（34,40）。通道结构（26）同时形成用于将闪烁光（52）朝向对应的通道部分（32,38）的纵向端引导的导光结构。闪烁检测器（24）还包括多个光电检测器（54），其布置成接收所述闪烁光（50）。

4. 发明申请

US20130234031A1 RADIATION DETECTION APPARATUS AND METHOD OF USING SAME 有权
标题翻译：辐射检测装置及其使用方法
公开(公告)号：US20130234031A1
公开(公告)日：2013-09-12
申请号：US13602426
申请日：2012-09-04
申请人： John M. Frank
发明人： John M. Frank
IPC分类号： G01T1/20
CPC分类号： G01T1/2006 , G01T3/06 , G01T5/08
摘要： A radiation detection apparatus can include a semi-cylindrical radiation sensor having a corresponding radiation sensing region, and a photosensor that is optically coupled to the radiation sensor.
摘要翻译：辐射检测装置可以包括具有对应的辐射感测区域的半圆柱形辐射传感器和光学耦合到辐射传感器的光电传感器。

5. 发明授权

US07326933B2 Radiation or neutron detector using fiber optics 有权
标题翻译：使用光纤的辐射或中子探测器
公开(公告)号：US07326933B2
公开(公告)日：2008-02-05
申请号：US11640238
申请日：2006-12-18
申请人： Masaki Katagiri , Masahito Matsubayashi
发明人： Masaki Katagiri , Masahito Matsubayashi
IPC分类号： G01T1/20 , G01T1/00
CPC分类号： G01T5/08
摘要： A radiation or neutron detector wherein lateral side light detecting optical fibers prepared from clear optical fibers that are scraped on a lateral side to permit side incidence of fluorescence are used to detect the fluorescence from a phosphor or a scintillator such that the background to gamma-rays is reduced. If desired, the optical fibers may be bent at 90 degrees and guided to a photomultiplier tube in order to reduce the size of the detector. Fabrication and maintenance of the detector can be facilitated by adopting such a design that a detecting block comprising a detection medium and lateral side light detecting optical fibers is separated from a readout block comprising clear optical fibers.
摘要翻译：使用辐射或中子检测器，其中使用由在侧面刮擦以允许侧向荧光的透明光纤制备的侧面光检测光纤用于检测来自荧光体或闪烁体的荧光，使得伽马射线的背景降低了。如果需要，光纤可以以90度弯曲并被引导到光电倍增管，以便减小检测器的尺寸。通过采用这样的设计，可以促进检测器的制造和维护，使得包括检测介质和侧面光检测光纤的检测块与包括透明光纤的读出块分离。

6. 发明授权

US06909098B2 Systems and methods for detecting nuclear radiation in the presence of backgrounds 失效
标题翻译：在有背景的情况下检测核辐射的系统和方法
公开(公告)号：US06909098B2
公开(公告)日：2005-06-21
申请号：US10308950
申请日：2002-12-03
申请人： Alan D. Bross , Kerry L. Mellott , Anna Pla-Dalmau
发明人： Alan D. Bross , Kerry L. Mellott , Anna Pla-Dalmau
IPC分类号： G01T1/16 , G01T1/20 , G01T1/203 , G01T5/08
CPC分类号： G01T5/08 , G01T1/16 , G01T1/203
摘要： Systems and methods for the simultaneous detection and identification of radiation species, including neutrons, gammas/x-rays and minimum ionizing particles (MIPs). A plurality of rectangular and/or triangularly shaped radiation sensitive scintillators can be configured from a plurality of nano-sized particles, dopants and an extruded plastic material. A wavelength-shifting fiber can then be located within a central hole of each extruded scintillator, wherein the wavelength-shifting fiber absorbs scintillation light and re-emits the light at a longer wavelength, thereby piping the light to a photodetector whose response to the light indicates the presence of radiation The resulting method and system can simultaneously detect neutrons, gamma rays, x-rays and cosmic rays (MIPs) and identify each.
摘要翻译：用于同时检测和识别辐射物种的系统和方法，包括中子，伽马/ x射线和最小电离粒子（MIP）。多个矩形和/或三角形的辐射敏感的闪烁体可以由多个纳米尺寸的颗粒，掺杂剂和挤出的塑料材料构成。然后，波长移位光纤可以位于每个挤出的闪烁体的中心孔内，其中波长移动光纤吸收闪烁光并且以更长的波长再次发射光，从而将光线配管到对光的响应的光电检测器表示辐射的存在所得到的方法和系统可以同时检测中子，γ射线，X射线和宇宙射线（MIP）并识别每个。

7. 发明授权

US06407392B1 Radiation detector 有权
标题翻译：辐射检测器
公开(公告)号：US06407392B1
公开(公告)日：2002-06-18
申请号：US09549034
申请日：2000-04-13
申请人： Akira Tsuyuki , Tatsuyuki Maekawa , Akio Sumita , Shunichiro Makino
发明人： Akira Tsuyuki , Tatsuyuki Maekawa , Akio Sumita , Shunichiro Makino
IPC分类号： G01T120
CPC分类号： G01T5/08 , G01T1/2018
摘要： A radiation detector for detecting radiation comprises a scintillator, a first light guide, a plurality of second light guides and a photo detector. The scintillator generates a scintillated light in response to received radiation. The first light guide, which is connected to the scintillator, has a fluorescence characteristic. The second light guide has a common surface arranged at the opposite side of the surface of the scintillator where radiation is received, and the second light guide has a fluorescence characteristic. The photo detector is connected to the first light guide and the second light guide, and detects a fluorescent light therein.
摘要翻译：用于检测辐射的辐射检测器包括闪烁体，第一光导，多个第二光导和光检测器。闪烁体响应于接收的辐射产生闪烁的光。与闪烁体连接的第一光导具有荧光特性。第二光导具有布置在接收辐射的闪烁体的表面的相反侧的公共表面，并且第二光导具有荧光特性。光检测器连接到第一光导和第二光导，并检测其中的荧光。

8. 发明授权

US5434415A Radiation-detecting light-transmission apparatus 失效
标题翻译：辐射检测光传输装置
公开(公告)号：US5434415A
公开(公告)日：1995-07-18
申请号：US174701
申请日：1993-12-28
申请人： Hideo Terada , Kazuo Sakuma , Masahiro Takebe , Yoshihiro Atsumi , Katsumi Urayama , Michio Wakahara
发明人： Hideo Terada , Kazuo Sakuma , Masahiro Takebe , Yoshihiro Atsumi , Katsumi Urayama , Michio Wakahara
IPC分类号： G01T1/20 , G01T5/08 , G02B6/00 , H04B10/00 , H04B10/079 , H04B10/2507 , H04B10/90 , G01T1/203
CPC分类号： G01T1/20 , G01T5/08
摘要： A radiation induced light wavelength shifter and an apparatus for detecting radiation and transmitting detected signal through an optical fiber are disclosed. A radiation induced light wavelength shifter used in such apparatus comprises a cylindrical scintillator, a fluorescent optical fiber an end of which is inserted into the scintillator, the fluorescent optical fiber extending out of the scintillator, a light shielding member covering the scintillator and the fluorescent optical fiber, and a light reflecting material covering the scintillator.
摘要翻译：公开了一种辐射诱导光波长移位器和用于检测辐射并通过光纤传输检测信号的装置。在这种设备中使用的辐射诱导光波长移位器包括圆柱形闪烁体，其末端插入闪烁体的荧光光纤，从闪烁体延伸的荧光光纤，覆盖闪烁体的荧光光纤和荧光光光纤和覆盖闪烁体的光反射材料。

9. 发明授权

US09971048B2 Device for detecting therapeutic proton beam emitted in scattering mode 有权
公开(公告)号：US09971048B2
公开(公告)日：2018-05-15
申请号：US15108984
申请日：2014-12-10
申请人： NATIONAL CANCER CENTER
发明人： Dong Ho Shin , Me Young Kim , Joo Young Kim , Jae Man Son , Se Byeong Lee , Young Kyung Lim , Ui Jung Hwang
IPC分类号： G01T1/20 , G01T5/08 , A61N5/10 , G01T1/22 , G01T1/29
CPC分类号： G01T5/08 , A61N5/1071 , A61N5/1075 , A61N2005/1087 , G01T1/22 , G01T1/29
摘要： Disclosed is a proton beam detection device comprising a sensor having optical fiber of an arrangement structure capable of accurately and efficiently detecting proton dose distribution such as bragg peak, spread out bragg peak (SOBP) and symmetry of a therapeutic proton beam emitted in a scattering mode. The proton beam detection device, which detects a proton beam emitted from a proton beam source in a scattering mode, comprises a sensor having a plurality of detection modules including reference optical fiber and detection optical fiber having a length longer than the length of the reference optical fiber, the plurality of detection modules being diagonally arranged in the depth direction along which the proton beam emitted from the proton beam source proceeds.

10. 发明申请

US20140233690A1 X-RAY DETECTION SUBMODULE, X-RAY DETECTION MODULE, AND X-RAY CT APPARATUS 有权
标题翻译： X射线检测子模块，X射线检测模块和X射线CT装置
公开(公告)号：US20140233690A1
公开(公告)日：2014-08-21
申请号：US14261976
申请日：2014-04-25
申请人： KABUSHIKI KAISHA TOSHIBA , TOSHIBA MEDICAL SYSTEMS CORPORATION
发明人： Atsushi HASHIMOTO , Akira Nishijima , Shuya Nambu , Yoji Kudo , Masahiko Yamazaki , Tomonori Asada
IPC分类号： G01T1/208 , G01N23/04 , G01T1/20
CPC分类号： A61B6/4411 , A61B6/4233 , A61B6/4266 , G01T1/2018 , G01T1/243 , G01T5/08 , H01L27/14601 , H01L27/14634 , H01L27/14636
摘要： An X-ray detection submodule, comprising: a substrate; a photodiode mounted on the substrate; an X-ray detection element configured to detect an X-ray and convert the X-ray into light; and a light waveguide provided between the photodiode and the X-ray detection element, wherein the light waveguide connects the X-ray detection element with the photodiode such that the substrate is inclinedly disposed with respect to an X-ray detection surface of the X-ray detection element.
摘要翻译：一种X射线检测子模块，包括：基板; 安装在基板上的光电二极管; X射线检测元件，被配置为检测X射线并将X射线转换为光; 以及设置在所述光电二极管和所述X射线检测元件之间的光波导，其中所述光波导将所述X射线检测元件与所述光电二极管连接，使得所述基板相对于所述X射线检测元件的X射线检测面倾斜地配置，射线检测元件。

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