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1. 发明申请

US20180308600A1 Method And Apparatus For The Production of Lead 212 For Medical Use 审中-公开
公开(公告)号：US20180308600A1
公开(公告)日：2018-10-25
申请号：US16000615
申请日：2018-06-05
申请人： ORANO MED
发明人： Julien Torgue , Patrick Maquaire , John Young , Gilbert Andreoletti , Patrick Bourdet
IPC分类号： G21G1/00 , C22C11/00 , C22B13/06 , C22B13/02
CPC分类号： G21G1/0005 , A61K51/12 , C22B13/02 , C22B13/06 , C22C11/00 , G21G4/08 , G21G2001/0094
摘要： The invention relates to a method for preparing lead (212) for medical use. This method comprises the production of lead (212) by the decay of radium (224) in a generator comprising a solid medium to which the radium (224) is bound, followed by the extraction of the lead (212) from the generator in the form of an aqueous solution A1, characterised in that the lead (212) contained in the aqueous solution A1 is purified from the radiological and chemical impurities, also contained in said aqueous solution, by a liquid chromatography on a column. The invention also relates to an apparatus specially designed for automated implementation in a closed system of said method. It further relates to lead (212) produced by means of this method and this apparatus. Applications: manufacture of radiopharmaceuticals based on lead (212), useful in nuclear medicine for the treatment of cancers, particularly by a-radioimmunotherapy, or for medical imaging, in both humans and animals.

2. 发明授权

US10078772B2 Scanning system for scanning objects in radioactive environment 有权
公开(公告)号：US10078772B2
公开(公告)日：2018-09-18
申请号：US15408006
申请日：2017-01-17
申请人： Mallinckrodt Nuclear Medicine LLC
发明人： Bryan S. Petrofsky , Kevin B. Graves , Sumit Verma , Michael J. D'Hooge , John Schmitz
IPC分类号： G06K7/10 , G06K7/14 , G06K19/06 , G06K19/07 , G21F7/00 , G21G1/00
CPC分类号： G06K7/1417 , G06K7/10405 , G06K7/10722 , G06K7/10821 , G06K7/10861 , G06K7/1447 , G06K19/06037 , G06K19/0717 , G21F7/00 , G21G1/0005
摘要： A system for manufacturing radionuclide generators includes an enclosure defining a radioactive environment. The enclosure includes radiation shielding to prevent radiation within the radioactive environment from moving to an exterior of the enclosure. The system also includes a barcode positioned on an object within the enclosure and a scanning system for scanning the barcode. The scanning system includes a camera on the exterior of the enclosure, a mirror, and a conduit extending through a wall of the enclosure for light to travel between the camera and the mirror.

3. 发明授权

US09953733B2 Radioisotope concentrator 有权
公开(公告)号：US09953733B2
公开(公告)日：2018-04-24
申请号：US14438575
申请日：2013-10-25
申请人： Cyclopharm Limited
发明人： Van So Le , Nabil Marcos , James McBrayer
IPC分类号： G21G1/06 , G21G1/00 , A61K51/12
CPC分类号： G21G1/0005 , A61K51/1286
摘要： A system using a radioisotope concentrator device comprising a body having at least one injection port and at least one valve being configurable between a first open configuration for allowing fluid communication between the at least one injection port and the concentrator column and a second open configuration to prevent fluid communication between the at least one injection port and the concentrator column in use, the system further comprising an injection device comprising an eluent for eluting through the concentrator column via the at least one injection port when the at least one valve of the radioisotope concentrator device is in a selected open configuration in use.

4. 发明申请

US20180018490A1 SCANNING SYSTEM FOR SCANNING OBJECTS IN RADIOACTIVE ENVIRONMENT 审中-公开
公开(公告)号：US20180018490A1
公开(公告)日：2018-01-18
申请号：US15408006
申请日：2017-01-17
申请人： Mallinckrodt Nuclear Medicine LLC
发明人： Bryan S. Petrofsky , Kevin B. Graves , Sumit Verma , Michael J. D'Hooge , John Schmitz
IPC分类号： G06K7/14 , G06K19/06 , G06K7/10 , G06K19/07
CPC分类号： G06K7/1417 , G06K7/10405 , G06K7/10722 , G06K7/10821 , G06K7/10861 , G06K7/1447 , G06K19/06037 , G06K19/0717 , G21F7/00 , G21G1/0005
摘要： A system for manufacturing radionuclide generators includes an enclosure defining a radioactive environment. The enclosure includes radiation shielding to prevent radiation within the radioactive environment from moving to an exterior of the enclosure. The system also includes a barcode positioned on an object within the enclosure and a scanning system for scanning the barcode. The scanning system includes a camera on the exterior of the enclosure, a mirror, and a conduit extending through a wall of the enclosure for light to travel between the camera and the mirror.

5. 发明申请

US20170274138A1 INTEGRATED STRONTIUM-RUBIDIUM RADIOISOTOPE INFUSION SYSTEMS 有权
公开(公告)号：US20170274138A1
公开(公告)日：2017-09-28
申请号：US15620320
申请日：2017-06-12
申请人： Bracco Diagnostics Inc.
发明人： Stephen E. Hidem , Aaron M. Fontaine , Janet L. Gelbach , Patrick M. McDonald , Kathryn M. Hunter , Rolf E. Swenson , Julius P. Zodda
IPC分类号： A61M5/00 , A61B50/13 , A61B6/00 , A61B6/03 , A61B6/10 , A61B90/00 , A61K51/00 , A61M5/14 , A61M5/142 , A61M5/145 , A61M5/158 , A61M5/168 , A61N5/10 , G06F21/31 , G21F3/00 , G21F7/00 , G21G1/00 , G21G4/08 , A61B50/10 , B62B3/00
CPC分类号： A61M5/007 , A61B6/037 , A61B6/107 , A61B6/481 , A61B6/507 , A61B50/13 , A61B90/39 , A61B2050/105 , A61B2090/392 , A61K51/00 , A61M5/14 , A61M5/1409 , A61M5/142 , A61M5/1452 , A61M5/158 , A61M5/16854 , A61M5/16881 , A61M5/365 , A61M2005/1403 , A61M2205/18 , A61M2205/276 , A61M2205/3375 , A61M2205/50 , A61M2205/505 , A61M2205/52 , A61M2205/584 , A61M2205/587 , A61M2205/6009 , A61M2205/6054 , A61M2205/6072 , A61M2205/70 , A61M2205/75 , A61M2209/084 , A61N5/1001 , A61N5/1007 , A61N5/1075 , A61N2005/1021 , A61N2005/1022 , A61N2005/1074 , A61N2005/1094 , B62B3/005 , G06F19/00 , G06F19/3468 , G06F21/31 , G21F3/00 , G21F7/00 , G21G1/0005 , G21G1/001 , G21G4/08 , G21G2001/0031
摘要： Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer may include pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.

6. 发明申请

US20170125213A1 ISOTOPE TAGGING FOR WORKPIECE AUTHENTICATION 审中-公开
公开(公告)号：US20170125213A1
公开(公告)日：2017-05-04
申请号：US15197940
申请日：2016-06-30
申请人： Board of Trustees of Michigan State University
发明人： Wolfgang Bauer , Bradley Sherrill
IPC分类号： H01J37/317 , H01J37/30
CPC分类号： G21H5/02 , B42D25/405 , G01N2458/15 , G09F3/00 , G21G1/0005 , G21G1/10 , H01J2237/31711 , H04W12/00 , H05H2277/12 , Y10T428/24802
摘要： A method of assisting with authenticating a workpiece is provided. In another aspect, ions are generated, accelerated in an accelerator, an isotope is created, and then the isotope is implanted within a workpiece to assist with authenticating of the workpiece. A further aspect includes a workpiece substrate, a visual marker and an isotope internally located within the substrate adjacent the visual marker.

7. 发明授权

US09240253B2 Column geometry to maximize elution efficiencies for molybdenum-99 有权
标题翻译：色谱柱几何结构，可最大限度地提高钼-99的洗脱效率
公开(公告)号：US09240253B2
公开(公告)日：2016-01-19
申请号：US12755714
申请日：2010-04-07
申请人： Jennifer Varnedoe , William Earl Russell, II , Bradley D. Bloomquist , Melissa Allen , James Edward Paine , Alan Anthony Alvarez
发明人： Jennifer Varnedoe , William Earl Russell, II , Bradley D. Bloomquist , Melissa Allen , James Edward Paine , Alan Anthony Alvarez
IPC分类号： A61K51/02 , B01D15/14 , B01D15/18 , B01D15/22 , C22B34/12 , C22B34/34 , G01N30/60 , G21G1/00
CPC分类号： G21G1/0005 , A61K51/025 , B01D15/14 , B01D15/18 , B01D15/22 , C22B34/12 , C22B34/34 , G01N30/6052 , G01N30/6065 , G21G2001/0042
摘要： At least one system for eluting a radioactive material and a method of eluting a radioactive material is provided. The system for eluting a radioactive material may include an elution column configured to enclose an radioactive material, a first sealing member sealing a first end of the elution column, a second sealing member sealing a second end of the elution column, an elution supply source connected to the first end of the elution column via a first needle, a collection system connected to the second end of the elution column via a second needle, and a filter in the elution column, the filter being configured to support the radioactive material and prevent the radioactive material from contacting the second needle.
摘要翻译：提供至少一种用于洗脱放射性物质的系统和一种洗脱放射性物质的方法。用于洗脱放射性物质的系统可以包括被配置为包围放射性物质的洗脱塔，密封洗脱塔的第一端的第一密封构件，密封洗脱塔的第二端的第二密封构件，连接的洗脱供应源通过第一针，经由第二针连接到洗脱塔的第二端的收集系统和洗脱塔中的过滤器，洗涤塔的第一端，所述过滤器被配置为支撑放射性物质并防止与第二针接触的放射性物质。

8. 发明授权

US09123449B2 Infusion system configurations 有权
标题翻译：输液系统配置
公开(公告)号：US09123449B2
公开(公告)日：2015-09-01
申请号：US12865924
申请日：2009-06-11
申请人： Charles R. Quirico , Ernest Balestracci , Rolf E. Swenson , Daniel D. Darst , Eric J. Krause , Vishal N. Lokhande , Jacob S. Childs
发明人： Charles R. Quirico , Ernest Balestracci , Rolf E. Swenson , Daniel D. Darst , Eric J. Krause , Vishal N. Lokhande , Jacob S. Childs
IPC分类号： A61M3/00 , G21G4/08 , A61M5/14 , G21F7/00 , G21G1/00 , A61B6/10 , A61B19/00 , A61M5/00 , A61M5/142 , G21F3/00 , A61K51/00 , A61B6/00 , A61B6/03
CPC分类号： A61M5/007 , A61B6/037 , A61B6/107 , A61B6/481 , A61B6/507 , A61B50/13 , A61B90/39 , A61B2050/105 , A61B2090/392 , A61K51/00 , A61M5/14 , A61M5/1409 , A61M5/142 , A61M5/1452 , A61M5/158 , A61M5/16854 , A61M5/16881 , A61M5/365 , A61M2005/1403 , A61M2205/18 , A61M2205/276 , A61M2205/3375 , A61M2205/50 , A61M2205/505 , A61M2205/52 , A61M2205/584 , A61M2205/587 , A61M2205/6009 , A61M2205/6054 , A61M2205/6072 , A61M2205/70 , A61M2205/75 , A61M2209/084 , A61N5/1001 , A61N5/1007 , A61N5/1075 , A61N2005/1021 , A61N2005/1022 , A61N2005/1074 , A61N2005/1094 , B62B3/005 , G06F19/00 , G06F19/3468 , G06F21/31 , G21F3/00 , G21F7/00 , G21G1/0005 , G21G1/001 , G21G4/08 , G21G2001/0031
摘要： Infusion system configurations and assemblies facilitate routing of infusion circuit tubing lines. Tubing lines are routed into and out from compartments of a shielding assembly for the infusion system, at locations which prevent kinking and/or crushing of the lines, and/or provide for ease in assembling the circuit. A plurality of the lines may be held together by a support frame to form a disposable infusion circuit subassembly, that can further facilitate routing of the lines.
摘要翻译：输液系统配置和组件便于输注电路管线的布线。在防止线路扭结和/或破碎的位置处和/或为组装电路提供便利的位置，将管道线路输入和输出用于输注系统的屏蔽组件的隔间。多个线可以由支撑框架保持在一起以形成一次性输注电路子组件，其可以进一步促进线路的布线。

9. 发明申请

US20150179290A1 System and method for generating molybdenum-99 and metastable technetium-99, and other isotopes 有权
标题翻译：用于生成钼-99和亚稳锝-99以及其他同位素的系统和方法
公开(公告)号：US20150179290A1
公开(公告)日：2015-06-25
申请号：US12928227
申请日：2010-12-07
申请人： James E. Clayton
发明人： James E. Clayton
IPC分类号： G21G1/00 , G21G1/02
CPC分类号： G21G1/0005 , G21G1/001 , G21G1/02 , G21G1/06 , G21G1/10 , G21G1/12 , G21G2001/0036 , G21G2001/0042
摘要： An accelerator based systems are disclosed for the generation of isotopes, such as molybdenum-98 (“99Mo”) and metastable technetium-99 (“99mTc”) from molybdenum-98 (“98Mo”). Multilayer targets are disclosed for use in the system and other systems to generate 99mTc and 98Mo, and other isotopes. In one example a multilayer target comprises a first, inner target of 98Mo surrounded, at least in part, by a separate, second outer layer of 98Mo. In another example, a first target layer of molybdenum-100 is surrounded, at least in part, by a second target layer of 98Mo. In another example, a first inner target comprises a Bremsstrahlung target material surrounded, at least in part, by a second target layer of molybdenum-100, surrounded, at least in part, by a third target layer of 98Mo.
摘要翻译：公开了一种用于产生钼-98（“99Mo”）和亚稳态锝-99（“99mTc”）的钼同位素（“98Mo”）的同位素的加速器系统。公开了多层目标用于系统和其他系统中以产生99mTc和98Mo以及其他同位素。在一个示例中，多层靶包括98Mo的第一内部目标，至少部分由98Mo的单独的第二外层包围。在另一个实例中，钼-100的第一目标层至少部分地被98Mo的第二目标层包围。在另一个示例中，第一内部目标包括至少部分地被第一靶标的钼-100包围的Bre致射线靶材料，至少部分由98Mo的第三目标层包围。

10. 发明申请

US20150170776A1 METHOD AND APPARATUS FOR THE PRODUCTION OF LEAD 212 FOR MEDICAL USE 有权
标题翻译：用于生产用于医疗用途的引线212的方法和装置
公开(公告)号：US20150170776A1
公开(公告)日：2015-06-18
申请号：US14402325
申请日：2013-05-23
申请人： AREVA MED SAS
发明人： Julien Torgue , Patrick Maquaire , John Young , Gilbert Andreoletti , Patrick Bourdet
IPC分类号： G21G1/00 , C22B13/06 , C22B13/02 , A61K51/12 , C22C11/00
CPC分类号： G21G1/0005 , A61K51/12 , C22B13/02 , C22B13/06 , C22C11/00 , G21G4/08 , G21G2001/0094
摘要： The invention relates to a method for preparing lead (212) for medical use. This method comprises the production of lead (212) by the decay of radium (224) in a generator comprising a solid medium to which the radium (224) is bound, followed by the extraction of the lead (212) from the generator in the form of an aqueous solution A1, characterised in that the lead (212) contained in the aqueous solution A1 is purified from the radiological and chemical impurities, also contained in said aqueous solution, by a liquid chromatography on a column. The invention also relates to an apparatus specially designed for automated implementation in a closed system of said method. It further relates to lead (212) produced by means of this method and this apparatus. Applications: manufacture of radiopharmaceuticals based on lead (212), useful in nuclear medicine for the treatment of cancers, particularly by a-radioimmunotherapy, or for medical imaging, in both humans and animals.
摘要翻译：本发明涉及一种用于制备用于医疗用途的铅（212）的方法。该方法包括在包括固体介质的发生器中通过镭（224）的衰变产生铅（212），镭（224）结合到该固体介质上，随后在发生器中从引线（212）中提取铅水溶液A1的形式，其特征在于，通过柱上的液相色谱法，包含在水溶液A1中的铅（212）从也含在所述水溶液中的放射性和化学杂质中纯化。本发明还涉及专门设计用于所述方法的封闭系统中的自动化实施的装置。它还涉及通过该方法和该装置产生的引线（212）。应用：在人类和动物中制造基于铅（212）的放射性药物，用于治疗癌症，特别是放射免疫疗法或用于医学成像的核医学。

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