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1. 发明公开

US20230207302A1 MASS SPECTROMETER 审中-公开
公开(公告)号：US20230207302A1
公开(公告)日：2023-06-29
申请号：US17999136
申请日：2021-05-18
申请人： ASCEND DIAGNOSTICS LIMITED
发明人： John ALLISON , Dimitris PAPANASTASIOU , Alexander LEKKAS
IPC分类号： H01J49/40 , H01J49/00 , H01J49/16 , H01J49/06
CPC分类号： H01J49/403 , H01J49/0081 , H01J49/164 , H01J49/068 , H01J49/067 , H01J49/0027
摘要： A time-of-flight, TOF, mass spectrometer, MS, comprising: an ion source for supplying a group of ions, including a first ion having a first mass-to-charge ratio m1/z1, a second ion having a second mass-to-charge ratio m2/z2 and a third ion having a third mass-to-charge ratio m3/z3 wherein m3/z3>m2/z2>at a time t0; a first set of electrodes, including a first electrode, and a second set of electrodes, including a first electrode and an Nth electrode, wherein the first set of electrodes and the second set of electrodes are mutually spaced apart by a gap therebetween; an ion detector for detecting the ions; a set of power supplies, including a first power supply, electrically coupled to the first set of electrodes and to the second set of electrodes; and a controller configured to control the set of power supplies to apply respective potentials to the first set of electrodes and the second set of electrodes; wherein the controller is configured to control the set of power supplies to: provide a first substantially field-free region between the ion source and the first set of electrodes to allow the group of ions to expand theretowards and/or therein, at the time t0; apply an extraction potential Vextraction to the first set of electrodes at a time textraction>t0, to extract the expanded group of ions, while maintaining a second substantially field-free region beyond the first set of electrodes, in the gap between the first set of electrodes and the second set of electrodes; and optionally, change an acceleration potential Vacceleration applied to the second set of electrodes during a time period Δt=toff−ton, wherein ton>textraction, to vary acceleration of the extracted group of ions based, at least in part, on respective mass-to-charge ratios.

2. 发明申请

US20180277345A1 METHODS AND SYSTEMS FOR QUANTITATIVE MASS ANALYSIS 审中-公开
公开(公告)号：US20180277345A1
公开(公告)日：2018-09-27
申请号：US15911304
申请日：2018-03-05
申请人： Thermo Finnigan LLC
发明人： Linfan LI , Jae C. SCHWARTZ
IPC分类号： H01J49/00 , G01N27/62 , H01J49/42
CPC分类号： H01J49/0031 , G01N27/62 , H01J49/0009 , H01J49/0081 , H01J49/4225 , H01J49/429
摘要： A method of quantitative mass analysis of precursor ion species of different mass-to-charge (m/z) ratios from the same or common ion injection event is disclosed. A plurality of precursor ion species with different respective m/z ratios are introduced into an ion trap mass analyzer at the same time. The precursor ion species are isolated. A first subset of the isolated precursor ions, which are multiply charged and have a first m/z ratio range, is fragmented and scanned by dividing the scan into at least two separate scan windows. A first mass spectrum is generated for the fragment ions of the first subset of precursor ions. A second subset of the isolated precursor ions having a second m/z ratio is fragmented and scanned, and a second mass spectrum is generated for the fragment ions of the second subset of precursor ions.

3. 发明申请

US20170287688A1 METHODS OF DETECTING REVERSE TRIIODOTHYRONINE BY MASS SPECTROMETRY 审中-公开
公开(公告)号：US20170287688A1
公开(公告)日：2017-10-05
申请号：US15626485
申请日：2017-06-19
申请人： Quest Diagnostics Investments Incorporated
发明人： J. Fred BANKS , Peter P. CHOU , Noriya M. MATT
IPC分类号： H01J49/04 , H01J49/10 , G01N33/68 , H01J49/00 , G01N30/72 , G01N33/78
CPC分类号： H01J49/04 , G01N30/7233 , G01N33/6848 , G01N33/78 , G01N2560/00 , H01J49/00 , H01J49/0027 , H01J49/0031 , H01J49/004 , H01J49/0081 , H01J49/0431 , H01J49/10
摘要： Provided are methods for determining the amount of reverse T3 in a sample using mass spectrometry. The methods generally involve ionizing reverse T3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse T3 in the sample.

4. 发明授权

US09685311B2 Methods for detecting reverse triiodothyronine by mass spectrometry 有权
公开(公告)号：US09685311B2
公开(公告)日：2017-06-20
申请号：US14951203
申请日：2015-11-24
申请人： Quest Diagnostics Investments Incorporated
发明人： J. Fred Banks , Peter P. Chou , Noriya M. Matt
IPC分类号： G01N33/58 , G01N33/68 , H01J49/04 , G01N33/78 , H01J49/00 , G01N30/72 , H01J49/10
CPC分类号： H01J49/04 , G01N30/7233 , G01N33/6848 , G01N33/78 , G01N2560/00 , H01J49/00 , H01J49/0027 , H01J49/0031 , H01J49/004 , H01J49/0081 , H01J49/0431 , H01J49/10
摘要： Provided are methods for determining the amount of reverse T3 in a sample using mass spectrometry. The methods generally involve ionizing reverse T3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse T3 in the sample.

5. 发明授权

US09576780B2 Mass spectrometer with timing determination based on a signal intensity in a chromatogram 有权
标题翻译：质谱仪根据色谱图中的信号强度进行定时测定
公开(公告)号：US09576780B2
公开(公告)日：2017-02-21
申请号：US14359744
申请日：2011-11-22
申请人： Akihiko Niwa
发明人： Akihiko Niwa
IPC分类号： H01J49/00 , H01J49/04 , G01N30/86 , G01N30/72 , H01J49/42
CPC分类号： H01J49/0081 , G01N30/72 , G01N30/8696 , H01J49/0031 , H01J49/004 , H01J49/4265
摘要： A mass spectrometer including chromatogram creation means for creating a chromatogram showing changes over time in an ion intensity within a predetermined mass range based on the MS analysis results, and timing determination means for determining a timing to perform MS/MS analysis based on the chromatogram. The timing determination means determines, as a timing to perform MS/MS analysis, a point in time at which a signal intensity in the chromatogram reaches a predetermined upper limit after exceeding a predetermined lower limit or a point in time at which a signal intensity in the chromatogram reaches a top of a peak without reaching the upper limit after exceeding the lower limit. It is thus possible to collect precursor ions at a timing at which the signal intensity of a peak originating from sample components is highest between the upper limit and lower limit, thereby obtaining a high quality MS/MS spectrum.
摘要翻译：一种质谱仪，包括色谱图创建装置，用于根据MS分析结果产生表示在预定质量范围内的离子强度随时间变化的色谱图;以及定时确定装置，用于基于色谱图确定进行MS / MS分析的时间。定时确定装置确定作为执行MS / MS分析的定时，在超过预定下限之后色谱图中的信号强度达到预定上限的时间点或时间点内的信号强度色谱图达到峰值的上限，而不超过下限值则达到上限。因此，可以在来自样品成分的峰值的信号强度在上限和下限之间的时刻收集前体离子，从而获得高质量的MS / MS谱。

6. 发明授权

US09472390B2 Tandem time-of-flight mass spectrometry with non-uniform sampling 有权
标题翻译：具有非均匀取样的串联飞行时间质谱
公开(公告)号：US09472390B2
公开(公告)日：2016-10-18
申请号：US14409367
申请日：2013-06-18
申请人： LECO Corporation
发明人： Anatoly N. Verenchikov , Vasily Makarov
IPC分类号： H01J49/00 , H01J49/40 , H01J49/10
CPC分类号： H01J49/406 , H01J49/0027 , H01J49/0031 , H01J49/005 , H01J49/0081 , H01J49/10
摘要： A method and apparatus are disclosed for parallel all-mass tandem mass spectrometry employing multi-reflecting time-of-flight analyzer for both MS stages, preferably arranged within the same analyzer to secure ultra-high resolution. Sensitivity and speed of TOF-TOF tandem are enhanced by non-redundant multiplexing based on signal sparseness and on avoiding repetitive signal overlaps at multiple repetitions of true fragment signals. Non-redundant matrices of gate and delay timing are constructed by extending orthogonal Latin square matrices. The method is generalized for multiplexing of any multiple repetitive signal sources being sparse either spectrally, or spatially, or in time.
摘要翻译：公开了用于并行全质量串联质谱法的方法和装置，其采用多反射飞行时间分析器用于两个MS级，优选地布置在同一分析仪内以确保超高分辨率。 TOF-TOF串联的灵敏度和速度通过基于信号稀疏度的非冗余多路复用和在多次重复的真分片信号上避免重复信号重叠来增强。通过扩展正交拉丁方阵来构造栅极和延迟定时的非冗余矩阵。该方法被广泛用于复用任何频谱上或空间上或时间上稀疏的多个重复信号源。

7. 发明申请

US20160245822A1 MASS SPECTROMETRY-CLEAVABLE CROSS-LINKING AGENTS TO FACILITATE STRUCTURAL ANALYSIS OF PROTEINS AND PROTEIN COMPLEXES, AND METHOD OF USING SAME 审中-公开
公开(公告)号：US20160245822A1
公开(公告)日：2016-08-25
申请号：US14927332
申请日：2015-10-29
申请人： The Regents of The University of California
发明人： Scott D. Rychnovsky , Lan Huang
IPC分类号： G01N33/68 , H01J49/42 , C07D207/46 , H01J49/00 , G06F19/16 , G06F19/26
CPC分类号： G01N33/6848 , C07D207/46 , G16B5/00 , G16B15/00 , G16B40/00 , G16B45/00 , G16C20/40 , G16C20/50 , H01J49/0036 , H01J49/0081 , H01J49/4225
摘要： Novel cross-linking compounds that can be used in mass spectrometry, tandem mass spectrometry, and multi-stage tandem mass spectrometry to facilitate structural analysis of proteins and protein complexes are provided and have the formula: where X is an N-hydroxy-succinimidyl or similar heterocyclic group. Also provided is a method of mapping protein-protein interactions of protein complexes using various mass spectrometry techniques.

8. 发明授权

US09396919B2 Collision cell 有权
公开(公告)号：US09396919B2
公开(公告)日：2016-07-19
申请号：US15005881
申请日：2016-01-25
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Alexander Makarov , Eduard V. Denisov , Wilko Balschun , Dirk Nolting , Jens Griep-Raming
IPC分类号： H01J49/04 , H01J49/00
CPC分类号： H01J49/0422 , H01J49/0031 , H01J49/0045 , H01J49/0072 , H01J49/0081 , H01J49/0481 , H01J49/06 , H01J49/26 , H01J49/40
摘要： A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.

9. 发明授权

US09245723B2 Collision cell 有权
公开(公告)号：US09245723B2
公开(公告)日：2016-01-26
申请号：US14834291
申请日：2015-08-24
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Alexander Makarov , Eduard V. Denisov , Wilko Balschun , Dirk Nolting , Jens Griep-Raming
IPC分类号： H01J49/04 , H01J49/00
CPC分类号： H01J49/0422 , H01J49/0031 , H01J49/0045 , H01J49/0072 , H01J49/0081 , H01J49/0481 , H01J49/06 , H01J49/26 , H01J49/40
摘要： A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.

10. 发明授权

US09196468B2 Method and system for introducing make-up flow in an electrospray ion source system 有权
标题翻译：在电喷雾离子源系统中引入补充流的方法和系统
公开(公告)号：US09196468B2
公开(公告)日：2015-11-24
申请号：US14395705
申请日：2013-05-17
申请人： DH Technologies Development Pte. Ltd.
发明人： John L. Campbell , Thomas Covey , Yves LeBlanc , Bradley B. Schneider
IPC分类号： B05B5/025 , G01N30/02 , H01J49/00 , F23D11/22 , H01J49/16 , G01N27/62 , H01J49/04
CPC分类号： H01J49/165 , G01N27/622 , H01J49/0081 , H01J49/0431
摘要： An electrospray ion source method and system is provided for detecting emitter failure comprising a liquid chromatography column suitable for chromatographic separation of a sample. The column can have an inlet for receiving the sample; and an outlet for ejecting the sample. A make-up flow channel is provided for introducing make-up flow of liquid to the sample post-column, wherein the make-up flow normalizes the spray current. An electrospray ionization source is provided having one or more electrospray ionization emitter nozzles for receiving the make-up flow containing sample. A power supply can provide a voltage to the one or more emitter nozzles, and a measurement device can measure and monitor the spray current.
摘要翻译：提供了一种用于检测发射器故障的电喷雾离子源方法和系统，其包括适于样品色谱分离的液相色谱柱。该柱可以具有用于接收样品的入口; 以及用于喷射样品的出口。提供了补充流动通道，用于将液体的补充流引入样品后柱，其中补充流使归一化喷雾电流。提供了具有一个或多个电喷雾电离发射器喷嘴的电喷雾离子源，用于接收含有补充流的样品。电源可以向一个或多个发射器喷嘴提供电压，并且测量装置可以测量和监测喷射电流。

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