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1. 发明授权

US5531662A Dual mode microwave/ionizing probe 失效
标题翻译：双模微波/电离探头
公开(公告)号：US5531662A
公开(公告)日：1996-07-02
申请号：US170064
申请日：1993-12-20
申请人： Kenneth L. Carr
发明人： Kenneth L. Carr
IPC分类号： A61B18/18 , A61M36/02 , A61N5/10 , A61N5/02
CPC分类号： A61N5/1027 , A61B18/18 , A61B18/1815 , A61N5/1014 , A61B2018/1861
摘要： A microwave radiator formed at least partially of a radioactive substance and adapted to simultaneously deliver microwave energy and nuclear radiation to living tissue. The radiator is incorporated into an interstitial or intracavitary probe. The radiator is a helical electrical conductor, formed of a radioactive substance such as iridium.sup.192, and electrically connecting a central electrical conductor to a coaxial electrically-conducting jacket. Alternatively, a microwave antenna is formed as part of a probe with a cavity adapted to receive sources of ionizing radiation. Preferably, the cavity is part of a channel through a conduit carrying the probe, the channel being connected to a device for delivering ionizing radiation sources to the probe after positioning at the target tissue and after a heating regime. The device is able to remove the ionizing sources while leaving the microwave source in place for an additional heating regime. Other therapeutic regimes are facilitated by the combination.
摘要翻译：微波辐射器至少部分地由放射性物质形成并且适于同时向生物组织递送微波能量和核辐射。散热器被并入到间质或腔内探针中。散热器是由诸如铱192等放射性物质形成的螺旋导电体，并且将中心导体电连接到同轴导电外套。或者，微波天线形成为具有适于接收电离辐射源的腔的探针的一部分。优选地，空腔是通过承载探针的导管的通道的一部分，通道连接到用于在定位在靶组织之后和加热状态之后将电离辐射源传送到探针的装置。该设备能够在离开微波源的同时移除电离源以达到额外的加热方式。通过组合促进其它治疗方案。

2. 发明申请

US20050015056A1 Syringe plunger locking mechanism 有权
标题翻译：注射器柱塞锁定机构
公开(公告)号：US20050015056A1
公开(公告)日：2005-01-20
申请号：US10854966
申请日：2004-05-27
申请人： Douglas Duchon , Jason Gerold , Thomas McPeak
发明人： Douglas Duchon , Jason Gerold , Thomas McPeak
IPC分类号： A61M5/145 , A61M5/315 , A61M36/02
CPC分类号： A61M5/14216 , A61B6/548 , A61M5/14546 , A61M5/31511 , A61M5/31515 , A61M5/365 , A61M2005/14208
摘要： A injection system having a syringe body which defines a pumping chamber. A syringe plunger is located in the pumping chamber and is adapted for reciprocal motion within the pumping chamber. The syringe plunger includes a capture member projecting outwardly in a proximal direction. An actuating shaft is coupled to the syringe plunger and is movable through the syringe body to control movement of the syringe plunger. The capture member is adapted to flex radially outwardly when contacted by the actuating shaft to form a releasable engagement with the actuating shaft when the actuating shaft and the capture member are in an engagement position. A release actuator is disposed proximal to the syringe body, and the capture member releases the actuating shaft upon engagement with the release actuator.
摘要翻译：一种具有限定泵送室的注射器主体的注射系统。注射器柱塞位于泵送室中并且适于在泵送室内的往复运动。注射器柱塞包括沿近端方向向外突出的捕获构件。致动轴联接到注射器柱塞并且可移动穿过注射器主体以控制注射器柱塞的运动。捕获构件适于当致动轴接触时径向向外弯曲，以在致动轴和捕获构件处于接合位置时形成与致动轴的可释放接合。释放致动器设置在注射器本体的近侧，并且捕获构件在与释放致动器接合时释放致动轴。

3. 发明授权

US5364336A Therapeutic probe for radiating microwave and ionizing radiation 失效
标题翻译：用于辐射微波和电离辐射的治疗探针
公开(公告)号：US5364336A
公开(公告)日：1994-11-15
申请号：US126106
申请日：1993-09-23
申请人： Kenneth L. Carr
发明人： Kenneth L. Carr
IPC分类号： A61B18/18 , A61M36/02 , A61N5/10 , A61N5/02
CPC分类号： A61N5/1027 , A61B18/18 , A61B18/1815 , A61N5/1014
摘要： A microwave radiator formed of a radioactive substance and adapted to simultaneously deliver microwave energy and nuclear radiation to living tissue. The radiator is incorporated into an interstitial or intracavitary probe. The radiator is a helical electrical conductor, formed of a radioactive substance such as iridium.sup.192, and electrically connecting a central electrical conductor to a coaxial electrically-conducting jacket.
摘要翻译：由放射性物质形成的微波辐射器，适用于同时向生物体提供微波能量和核辐射。散热器被并入到间质或腔内探针中。散热器是由诸如铱192等放射性物质形成的螺旋导电体，并且将中心导体电连接到同轴导电外套。

4. 发明授权

US4763671A Method of treating tumors using selective application of heat and radiation 失效
标题翻译：使用热和辐射的选择性治疗肿瘤的方法
公开(公告)号：US4763671A
公开(公告)日：1988-08-16
申请号：US858891
申请日：1986-04-25
申请人： Don R. Goffinet
发明人： Don R. Goffinet
IPC分类号： A61B18/14 , A61F7/12 , A61M36/02 , A61N1/40 , A61N5/10 , A61N1/06
CPC分类号： A61F7/12 , A61B18/14 , A61N1/403 , A61N5/1027 , A61F2007/126
摘要： A catheter for use in treating tumors is flexible and relatively small in diameter so that it can be inserted interstitially into the tumor mass. A conductor is provided along the length of the catheter and is electrically insulated except for a small length thereof which is adapted to be received within the tumor volume. By placing at least a pair of such catheters within the tumor mass and by connecting the conductors to a high frequency power source a heat producing current can be generated through the tumor tissue between the exposed portions of the catheter to damage the tumor cells. In addition, each catheter includes an axial passage permitting radioactive seeds or other tumor treating materials to be inserted within the tumor mass to cause further damage to and ultimately necrosis of the tumor without significantly affecting the adjacent healthy tissue of the body.
摘要翻译：用于治疗肿瘤的导管是柔性的并且直径相对较小，使得其可以间插入肿瘤块。导体沿着导管的长度设置，并且除了适于容纳在肿瘤体积内的小的长度之外是电绝缘的。通过将至少一对这样的导管放置在肿瘤块内，并且通过将导体连接到高频电源，可以通过导管的暴露部分之间的肿瘤组织产生发热电流，以损坏肿瘤细胞。此外，每个导管包括允许放射性种子或其他肿瘤治疗材料插入肿瘤块内的轴向通道，以进一步损伤肿瘤，最终导致肿瘤坏死，而不会显着影响身体的相邻健康组织。

5. 发明申请

US20090198093A1 System and method for combined embolization and ablation therapy 审中-公开
标题翻译：联合栓塞和消融治疗的系统和方法
公开(公告)号：US20090198093A1
公开(公告)日：2009-08-06
申请号：US12012960
申请日：2008-02-06
申请人： Oliver Meissner , Thomas Redel
发明人： Oliver Meissner , Thomas Redel
IPC分类号： A61M36/02 , A61B18/04 , A61M25/10 , A61B18/02 , A61B17/00 , A61B8/00 , A61N7/02 , H05G1/00
CPC分类号： A61N7/02 , A61B17/12136 , A61B17/12186 , A61B18/02 , A61B2034/2051 , A61B2090/376 , A61B2090/378
摘要： A system and method of treating cancerous tissues using a combination of embolization and ablation therapies is described. An imaging device is used to determine the tissue volume to be treated, and the steps of embolization and ablation are performed while the patient remains on a treatment table. The embolization treatment may be combined with chemotherapy directly administered to the tumor. The position of the volume to be treated is visualized by the imaging device to monitor the progress of the treatment and to guide ablation treatment so as to mitigate collateral tissue damage. The imaging device may be a C-arm X-ray device, a MRI device, an acoustic device or other device capable of producing CT-like images.
摘要翻译：描述了使用栓塞和消融治疗的组合治疗癌组织的系统和方法。成像装置用于确定待治疗的组织体积，并且在患者保持在治疗台上时执行栓塞和消融的步骤。栓塞治疗可以与直接给予肿瘤的化学疗法结合。待处理体积的位置由成像装置显现，以监测治疗进展并引导消融治疗以减轻侧支组织损伤。成像装置可以是能够产生CT样图像的C臂X射线装置，MRI装置，声学装置或其他装置。

6. 发明授权

US6074337A Combination radioactive and temperature self-regulating thermal seed implant for treating tumors 失效
标题翻译：组合放射性和温度自调节热种植体治疗肿瘤
公开(公告)号：US6074337A
公开(公告)日：2000-06-13
申请号：US192250
申请日：1998-11-16
申请人： Robert D. Tucker , Joseph A. Paulus
发明人： Robert D. Tucker , Joseph A. Paulus
IPC分类号： A61M36/02 , A61N5/10 , A61N5/02
CPC分类号： A61N5/1027 , A61N2005/1024
摘要： An implantable seed for simultaneous delivery of thermal and radioactive radiation to target tissue comprises a tube or rod of a ferromagnetic alloy which, when subjected to an oscillating magnetic field will heat up, the alloy also being coated or otherwise treated with a radioactive isotope which gives off X-ray radiation during the decay thereof.
摘要翻译：用于同时向靶组织传递热和放射性辐射的可植入种子包括铁磁合金的管或杆，当受到振荡磁场的加热时，该合金也被涂覆或以其它方式用放射性同位素处理，该放射性同位素在其衰变期间关闭X射线辐射。

7. 发明授权

US5976067A Combination radioactive and temperature self-regulating thermal seed implant for treating tumors 失效
公开(公告)号：US5976067A
公开(公告)日：1999-11-02
申请号：US864486
申请日：1997-05-28
申请人： Robert D. Tucker , Joseph A. Paulus
发明人： Robert D. Tucker , Joseph A. Paulus
IPC分类号： A61M36/02 , A61N5/10 , A61N5/02
CPC分类号： A61N5/1027 , A61N2005/1024
摘要： An implantable seed for simultaneous delivery of thermal and radioactive radiation to target tissue comprises a tube or rod of a ferromagnetic alloy which, when subjected to an oscillating magnetic field will heat up, the alloy also being coated or otherwise treated with a radioactive isotope which gives off X-ray radiation during the decay thereof.

8. 发明授权

US5473726A Audio and amplitude modulated photo data collection for speech recognition 失效
标题翻译：用于语音识别的音频和幅度调制照片数据采集
公开(公告)号：US5473726A
公开(公告)日：1995-12-05
申请号：US086577
申请日：1993-07-06
申请人： Patrick T. Marshall
发明人： Patrick T. Marshall
IPC分类号： G10L15/24 , G10L5/06 , A61M36/02 , G10L7/08
CPC分类号： G10L15/25
摘要： A speech recognition data collection arrangement in which audio sounds spoken by the user are supplemented with lip and mouth movement information obtained from a combination of a light emitting diode and photodiode disposed immediately before the user's face is disclosed. The lip and mouth movement photo information is obtained in the form of an AC coupled amplitude modulated carrier waveform which results from energization of the light emitting diode from a pulsating or alternating current component inclusive source of electrical energy. The lip and mouth movement amplitude modulated carrier waveform is processed with filtering and envelope detection and communicated to a programmed digital computer for the purpose of dual-channel audio and photo based accomplishment of human speech recognition.
摘要翻译：一种语音识别数据收集装置，其中由用户说出的音频声音补充了从紧接在用户的脸部之前布置的发光二极管和光电二极管的组合获得的嘴唇和嘴部移动信息。唇形和嘴巴运动的照片信息以AC耦合幅度调制载波波形的形式获得，该载波波形是由脉冲或交流电分量包括电能源激发发光二极管产生的。嘴唇和运动幅度调制载波波形通过滤波和包络检测进行处理，并传达给编程的数字计算机，以实现双声道音频和照片的完成人类语音识别。

9. 发明申请

US20130053618A1 RADIATION SENSITIVE LIPOSOMES 有权
标题翻译：辐射敏感性脂质体
公开(公告)号：US20130053618A1
公开(公告)日：2013-02-28
申请号：US13609058
申请日：2012-09-10
申请人： David F. O'Brien , Kathy A. McGovern , Bruce Bondurant , Robert Sutherland
发明人： David F. O'Brien , Kathy A. McGovern , Bruce Bondurant , Robert Sutherland
IPC分类号： A61M36/02 , A61N5/10
CPC分类号： A61K9/0009 , A61K9/1273
摘要： The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.
摘要翻译：本发明涉及一种辐射敏感性脂质体，以及该脂质体作为治疗和诊断剂的载体的用途。特别地，本发明包括脂质体递送系统，其包含稳定的形成脂质体的脂质和可聚合的脂肪，其中一部分可聚合的辛酸在暴露于电离辐射时聚合，从而使脂质体膜失稳。脂质体的不稳定性允许脂质体内容物的泄漏。本发明还考虑了诊断和治疗对脂质体包封或相关药物有反应的病症和疾病的方法。

10. 发明申请

US20090202650A1 METHODS OF TREATING CANCERS 有权
标题翻译：治疗癌症的方法
公开(公告)号：US20090202650A1
公开(公告)日：2009-08-13
申请号：US12028026
申请日：2008-02-08
申请人： Yeu-Kuang Hwu , Tsung-Yeh Yang , Chi-Jen Liu , Chang-Hai Wang
发明人： Yeu-Kuang Hwu , Tsung-Yeh Yang , Chi-Jen Liu , Chang-Hai Wang
IPC分类号： A61K9/14 , A61P35/00 , A61N5/10 , A61K33/24 , A61K33/30 , A61K33/38 , A61M36/02
CPC分类号： A61K33/24 , A61K9/0009 , A61K33/30 , A61K41/00 , A61N5/10 , A61N2005/1098 , A61K2300/00
摘要： A method of treating cancer. The method includes introducing an effective amount of an oxidative catalyzing agent including titanium oxide, zinc oxide, zirconium oxide, tungsten oxide or tin oxide into a biological entity, and irradiating the biological entity with a ray. The oxidative catalyzing agent produces hydroxyl or hydrogen peroxide radicals after irradiation with the ray thereon.
摘要翻译：一种治疗癌症的方法。该方法包括将有效量的包含氧化钛，氧化锌，氧化锆，氧化钨或氧化锡的氧化催化剂引入生物体中，并用射线照射生物体。氧化催化剂在用其上的射线照射后产生羟基或过氧化氢自由基。

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