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1. 发明授权

US11638820B2 Transcutaneous neuromodulation system and methods of using same 有权
公开(公告)号：US11638820B2
公开(公告)日：2023-05-02
申请号：US17140896
申请日：2021-01-04
申请人： The Regents of the University of California
发明人： Victor Reggie Edgerton , Yury P. Gerasimenko , Parag Gad , Nicholas A. Terrafranca
IPC分类号： A61N1/36 , A61N1/04 , A61N1/06
摘要： A neuromodulation system and a method of inducing voluntary movement in a mammal with a spinal injury are disclosed. In an example, a neuromodulation system includes a processor, a signal generator, and at least one electrode. The processor, in cooperation with the signal generator and the at least one electrode are configured to deliver a transcutaneous stimulation to a mammal. The transcutaneous stimulation includes during a first time period, a transcutaneous electrical spinal cord stimulation (“tESCS”) applied to the mammal during physical conditioning of the mammal. The transcutaneous stimulation also includes during a second time period after the first time period, the tESCS applied to the mammal during reduced or no physical conditioning of the mammal. The tESCS applied during the first time period and the second time period is used to establish a functional baseline of the mammal.

2. 发明申请

US20230117604A1 AESTHETIC METHOD OF BIOLOGICAL STRUCTURE TREATMENT BY MAGNETIC FIELD 有权
公开(公告)号：US20230117604A1
公开(公告)日：2023-04-20
申请号：US18069810
申请日：2022-12-21
申请人： BTL Medical Solutions A.S.
发明人： Tomás SCHWARZ , Ondra PROUZA
IPC分类号： A61N2/00 , A61B18/20 , A61F7/00 , A61N1/06 , A61N1/40 , A61N2/02 , A61N5/06 , A61N7/00 , A61B90/50
摘要： A device for enhancement of visual appearance including a first applicator to be coupled to a first area of a body region, with a first magnetic field generating device and a first radiofrequency electrode, a second applicator to be coupled to a second area of the body region, with a second magnetic field generating device. The device further includes a first energy storage device, a second energy storage device, and a first switching device to discharge energy from the first energy storage device to the first magnetic field generating to generate a first time-varying magnetic field to cause muscle contraction, and a second switching to discharge energy from the second energy storage device to the second magnetic field generating device to generate a second time-varying magnetic field. The first radiofrequency electrode may provide first radiofrequency waves causing heating of tissue within the first area of the body region.

3. 发明申请

US20230082389A1 METHODS, APPARATUSES, AND SYSTEMS FOR THE TREATMENT OF DISEASE STATES AND DISORDERS 有权
公开(公告)号：US20230082389A1
公开(公告)日：2023-03-16
申请号：US17941815
申请日：2022-09-09
申请人： Galvanize Therapeutics, Inc.
发明人： Jonathan Reuben Waldstreicher , William Sanford Krimsky , Denise M. Zarins , Robert J. Beetel , Paul Brian Friedrichs , Kevin James Taylor , Roman Turovskiy , Robert E. Neal, II
IPC分类号： A61B18/12 , A61N1/06
摘要： Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without limitation, the epithelium (the goblet cells, ciliated pseudostratified columnar epithelial cells, and basal cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The system may be used to treat a variety of pulmonary diseases or disorders such as or associated with COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis, bronchiectasis, primary ciliary dyskinesia (PCD), acute bronchitis and/or other pulmonary diseases or disorders.

4. 发明授权

US11547856B2 Differential charge-balancing during high-frequency neural stimulation 有权
公开(公告)号：US11547856B2
公开(公告)日：2023-01-10
申请号：US16566025
申请日：2019-09-10
申请人： Verily Life Sciences LLC
发明人： James Salvia , Meisam Heidarpour Roshan
IPC分类号： A61N1/36 , A61N1/06 , A61N1/02
摘要： Differential charge-balancing can be used in high-frequency neural stimulation. For example, a neural stimulation apparatus can have first and second electrodes configured to be coupled proximate to a nerve fiber to implement a neural stimulation procedure. A neural stimulation circuit can be electrically coupled to the first and second electrodes. The neural stimulation circuit can apply stimulation currents to the nerve fiber through the first and second electrodes during a first stimulation phase of the neural stimulation procedure. The neural stimulation circuit can also apply a modified stimulation current to the nerve fiber through the first electrode during a second stimulation phase of the neural stimulation procedure. The modified stimulation current can be generated based on a difference between (i) a voltage at the first electrode, and (ii) a reference voltage derived from voltages on the first and second electrodes.

5. 发明授权

US11541229B2 Apparatus of muscle treatment comprising electrical muscle stimulation electrode and method of muscle treatment using that 有权
公开(公告)号：US11541229B2
公开(公告)日：2023-01-03
申请号：US17129026
申请日：2020-12-21
申请人： LUTRONIC CORPORATION
发明人： Kwang Chon Ko , James Bartholomeusz
IPC分类号： A61N1/04 , A61N1/06 , A61N1/36
摘要： An apparatus of muscle treatment may have a plurality of treatment modes and may generate a specific motion of a human body simultaneously or with an interval for muscles anatomically distinguished and related to each other, thereby being able to simultaneously strength the muscles related to each other. Since muscles are treated in accordance with a transmitting pattern of RF energy enabling composite motions of a human body, thereby being able to increase the treatment effect.

6. 发明授权

US11439817B2 Swallowable capsule and method for stimulating incretin production within the intestinal tract 有权
公开(公告)号：US11439817B2
公开(公告)日：2022-09-13
申请号：US16552570
申请日：2019-08-27
申请人： InCube Labs, LLC
发明人： Mir A. Imran , Mir Hashim , Emily Arnsdorf
IPC分类号： A61N1/36 , A61N1/05 , A61N1/372 , A61K38/26 , A61N1/06
摘要： Embodiments of the invention provide apparatus and methods for stimulating L cells in the intestinal tract to produce incretins for the treatment of conditions including diabetes and obesity. Many embodiments provide a method and apparatus for the treatment of diabetes by electrically stimulating L-cells to secrete incretins to stimulate or otherwise modulate the production of insulin. Particular embodiments provide a swallowable capsule for stimulating L-cells in the intestinal tract as the capsule moves through the tract. The capsule can include two or more electrodes for providing electrical stimulation to L-cells, a power source for powering one or more components of the capsule, a sensor for sensing the location of the capsule in the intestinal tract; a controller and a waveform generator for generating the electrical signals emitted by the electrodes to stimulate the L-cells to secrete incretins such as GLP-1 to stimulate insulin production for glucose regulation of diabetic conditions.

7. 发明授权

US11433259B2 Internal organ, injury and pain treatment 有权
公开(公告)号：US11433259B2
公开(公告)日：2022-09-06
申请号：US16628769
申请日：2018-07-04
申请人： B.R.H. Medical Ltd.
发明人： Ilan Feferberg
IPC分类号： A61N7/00 , A61N1/06
摘要： Ultrasound (US) apparatus and method for applying low energy US onto an internal tissue/organ, including a non-invasive US appliance used on a treatment region over the internal tissue/organ, and an electrical stimulation apparatus for simultaneously inducing interferential electrical stimulation. A controller controls parameters of the electrical stimulation apparatus and the US appliance, and dynamically changes at least one of the parameters, for maintaining the impedance of the body tissue in the treatment region within an impedance range. The US apparatus includes an impedance monitoring apparatus for continuously measuring, tracking, and monitoring impedance in the treatment region, wherein the controller dynamically changes at least one of the parameter in response to the impedance as monitored, for maintaining the impedance within the predefined range. The internal tissue/organ can be a female fertility organ, which can be, an ovarian follicle, a blood vessel of the uterus (womb), the ovary, the endometrial lining, and the Fallopian tube, ulcer, closed wound, internal injury, inflammation. and nerves.

8. 发明申请

US20220257935A1 SYSTEMS AND METHODS FOR NERVE FIBER CONDUCTION BLOCK 有权
公开(公告)号：US20220257935A1
公开(公告)日：2022-08-18
申请号：US17674212
申请日：2022-02-17
申请人： Duke University
发明人： Edgar Pena , Nicole A. Pelot , Warren Grill
IPC分类号： A61N1/06 , A61N1/05 , A61B5/279
摘要： The present disclosure provides systems and methods relating to neuromodulation. In particular, the present disclosure provides systems and methods for selective and/or unidirectional nerve fiber conduction block though the application of a hybrid waveform using a neuromodulation device. The systems and methods of neuromodulation disclosed herein facilitate the treatment of various diseases associated with pathological neural activity.

9. 发明授权

US11376398B2 Catheters with enhanced flexibility and associated devices, systems, and methods 有权
公开(公告)号：US11376398B2
公开(公告)日：2022-07-05
申请号：US17503866
申请日：2021-10-18
申请人： Medtronic Ardian Luxembourg S.a.r.l.
发明人： Rudy Beasley , Justin Goshgarian , Vincent Ku
IPC分类号： A61M25/00 , A61B18/14 , A61B17/32 , A61N1/05 , A61N1/06 , A61B18/00 , A61B18/02 , A61B18/06 , A61F7/00 , A61F7/12 , A61N7/00
摘要： A neuromodulation catheter includes an elongate shaft and a neuromodulation element. The shaft includes two or more first cut shapes and two or more second cut shapes along a helical path extending around a longitudinal axis of the shaft. The first cut shapes are configured to at least partially resist deformation in response to longitudinal compression and tension on the shaft and torsion on the shaft in a first circumferential direction. The second cut shapes are configured to at least partially resist deformation in response to longitudinal compression on the shaft and torsion on the shaft in both first and second opposite circumferential directions.

10. 发明授权

US11376374B2 Medicine injecting tip, hand piece, and skin treating device 有权
公开(公告)号：US11376374B2
公开(公告)日：2022-07-05
申请号：US16697163
申请日：2019-11-26
申请人： JEISYS MEDICAL INC.
发明人： Kyoung Ho An
IPC分类号： A61M5/42 , A61M5/142 , A61M5/31 , A61M5/32 , A61M5/46 , A61N1/05 , A61N1/06
摘要： Provided are a medicine injecting tip, which injects a medicine into a hole in a skin formed by a needle while invading the needle to a preset depth of a deep portion of the skin, a hand piece equipped with the medicine injecting tip, and a skin treatment device using the medicine injecting tip. The medicine injecting tip includes a cylinder, a plunger that reciprocates downward and upward, and has a first space and a second space formed inside the cylinder, and a needle disposed in the plunger and disposed in the second space of the cylinder. The needle is inserted into a skin and a negative pressure state is formed in the second space when the plunger moves downward, and the needle is discharged from the skin and a positive pressure state is formed in the second space, when the plunger moves upward.

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