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1. 发明授权

US11607623B2 Dynamic interface system and its application in supercritical fluid extraction and chromatography 有权
公开(公告)号：US11607623B2
公开(公告)日：2023-03-21
申请号：US16989078
申请日：2020-08-10
申请人： CORNERSTONE TECHNOLOGIES LLC
发明人： Zachariah J. G. X. Schindlbeck , Jeremy Michael Ebersole , Laurence Bernard Woznicki
IPC分类号： B01D15/14 , C07D311/80 , C07C37/82 , C07C51/47 , B01D15/40 , B01D11/02 , B01D15/16
摘要： The present invention provides a dynamic interface system between an extraction device and a chromatographic purification device for separating and purifying substance(s) from a mixture or matrix. One embodiment is the Supercritical Fluid Interface (“SFI”) between Supercritical Fluid Extraction (“SFE”), and Supercritical Fluid Chromatography (“SFC”). The SFI is capable of interfacing; gas, subcritical and supercritical fluid extraction methods and pair with gas, subcritical and supercritical fluid chromatography technologies that operate within the pressure and temperature parameters of the SFI. The SFI can operate up to 200 degrees celsius and 5000 psi. This interface technology allows for an inline oil extraction and chromatographic separation, the SFI can pair extraction and chromatography with the same solvent in different mobile phases, whereas the extraction can be performed using CO2 as a solvent in sub-critical phase and the SFI can receive the subcritical solution and then increase pressure and/or temperature to achieve supercritical state as required for injection into supercritical fluid chromatography technologies. The SFI coupling between SFE and SFC can to extract and refine cannabinoids from the cannabis industrious, hemp, plant and can also be applied to improve efficiency in an industry that extracts and refines oils, through chromatography, from organic materials using a gas, or sub/supercritical fluid as a solvent and mobile phase.

2. 发明授权

US11529569B2 Column tube for chromatography, and column for chromatography employing same 有权
公开(公告)号：US11529569B2
公开(公告)日：2022-12-20
申请号：US16614156
申请日：2018-05-15
申请人： DAICEL CORPORATION
发明人： Ichiro Okamoto , Takafumi Onishi , Tsuyoshi Maruyama
IPC分类号： B01D15/22 , B01D15/40 , G01N30/02 , G01N30/60
摘要： Provided is a column tube for chromatography that can prevent a peak shape abnormality referred to as a foot in a resulting chromatogram. The object is accomplished by the column tube for chromatography, through which a fluid flows, this column tube including a plurality of polishing traces extending on an inner circumferential surface of the column tube in a flow direction of the fluid.

3. 发明授权

US11491419B2 Gas-liquid separator for collecting chromatographic fractions 有权
$Gas-liquid separator for collecting chromatographic fractions$
公开(公告)号：US11491419B2
公开(公告)日：2022-11-08
申请号：US16325855
申请日：2016-08-15
申请人： Agilent Technologies, Inc.
发明人： Edwin E. Wikfors , Samuel O. Colgate
IPC分类号： B01D19/00 , B01D15/08 , B01D15/24 , G01N30/80 , G01N30/84 , B01D15/40
摘要： A gas-liquid separator includes a fluid inlet, a shell including an inside surface enclosing an interior space, an outlet structure with fingers converging toward a longitudinal axis, and a dripper including a dripper tip. The fingers terminate at fingertips located proximate to an outside surface of the dripper. Gas exit ports are defined between adjacent fingers, and by the dripper. The gas-liquid separator defines a liquid flow path from the fluid inlet, along the inside surface, along one or more of the fingers, converging along the dripper outside surface, and to the dripper tip. The gas-liquid separator also defines a gas flow path from the fluid inlet, through the interior space, and through the gas exit ports. The gas-liquid separator may be utilized in fluid separation systems such as liquid chromatography or supercritical fluid chromatography/extraction systems.

4. 发明授权

US11340197B2 Mechanisms and methods for liquid sample introduction into a chromatography system 有权
公开(公告)号：US11340197B2
公开(公告)日：2022-05-24
申请号：US16678762
申请日：2019-11-08
申请人： Waters Technologies Corporation
发明人： Jason Hill , Abhijit Tarafder , Joshua Burnett , Michael O. Fogwill
IPC分类号： G01N30/20 , B01D15/40 , B01D15/14 , G01N35/10 , G01N30/02
摘要： The disclosure relates to a system for liquid sample introduction into a chromatography system. The system includes a metering device for drawing up the liquid sample, a first multi-port valve in fluid communication with a first end of the metering device and the liquid sample, a second multi-port valve in fluid communication with a second end of the metering device and a chromatography column, and a pump in fluid communication with the second multi-port valve and a mobile phase. When the valves are in a first position the metering device draws up the liquid sample filling a portion of the metering device. When the valves are in a second position, a remaining portion of the metering device is filled with the mobile phase thereby mixing with and pressurizing the liquid sample. When the valves are in a third position, the mixed and pressurized sample flows to the chromatography column.

5. 发明授权

US11203007B2 Method of chromatography on a porous packing produced by a drawing process 有权
公开(公告)号：US11203007B2
公开(公告)日：2021-12-21
申请号：US15764299
申请日：2016-09-27
申请人： Francois Parmentier
发明人： Francois Parmentier
IPC分类号： B01J20/28 , B01J20/283 , B01J20/285 , B01J20/30 , B01D15/40 , B01D15/08 , B01D53/04
摘要： The invention relates to a method of chromatography wherein a gaseous, liquid or supercritical fluid mobile phase, which contains substances to be separated, flows through a porous packing which comprises a plurality of capillary channels which extend in the direction of flow of said mobile phase, said packing being manufactured by a method wherein: a bundle of elementary fibres is assembled, said fibres comprising a core made of a solid, liquid or gaseous material, and a shell made of a drawable material, said bundle is drawn in order to reduce the diameter of said fibres, a porous matrix is formed around the core of the drawn fibres, the formation of said porous matrix comprising a transformation of the shell material, where said porous matrix comprises at least one population of connected pores interconnecting the channels, where the thickness of the porous matrix between two adjacent channels is less than the diameter of the channels, preferably less than half the diameter of the channels, where necessary the core material is removed so as to leave free channels in the porous matrix.

6. 发明授权

US11071928B2 Hybrid supercritical fluid chromatography method 有权
公开(公告)号：US11071928B2
公开(公告)日：2021-07-27
申请号：US16310736
申请日：2017-06-16
申请人： PIC SOLUTION
发明人： Mohamed Shaimi
IPC分类号： B01D15/40 , B01D15/18 , G01N30/46 , G01N30/88
摘要： Method of supercritical fluid or liquid chromatography of a product, including the steps of, continuously in this order: an analytical step according to an analytical route; a switching step comprising a route changing operation between the analytical route and a preparative route; if the preparative route is selected in the switching step, a preparative step according to the preparative route.

7. 发明申请

US20210053025A1 POROUS CYCLODEXTRIN POLYMERIC MATERIALS AND METHODS OF MAKING AND USING SAME 有权
公开(公告)号：US20210053025A1
公开(公告)日：2021-02-25
申请号：US17082976
申请日：2020-10-28
申请人： Cornell University
发明人： William R. Dichtel , Alaaeddin Alsbaiee , Brian J. Smith , Juan Hinestroza , Diego Alzate-Sanchez , Leilei Xiao , Yuhan Ling , Damian Helbling
IPC分类号： B01J20/24 , C08B37/16 , C08B15/00 , C02F1/28 , G01N30/02 , G01N30/72 , B01J20/32 , B01J20/34 , B01D15/40 , B01D53/02 , B01J20/28 , B01J20/289 , G01N30/14 , G01N30/30 , G01N33/02
摘要： A nucleophilic substitution reaction to crosslink cyclodextrin (CD) polymer with rigid aromatic groups, providing a high surface area, mesoporous CD-containing polymers (P-CDPs). The P-CDPs can be used for removing organic contaminants from water. By encapsulating pollutants to form well-defined host-guest complexes with complementary selectivities to activated carbon (AC) sorbents. The P-CDPs can rapidly sequester pharmaceuticals, pesticides, and other organic micropollutants, achieving equilibrium binding capacity in seconds with adsorption rate constants 15-200 times greater than ACs and nonporous CD sorbents. The CD polymer can be regenerated several times, through a room temperature washing procedure, with no loss in performance.

8. 发明申请

US20200333301A1 MATCHING THERMALLY MODULATED VARIABLE RESTRICTORS TO CHROMATOGRAPHY SEPARATION COLUMNS 审中-公开
公开(公告)号：US20200333301A1
公开(公告)日：2020-10-22
申请号：US16917178
申请日：2020-06-30
申请人： Waters Technologies Corporation
发明人： Michael O. Fogwill , Joseph D. Michienzi , Geoff Gerhardt , James P. Murphy
IPC分类号： G01N30/32 , B01D15/16 , G01N30/86 , B01D15/08 , B01D15/40
摘要： Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatography column. A method for configuring a chromatography system with independent control of system pressure and mass flow rate of a compressible mobile phase includes determining a type of chromatography separation column to be used in the chromatography system, matching a thermally modulated variable restrictor to the type of chromatography separation column for use together during operation of the chromatography system, and bundling the chromatography column with its matching thermally modulated variable restrictor for distribution as a single package.

9. 发明授权

US10792589B2 Gas liquid separator for chromatography applications 有权
公开(公告)号：US10792589B2
公开(公告)日：2020-10-06
申请号：US15791622
申请日：2017-10-24
申请人： Waters Technologies Corporation
发明人： Emily J. Berg , Joshua A. Shreve , Edwin H. Denecke
IPC分类号： B01D15/40 , B01D15/16 , B01D19/00 , B01D15/10 , G01N30/84
摘要： Examples of gas liquid separators include a chamber, a fluid mixture inlet, a gas outlet and a liquid outlet. The fluid mixture inlet and the gas and liquid outlets are in fluid communication with the chamber. A fluid mixture received at the fluid mixture inlet diffuses inside the chamber and is separated into a liquid and a gas. The separated liquid is gravity-fed to the liquid outlet. The gas liquid separators have reduced dispersion and increased liquid recovery in comparison to conventional gas liquid separators used for chromatographic separations. The reduced dispersion yields an improvement in the shape of chromatographic peaks.

10. 发明申请

US20200309745A1 CHROMATOGRAPHY METHOD 审中-公开
公开(公告)号：US20200309745A1
公开(公告)日：2020-10-01
申请号：US16754676
申请日：2017-10-12
申请人： François PARMENTIER
发明人： François PARMENTIER
IPC分类号： G01N30/60 , B01D15/40
摘要： Method for exchanging materials, wherein a gaseous, liquid or supercritical mobile phase containing species to be separated is circulated through a packing comprising a stationary phase, the method being characterised in that:—the packing comprises a plurality of capillary ducts formed in at least one first material, the ducts passing through the packing between an upstream face through which the mobile phase enters the packing and a downstream face through which the mobile phase leaves the packing,—each duct comprises, on at least one portion of the inner wall thereof, at least one secondary material consisting of an organic gel or porous mineral,—the thickness of the secondary material defines, inside the duct, at least one empty tubular channel of solid material, the channel being open so as to allow the mobile phase to enter and extending continuously between the upstream and downstream faces of the capillary duct—the secondary material has a thickness between 0.05 times and 0.5 times the diameter of the channel—the method is carried out with a velocity of the mobile phase between 5.0 times and 50 times the speed of the optimum mobile phase defined by the minimum of the Van Deemter curve of the majority separating compound under the method conditions—the cumulative volume of the capillary ducts is more than 15% of the total packing volume.

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