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1. 发明申请

US20230112993A1 BRACKETING FLUIDIC SAMPLE USING STRONG SOLVENT 有权
公开(公告)号：US20230112993A1
公开(公告)日：2023-04-13
申请号：US17913313
申请日：2021-03-15
申请人： Agilent Technologies, Inc.
发明人： Dwight Robert Stoll , Stephan Buckenmaier , Sascha Lege , Thomas Ortmann , Konstantin Shoykhet
IPC分类号： G01N30/34 , B01D15/14 , B01D15/16 , G01N30/20 , G01N30/46
摘要： A sample separation device for separating a fluidic sample includes a fluid drive for driving a mobile phase and the fluidic sample when injected in the mobile phase, a sample separation unit for separating the fluidic sample in the mobile phase, and a control unit configured for bracketing the fluidic sample between two mobile phase portions of the mobile phase. At least one of the mobile phase portions is arranged directly next to the fluidic sample and has a higher solvent strength compared to a solvent of the fluidic sample.

2. 发明授权

US11531009B2 Single-use, disposable high-pressure liquid chromatography columns for high-throughput analysis 有权
公开(公告)号：US11531009B2
公开(公告)日：2022-12-20
申请号：US16474697
申请日：2017-12-28
申请人： PureHoney Technologies, Inc.
发明人： Can Ozbal
IPC分类号： G01N30/46 , B01J20/281 , G01N30/60 , G01N30/74 , G01N30/80 , G01N35/00 , G01N30/02 , G01N30/00
摘要： A device for separating one or more molecules of interest in a liquid specimen including a monolithic body defining a fractionation column. The column includes an inlet opening at a proximal end of the fractionation column; an outlet opening at a distal, opposite end of the fractionation column; a solid phase chamber positioned between the inlet opening and the outlet opening; a specimen introduction area adjacent a proximal end of the solid phase chamber; an analyte exit area adjacent a distal end of the solid phase chamber; an inlet chamber adjacent the inlet opening that tapers into the specimen introduction area; and an outlet chamber that extends from the analyte exit area to the outlet opening. A metered amount of solid phase packed within the solid phase chamber between a first porous frit and a second porous frit of the solid phase chamber.

3. 发明申请

US20220305405A1 SYSTEM AND METHOD FOR ISOLATION OF INTACT EXTRACELLULAR VESICLES WITH NEAR-SINGLE-VESICLE RESOLUTION COUPLED WITH ON-LINE CHARACTERIZATION 有权
公开(公告)号：US20220305405A1
公开(公告)日：2022-09-29
申请号：US17607960
申请日：2020-05-01
申请人： The Research Foundation for The State University of New York
发明人： Chioma OKEOMA , Hussein SADDOUR
IPC分类号： B01D15/34 , G01N30/82 , G01N30/46 , B01D15/18
摘要： A method and system are disclosed for isolating intact acellular particles using size exclusion and for obtaining size and concentration of such isolated particles. In one embodiment, the disclosure is directed to use of Particle Purification Liquid Chromatography (PPLC), a high-resolution chromatographic size-guided turbidimetry-enabled system for dye-free isolation, on-line characterization, and retrieval of intact acellular particles, including extracellular vesicles (EVs) and membraneless condensate particles (MCs) from various biofluids.

4. 发明申请

US20220283132A1 PREPARATIVE LIQUID CHROMATOGRAPH 有权
公开(公告)号：US20220283132A1
公开(公告)日：2022-09-08
申请号：US17676164
申请日：2022-02-20
申请人： SHIMADZU CORPORATION
发明人： Shiori UEDA , Tomohiro SHAGAWA , Soichiro TAMAOKI , Tomoyuki YAMAZAKI , Shohei SATO
IPC分类号： G01N30/82 , G01N30/16 , G01N30/86 , G01N30/46
摘要： A preparative liquid chromatograph for separating and extracting components in a sample, the preparative liquid chromatograph including a separation channel (2) through which a mobile phase flows, an injector (6) that injects the sample into the mobile phase, a separation column (8) for separating components in the sample injected into the mobile phase, the separation column (8) being provided downstream of the injector (6) on the separation channel (2), a detector (10) for detecting peaks of the components separated by the separation column (8), a fraction collector (12) configured to collect an eluate from the separation column (8) into a plurality of collection containers (20:22) at a downstream of the detector (10) while fractionating the eluate, and a controller (14) for controlling operation of the fraction collector (12), wherein the fraction collector (12) is provided with peak collection containers (20) and waste liquid collection containers (22), each peak collection container (20) is used for collecting a peak portion including a collection target peak detected by the detector (10) in the eluate, and each waste liquid collection container (22) is used for collecting a waste liquid portion not including the collection target peak in the eluate, and the controller (14) is configured to collect the peak portion including the collection target peak detected by the detector (10) in the eluate in the peak collection container (20), and to collect at least a part of the waste liquid portion in the waste liquid collection container (22).

5. 发明申请

US20220252559A1 TWO-DIMENSIONAL LC-MS/MS SYSTEMS 有权
公开(公告)号：US20220252559A1
公开(公告)日：2022-08-11
申请号：US17615291
申请日：2020-05-29
申请人： Genzyme Corporation
发明人： Wei-Lien Chuang , Felipe Gazos Lopes , Joshua Pacheco , Gerard Sanderink
IPC分类号： G01N30/46 , G01N30/72 , G01N30/14 , B01D15/18 , B01D15/32
摘要： The present invention relates to a novel analytical method for detecting one or more analytes in a source sample by continuous flow 2D LC-MS/MS using a single LC system.

6. 发明申请

US20220107293A1 Analysis Apparatus 有权
公开(公告)号：US20220107293A1
公开(公告)日：2022-04-07
申请号：US17432538
申请日：2020-02-25
申请人： Hitachi High-Tech Corporation
发明人： Makoto NOGAMI , Daisuke AKIEDA , Shinya MATSUOKA , Shinya ITO
IPC分类号： G01N30/46 , G01N30/30
摘要： An analysis apparatus capable of adjusting holding time of each stream in a plurality of HPLC streams without adjusting a pipe length, and capable of determining degradation of a separation column, a liquid-delivery failure, or the like without removing a pipe from the apparatus is implemented. Air is suctioned from the shipper 109 and injected into the verification flow paths 122 and 123, and holding time when a baseline of the detector 125 changes is stored in the control unit 130. The air in the verification flow paths 122 and 123 of the stream 101 and the stream 102 is measured, and holding time of the stream 101 and holding time of the stream 102 are compared to determine whether or not there is a difference of 1 second or more in the holding time. When the difference in holding time is 1 second or more, correction is performed. Holding time information of the same verification flow paths 122 and 123 in the stream 101 and the stream 102 are compared with holding time information stored in the control unit 130 and correction is performed when the difference in holding time is 1 second or more.

7. 发明申请

US20220016547A1 Parallel Separation System 有权
公开(公告)号：US20220016547A1
公开(公告)日：2022-01-20
申请号：US17488046
申请日：2021-09-28
申请人： Cytiva BioProcess R&D AB
发明人： Klaus Gebauer
IPC分类号： B01D15/18 , G01N30/46 , G01N30/32
摘要： A separation system may include a number of parallel fluid paths. Each parallel fluid path may include a separation module, and an adjustable flow restrictor. Each adjustable flow restrictor is operable sequentially and operable such that the hydraulic resistance of all the parallel fluid paths is substantially the same and is equal to or higher than the hydraulic resistance of a fluid path identified to have the highest hydraulic resistance. The system includes a pressure sensor that measures pressure loss over the whole separation system. The system is operable such that the hydraulic resistances of the respective separation modules are synchronised, and such that when operated in parallel and at substantially the same time, the respective modules have substantially the same time residence times. The system may include a control system for automated operation.

8. 发明申请

US20210382021A1 SYSTEMS AND METHODS FOR TWO-DIMENSIONAL LIQUID CHROMATOGRAPHY USING SIZE EXCLUSION CHROMATOGRAPHY AS A FIRST DIMENSION 有权
公开(公告)号：US20210382021A1
公开(公告)日：2021-12-09
申请号：US17335539
申请日：2021-06-01
申请人： Waters Technologies Corporation
发明人： Stephan M. Koza , Pamela Iraneta , Hua Yang
IPC分类号： G01N30/46 , B01D15/34 , G01N33/68 , G01N30/72 , G01N30/32
摘要： Described herein are systems and methods used for carrying out a two-dimensional liquid chromatography process using size exclusion chromatography as a first dimension.

9. 发明申请

US20210349060A1 MULTIDIMENSIONAL LIQUID CHROMATOGRAPHY SYSTEM 有权
公开(公告)号：US20210349060A1
公开(公告)日：2021-11-11
申请号：US17307389
申请日：2021-05-04
申请人： Waters Technologies Corporation
发明人： Michael O. Fogwill , Sylvain Gilles Cormier , Thomas Swann , Francis Patrick Tracey
IPC分类号： G01N30/46
摘要： Described are multidimensional liquid chromatography (MDLC) systems and methods of performing MDLC. The MDLC systems includes valve configurations that enable a flow containing analytes in the eluent of a first dimension liquid chromatography system to be modulated such that the analytes can be captured in fluidic loops and subsequently provided to a second dimension liquid chromatography system. Various system embodiments are provided in a smaller instrument size, include an option to use the same detector for both first and second dimensions, enable improvement in valve timing operations and provide a reduction in the magnitude and effects of pressure pulses. In addition, the modulator can enable dilution of the analytes and enable incompatible mobile phases and mobile phase flow rates to be used in the first and second dimensions.

10. 发明申请

US20210341422A1 INTEGRATED MICRO-PHOTOIONIZATION DETECTOR WITH AN ULTRATHIN ULTRAVIOLET TRANSMISSION WINDOW 有权
公开(公告)号：US20210341422A1
公开(公告)日：2021-11-04
申请号：US17282671
申请日：2019-10-02
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： Xudong FAN , Hongbo ZHU , Katsuo KURABAYASHI
IPC分类号： G01N27/64 , G01N30/64 , G01N30/46
摘要： An integrated microfluidic photoionization detector (PID) is provided including a microfluidic ionization chamber a microfluidic ultraviolet radiation chamber that is configured to generate ultraviolet photons. An ultrathin transmissive window is disposed between the microfluidic ionization chamber and the microfluidic ultraviolet radiation chamber that permits the ultraviolet photons to pass from the microfluidic ultraviolet radiation chamber into the microfluidic ionization chamber. Detection systems for one or more VOC analytes are also provided that include a gas chromatography (GC) unit including at least one gas chromatography column and an integrated microfluidic photoionization detector (PID) disposed downstream of the gas chromatography (GC) unit.

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