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    • 10. 发明授权
    • Microphasic micro-components and methods for controlling morphology via electrified jetting
    • 微电子微组件及通过电气喷射控制形态的方法
    • US08187708B2
    • 2012-05-29
    • US12506712
    • 2009-07-21
    • Joerg LahannAbbass Kazemi
    • Joerg LahannAbbass Kazemi
    • B29C59/10B32B1/00
    • A61K9/1694A61K9/1676A61K9/5026A61K9/5089B01J13/04B01J13/14B01J13/20B82Y5/00Y10T428/2991
    • The disclosure provides methods for preparation of multiphasic micro-components, such as core-shell or anisotropic (e.g., Janus) multiphasic particles with well-defined structures using electrohydrodynamic co-jetting of two polymer solutions containing polyelectrolytes. Suitable polyelectrolytes include polyacrylic acid (PAA), poly(acrylamide acrylic acid (PAAm), and/or poly(acryl amide-co-acrylic acid) (PAAm-AA), sodium polystyrene sulfonate (PSS), polyethylene imine (PEI), polypeptides, copolymers and combinations of these. Control of certain variables, such as relative conductivities of the two jetting solutions, controls the particle morphologies formed, leading to a predetermined phase orientation for the same polymer system. In certain aspects, after cross-linking, core-shell particles are stable in aqueous solutions and exhibit reproducible swelling behavior, while maintaining the original core-shell geometry. In addition, micro-components formed in accordance with the present teachings are pH-responsive based on external environmental pH. Thus, such micro-components are useful for a variety of different applications, including micro- and nano-active ingredient delivery systems.
    • 本公开提供了使用具有包含聚电解质的两种聚合物溶液的电动水力共同喷射来制备具有良好限定结构的多相微组件(例如核壳或各向异性(例如Janus)多相颗粒)的方法。 合适的聚电解质包括聚丙烯酸(PAA),聚丙烯酰胺丙烯酸(PAAm)和/或聚丙烯酰胺 - 共 - 丙烯酸(PAAm-AA),聚苯乙烯磺酸钠(PSS),聚乙烯亚胺(PEI) 这些的多肽,共聚物和组合对某些变量的控制,例如两个喷射溶液的相对电导率控制形成的颗粒形态,导致相同聚合物体系的预定相取向。在某些方面,在交联后, 核 - 壳颗粒在水溶液中是稳定的并且表现出可重复的溶胀行为,同时保持原始的核 - 壳几何形状。此外,根据本教导形成的微组分基于外部环境pH值是pH响应的,因此, 微量组分可用于各种不同的应用,包括微量和纳米活性成分递送系统。