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1. 发明公开

US20240018088A1 SEPARATION AND PURIFICATION METHOD OF 2-NITROETHANOL 审中-公开
公开(公告)号：US20240018088A1
公开(公告)日：2024-01-18
申请号：US18361533
申请日：2023-07-28
申请人： Fudan University
发明人： Fener CHEN , Minjie LIU
IPC分类号： C07C201/16
CPC分类号： C07C201/16
摘要： A separation and purification method of 2-nitroethanol, including: (a) reacting paraformaldehyde with nitromethane in the presence of a base to obtain a mixture of 2-nitroethanol (I), 2-nitro-1,3-propanediol (II) and tris(hydroxymethyl) nitromethane (III); and (b) selecting an extraction solvent in which 2-nitroethanol (I), 2-nitro-1,3-propanediol (II) and tris(hydroxymethyl) nitromethane (III) are different in solubility; adding the extraction solvent to the mixture followed by extraction, separation, and vacuum concentration to obtain the 2-nitroethanol (I).

2. 发明授权

US09738592B2 Method for removing impurities from dinitrotoluenes 有权
公开(公告)号：US09738592B2
公开(公告)日：2017-08-22
申请号：US15323800
申请日：2015-04-30
申请人： Josef Meissner GmbH & Co. KG
发明人： Jürgen Pöhlmann , Heinrich Hermann , Mirko Händel , Jürgen Gebauer , Tim Bergmann
IPC分类号： C07C201/16 , B01D11/04 , B01D19/00 , B01J19/24 , C07C205/06
CPC分类号： C07C201/16 , B01D11/0488 , B01D19/0005 , B01J19/24 , B01J2219/24 , Y02P20/582 , C07C205/06
摘要： The present invention relates to a method for purifying raw dinitrotoluenes resulting from dinitration of toluene in the presence of a nitric acid/sulfuric acid/nitrating acid mixture, and a device or plant for performing the method, and a corresponding production plant for producing dinitrotoluene, characterized in that (a) the raw dinitrotoluenes are first subjected to a wash with at least one washing medium after separation of the nitrating acid mixture, followed by a separation of the washing medium; and that (b) subsequently the washed dinitrotoluenes resulting from method step (a) are subjected to stripping (stripping gas treatment) with at least one gas (stripping gas).

3. 发明授权

US09688606B2 Process for acidic scrubbing of dinitrotoluene in the presence of hydrocyanic acid 有权
公开(公告)号：US09688606B2
公开(公告)日：2017-06-27
申请号：US15031100
申请日：2014-10-22
申请人： BASF SE , Josef Meissner GmbH & Co. KG
发明人： Samuel Neto , Rüdiger Fritz , Renate Hempel , Holger Allardt , Yuan Shen Dai , Barbara Becker , Sebastian Ahrens , Julia Leschinski , Henrich Hermann , Mirko Haendel , Jürgen Pöhlmann
IPC分类号： C07C201/16 , C07C205/06 , B01D11/04 , C02F1/20 , C02F1/26 , C02F3/00 , B01D11/00 , C02F101/18 , C02F103/36
CPC分类号： C07C201/16 , B01D11/0488 , B01D11/0492 , B01D2011/002 , C02F1/20 , C02F1/26 , C02F3/00 , C02F2101/18 , C02F2103/36 , C07C205/06
摘要： Process for scrubbing a crude mixture which is obtained in the nitration of toluene after separating off the nitrating acid and comprises dinitrotoluene, nitric acid, nitrogen oxides and sulfuric acid, which comprises two scrubbing steps (WS-I) and (WS-II), whereini) in a first scrubbing step (WS-I), the crude mixture is extracted with a scrubbing acid I comprising nitric acid, nitrogen oxides and sulfuric acid in a scrub comprising at least one extraction stage, where the scrubbing acid discharged from the first extraction stage (WS-I-1) of the first scrubbing step (WS-I) has a total acid content of from 10 to 40% by weight and a content of from 80 to 350 ppm of hydrocyanic acid, giving a prescrubbed crude mixture,ii) in a second scrubbing step (WS-II), the prescrubbed crude mixture comprising dinitrotoluene is extracted with a scrubbing acid II in a scrub comprising at least one, preferably at least 2, extraction stage(s), where the scrubbing acid discharged from the first extraction stage (WS-II-1) of the second scrubbing step (WS-II) has a pH of less than or equal to 4, giving a dinitrotoluene-comprising mixture which is essentially free of nitric acid, sulfuric acid, nitrogen oxides and hydrocyanic acid and has a content of not more than 300 ppm of nitric acid and nitrogen oxides, not more than 3 ppm of sulfate and not more than 50 ppm of hydrocyanic acid.

4. 发明授权

US09498448B2 Pharmaceutical compositions comprising monoterpenes 有权
公开(公告)号：US09498448B2
公开(公告)日：2016-11-22
申请号：US14843097
申请日：2015-09-02
申请人： NEONC Technologies, Inc.
发明人： Thomas Chen , Daniel Levin , Satish Puppali
IPC分类号： C07C35/18 , A61K31/045 , C07C29/92 , C07C67/14 , C07C201/12 , C07C29/78 , C07C29/88 , C07C201/16 , A61K31/4188 , A61K45/06 , A61N5/10
CPC分类号： C07C29/92 , A61K31/045 , A61K31/4188 , A61K45/06 , A61N5/10 , C07B2200/07 , C07C29/78 , C07C29/86 , C07C29/88 , C07C67/14 , C07C201/12 , C07C201/16 , C07C2601/16 , C07C33/14 , C07C205/57 , C07C69/76 , C07C69/92
摘要： The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

5. 发明授权

US09480659B2 Pharmaceutical compositions comprising monoterpenes 有权
公开(公告)号：US09480659B2
公开(公告)日：2016-11-01
申请号：US14817286
申请日：2015-08-04
申请人： NEONC Technologies, Inc.
发明人： Thomas Chen , Daniel Levin , Satish Puppali
IPC分类号： C07C35/18 , A61K31/045 , C07C29/92 , C07C67/14 , C07C201/12 , C07C29/78 , C07C29/88 , C07C201/16 , A61K31/4188 , A61K45/06 , A61N5/10
CPC分类号： C07C29/92 , A61K31/045 , A61K31/4188 , A61K45/06 , A61N5/10 , C07B2200/07 , C07C29/78 , C07C29/86 , C07C29/88 , C07C67/14 , C07C201/12 , C07C201/16 , C07C2601/16 , C07C33/14 , C07C205/57 , C07C69/76 , C07C69/92
摘要： The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

6. 发明申请

US20140221703A1 METHOD AND APPARATUS FOR PURIFYING NITRATION PRODUCTS 有权
标题翻译：用于净化硝化产品的方法和装置
公开(公告)号：US20140221703A1
公开(公告)日：2014-08-07
申请号：US14118737
申请日：2012-05-18
申请人： Jürgen Pöhlmann , Heinrich Hermann , Mirko Handel , Jürgen Gebauer
发明人： Jürgen Pöhlmann , Heinrich Hermann , Mirko Handel , Jürgen Gebauer
IPC分类号： C07C201/16
CPC分类号： C07C201/16 , B01J19/24 , B01J2219/24 , C07C205/06
摘要： The present invention relates to a method for removing impurities from nitrated crude products obtained during the nitration of nitratable aromatic compounds, after removal of the final nitrating acid, by treatment with a washing medium, and also to a plant or apparatus suitable for implementing this method. Further provided by the invention is a production plant for the nitration of nitratable aromatic compounds with subsequent purification of the nitrated products.
摘要翻译：本发明涉及一种从硝化硝化硝酸中除去硝化酸后，通过用洗涤介质处理而得到的硝化粗产物中除去杂质的方法，以及适用于实施该方法的设备或装置。本发明进一步提供了一种用于硝化硝化的芳族化合物的生产设备，随后硝化产物的纯化。

7. 发明授权

US08536366B2 Formation of nitrate esters in microreactors and millireactors using a continuous product extraction in a turbulent flow regime 有权
标题翻译：在湍流状态下，使用连续的产物萃取法在微反应器和磨粒反应器中形成硝酸酯
公开(公告)号：US08536366B2
公开(公告)日：2013-09-17
申请号：US12808829
申请日：2008-12-19
申请人： Sascha Braune , Stefan Steinhofer , Peter Poechlauer , Rafael Wilhelmus E. G. Reintjens , Nicole Theodora W. Linssen , Mehul Thathagar
发明人： Sascha Braune , Stefan Steinhofer , Peter Poechlauer , Rafael Wilhelmus E. G. Reintjens , Nicole Theodora W. Linssen , Mehul Thathagar
IPC分类号： C07C201/02 , C07C201/16 , B01J14/00 , B01D11/04
CPC分类号： B01J19/0093 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00966 , B01J2219/00984 , C07C201/02 , C07C203/04
摘要： A process for the continuous production of a compound of Formula (II), HO—R1—ONO2 (II) wherein R1 is a straight chain alkyl radical having from 3 to 6 carbon atoms, in a two-phase solvent system, comprising contacting a compound of Formula (I), HO—R1—OH (I) wherein R1 is as defined above, with nitric acid in the presence of a first solvent, wherein the compound of Formula (II) is continuously extracted into a second solvent, and the reaction is carried out in a mixing microreactor which provides a power loss of at least 1.3 times the power loss provided under identical conditions by a circular cross-section straight-channel microreactor having an internal diameter equal to the average hydraulic diameter of the mixing microreactor and a length equal to the length of the mixing microreactor.
摘要翻译：在二相溶剂系统中连续制备其中R 1为具有3至6个碳原子的直链烷基的式（II）化合物HO-R1-ONO2（Ⅱ）的方法，包括使式（I）化合物，其中R 1如上定义的HO-R 1 -OH（I）与硝酸在第一溶剂存在下反应，其中将式（II）化合物连续萃取到第二溶剂中，反应在混合微反应器中进行，该混合微反应器通过圆形截面直通微反应器提供至少1.3相同条件下功率损耗的功率损失，该反应器的内径等于混合微反应器的平均水力直径长度等于混合微反应器的长度。

8. 发明申请

US20120136181A1 WASHING SYSTEM FOR NITROAROMATIC COMPOUNDS 有权
标题翻译：硝基化合物洗涤系统
公开(公告)号：US20120136181A1
公开(公告)日：2012-05-31
申请号：US13388836
申请日：2009-08-18
申请人： Sergio Berretia
发明人： Sergio Berretia
IPC分类号： C07C201/16 , B01J19/00
CPC分类号： C07C201/16 , C02F1/04 , C02F1/20 , C02F2101/38 , C02F2209/06 , C07C205/06
摘要： A method of removing alkalinity and salt from a nitroaromatic product downstream of water washing to remove mineral acids and alkaline washing to remove salts of organic acids, comprises washing the product stream with an acidic aqueous solution, prior to the step of removing excess organic reactant, by steam stripping or distillation. Acid removed from the stripper or column is recycled back for use in the acidic washing. The acidic washing is done instead of the neutral washing step of the prior art. It removes residual salt and decreases the level of entrained colloidal water in the nitroaromatic product.
摘要翻译：一种从水洗下游的硝基芳族化合物产物中去除碱度和盐的方法，以除去无机酸和碱洗涤以除去有机酸的盐，包括在除去过量有机反应物的步骤之前用酸性水溶液洗涤产物流，通过汽提或蒸馏。从汽提塔或塔中除去的酸被循环使用，用于酸洗。进行酸性洗涤代替现有技术的中性洗涤步骤。它去除残留的盐并降低硝基芳族产物中夹带的胶体水的含量。

9. 发明申请

US20050256343A1 Process for preparation of a nitrophenol 审中-公开
标题翻译：硝基苯酚的制备方法
公开(公告)号：US20050256343A1
公开(公告)日：2005-11-17
申请号：US10520725
申请日：2003-07-09
申请人： Eric Fache , Sebastien Righini
发明人： Eric Fache , Sebastien Righini
IPC分类号： C07C201/12 , C07C21/12 , C07C201/16 , C07C205/22
CPC分类号： C07C201/16 , C07C205/22
摘要： The invention relates to a method of preparing a high-purity nitrophenol and, more specifically, p-nitrophenol from a nitrohalobenzene. The inventive method comprises the following steps: (a) hydrolysis of a nitrohalobenzene compound by reacting said compound with a base; (b) acidification in order to produce the nitrophenol compound from the salt thereof by means of an acid treatment; (c) crystallisation of the nitrophenol compound obtained; and (d) separation of the product obtained. The invention is characterised in that it also comprises at least the following steps: (e) concentration of the reaction medium after hydrolysis (a) and before acidification (b); and (f) liquid/liquid decantation after acidification (b) and before crystallisation (c), which is intended to eliminate the water phase obtained after acidification (b).
摘要翻译：本发明涉及一种从硝基卤苯制备高纯度硝基苯酚，更具体地说是对硝基苯酚的方法。本发明的方法包括以下步骤：（a）通过使所述化合物与碱反应来水解硝基卤苯化合物; （b）酸化以通过酸处理从其盐生产硝基苯酚化合物; （c）获得的硝基苯酚化合物的结晶; 和（d）所得产物的分离。本发明的特征在于其还包括至少以下步骤：（e）水解（a）和酸化（b）之前浓缩反应介质; 和（f）在酸化（b）和结晶（c）之前的液体/液体倾析，其旨在消除酸化后获得的水相（b）。

10. 发明授权

US5990354A Conversion of ammonium picrate to m-phenylenediamine, aniline, and primary amines 有权
标题翻译：苦味酸铵转化为间苯二胺，苯胺和伯胺
公开(公告)号：US5990354A
公开(公告)日：1999-11-23
申请号：US193922
申请日：1998-11-17
申请人： Duane A. Goetsch , Kym B. Arcuri
发明人： Duane A. Goetsch , Kym B. Arcuri
IPC分类号： C07C201/16 , C07C205/24 , C07C209/68 , C07C211/46 , C07C211/50 , C07C211/51 , C07C213/00 , C07C209/00
CPC分类号： C07C209/68 , C07C213/00
摘要： Ammonium picrate, Explosive "D", is converted to picric acid, which is then converted to triaminophenol by the conversion of the aromatic nitro groups to amino groups. The triaminophenols are then converted to triaminobenzenes by the removal of the hydroxyl groups and the triaminobenzenes are converted to m-phenylenediamine, aniline, and primary aliphatic amines by the removal of amino groups.
摘要翻译：将苦味酸铵，爆炸性“D”转化成苦味酸，然后通过将芳族硝基转化为氨基将其转化成三氨基苯酚。然后通过除去羟基将三氨基酚转化为三氨基苯，并且通过除去氨基将三氨基苯转化成间苯二胺，苯胺和伯脂肪族胺。

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