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1. 发明申请

US20190202785A1 NEW PROCESSES AND INTERMEDIATES FOR NEP INHIBITOR SYNTHESIS 审中-公开
公开(公告)号：US20190202785A1
公开(公告)日：2019-07-04
申请号：US16325880
申请日：2017-08-16
申请人： Novartis AG
发明人： Florian Karl KLEINBECK-RINIKER , Ives MAFLI , Benjamin MARTIN , Gerhard PENN , Gottfried SEDELMEIER , Joerg SEDELMEIER , Francesco VENTURONI
IPC分类号： C07D213/16 , C07C45/49 , C07C249/02 , C07C229/06 , C07C201/12 , C07D207/267
CPC分类号： C07D213/16 , C07B2200/07 , C07C45/49 , C07C67/347 , C07C201/06 , C07C201/12 , C07C201/16 , C07C205/51 , C07C205/53 , C07C227/18 , C07C229/06 , C07C231/02 , C07C249/02 , C07C249/08 , C07C251/38 , C07C269/00 , C07C271/22 , C07D207/12 , C07D207/267 , C07D213/36 , C07C229/34 , C07C233/51 , C07C69/738
摘要： The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.

2. 发明申请

US20180161754A1 ZEOLITIC ADSORBENTS WITH LARGE EXTERNAL SURFACE AREA, PROCESS FOR PREPARING THEM AND USES THEREOF 审中-公开
公开(公告)号：US20180161754A1
公开(公告)日：2018-06-14
申请号：US15880201
申请日：2018-01-25
申请人： Arkema France , IFP Energies Nouvelles
发明人： Catherine Laroche , Philibert LEFLAIVE , Ludivine BOUVIER , Serge NICOLAS , Cecile LUTZ , Marie-Laurence LABEDE
IPC分类号： B01J20/18 , B01D53/08 , C07C29/76 , B01D53/02 , B01J20/30 , B01J20/12 , C07C37/82 , B01J20/28 , C07C7/13 , C07C201/16 , C07C209/86 , C07C15/08 , C07C15/02 , C07C211/50 , C07C205/06 , C07C39/07
CPC分类号： B01J20/18 , B01D53/02 , B01D53/08 , B01D2253/108 , B01D2257/556 , B01J20/12 , B01J20/186 , B01J20/28004 , B01J20/28059 , B01J20/28061 , B01J20/28071 , B01J20/3028 , B01J20/3071 , B01J20/3085 , C07C7/13 , C07C29/76 , C07C37/82 , C07C201/16 , C07C209/86 , C07C15/08 , C07C15/02 , C07C211/50 , C07C205/06 , C07C39/07
摘要： The present invention relates to zeolitic adsorbents based on agglomerated crystals of FAU zeolite containing barium and/or potassium, with large external surface area, combining optimum properties in terms of selectivity and mechanical strength. These adsorbents find applications in the separation of cuts of C8-aromatic isomers and notably of xylenes, in the separation of isomers of substituted toluene such as nitrotoluene, diethyltoluene, toluenediamine, in the separation of cresols, and in the separation of polyhydric alcohols such as sugars.

3. 发明授权

US09914109B2 Zeolitic adsorbents with large external surface area, process for preparing them and uses thereof 有权
公开(公告)号：US09914109B2
公开(公告)日：2018-03-13
申请号：US14917457
申请日：2014-09-05
申请人： CECA S.A. , IFP Energies Nouvelles
发明人： Catherine Laroche , Philibert Leflaive , Ludivine Bouvier , Serge Nicolas , Cecile Lutz , Marie-Laurence Labede
IPC分类号： B01J20/12 , B01J20/18 , B01J20/28 , B01J20/30 , C07C29/76 , C07C37/82 , C07C7/13 , C07C201/16 , C07C209/86 , B01D53/02 , B01D53/08
CPC分类号： B01J20/18 , B01D53/02 , B01D53/08 , B01D2253/108 , B01D2257/556 , B01J20/12 , B01J20/186 , B01J20/28004 , B01J20/28059 , B01J20/28061 , B01J20/28071 , B01J20/3028 , B01J20/3071 , B01J20/3085 , C07C7/13 , C07C29/76 , C07C37/82 , C07C201/16 , C07C209/86 , C07C15/08 , C07C15/02 , C07C211/50 , C07C205/06 , C07C39/07
摘要： The present invention relates to zeolitic adsorbents based on agglomerated crystals of FAU zeolite comprising barium and/or potassium, with large external surface area, combining optimum properties in terms of selectivity and mechanical strength.These adsorbents find applications in the separation of cuts of C8-aromatic isomers and notably of xylenes, in the separation of isomers of substituted toluene such as nitrotoluene, diethyltoluene, toluenediamine, in the separation of cresols, and polyhydric alcohols, such as sugars.

4. 发明授权

US09896407B2 Exhaust gas cleaning in a method for continuously producing dinitrotoluene 有权
公开(公告)号：US09896407B2
公开(公告)日：2018-02-20
申请号：US15514107
申请日：2015-09-29
申请人： Covestro Deutschland AG
发明人： Thomas Knauf , Jürgen Münnig , Wolfgang Lorenz , Bernd Pennemann
IPC分类号： C07C201/08 , C07C201/16 , C07C205/06 , B01D53/00
CPC分类号： C07C201/08 , B01D53/002 , B01D2257/7027 , C07C201/16 , C07C205/06
摘要： The invention relates to a method for producing dinitrotoluene, comprising the following steps: a) nitrating toluene with a mixture of nitric acid and sulfuric acid and subsequently separating a sulfuric-acid-containing aqueous phase that arises in the nitration, wherein a raw dinitrotoluene is obtained, b) washing the raw dinitrotoluene in a water wash with neutral and/or alkaline washing water, wherein a pre-cleaned dinitrotoluene, which contains at least water in addition to dinitrotoluene, is obtained after the washing water used in the last wash has been separated, and c) separating the water from the pre-cleaned dinitrotoluene, d) collecting the waste water from steps a), b), and/or c), e) optionally extracting the collected waste water from step d) with toluene and returning the thus obtained organic phase to step a), f) freeing the collected waste water from step d), or, if the optional step e) is performed, the extracted waste water from step e), of toluene in a toluene stripper, wherein a toluene-containing exhaust gas flow is obtained, g) feeding at least one exhaust gas flow from steps a), b), c), d), e), or f) into an exhaust gas condenser and removing the toluene contained in the at least one exhaust gas flow in said exhaust gas condenser, wherein the method comprises the following further step: h) feeding the exhaust gas flow arising in step g) after the condensing out of the toluene to a thermal exhaust air cleaning, wherein nitrogen is added to the exhaust gas flow to be fed to the exhaust gas condenser or to the exhaust gas flow leaving the exhaust gas condenser, wherein preferably a nitrogen concentration in the exhaust gas flow of at least 0.1 vol % is set, especially preferably of at least 0.5 vol %.

5. 发明申请

US20170291869A1 EXHAUST GAS CLEANING IN A METHOD FOR CONTINUOUSLY PRODUCING DINITROTOLUENE 有权
公开(公告)号：US20170291869A1
公开(公告)日：2017-10-12
申请号：US15514107
申请日：2015-09-29
申请人： Covestro Deutschland AG
发明人： Thomas KNAUF , Jürgen MÜNNIG , Wolfgang LORENZ , Bernd PENNEMANN
IPC分类号： C07C201/08 , C07C201/16 , B01D53/00
CPC分类号： C07C201/08 , B01D53/002 , B01D2257/7027 , C07C201/16 , C07C205/06
摘要： The invention relates to a method for producing dinitrotoluene, comprising the following steps: a) nitrating toluene with a mixture of nitric acid and sulfuric acid and subsequently separating a sulfuric-acid-containing aqueous phase that arises in the nitration, wherein a raw dinitrotoluene is obtained, b) washing the raw dinitrotoluene in a water wash with neutral and/or alkaline washing water, wherein a pre-cleaned dinitrotoluene, which contains at least water in addition to dinitrotoluene, is obtained after the washing water used in the last wash has been separated, and c) separating the water from the pre-cleaned dinitrotoluene, d) collecting the waste water from steps a), b), and/or c), e) optionally extracting the collected waste water from step d) with toluene and returning the thus obtained organic phase to step a), f) freeing the collected waste water from step d), or, if the optional step e) is performed, the extracted waste water from step e), of toluene in a toluene stripper, wherein a toluene-containing exhaust gas flow is obtained, g) feeding at least one exhaust gas flow from steps a), b), c), d), e), or f) into an exhaust gas condenser and removing the toluene contained in the at least one exhaust gas flow in said exhaust gas condenser, wherein the method comprises the following further step: h) feeding the exhaust gas flow arising in step g) after the condensing out of the toluene to a thermal exhaust air cleaning, wherein nitrogen is added to the exhaust gas flow to be fed to the exhaust gas condenser or to the exhaust gas flow leaving the exhaust gas condenser, wherein preferably a nitrogen concentration in the exhaust gas flow of at least 0.1 vol % is set, especially preferably of at least 0.5 vol %.

6. 发明授权

US09700524B2 Pharmaceutical compositions comprising monoterpenes 有权
公开(公告)号：US09700524B2
公开(公告)日：2017-07-11
申请号：US15040002
申请日：2016-02-10
申请人： NEONC Technologies, Inc.
发明人： Thomas Chen , Daniel Levin , Satish Puppali
IPC分类号： A61K31/045 , C07C29/92 , C07C67/14 , C07C201/12 , C07C29/78 , C07C29/88 , C07C201/16 , A61K31/4188 , A61K45/06 , A61N5/10
CPC分类号： C07C29/92 , A61K31/045 , A61K31/4188 , A61K45/06 , A61N5/10 , C07B2200/07 , C07C29/78 , C07C29/86 , C07C29/88 , C07C67/14 , C07C201/12 , C07C201/16 , C07C2601/16 , C07C33/14 , C07C205/57 , C07C69/76 , C07C69/92
摘要： The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

7. 发明授权

US09540313B2 Method and apparatus for purifying nitration products 有权
标题翻译：净化硝化产物的方法和装置
公开(公告)号：US09540313B2
公开(公告)日：2017-01-10
申请号：US14632086
申请日：2015-02-26
申请人： JOSEF MEISSNER GMBH & CO. KG
发明人： Jürgen Pöhlmann , Heinrich Hermann , Mirko Händel , Jürgen Gebauer
IPC分类号： C07C201/16 , B01J19/24
CPC分类号： C07C201/16 , B01J19/24 , B01J2219/24 , C07C205/06
摘要： The present invention relates to a method for removing impurities from nitrated crude products obtained during the nitration of nitratable aromatic compounds, after removal of the final nitrating acid, by treatment with a washing medium, and also to a plant or apparatus suitable for implementing this method. Further provided by the invention is a production plant for the nitration of nitratable aromatic compounds with subsequent purification of the nitrated products.
摘要翻译：本发明涉及一种从硝化硝化硝酸中除去硝化酸后，通过用洗涤介质处理而得到的硝化粗产物中除去杂质的方法，以及适用于实施该方法的设备或装置。本发明进一步提供了一种用于硝化硝化的芳族化合物的生产设备，随后硝化产物的纯化。

8. 发明申请

US20160251302A1 PROCESS FOR ACIDIC SCRUBBING OF DINITROTOLUENE IN THE PRESENCE OF HYDROCYANIC ACID 有权
标题翻译：氨基酸在酸性酸存在下的酸洗过程
公开(公告)号：US20160251302A1
公开(公告)日：2016-09-01
申请号：US15031100
申请日：2014-10-22
申请人： BASF SE , JOSEF MEISSNER GMBH & CO. KG
发明人： SAMUEL NETO , Rüdiger FRITZ , Renate HEMPEL , Holger ALLARDT , Yuan Shen DAI , Barbara BECKER , Sebastian AHRENS , Julia LESCHINSKI , Henrich HERMANN , Mirko HAENDEL , Jürgen PÖHLMANN
IPC分类号： C07C201/16 , C02F1/26 , C02F1/20 , B01D11/04 , C02F3/00
CPC分类号： C07C201/16 , B01D11/0488 , B01D11/0492 , B01D2011/002 , C02F1/20 , C02F1/26 , C02F3/00 , C02F2101/18 , C02F2103/36 , C07C205/06
摘要： Process for scrubbing a crude mixture which is obtained in the nitration of toluene after separating off the nitrating acid and comprises dinitrotoluene, nitric acid, nitrogen oxides and sulfuric acid, which comprises two scrubbing steps (WS-I) and (WS-II), wherein i) in a first scrubbing step (WS-I), the crude mixture is extracted with a scrubbing acid I comprising nitric acid, nitrogen oxides and sulfuric acid in a scrub comprising at least one extraction stage, where the scrubbing acid discharged from the first extraction stage (WS-I-1) of the first scrubbing step (WS-I) has a total acid content of from 10 to 40% by weight and a content of from 80 to 350 ppm of hydrocyanic acid, giving a prescrubbed crude mixture, ii) in a second scrubbing step (WS-II), the prescrubbed crude mixture comprising dinitrotoluene is extracted with a scrubbing acid II in a scrub comprising at least one, preferably at least 2, extraction stage(s), where the scrubbing acid discharged from the first extraction stage (WS-II-1) of the second scrubbing step (WS-II) has a pH of less than or equal to 4, giving a dinitrotoluene-comprising mixture which is essentially free of nitric acid, sulfuric acid, nitrogen oxides and hydrocyanic acid and has a content of not more than 300 ppm of nitric acid and nitrogen oxides, not more than 3 ppm of sulfate and not more than 50 ppm of hydrocyanic acid.
摘要翻译：在分离出硝酸后，除去硝化硝酸甲苯后得到的粗混合物的方法，包括二硝基甲苯，硝酸，氮氧化物和硫酸，其包括两个洗涤步骤（WS-I）和（WS-II）其中i）在第一洗涤步骤（WS-1）中，所述粗混合物用包含硝酸，氮氧化物和硫酸的洗涤酸I在包含至少一个萃取阶段的洗涤中萃取，其中所述洗涤酸从第一洗涤步骤（WS-1）的第一提取阶段（WS-I-1）的总酸含量为10至40重量％，含量为80至350ppm的氢氰酸，得到预先粗制的粗品混合物，ii）在第二次洗涤步骤（WS-II）中，包含二硝基甲苯的预先混合的粗混合物用洗涤酸II在洗涤中提取，所述洗涤包括至少一个，优选至少2个萃取阶段，其中洗涤酸从第一次提取出来在第二洗涤步骤（WS-II）的阶段（WS-II-1）上具有小于或等于4的pH，得到基本上不含硝酸，硫酸，氮氧化物的二硝基甲苯混合物，氢氰酸，硝酸和氮氧化物含量不超过300ppm，硫酸盐不超过3ppm，氢氰酸不大于50ppm。

9. 发明授权

US09302978B1 Process for the preparation of nitrobenzene by adiabatic nitration 有权
标题翻译：通过绝热硝化制备硝基苯的方法
公开(公告)号：US09302978B1
公开(公告)日：2016-04-05
申请号：US14785763
申请日：2014-04-24
申请人： Covestro Deutschland AG
发明人： Antoni Mairata , Thomas Knauf
IPC分类号： C07C205/00 , C07C201/08 , C07C201/16
CPC分类号： C07C201/08 , C07C201/16 , C07C205/06
摘要： The present invention relates to a continuously operated adiabatic process for the preparation of nitrobenzene by nitration of benzene with nitric acid and sulfuric acid, in which the dilute sulfuric acid obtained after the nitration has taken place and the crude nitrobenzene has been separated off from the aqueous phase is concentrated for the purpose of re-use in the nitration, and after its concentration, at least one minute before it comes into contact with fresh nitric acid again an oxidizing agent is added such that a concentration of the oxidizing agent of from 10 ppm to 5,000 ppm, based on the total weight of the concentrated sulfuric acid to be recycled into the nitration, is established.
摘要翻译：本发明涉及用硝酸和硫酸硝化苯来制备硝基苯的连续操作的绝热方法，其中在硝化发生后获得的稀硫酸和粗硝基苯已从水溶液中分离出来浓缩的浓度是为了在硝化中重复使用，并且在其浓缩之后，再次与新鲜硝酸接触至少一分钟，加入氧化剂使得氧化剂的浓度为10ppm 至5,000ppm，基于要再循环到硝化中的浓硫酸的总重量。

10. 发明授权

US09284256B2 Process for the production of nitrobenzene by adiabatic nitration 有权
标题翻译：通过绝热硝化生产硝基苯的方法
公开(公告)号：US09284256B2
公开(公告)日：2016-03-15
申请号：US14415794
申请日：2013-07-23
申请人： Bayer MaterialScience AG
发明人： Thomas Knauf , Michael Merkel
IPC分类号： C07C201/00 , C07C201/08 , C07C201/16
CPC分类号： C07C201/08 , C07C201/16 , C07C205/06
摘要： The present invention provides a continuous process for the production of nitrobenzene by nitration of benzene with mixtures of sulfuric and nitric acid using a stoichiometric excess of benzene, in which the content of aliphatic organic compounds in the feed benzene during the start-up period of the production plant is always maintained at less than 1.5 wt. %, based on the total mass of the feed benzene. This is achieved either by mixing the feed benzene comprising recycled unreacted benzene (recycled benzene) and benzene newly supplied to the reaction (fresh benzene) in appropriate quantitative ratios during the start-up period, depending on the purity of the two streams, or by completely omitting the recycling of unreacted benzene during the start-up period, i.e. the feed benzene consists only of benzene newly supplied to the reaction.
摘要翻译：本发明提供了一种使用化学计量过量的苯硝化苯与硫酸和硝酸的混合物来生产硝基苯的连续方法，其中在起始时期的进料苯中的脂族有机化合物的含量生产厂总是维持在1.5重量％以下。％，基于进料苯的总质量。这可以通过在启动期间将包含再循环的未反应苯（再循环苯）和新提供给反应的苯（新鲜苯）的进料苯与合适的定量比例混合，取决于两个流的纯度，或者通过在启动期间完全省略未反应苯的再循环，即进料苯仅由新提供给反应的苯组成。

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