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1. 发明授权

US11028350B2 Powders and granules and process for making such powders and granules 有权
公开(公告)号：US11028350B2
公开(公告)日：2021-06-08
申请号：US16309339
申请日：2017-06-01
申请人： BASF SE
发明人： Michael Klemens Mueller , Armin Stamm , Frank Jaekel , Carsten Sueling
IPC分类号： C11D7/26 , C11D7/32 , C11D11/00 , C11D3/33 , C11D11/02 , C07C229/16 , C07C227/00 , C07C227/44 , C11D3/37
摘要： Process for making a powder or granule containing at least one chelating agent selected from alkali metal salts of methyl glycine diacetic acid (MGDA) and glutamic acid diacetate (GLDA) and iminodisuccinic acid (IDS), said process comprising the steps of (a) introducing an aqueous solution or aqueous slurry of the respective chelating agent (A) into a spray-dryer or spray-granulator, and removing most of said water by spray-drying or spray granulation using a gas with an inlet temperature of 125 to 250° C., (b) withdrawingpowder or granules, respectively, from the spray-dryer or spray-granulator, respectively, (c) separating off fines from said powder or granules, wherein said fines have a maximum particle diameter of 350 μm, (d) separating off lumps from said powder or granules, wherein said lumps have a particle diameter of 1,500 μm or more, (e) milling said lumps to a maximum particle diameter of 500 μm, (f) re-introducing said fines from step (c) and milled lumps from step (e) into the spray-dryer or spray-granulator, wherein the share of fines is in the range of from 0.5 to 20% by weight of the total chelating agent (A) withdrawn in step (b) and the share of milled lumps is in the range of from 5 to 60% by weight of the total chelating agent (A) withdrawn in step (b).

2. 发明申请

US20210070708A1 Pharmaceutically Active Compounds 有权
公开(公告)号：US20210070708A1
公开(公告)日：2021-03-11
申请号：US16928142
申请日：2020-07-14
申请人： BerGenBio ASA
发明人： Jason John Shiers , John Paul Watts , Stuart Thomas Onions , Mohammed Abdul Quddus , Joseph William Wrigglesworth , Colin Peter Sambrook-Smith , Alan Naylor , Derek Londesbrough
IPC分类号： C07D213/75 , C07D403/12 , C07D401/12 , C07D237/20 , C07D405/10 , C07D405/12 , C07D409/04 , C07D409/14 , C07D413/12 , C07C227/12 , C07C227/00 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/50 , A61K31/501 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D405/14 , C07D413/14
摘要： The invention is directed to compounds of general formula (I) and pharmaceutical compositions containing such compounds. The compounds and compositions have valuable pharmaceutical properties. In particular, they may be used for the treatment of cancer. Novel intermediates and novel methods of preparation are also disclosed.

3. 发明授权

US10343978B2 Process for producing long chain amino acids and dibasic acids 有权
公开(公告)号：US10343978B2
公开(公告)日：2019-07-09
申请号：US15880293
申请日：2018-01-25
申请人： Vitaworks IP, LLC
发明人： Songzhou Hu
IPC分类号： C07C227/00 , C07C227/08 , C07C229/08 , C07C51/47 , C07C227/40 , C07C209/62 , C07C227/20
摘要： There is disclosed a process for the production of long chain amino acid and long chain dibasic acid, comprising: (1) reacting long chain keto fatty acid with hydroxylamine or subjecting keto fatty acid to an ammoximation reaction to yield an oxime fatty acid; (2) reacting the oxime fatty acid with an alcohol or a primary amine or a secondary amine to prepare an ester or amide; (3) subjecting the oxime fatty acid ester or amide to the Beckmann rearrangement to yield a mixture of two amide fatty acids; (4) hydrolyzing the mixed amide fatty acids to produce long chain amino acid, long chain dibasic acid, short chain alkylamine, and alkanoic acid.

4. 发明授权

US09624621B2 Process for the production of coated textiles 有权
公开(公告)号：US09624621B2
公开(公告)日：2017-04-18
申请号：US14353054
申请日：2012-10-16
申请人： Bayer Intellectual Property GmbH
发明人： Rolf Irnich , Shaojun Yang
IPC分类号： B05D3/02 , D06N3/14 , C07C227/00 , C14C11/00 , D06M15/564 , D06M23/04 , C08G18/66 , C08G18/08 , D06N3/00 , C08G101/00
CPC分类号： D06N3/145 , C07C227/00 , C08G18/0823 , C08G18/6625 , C08G2101/0008 , C14C11/00 , D06M15/564 , D06M23/04 , D06N3/0045 , D06N3/0047 , D06N3/0088 , D06N3/14 , D06N2211/28 , Y10T428/249981 , C08G18/12 , C08G18/3225
摘要： A process for the production of coated textiles comprises the steps of: providing a textile substrate having a first side and a second side opposing the first side; contacting at least a part of the first side of the textile substrate with a spreadable polyurethane mechanical foam; applying a reduced pressure to at least a part of the second side of the textile substrate opposing the first side which has been contacted with the polyurethane mechanical foam; and solidifying the polyurethane mechanical foam with which the textile substrate has been contacted. The invention further relates to a coated textile obtainable by such a process, in particular a synthetic leather.

5. 发明授权

US09388110B2 Liquid phase oxidation of aromatic feedstocks with manganate recycling to produce carboxylic acids 有权
标题翻译：芳烃原料的液相氧化与锰酸盐再循环以产生羧酸
公开(公告)号：US09388110B2
公开(公告)日：2016-07-12
申请号：US14104571
申请日：2013-12-12
申请人： Saudi Arabian Oil Company
发明人： Veera Venkata Ramakrishna Tammana , Kareemuddin M. Shaik , Guillaume Robert Jean-Francois Raynel
IPC分类号： C07C227/00 , C07C51/295 , C07C51/285
CPC分类号： C07C51/295 , B01J8/006 , B01J8/085 , B01J19/0046 , B01J2219/0059 , B01J2219/00599 , B01J2219/0072 , B01J2219/00759 , C07C51/285 , C07C63/06 , C07C63/16 , C07C63/24 , C07C63/26
摘要： Systems and methods for liquid-phase oxidation of an aromatic feedstock containing at least one oxidizable aromatic compound may incorporate an oxidation reactor, a separation apparatus in fluidic communication with the oxidation reactor, a solids treatment unit, and a product recovery unit in fluidic communication with the separation apparatus. The oxidation reactor may conduct liquid-phase oxidation of the oxidizable aromatic compound in the aromatic feedstock in the presence of a manganate salt to form a slurry containing liquid product and solid manganese dioxide. The separation apparatus may accept the slurry from the oxidation reactor and separate the liquid component from the solid component. The solids treatment unit accepts the solid component from the separation apparatus, treats the solid component with a basic liquid to oxidize the manganese dioxide in the solid component and form a regenerated manganate salt, which may be recycled back to the oxidation reactor.
摘要翻译：含有至少一种可氧化芳族化合物的芳族原料的液相氧化的系统和方法可以包括氧化反应器，与氧化反应器流体连通的分离装置，固体处理单元和与分离装置。氧化反应器可以在锰酸盐存在下在芳族原料中进行可氧化芳族化合物的液相氧化，形成含有液体产物和固体二氧化锰的浆料。分离装置可以接受来自氧化反应器的浆料并将液体组分与固体组分分离。固体处理单元接受来自分离装置的固体组分，用碱性液体处理固体组分以氧化固体组分中的二氧化锰，并形成可再循环回氧化反应器的再生锰酸盐。

6. 发明授权

US09315443B2 Liquid cation exchanger 有权
标题翻译：液体阳离子交换剂
公开(公告)号：US09315443B2
公开(公告)日：2016-04-19
申请号：US14000067
申请日：2011-12-01
申请人： Frank Erhardt , Thomas Haas , Martin Roos , Daniel Demicoli , Markus Poetter , Anja Schubert , Jan Christoph Pfeffer , Thomas Tacke , Harald Haeger , Andreas Pfennig , Marie-Dominique Przybylski-Freund
发明人： Frank Erhardt , Thomas Haas , Martin Roos , Daniel Demicoli , Markus Poetter , Anja Schubert , Jan Christoph Pfeffer , Thomas Tacke , Harald Haeger , Andreas Pfennig , Marie-Dominique Przybylski-Freund
IPC分类号： C07C227/00 , C07C67/62 , B01D11/04 , B01J39/04 , B01J39/16 , C07C227/40 , C07C229/08 , C02F1/26 , C02F1/42 , C02F101/34
CPC分类号： C07C67/62 , B01D11/0492 , B01J39/04 , B01J39/16 , C02F1/26 , C02F2001/425 , C02F2101/34 , C07C227/40 , C07C229/08
摘要： The invention relates to a method for removing an organic compound having one or more positive charges from an aqueous solution. Said method consists of the following steps a) the aqueous solution containing the organic compound, and a hydrophobic organic solution which contains a hydrophobic liquid cation exchanger having one or more negative charges and a negative total charge, are provided, b) the aqueous solution and the organic solution are brought into contact with each other and c) the organic solution is separated from the aqueous solution.
摘要翻译：本发明涉及从水溶液中除去具有一个或多个正电荷的有机化合物的方法。所述方法包括以下步骤a）含有有机化合物的水溶液和含有具有一个或多个负电荷和负总电荷的疏水液体阳离子交换剂的疏水性有机溶液，b）水溶液和使有机溶液彼此接触并且c）将有机溶液与水溶液分离。

7. 发明授权

US08884041B2 Method for synthesizing an omega-amino acid or ester from a monounsaturated fatty acid or ester 有权
标题翻译：从单不饱和脂肪酸或酯合成ω-氨基酸或酯的方法
公开(公告)号：US08884041B2
公开(公告)日：2014-11-11
申请号：US14234879
申请日：2012-07-26
申请人： Jean-Luc Couturier , Jean-Luc Dubois
发明人： Jean-Luc Couturier , Jean-Luc Dubois
IPC分类号： C07C227/00 , C07B43/00 , C07C229/08 , C07C227/04 , C07C227/08
CPC分类号： C07C227/08 , C07C227/04 , C07C229/08
摘要： A method for synthesizing ω-amino-alkanoic acids or the esters thereof from natural unsaturated fatty acids passing through an intermediate ω-unsaturated nitrile compound. The method is simple to implement and, relative to known methods, avoids the environmental constraints and economic disadvantages resulting from the reaction by-products. The method includes synthesizing an ω-amino acid (ester) of formula R3OOC—(CH2)q-CH2NH2, in which R3 is H or an n-butyl radical and q is an integral index of between 2 and 13, from a monounsaturated fatty acid (ester) of formula (R1-CH═CH—(CH2)p-COO)xR2, in which x represents 1, 2 or 3, R1 is H or a hydrocarbon radical comprising from 4 to 11 carbon atoms and, where appropriate, a hydroxyl function, R2 is H or an alkyl radical comprising from 2 to 4 carbon atoms, and may contain one or more heteroatoms, and p is an integral index of between 2 and 11, including a reaction step of ammoniation.
摘要翻译：由通过中间体ω-不饱和腈化合物的天然不饱和脂肪酸合成ω-氨基 - 链烷酸或其酯的方法。该方法易于实施，并且相对于已知方法，避免了由反应副产物引起的环境限制和经济缺点。该方法包括从单不饱和脂肪酸合成式R3OOC-（CH2）q-CH2NH2的ω-氨基酸（酯），其中R3是H或正丁基，q是2和13之间的整数指数式（R1-CH =（CH2）p-COO）xR2的酸（酯），其中x表示1,2或3，R1是H或包含4至11个碳原子的烃基，并且在适当的情况下羟基官能团，R2是H或包含2至4个碳原子的烷基，并且可以含有一个或多个杂原子，p是2和11之间的整数指数，包括氨化的反应步骤。

8. 发明授权

US08088949B2 Process for purifying L-cysteine 有权
标题翻译： L-半胱氨酸纯化方法
公开(公告)号：US08088949B2
公开(公告)日：2012-01-03
申请号：US12026567
申请日：2008-02-06
申请人： Andreas Boehm
发明人： Andreas Boehm
IPC分类号： C07C227/00
CPC分类号： C07C319/28 , C07C323/58
摘要： L-cysteine-is separated from an L-cysteine-containing fermenter broth containing an oxidizing agent which is capable of oxidizing L-cysteine at pH
摘要翻译：将L-半胱氨酸与含有L-半胱氨酸的发酵罐肉汤分开，所述发酵罐含有能够在pH <5时氧化L-半胱氨酸的氧化剂，通过使L-半胱氨酸发酵罐肉汤与离子交换剂在pH为如图5至图9所示，发酵罐肉汤中的pH变为<5，优选<2。 L-半胱氨酸结合到离子交换剂上，然后通过洗脱剂从离子交换剂中除去结合的L-半胱氨酸。

9. 发明申请

US20110300567A1 METHOD FOR DETERMINING REDOX ACTIVITY AND SCREENING COMPOUNDS BASED ON REDOX ACTIVITY 失效
标题翻译：用于确定氧化还原活性的方法和基于氧化还原活性的筛选化合物
公开(公告)号：US20110300567A1
公开(公告)日：2011-12-08
申请号：US13206364
申请日：2011-08-09
申请人： Jonathan J. Abramson , Benjamin S. Marinov
发明人： Jonathan J. Abramson , Benjamin S. Marinov
IPC分类号： C12Q1/26 , C07H15/252 , C07C229/60 , C07C227/00 , C07D305/14 , C07C255/43 , C07C57/03 , C07C51/00 , C07D295/13 , C07D471/08 , G01N21/78 , C07C253/00
CPC分类号： G01N33/52 , Y10T436/141111 , Y10T436/142222 , Y10T436/143333 , Y10T436/145555 , Y10T436/172307 , Y10T436/173845 , Y10T436/174614
摘要： A method for identifying the redox activity of a subject compound is disclosed. The method can be performed aerobically and can include forming a mixture comprising a free-radical precursor and a compound to be tested, and converting the free-radical precursor into a free-radical anion and a free-radical cation. After the free radical cation and the free radical anion have been formed, the relative redox activity of the subject compound may cause a difference in the rate of photo-bleaching of the mixture and/or the rate of superoxide generation. These differences can be quantified and used to identify the redox activity of the subject compound. This sensitive technique for measuring redox activity can be used to screen compounds for various biological applications. Drugs also can be developed based on the relationship between redox activity and biological activity for particular biological applications.
摘要翻译：公开了用于鉴定目标化合物的氧化还原活性的方法。该方法可以有氧地进行，并且可以包括形成包含自由基前体和待测化合物的混合物，并将自由基前体转化为自由基阴离子和自由基阳离子。形成自由基阳离子和自由基阴离子后，本发明化合物的相对氧化还原活性可能导致混合物的光漂白速率和/或超氧化物产生速率的差异。这些差异可以被量化并用于鉴定主题化合物的氧化还原活性。这种用于测量氧化还原活性的敏感技术可用于筛选各种生物应用的化合物。药物也可以基于氧化还原活性与特定生物应用的生物活性之间的关系而开发。

10. 发明申请

US20110039933A1 S1P-1 RECEPTOR AGONISTS 审中-公开
标题翻译： S1P-1受体激动剂
公开(公告)号：US20110039933A1
公开(公告)日：2011-02-17
申请号：US12438063
申请日：2007-08-07
申请人： Ghotas Evindar , Hongfeng Deng
发明人： Ghotas Evindar , Hongfeng Deng
IPC分类号： A61K31/197 , C07C229/42 , A61P43/00 , C07C227/00
CPC分类号： C07C237/04
摘要： The invention provides compounds formula (I), their preparation, and their use as pharmaceutically active immuno-suppressive agents for the treatment of autoimmune disorders, organ transplant rejection, disorders associated with an activated immune system, as well as other disorders modulated by lymphopenia or SIP receptors.
摘要翻译：本发明提供化合物式（I），其制备方法及其作为药物活性免疫抑制剂用于治疗自身免疫性疾病，器官移植排斥，与活化的免疫系统相关的疾病以及由淋巴细胞减少或其它疾病调节的其它障碍 SIP受体。

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