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1. 发明申请

US20150152082A1 METHOD FOR PRODUCING OPTICALLY ACTIVE NAPHTHALENE COMPOUND 有权
标题翻译：用于生产光学活性萘基化合物的方法
公开(公告)号：US20150152082A1
公开(公告)日：2015-06-04
申请号：US14240466
申请日：2012-08-24
申请人： Koji Matsuyama , Masanori Hatsuda , Masahiko Yoshinaga , Mitsuhiro Yada , Koichi Tanimoto
发明人： Koji Matsuyama , Masanori Hatsuda , Masahiko Yoshinaga , Mitsuhiro Yada , Koichi Tanimoto
IPC分类号： C07D401/04 , C07C255/03 , C07C25/06
CPC分类号： C07D401/04 , C07B53/00 , C07C25/06 , C07C255/03
摘要： The present invention provides an industrially advantageous method for producing an optically active naphthalene compound useful as a therapeutic agent for dermatitis or the like. Specifically, the present invention provides a method for producing an optically active naphthalene compound [I], which comprises: a step of reacting a compound [a-1] and a compound [b-1] with each other in the presence of a base and a catalyst that is composed of a Pd compound and a tertiary phosphine ligand (step a); a step of asymmetrically hydrogenating a compound [c-1] in the presence of a hydrogen donor and a complex that is prepared from a ruthenium compound and a chiral ligand, or alternatively in the presence of an optically active oxazaborolidine compound (a CBS catalyst) and a boron hydride compound (step b); and a step of treating a compound [d-1] with a reducing agent (step c). (In the above formulae, Ra and Rb represent the same or different lower alkyl groups; and X1 represents a halogen atom.)
摘要翻译：本发明提供了用于制造用作皮炎等的治疗剂的光学活性萘化合物的工业上有利的方法。具体而言，本发明提供了一种光学活性萘化合物[I]的制造方法，其特征在于，在碱的存在下，使化合物[a-1]和化合物[b-1] 和由Pd化合物和叔膦配体组成的催化剂（步骤a）; 在氢供体和由钌化合物和手性配体制备的络合物的存在下，或者在光学活性的恶唑硼烷化合物（CBS催化剂）存在下，不对称地氢化化合物[c-1] 和硼氢化合物（步骤b）; 和用还原剂处理化合物[d-1]（步骤c）的步骤。（上式中，Ra和Rb表示相同或不同的低级烷基，X1表示卤素原子。）

2. 发明申请

US20140364659A1 PROCESS FOR THE CONVERSION OF ISOMERIC MIXTURE OF DICHLORODIPHENYL SULFONES TO CHLOROBENZENE 有权
标题翻译：二氯二苯醚等离子体混合物转化为氯仿的方法
公开(公告)号：US20140364659A1
公开(公告)日：2014-12-11
申请号：US14368955
申请日：2012-04-12
申请人： Hemant Ratanakar Bandodkar , Dilip Chandrakant Sawant
发明人： Hemant Ratanakar Bandodkar , Dilip Chandrakant Sawant
IPC分类号： C07C17/361
CPC分类号： C07C17/361 , C07C315/00 , C07C317/14 , C07C25/06
摘要： The invention relates to a process for the single step conversion of isomeric mixture of dichlorodipheriyi sulfones to chlorobenzene. The invention further relates a process of using dilute sulfuric acid and re-circulating the dilute sulfuric acid.
摘要翻译：本发明涉及一步法将二氯二苯代砜的异构体混合物转化为氯苯的方法。本发明还涉及使用稀硫酸并再循环稀硫酸的方法。

3. 发明申请

US20140135374A1 Opsin-Binding Ligands, Compositions and Methods of Use 有权
公开(公告)号：US20140135374A1
公开(公告)日：2014-05-15
申请号：US14126177
申请日：2012-06-13
申请人： David S. Garvey
发明人： David S. Garvey
IPC分类号： C07C255/56 , C07C49/792 , C07C25/13 , C07C25/06 , C07D333/16 , C07C255/53 , C07D307/46 , C07D333/22 , C07C33/34 , C07D307/42
CPC分类号： C07D333/22 , A61K31/045 , A61K31/12 , A61K31/277 , C07C25/06 , C07C25/13 , C07C25/18 , C07C33/14 , C07C33/34 , C07C33/50 , C07C43/23 , C07C49/792 , C07C49/813 , C07C49/84 , C07C255/53 , C07C255/56 , C07C259/18 , C07C2601/14 , C07C2601/16 , C07D307/42 , C07D307/46 , C07D333/16
摘要： Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.

4. 发明申请

US20110251398A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE 有权
标题翻译： ISOXAZOLINE-替代苄基化合物和杀虫剂
公开(公告)号：US20110251398A1
公开(公告)日：2011-10-13
申请号：US13166294
申请日：2011-06-22
申请人： Takeshi MITA , Takamasa KIKUCHI , Takashi MIZUKOSHI , Manabu YAOSAKA , Mitsuaki KOMODA
发明人： Takeshi MITA , Takamasa KIKUCHI , Takashi MIZUKOSHI , Manabu YAOSAKA , Mitsuaki KOMODA
IPC分类号： C07D261/04 , C07D413/10 , C07D413/14 , C07D413/04
CPC分类号： A61K31/421 , A01N43/80 , A61K9/0053 , C07C25/02 , C07C25/06 , C07C25/08 , C07C25/13 , C07C25/24 , C07C43/1742 , C07C43/1745 , C07C205/11 , C07C205/12 , C07C211/52 , C07C251/48 , C07C255/29 , C07C255/50 , C07C255/60 , C07C281/02 , C07C323/09 , C07D261/04 , C07D261/16 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07F7/0812
摘要： A 3,5-Bis (substituted aryl) substituted isoxazoline compound of formula (2) or a salt thereof: wherein A1 is a carbon atom or nitrogen atom; X1 is selected from the group consisting of a halogen atom, —SF5, C1-C6haloalkyl, hydroxy C1-C6haloalkyl, C1-C6alkoxy C1-C6haloalkyl, C1-C6haloalkoxy C1-C6haloalkyl, C3-C8halocycloalkyl, C1-C6haloalkoxy, C1-C3haloalkoxy C1-C3haloalkoxy, C1-C6haloalkylthio, C1-C6haloalkylsulfinyl and C1-C6haloalkylsulfonyl; X2 is selected from the group consisting of a halogen atom, cyano, nitro, C1-C6alkyl, C1-C6haloalkyl, —OR5, —OSO2R5 and —S(O)rR5; Y is selected from the group consisting of a halogen atom, cyano, nitro, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy, C1-C6alkylthio, C1-C6haloalkylthio, C1-C6alkylsulfonyl, C1-C6haloalkylsulfonyl, —NHR7 and —N(R7)R6; R is selected from the group consisting of a halogen atom, cyano, nitro, —NH2, halosulfonyloxy, C1-C6alkylsulfonyloxy, C1-C6haloalkylsulfonyloxy, phenylsulfonyloxy, phenylsulfonyloxy substituted with (Z)p1 and —C(O)Ra; m1 is an integer of 0 to 2; n is an integer of 0 or 1; p1 is an integer of 1 to 5; and r is an integer of 0 to 2.
摘要翻译：式（2）的3,5-双（取代的芳基）取代的异恶唑啉化合物或其盐：其中A1是碳原子或氮原子; X1选自卤素原子，-SF 5，C 1 -C 6卤代烷基，羟基C 1 -C 6卤代烷基，C 1 -C 6烷氧基C 1 -C 6卤代烷基，C 1 -C 6卤代烷氧基C 1 -C 6卤代烷基，C 3 -C 8卤代环烷基，C 1 -C 6卤代烷氧基，C 1 -C 3卤代烷氧基C1 C 3卤代烷氧基，C 1 -C 6卤代烷硫基，C 1 -C 6卤代烷基亚磺酰基和C 1 -C 6卤代烷基磺酰基; X 2选自卤素原子，氰基，硝基，C 1 -C 6烷基，C 1 -C 6卤代烷基，-OR 5，-OSO 2 R 5和-S（O）r R 5; Y选自卤素原子，氰基，硝基，C 1 -C 4烷基，C 1 -C 4卤代烷基，C 1 -C 4烷氧基，C 1 -C 4卤代烷氧基，C 1 -C 6烷硫基，C 1 -C 6卤代烷硫基，C 1 -C 6烷基磺酰基，C 1 -C 6卤代烷基磺酰基，-NHR 7 和-N（R 7）R 6; R选自卤素原子，氰基，硝基，-NH 2，卤代磺酰氧基，C 1 -C 6烷基磺酰氧基，C 1 -C 6卤代烷基磺酰氧基，苯基磺酰氧基，被（Z）p1和-C（O）Ra取代的苯基磺酰氧基; m1为0〜2的整数; n为0或1的整数; p1为1〜5的整数， r为0〜2的整数。

5. 发明申请

US20040150123A1 Method for carrying out the distillation or reactive distillation of a mixture containing at least one toxic constituent 有权
标题翻译：对含有至少一种有毒成分的混合物进行蒸馏或反应蒸馏的方法
公开(公告)号：US20040150123A1
公开(公告)日：2004-08-05
申请号：US10477466
申请日：2003-11-12
发明人： Eckhard Strofer , Gerd Kaibel , Achim Stammer , Carsten Oost , Martin Sohn , Manfred Stroezel , Walter Dobler
IPC分类号： F02M017/28 , B01D003/14 , B01D003/02 , B01D047/16 , F02M029/04 , F25J005/00 , F25J003/00
CPC分类号： B01D3/009 , B01J19/32 , B01J2219/3221 , B01J2219/32213 , B01J2219/32227 , B01J2219/32258 , B01J2219/32272 , B01J2219/32408 , B01J2219/32466 , B01J2219/3306 , B01J2219/3325 , C07C17/38 , C07C17/383 , C07C263/20 , Y02P20/127 , Y10S203/06 , Y10S203/11 , Y10S261/72 , C07C25/06 , C07C265/14
摘要： A process is proposed for the distillation or reactive distillation of a mixture that comprises at least one toxic component, the process being carried out in a column containing a structured packing, having at least one packing layer (1) having a lower end (2) and an upper end (3), the packing layer having an internal geometry varying over its height, in such a manner that in the distillation or reactive distillation, in a first, lower region (6) of the packing layer (1) a bubbling layer having a predominantly disperse gas phase can be established and simultaneously in a second, upper region (7) of the packing layer (1) a film flow having a predominantly continuous gas phase can be established.
摘要翻译：提出了一种包括至少一种有毒成分的混合物的蒸馏或反应蒸馏的方法，该方法在含有规整填料的塔中进行，该塔具有至少一个具有下端（2）的填料层（1）和上端（3），所述填充层具有在其高度上变化的内部几何形状，使得在所述蒸馏或反应蒸馏中，在所述填充层（1）的第一下部区域（6）中具有鼓泡可以建立具有主要分散气相的层，同时在填料层（1）的第二上部区域（7）中建立具有主要连续气相的膜流。

6. 发明授权

US3214482A Process for the halogenation of hydrocarbons 失效
标题翻译：烃的卤化方法
公开(公告)号：US3214482A
公开(公告)日：1965-10-26
申请号：US19933162
申请日：1962-06-01
申请人： PULLMAN INC
发明人： CAROPRESO FRANK E , CRADDOCK JOHN H , SPECTOR MARSHALL L
IPC分类号： B01J27/06 , C07C17/02 , C07C17/04 , C07C17/12 , C07C17/15 , C07C17/156 , C07C17/158 , C07C17/25 , C07C21/08
CPC分类号： B01J27/06 , B01J2219/00006 , C07C17/02 , C07C17/12 , C07C17/15 , C07C17/156 , C07C17/158 , C07C21/08 , C07C19/045 , C07C19/01 , C07C19/075 , C07C25/02 , C07C25/06 , C07C25/08

7. 发明授权

US3214481A Process for the halogenation of hydrocarbons 失效
公开(公告)号：US3214481A
公开(公告)日：1965-10-26
申请号：US19932962
申请日：1962-06-01
申请人： PULLMAN INC
发明人： HEINZ HEINEMANN , MILLER JR KENNETH D
IPC分类号： B01J27/06 , C07C17/02 , C07C17/04 , C07C17/12 , C07C17/15 , C07C17/156 , C07C17/158 , C07C17/25 , C07C21/08
CPC分类号： B01J27/06 , B01J2219/00006 , C07C17/02 , C07C17/12 , C07C17/15 , C07C17/156 , C07C17/158 , C07C21/08 , C07C19/045 , C07C19/01 , C07C19/075 , C07C25/02 , C07C25/06 , C07C25/08

8. 发明授权

US2974178A Liquid enrichment and/or separation by absorption processes 失效
标题翻译：通过吸收过程进行液体富集和/或分离
公开(公告)号：US2974178A
公开(公告)日：1961-03-07
申请号：US61577956
申请日：1956-10-15
申请人： ROHM & HAAS
发明人： HWA JESSE C H , MCBURNEY CHARLES H , MEITZNER ERICH F
IPC分类号： B01D15/04 , B01D15/08 , B01J20/22 , C02F1/28 , C07B61/00 , C07C7/12 , C07C17/38 , C07C45/79 , C07C67/48 , C07C201/16 , C08F36/20 , C10G25/02
CPC分类号： C10G25/02 , B01D15/08 , B01D15/265 , B01J20/22 , C07C7/12 , C07C17/38 , C07C17/389 , C07C29/76 , C07C29/82 , C07C45/79 , C07C45/84 , C07C67/56 , C07C201/16 , C07C253/34 , C07C2601/14 , C08F36/20 , C07C205/06 , C07C19/045 , C07C9/21 , C07C13/18 , C07C19/041 , C07C25/06 , C07C15/04 , C07C255/08 , C07C49/08 , C07C33/03 , C07C69/24 , C07C69/50
摘要： In a method of concentrating or separating a component of a homogenous liquid mixture of at least two substantially non-ionogenic compounds, at least one of which is organic, the mixture is contacted with a resin absorbent having a large surface area per unit weight, the resin absorbent being (a) a crosslinked addition polymer other than an ionexchange resin, (b) insoluble in the liquid mixture and (c) having a preferential absorptive capacity for the component to be concentrated. Absorption may be tested for by agitating the resin with a mixture for a given time and analysing the mixture before and after absorption. The separatory capacity of a resin is defined as where m is the weight of the resin in grams, V is the volume of liquid mixture added in ml., and c0 and c are the volume fractions of the preferentially absorbed component in the liquid phase before and after absorption respectively. Separatory capacities of various specified resins are given for each of the following in admixture with iso-octane: 4-vinylcyclohexene, cyclohexanol, toluene, ethyl acetate, methyl ethyl ketone, styrene, chlorobenzene, ethylene dichloride, chloroform, dioxane, pyridine, naphthalene, nitrobenzene and pyrrole; for each of ethylene dichloride, styrene, and chlorobenzene in admixture with toluene; and for the first named component of each of the following mixtures: ethylene dichloride-ethyl acetate, styrene-4-vinylcyclohexene, chlorobenzene-allyl alcohol, benzene-acrylonitrile, allyl alcohol-water, chloroform-acetone. The treatment of hydrocarbon mixtures such as paraffin/naphthene, olefin/paraffin and solvent mixtures containing alcohols, ketones, hydrocarbons and esters; and also mixtures of capryl alcohol with methyl hexyl ketone and n-butanol with water is referred to. The absorption process can be carried out batchwise or continuously. In the former the liquid mixture is passed through a column packed with resin particles, or the resin particles may pass countercurrent to the liquid. When a two-component mixture A and B, of which A is preferentially absorbed, is passed over the resin, B issues first from the resin until the limit of the absorption capacity for A is reached, after which the original mixture A and B will issue. Enriched A is separated from the resin e.g. by heat, steam distillation, extraction or desorption with another solvent. In the continuous treatment the use of a desorbent C allows complete separation of A and B, and the resin supported in a column is fed alternately with liquid mixture and with desorbent. The desorbent consists of one or more liquids, is completely miscible with A and B, and has a swelling power for the resin of the same order as that of one of the components of the liquid mixture to be separated. Examples describe batch methods for partially separating tolueneiso-octane, dimethyl sebacate-iso-octane, methyl caprate-iso-octane, ethylene dichloride-cyclohexane mixtures using copolymers of divinyl benzene with 2-ethylhexyl acrylate, n-butyl acrylate, n-butyl methacrylate, ethoxyethyl acrylate, and methyl acrylate as absorbents. Examples also describe continuous methods for completely separating toluene from isooctane using n-pentane as desorbent; dimethyl sebacate from methyl stearate and/or methyl caprate using iso-octane as desorbent; ethylene dichloride from cyclohexane and chloroform from acetone using toluene as desorbent in each case; also chlorobenzene from allyl alcohol, benzene from acrylonitrile, and nitrobenzene from iso-octane using as desorbents methanol, methylene dichloride and benzene respectively. Resins used in the examples of continuous methods are n-butyl and methyl acrylates copolymerized with divinylbenzene. Specifications 786,755, 846,890 and 858,865 are referred to.ALSO:In a method of concentrating or separating a component of a homogeneous liquid mixture of at least two substantially non-ionogenic compounds, at least one of which is organic, the mixture is contacted with a resin absorbent having a large surface area per unit weight, the resin absorbent being (a) a cross-linked addition polymer other than an ion-exchange resin, (b) insoluble in the liquid mixture and (c) having a preferential absorptive capacity for the component to be concentrated. Absorption may be tested for by agitating the resin with a mixture for a given time and analysing the mixture before and after absorption. The separatory capacity of a resin is defined as where m is the weight of the resin in grams, V is the volume of liquid mixture added in ml., and Co and C are the Volume fractions of the preferentially absorbed component in the liquid phase before and after absorption respectively. Separatory capacities of various specified resins are given for each of the following in admixture with iso-octane: 4-vinylcyclohexene, cyclohexanol, toluene, ethyl acetate, methylethylketone, styrene, chlorobenzene, ethylene dichloride, chloroform dioxane, pyridine, naphthalene, nitrobenzene, and pyrrole; for each of ethylene dichloride, styrene, and chlorobenzene in admixture with toluene; and for the first named component of each of the following mixtures: ethylene dichloride-ethyl acetate, styrene, 4-vinylcyclohexene, chlorobenzene-allyl alcohol, benzene-acrylonitrile, allyl alcohol-water, chloroform-acetone. The treatment of hydrocarbon mixtures such as paraffin/naphthene, olefin/paraffin and solvent mixtures containing alcohols. Ketones, hydrocarbons and esters; and also mixtures of capryl alcohol with methylhexyl ketone and n-butanol with water is referred to. The absorption process can be carried out batchwise or continuously. In the former the liquid mixture is passed through a column packed with resin particles, or the resin particles may pass countercurrent to the liquid. When a two-component mixture A and B, of which A is preferentially absorbed, is passed over the resin, B issues first from the resin until the limit of the absorption capacity for A is reached, after which the original mixture A and B will issue. Enriched A is separated from the resin e.g. by heat, steam distallition, extraction or desorption with another solvent. In the continuous treatment the use of a desorbent C allows complete separation of A and B and the resin supported in a column is fed alternately with liquid mixture and with desorbent. The desorbent consists of one or more liquids, is completely miscible with A and B, and has a swelling power for the resin of the same order as that of one of the components of the liquid mixture to be separated. Examples describe batch methods for partially separating toluene-iso - octane, dimethyl sebacate-iso-octane, p methyl caprate-iso-octane, ethylene dichloride-cyclohexane mixtures using copolymers of divinyl benzene with 2-ethylhexyl acrylate, n-butyl acrylate, n-butyl methacrylate, ethoxy-ethyl acrylate, and methyl acrylate as absorbents. Examples also describe continuous methods for completely separating toluene from iso-octane using n-pentane as desorbent: dimethyl sebacate from methyl stearate and/or methyl caprate using iso-octane as desorbent; ethylene dichloride from cyclohexane and chloroform from acetone using toluene as desorbent in each case; also chlorobenzene from allyl alcohol, benzene from acrylonitrile, and nitrobenzene from iso-octane using as desorbents methanol, methylene dichloride and benzene respectively. Resins used in the examples of continuous methods are n-butyl and methyl acrylates copolymerized with divinyl-benzene. Specifications 786,755, 846,890 and 858,865 are referred to.

9. 发明授权

US2174574A Process for the production of nitrates and chlorinated organic compounds 失效
标题翻译：生产硝酸盐和氯化有机化合物的方法
公开(公告)号：US2174574A
公开(公告)日：1939-10-03
申请号：US12482037
申请日：1937-02-09
申请人： SOLVAY PROCESS CO
发明人： FARTHING FOGLER MAYOR
IPC分类号： C07B39/00 , C07C17/12
CPC分类号： C07B39/00 , C07C17/12 , C07C25/06

10. 发明授权

US2168260A Process of preparing monohalogenation products 失效
标题翻译：制备单卤素产物的方法
公开(公告)号：US2168260A
公开(公告)日：1939-08-01
申请号：US10891036
申请日：1936-11-02
申请人： IG FARBENINDUSTRIE AG
发明人： PAUL HEISEL , ALBERT HENDSCHEL
IPC分类号： C07B39/00 , C07C17/10
CPC分类号： C07C17/10 , C07B39/00 , C07C23/10 , C07C25/06 , C07C19/01

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