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1. 发明申请

US20170057937A1 Process for the preparation of Efavirenz and devices suitable therefore 有权
标题翻译：因此制备依法韦仑和装置的方法
公开(公告)号：US20170057937A1
公开(公告)日：2017-03-02
申请号：US14837500
申请日：2015-08-27
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
发明人： Camille A. Correia , Kerry Gilmore , David Tyler McQuade , Peter H. Seeberger
IPC分类号： C07D265/18 , B01J19/00 , C07C33/50 , C07C29/00 , C07C29/68 , C07C45/00 , C07C265/12 , C07F1/08
CPC分类号： C07D265/18 , B01J19/0093 , B01J2219/00792 , B01J2219/00795 , B01J2219/0081 , B01J2219/00813 , B01J2219/00833 , B01J2219/00835 , B01J2219/0086 , B01J2219/00867 , B01J2219/00873 , B01J2219/00889 , B01J2219/00894 , B01J2219/00963 , C07C29/00 , C07C29/42 , C07C29/68 , C07C33/50 , C07C45/00 , C07C45/46 , C07C265/12 , C07C2601/02 , C07F1/08 , C07C49/80
摘要： The invention relates to a process for the preparation of Efavirenz via an efficient transition metal catalyzed cyclization, to a device suitable to perform such process as well as to novel intermediates.
摘要翻译：本发明涉及通过有效的过渡金属催化环化制备依法韦仑的方法，涉及适用于进行这种方法的装置以及新型中间体。

2. 发明授权

US09211518B2 Process and apparatus for production and filtration of aminoalcohols using a continuous stirred tank slurry reactor 有权
标题翻译：使用连续搅拌釜淤浆反应器生产和过滤氨基醇的方法和装置
公开(公告)号：US09211518B2
公开(公告)日：2015-12-15
申请号：US14128398
申请日：2012-06-08
申请人： Michael D. Major , John D. Gummere
发明人： Michael D. Major , John D. Gummere
IPC分类号： B01J8/22 , C07C213/02 , C07C209/52 , B01J8/00 , B01J8/18 , C07C29/68 , C07C29/151
CPC分类号： B01J8/228 , B01J8/006 , B01J8/1809 , B01J8/222 , C07C29/151 , C07C29/68 , C07C209/52 , C07C213/02 , C07C2601/16 , C07C215/08 , C07C211/48 , C07C35/46
摘要： Disclosed are processes and apparatuses for producing a reaction product and enabling the reaction product to be removed from a reactor operating at an elevated pressure, while simultaneously maintaining the gas pressure and retaining the catalyst inside the apparatus.
摘要翻译：公开了用于生产反应产物的方法和装置，并且能够使反应产物从在高压下操作的反应器中除去，同时保持气体压力并将催化剂保持在设备内。

3. 发明授权

US09206100B2 Route to synthetic analogues of Rocaglamide and Aglafoline using cascade transformations initiated by oxy-cope rearrangement of bis-alkynes 有权
标题翻译：使用由双 - 炔的氧基 - 重排排列引发的级联转化，路由到罗格列酰胺和阿格拉福林的合成类似物
公开(公告)号：US09206100B2
公开(公告)日：2015-12-08
申请号：US13820176
申请日：2011-09-13
申请人： Igor Alabugin , Runa Pal
发明人： Igor Alabugin , Runa Pal
IPC分类号： C07C45/61 , C07C29/68 , C07C41/30 , C07C41/32 , C07C45/51 , C07C45/68 , C07F7/08
CPC分类号： C07C29/68 , C07C41/30 , C07C41/32 , C07C45/511 , C07C45/68 , C07C2601/10 , C07F7/083 , C07C33/28 , C07C33/486 , C07C49/798 , C07C49/747 , C07C43/1788 , C07C49/84 , C07C49/753
摘要： A method for preparing a cyclobutene compound or a cyclopentenone is provided. The method comprises contacting an α,β-diketone with a metal acetylide at a temperature below 0° C. to thereby form a reaction mixture comprising a bis-alkyne precursor. The bis-alkyne precursor rearranges into a bis-allenic intermediate, which undergoes further rearrangement into the cyclobutene compound or the cyclopentenone compound as the temperature of the reaction mixture increases from below 0° C. to above 0° C.
摘要翻译：提供了制备环丁烯化合物或环戊烯酮的方法。该方法包括在低于0℃的温度下使α和bgr-二酮与金属乙炔化物接触，从而形成包含双炔前体的反应混合物。双炔前体重新排列成双 - 烯类中间体，当反应混合物的温度从0℃升至0℃以上时，其进一步重排成环丁烯酮化合物或环戊烯酮化合物。

4. 发明申请

US20050222430A1 Process for preparing amines 失效
标题翻译：制备胺的方法
公开(公告)号：US20050222430A1
公开(公告)日：2005-10-06
申请号：US11079167
申请日：2005-03-15
申请人： Keisuke Yaegashi , Masafumi Mikami
发明人： Keisuke Yaegashi , Masafumi Mikami
IPC分类号： C07C209/68 , C07C213/00 , C07C213/08 , C07C215/08 , C07D207/12 , C07D27/12 , C07C29/68
CPC分类号： C07D207/12 , C07C213/00 , C07C215/08
摘要： A process for preparing an amine which comprises in preparing an amine by decarboxylating an α-amino acid under heating in a high boiling liquid polymer having average molecular weight 200 to 6000, and directly recovering this amine by distillation in the same reaction system, namely in one pot.
摘要翻译：一种制备胺的方法，其包括通过在平均分子量为200至6000的高沸点液体聚合物中加热使α-氨基酸脱羧制备胺，并通过在相同的反应体系中蒸馏直接回收该胺，即在一壶

5. 发明授权

US4667045A Organosalts of metalate anions and process for the production of alkylene glycols therewith 失效
标题翻译：金属盐阴离子的有机金属及其生产亚烷基二醇的方法
公开(公告)号：US4667045A
公开(公告)日：1987-05-19
申请号：US594264
申请日：1984-03-28
申请人： John R. Briggs , John H. Robson
发明人： John R. Briggs , John H. Robson
IPC分类号： C07C27/00 , C07C29/09 , C07C29/68 , C07C31/20 , C07C31/28 , C07C67/00 , C07F9/00 , C07F9/54 , C07F11/00 , C07F13/00
CPC分类号： C07F11/005 , C07C29/09 , C07C29/68 , C07C31/28 , C07F13/005 , C07C2101/14
摘要： Novel vicinal dioxyalkylene organometalates comprising a cation having a hydrocarbyl-containing substituent are disclosed. The vicinal dioxyalkylene organometalates can be reacted with water to yield alkylene glycols.
摘要翻译：公开了包含具有含烃基的取代基的阳离子的新颖的邻位二氧亚烷基有机金属盐。邻位二氧亚烷基有机金属盐可以与水反应得到亚烷基二醇。

6. 发明授权

US4663439A Process for the preparation of ceric alkoxides 失效
标题翻译：制备二氧化铈的方法
公开(公告)号：US4663439A
公开(公告)日：1987-05-05
申请号：US674640
申请日：1984-11-26
申请人： Peter S. Gradeff , Fred G. Schreiber
发明人： Peter S. Gradeff , Fred G. Schreiber
IPC分类号： C07C29/68 , C07C27/00 , C07C29/70 , C07C31/28 , C07C67/00 , C07F5/00
CPC分类号： C07C29/70 , C07C31/28 , C07F5/003
摘要： A process is provided for preparing ceric alkoxides, which comprises reacting ceric ammonium nitrate complexed with and in solution in ethylene or propylene glycol ether or tetrahydrofuran with an anhydrous alkali metal alkoxide at a temperature within the range from about -30.degree. C. to about 200.degree. C., preferably from 0.degree. to about 150.degree. C., until ceric alkoxide and the nitrate salt of the base are formed; the nitrate formed during the reaction is insoluble in the glycol ether and tetrahydrofuran and can be separated from the reaction mixture, and the cerium alkoxide when soluble in the glycol ether or tetrahydrofuran can be isolated from the solution pure, or as the complex with the alcohol or with the solvent, or in some cases the alkoxide can be used without separation from the reaction mixture in the presence of the nitrate.
摘要翻译：提供了一种制备二氧化铈的方法，其包括使与乙烯或丙二醇醚或四氢呋喃中的溶液中的和硝酸铈配合的硝酸铈铵与无水碱金属醇盐在约-30℃至约200℃的温度下反应优选0℃至约150℃，直到形成了铈醇盐和碱的硝酸盐; 反应过程中形成的硝酸盐不溶于乙二醇醚和四氢呋喃，可与反应混合物分离，可溶于乙二醇醚或四氢呋喃中的醇盐可以从溶液中纯化，或作为与醇的络合物或在一些情况下，在硝酸盐存在下，可以不用分离反应混合物使用醇盐。

7. 发明授权

US4377714A Methyl substituted oxobicyclo-4,4,0-decane derivatives, process for preparing same and organoleptic uses thereof 失效
标题翻译：甲基取代的氧代二环-4,4,0癸烷衍生物，其制备方法和感官用途
公开(公告)号：US4377714A
公开(公告)日：1983-03-22
申请号：US313931
申请日：1981-10-22
申请人： Takao Yoshida
发明人： Takao Yoshida
IPC分类号： A24B15/34 , C07C29/17 , C07C29/68 , C07C35/36 , C07C45/62 , C07C45/69 , C07C49/447 , C07C49/637 , C07F3/00 , C11B9/00 , C07C29/136
CPC分类号： C11B9/0053 , A24B15/34 , C07C29/172 , C07C29/68 , C07C35/36 , C07C45/62 , C07C45/69 , C07C49/447 , C07C49/637 , C07F3/003 , C07B2200/09 , C07C2102/28
摘要： Described are compounds having the generic structure: ##STR1## wherein the dashed line represents a carbon-carbon single bond or a carbon-carbon double bond; wherein X represents the moieties: ##STR2## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent hydrogen or methyl with the proviso that (i) at least three of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent hydrogen and (ii) when the dashed line is a carbon-carbon single bond and X is: ##STR3## then one of R.sub.1, R.sub.2, R.sub.3 or R.sub.4 is methyl and the other represents hydrogen; wherein R.sub.5 represents hydrogen, MgX, MgR.sub.7, CdR.sub.7, ZnR.sub.7, Na, K or Li; wherein X represents Chloro, Bromo or Iodo; wherein R.sub.6 represents hydrogren or methyl; and wherein R.sub.7 represents lower alkyl; and uses thereof for their organoleptic properties in augmenting or enhancing or enhancing the aromas or tastes of perfumes, perfumed articles, foodstuffs, chewing gums, smoking tobaccos, toothpastes, medicinal products, chewing tobacco and smoking tobacco articles, as well as processes for preparing same.
摘要翻译：描述的是具有通用结构的化合物：其中虚线表示碳 - 碳单键或碳 - 碳双键; 其中X表示部分：其中R 1，R 2，R 3和R 4表示氢或甲基，条件是（i）R 1，R 2，R 3和R 4中的至少3个表示氢，和（ii）虚线是碳 - 碳单键，X是：其中R1，R2，R3或R4之一是甲基，另一个代表氢; 其中R5表示氢，MgX，MgR7，CdR7，ZnR7，Na，K或Li; 其中X表示氯，溴或碘; 其中R6代表氢原子或甲基; 并且其中R 7表示低级烷基; 以及其用于增强或增强香料，香料，食品，口香糖，吸烟烟草，牙膏，药用产品，咀嚼烟草和烟草制品的香气或口味的感官特性，以及其制备方法。

8. 发明授权

US4375005A Branched chain olefinic alcohols, thiols, esters and ethers, organoleptic uses thereof, processes for preparing same and intermediates therefor 失效
公开(公告)号：US4375005A
公开(公告)日：1983-02-22
申请号：US322734
申请日：1981-11-19
申请人： Richard M. Boden
发明人： Richard M. Boden
IPC分类号： C07C29/40 , C07C29/68 , C07C33/025 , C07C33/03 , C07C45/46 , C11B9/00 , C11D3/50
CPC分类号： C11D3/50 , C07C29/40 , C07C29/68 , C07C33/025 , C07C33/03 , C07C45/455 , C11B9/0015
摘要： Described are compounds defined according to the structure: ##STR1## taken alone or in admixture wherein one of the dashed lines is a carbon-carbon double bond and each of the other of the dashed lines are carbon-carbon single bonds; wherein R.sub.1 represents C.sub.1 -C.sub.4 alkyl; R.sub.2 represents C.sub.1 -C.sub.4 alkyl; Z represents oxygen or sulfur; R.sub.3 represents hydrogen, MgX, Li, C.sub.1 -C.sub.3 lower alkyl or C.sub.1 -C.sub.3 lower acyl; and wherein X represents chloro, bromo or iodo and uses thereof in augmenting or enhancing the aroma and/or taste of consumable materials such as perfume compositions, colognes, perfumed articles, e.g., solid or liquid anionic, cationic, nonionic or zwitterionic detergents, fabric softener compositions or dryer-added fabric softener articles, smoking tobaccos, chewing gums, chewing tobaccos, medicinal products or toothpastes. Also described are processes for preparing such compounds hereinafter described as branched chain olefinic alcohols, thiols, esters and ethers.

9. 发明授权

US4278098A 2,6,6-Trimethyl-.alpha.-(iso)propenyl-1-cyclohexene-1-methanols and -1,3-cyclohexadiene-1-methanols and organoleptic uses thereof 失效
标题翻译： 2,6,6-三甲基-α-（异）丙烯-1-环己烯-1-甲醇和1,3-环己二烯-1-甲醇及其感官用途
公开(公告)号：US4278098A
公开(公告)日：1981-07-14
申请号：US119858
申请日：1980-02-08
申请人： Richard A. Wilson , William L. Schreiber , Braja D. Mookherjee , Jacob Kiwala , Joaquin F. Vinals , Manfred H. Vock , Gilbert Stork , Frederick L. Schmitt
发明人： Richard A. Wilson , William L. Schreiber , Braja D. Mookherjee , Jacob Kiwala , Joaquin F. Vinals , Manfred H. Vock , Gilbert Stork , Frederick L. Schmitt
IPC分类号： A24B15/30 , A24B15/34 , C07C29/09 , C07C29/40 , C07C29/68 , C07C33/14 , C11B9/00 , A24B3/12 , A24B15/36
CPC分类号： C11B9/0034 , A24B15/34 , C07C29/09 , C07C29/40 , C07C29/68 , C07C33/14 , C07C403/08 , C07B2200/09 , C07C2101/16
摘要： Processes and compositions are described for use in foodstuff, chewing gum, toothpaste and medicinal product flavor and aroma, smoking tobacco flavor and aroma and perfume and perfumed article aroma augmenting, enhancing and imparting compositions; and as foodstuff, chewing gum, toothpaste, medicinal product, smoking tobacco, perfume and perfumed article aroma and/or flavor imparting materials of 2,6,6-trimethyl-.alpha.-(iso)propenyl-1-cyclohexene-1-methanol and -1,3-cyclohexadiene-1-methanol derivatives or one or more of their geometric or stereoisomers as defined by the generic structure: ##STR1## wherein one of R.sub.1, R.sub.2 or R.sub.3 is methyl and the other two of R.sub.1, R.sub.2 and R.sub.3 represents hydrogen; the dashed line is a carbon-carbon double bond or a carbon-carbon single bond; with the proviso that when R.sub.1 is hydrogen, the dashed line is a carbon-carbon double bond.Addition of one or more of the 2,6,6-trimethyl-.alpha.-(iso)propenyl-1-cyclohexene-1-methanols or -1,3-cyclohexadiene-1-methanols of our invention to consumable materials is indicated to produce:A. In foodstuffs, chewing gums, toothpastes and medicinal products, sweet, camphoraceous, damascenone, raspberry-like, raspberry juice-like, rosey, woody/ionone-like, oriental, tobacco-like, tea-like, grape-like, fruity and ionone-like aromas and flavor notes;B. In perfumes, colognes and perfumed articles, leathery, hay, woody, mustard, minty, spicey (clove) and pulegone-like aromas and hay/tobacco and honey ionone-like topnotes with safronal-like nuances; andC. In tobaccos and tobacco flavors, a sweet-musty, hay-tobacco-like, fruity-raspberry, ionone-like aroma prior to smoking and a fruity tobacco-like, Virginia tobacco-like aroma on smoking both in the main stream and in the side stream.
摘要翻译：描述了用于食品，口香糖，牙膏和药用产品风味和香气，吸烟烟草风味和香气以及香料和香料制品香气增强，增强和赋予组合物的方法和组合物; 以及2,6,6-三甲基-α-（异）丙烯基-1-环己烯-1-甲醇的食品，口香糖，牙膏，药用产品，吸烟烟草，香料和香料制品香气和/或调味材料，以及 -1,3-环己二烯-1-甲醇衍生物或其一般结构定义的其几何或立体异构体中的一种或多种：其中R 1，R 2或R 3中的一个为甲基，R 1，R 2和R 3中的另外两个为表示氢; 虚线是碳 - 碳双键或碳 - 碳单键; 条件是当R1是氢时，虚线是碳 - 碳双键。将本发明的一种或多种2,6,6-三甲基-α-（异）丙烯-1-环己烯-1-甲醇或-1,3-环己二烯-1-甲醇添加到消耗材料中被指示产生：A.在食品，口香糖，牙膏和药用产品中，甜，樟脑，大马士革，覆盆子样，覆盆子汁，玫瑰，木/紫罗兰酮样，东方，烟草状，茶状，葡萄状，水果和紫罗兰酮样香气和风味香气; B.香水，古龙水和香水制品，革质，干草，木质，芥末，小茴香，香料（丁香）和香菇样香气和干草/烟草和蜂蜜类似紫罗兰酮的顶峰，具有丰富的细微差别; 在烟草和烟草香料中，在吸烟之前是一种甜味，干草烟样，果香 - 覆盆子，类胡萝卜素的香气，并且在主流中吸烟时具有类似烟草般的弗吉尼亚烟草样香气并在旁边的流。

10. 发明授权

US4275087A Flavoring with 2,6,6-trimethyl-.alpha.-propenyl-1,3-cyclohexadiene-1-methanol substances 失效
标题翻译：用2,6,6-三甲基-α-丙烯基-1,3-环己二烯-1-甲醇物质调味
公开(公告)号：US4275087A
公开(公告)日：1981-06-23
申请号：US120102
申请日：1980-02-08
申请人： Richard A. Wilson , William L. Schreiber , Braja D. Mookherjee , Jacob Kiwala , Joaquin F. Vinals , Manfred H. Vock , Gilbert Stork , Frederick L. Schmitt
发明人： Richard A. Wilson , William L. Schreiber , Braja D. Mookherjee , Jacob Kiwala , Joaquin F. Vinals , Manfred H. Vock , Gilbert Stork , Frederick L. Schmitt
IPC分类号： A23L27/20 , A24B15/34 , C07C29/09 , C07C29/40 , C07C29/68 , C07C33/14 , C11B9/00 , A23L1/226 , A23L1/235
CPC分类号： C11B9/0034 , A24B15/34 , C07C29/09 , C07C29/40 , C07C29/68 , C07C33/14 , C07C403/08 , C07B2200/09 , C07C2101/16
摘要： Processes and compositions are described for use in foodstuff, chewing gum, toothpaste and medicinal product flavor and aroma, smoking tobacco flavor and aroma and perfume and perfumed article aroma augmenting, enhancing and imparting compositions; and as foodstuff, chewing gum, toothpaste, medicinal product, smoking tobacco, perfume and perfumed article aroma and/or flavor imparting materials of 2,6,6-trimethyl-.alpha.-(iso)propenyl-1-cyclohexene-1-methanol and -1,3-cyclohexadiene-1-methanol derivatives or one or more of their geometric or stereoisomers as defined by the generic structure: ##STR1## wherein one of R.sub.1, R.sub.2 or R.sub.3 is methyl and the other two of R.sub.1, R.sub.2 and R.sub.3 represents hydrogen; the dashed line is a carbon-carbon double bond or a carbon-carbon single bond; with the proviso that when R.sub.1 is hydrogen, the dashed line is a carbon-carbon double bond.
摘要翻译：描述了用于食品，口香糖，牙膏和药用产品风味和香气，吸烟烟草风味和香气以及香料和香料制品香气增强，增强和赋予组合物的方法和组合物; 以及2,6,6-三甲基-α-（异）丙烯基-1-环己烯-1-甲醇的食品，口香糖，牙膏，药用产品，吸烟烟草，香料和香料制品香气和/或调味材料，以及 -1,3-环己二烯-1-甲醇衍生物或其一般结构定义的其几何或立体异构体中的一种或多种：其中R 1，R 2或R 3中的一个为甲基，R 1，R 2和R 3中的另外两个为表示氢; 虚线是碳 - 碳双键或碳 - 碳单键; 条件是当R1是氢时，虚线是碳 - 碳双键。

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