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1. 发明申请

US20210221769A1 METHOD FOR PREPARING PERFLUOROALKYL SULFINATE ESTER 有权
公开(公告)号：US20210221769A1
公开(公告)日：2021-07-22
申请号：US17205937
申请日：2021-03-18
申请人： SOOCHOW UNIVERSITY
发明人： Xiaobing WAN , Hanghang WANG
IPC分类号： C07C313/04
摘要： The present invention discloses a method for preparing a perfluoroalkyl sulfinate ester. The method includes reacting an α-carbonyldiazo compound and a sodium perfluoroalkyl sulfinate, in an organic solvent, in the presence of anhydrous copper acetate as an optimal catalyst and tert-butyl hydroperoxide (TBHP) as a green oxidant, to obtain the perfluoroalkyl sulfinate ester. Compared to the prior art, the present method has the advantages of a wide range of reaction substrates, a short reaction time, a high reaction yield, and mild reaction conditions. The reaction does not require pre-activation of sodium perfluoroalkyl sulfinate, which can participate in the reaction directly, making reaction operations simple. The present method uses TBHP as a green oxidant and produces tert-butanol and water after reaction. Moreover, the present method avoids using a bromide or a chloride as a reaction material, and thus avoids formation of a large amount of a halide salt.

2. 发明申请

US20190084925A1 METHOD FOR PREPARING OXYSULPHIDE AND FLUORINATED DERIVATIVES IN THE PRESENCE OF AN ORGANIC SOLVENT 审中-公开
公开(公告)号：US20190084925A1
公开(公告)日：2019-03-21
申请号：US15534083
申请日：2015-12-07
申请人： RHODIA OPERATIONS
发明人： Valery DAMBRIN , Denis REVELANT
IPC分类号： C07C303/32 , C07C313/04 , C07C303/22 , C07C303/00
摘要： The present invention concerns a method for preparing an oxysulphide and fluorinated derivative of formula (III) Ea-SO3R (III) that comprises bringing a compound of formula (II) Ea-SOOR (II)—Ea representing the fluorine atom or a group having 1 to 10 carbon atoms chosen from the fluoroalkyls, the perfluoroalkyls and the fluoroalkenyls; and—R representing hydrogen, a monovalent cation or an alkyl group; into contact, in the presence of a polar aprotic organic solvent, with an oxidising agent.

3. 发明授权

US09610257B2 Small molecule xanthine oxidase inhibitors and methods of use 有权
公开(公告)号：US09610257B2
公开(公告)日：2017-04-04
申请号：US14483055
申请日：2014-09-10
申请人： Baylor College of Medicine
发明人： Changyi Chen , Jian-Ming Lu , Qizhi Yao
IPC分类号： A61K31/11 , C07C205/44 , A61K31/185 , A61K31/277 , A61K45/06 , C07C255/56 , C07C309/44 , C07C317/22 , A61K31/519 , C07C47/544 , C07C47/565 , C07C255/57 , C07C47/54 , C07C313/04 , A61K9/00
CPC分类号： A61K31/11 , A61K9/0053 , A61K31/185 , A61K31/277 , A61K31/519 , A61K45/06 , C07C47/54 , C07C47/544 , C07C47/565 , C07C205/44 , C07C255/56 , C07C255/57 , C07C309/44 , C07C313/04 , C07C317/22
摘要： Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.

4. 发明授权

US09464087B2 Difluoromethylation of unsaturated compounds 有权
标题翻译：不饱和化合物的二氟甲基化
公开(公告)号：US09464087B2
公开(公告)日：2016-10-11
申请号：US14363974
申请日：2012-11-27
申请人： The Scripps Research Institute
发明人： Phil S. Baran , Janice Akemi Dixon , Ryan Baxter , Yuta Fujiwara
IPC分类号： C07C313/04 , C07F3/06 , C07D473/04 , C07B37/02 , C07B39/00 , C07D233/84 , C07D263/58 , C07D277/74
CPC分类号： C07D473/04 , C07B37/02 , C07B39/00 , C07C313/04 , C07D233/84 , C07D263/58 , C07D277/74
摘要： A reagent for carrying out a difluoromethylation reaction of unsaturated compounds and ring-nitrogen-containing aromatic compounds, a zinc difluoro-methanesulfinate, as well as a method for making the reagent and a method for its use are disclosed.
摘要翻译：公开了用于进行不饱和化合物和含环氮的芳族化合物的二氟甲基化反应的试剂，二氟 - 甲烷亚磺酸锌，以及制备该试剂的方法及其使用方法。

5. 发明申请

US20160280639A1 ANTIBACTERIAL AGENTS 有权
标题翻译：抗菌剂
公开(公告)号：US20160280639A1
公开(公告)日：2016-09-29
申请号：US15179751
申请日：2016-06-10
申请人： Achaogen, Inc.
发明人： Brian D. Patterson , Qing Lu , James Bradley Aggen , Paola Dozzo , Ramesh Annasaheb Kasar , Martin Sheringham Linsell , Timothy Robert Kane , Micah James Gliedt , Darin James Hildebrandt , Glenn A. McEnroe , Frederick Cohen
IPC分类号： C07C259/06 , C07D213/81 , C07D213/64 , C07C313/04 , C07C317/28 , C07D333/70 , C07D471/04 , C07C323/42
CPC分类号： C07C259/06 , C07C313/04 , C07C313/12 , C07C317/28 , C07C317/46 , C07C317/50 , C07C323/42 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/64 , C07D213/79 , C07D213/81 , C07D333/70 , C07D471/04
摘要： Antibacterial compounds of formula (I) are provided: as well as stereoisomers and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.
摘要翻译：以及立体异构体及其药学上可接受的盐; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 以及这些化合物的制备方法。

6. 发明授权

US09073828B2 Preparation method for perfluoroalkane sulfinate 有权
标题翻译：全氟烷基亚磺酸盐的制备方法
公开(公告)号：US09073828B2
公开(公告)日：2015-07-07
申请号：US13574138
申请日：2011-03-03
申请人： Takashi Kashiwaba , Tsutomu Nanmyo , Yoichi Takenaka
发明人： Takashi Kashiwaba , Tsutomu Nanmyo , Yoichi Takenaka
IPC分类号： C07C313/04
CPC分类号： C07C313/04
摘要： In a method for obtaining an alkali metal perfluoroalkanesulfinate by reacting a perfluoroalkanesulfonyl halide with a sulfur-containing reducing agent in the presence of water, a reaction liquid containing the alkali metal sulfinate obtained after the reaction is concentrated till a specific concentration, thereby inorganic salts, which are impurities in the solution, are precipitated and removed, and a filtrate after removing the inorganic salts is subjected to an operation such as concentration and drying, thereby obtaining the target alkali metal perfluorosulfinate with a high purity and a good operability. Furthermore, an organic solvent for extraction becomes unnecessary. Therefore, it is possible to greatly reduce wastes.
摘要翻译：在通过使全氟烷基磺酰卤与含硫还原剂在水的存在下反应来获得全氟烷基亚磺酸碱金属的方法中，将反应后得到的含有碱金属亚磺酸盐的反应液浓缩至特定浓度，将溶液中的杂质析出除去，除去无机盐后的滤液进行浓缩干燥等操作，得到纯度高，操作性好的目标碱金属全氟亚磺酸酯。此外，不需要用于萃取的有机溶剂。因此，可以大大减少废物。

7. 发明授权

US08946465B2 Preparation of oligomers and co-oligomers of highly fluorinated sulfinic acids and salts thereof 有权
标题翻译：制备高度氟化亚磺酸的低聚物和共低聚物及其盐
公开(公告)号：US08946465B2
公开(公告)日：2015-02-03
申请号：US13994819
申请日：2011-12-13
申请人： Miquel A. Guerra , Gregg D. Dahlke , Denis Duchesne , Tatsuo Fukushi , Werner M. A. Grootaert , Zai-Ming Qiu
发明人： Miquel A. Guerra , Gregg D. Dahlke , Denis Duchesne , Tatsuo Fukushi , Werner M. A. Grootaert , Zai-Ming Qiu
IPC分类号： C07C313/04 , C08G75/00 , C07C303/22 , C08F214/18
CPC分类号： C08G75/00 , C07C303/22 , C07C313/04 , C08F214/18 , C07C309/82
摘要： There is provided a method for preparing oligomers and co-oligomers of highly fluorinated sulfuric acids and salts thereof.
摘要翻译：提供了制备高度氟化亚磺酸及其盐的低聚物和共低聚物的方法。

8. 发明申请

US20110224427A1 SYSTEMS FOR CARBON DIOXIDE AND SULFUR DIOXIDE REMOVAL 有权
标题翻译：二氧化碳和二氧化硫去除系统
公开(公告)号：US20110224427A1
公开(公告)日：2011-09-15
申请号：US13045578
申请日：2011-03-11
申请人： Mark A. Scialdone
发明人： Mark A. Scialdone
IPC分类号： C07D235/28 , C07C313/04 , C07C323/45 , C07F7/10 , C07D273/01 , C07D233/84
CPC分类号： C07F7/0812 , B01D53/1475 , B01D53/1481 , B01D53/1493 , B01D2252/204 , B01D2252/2056 , B01D2252/30 , C07C335/38 , C07D233/84 , C07D235/28 , Y02A50/2349 , Y02C10/06 , Y02P20/152
摘要： This invention relates to sulfur based compounds useful in methods of carbon dioxide or sulfur dioxide removal.
摘要翻译：本发明涉及可用于二氧化碳或二氧化硫去除方法中的硫基化合物。

9. 发明授权

US07126005B2 Process for preparing florfenicol 失效
标题翻译：制备氟苯尼考的方法
公开(公告)号：US07126005B2
公开(公告)日：2006-10-24
申请号：US10735892
申请日：2003-12-16
申请人： Vijay Kumar Handa , Arun Kumar Gupta , Meenakshisunderam Sivakumaran
发明人： Vijay Kumar Handa , Arun Kumar Gupta , Meenakshisunderam Sivakumaran
IPC分类号： C07D263/04 , C07C313/04
CPC分类号： C07D263/06 , C07C233/18 , C07C315/04 , C07C319/20 , C07D263/04 , C07C317/32 , C07C323/41
摘要： The present invention is directed to a new process of preparing highly pure Florfenicol. The invention is further directed to new oxazolidine derivatives useful in making Florfenicol and processes of making these derivatives. Examples of such intermediates include (4R,5R)-3-acetyl-2,2-dimethyl-4-hydroxymethyl-5-[4-(methylsulfonyl)phenyl]-1,3-oxazolidine; and (4S,5R)-3-acetyl-2,2-dimethyl-4-fluoromethyl-5-[4-(methylsulfonyl)phenyl]-1,3-oxazolidine.
摘要翻译：本发明涉及一种制备高纯度氟苯尼考的新方法。本发明还涉及可用于制备氟苯尼考的新的恶唑烷衍生物和制备这些衍生物的方法。这样的中间体的实例包括（4R，5R）-3-乙酰基-2,2-二甲基-4-羟甲基-5- [4-（甲基磺酰基）苯基] -1,3-恶唑烷; 和（4S，5R）-3-乙酰基-2,2-二甲基-4-氟甲基-5- [4-（甲基磺酰基）苯基] -1,3-恶唑烷。

10. 发明授权

US07030158B2 Therapeutic compounds 有权
标题翻译：治疗化合物
公开(公告)号：US07030158B2
公开(公告)日：2006-04-18
申请号：US10295139
申请日：2002-11-15
申请人： Oleg Strelchenok , Julian Aleksov
发明人： Oleg Strelchenok , Julian Aleksov
IPC分类号： C07C309/23 , C07C313/04 , A61K31/19 , A61K31/215
CPC分类号： A61K31/185 , A61K31/337 , A61K45/06 , C07B2200/07 , C07B2200/09 , C07C309/18 , C07C313/04 , C07C2601/16 , A61K2300/00
摘要： A group of new compounds, N-(all-trans-Retinoyl)-L-cysteic acid, N-(13-cis-Retinoyl)-L-cysteic acid, N-(all-trans-Retinoyl)-L-cysteinesulfinic acid, N-(13-cis-Retinoyl)-L-cysteinesulfinic acid, N-(all-trans-Retinoyl)-L-homocysteic acid, N-(13-cis-Retinoyl)-L-homocysteic acid, and sodium salts of these compounds, including sodium salts of their esters and amides, is shown to exhibit therapeutic effects per se, and which compounds in combination with cytotoxic compounds, such as docetaxel, paclitaxel, doxorubicin and mitoxantrone, exhibit a synergistic effect. These compounds make it possible to manufacture new formulations of poorly soluble pharmaceutical compounds, and the present invention discloses a process of manufacturing water-soluble formulations of such compounds, exemplified by docetaxel, and paclitaxel, exhibiting enhanced pharmacological activity, and formulations of water-soluble pharmaceuticals exemplified by doxorubicin and mitoxantrone, exhibiting improved therapeutic efficacy.
摘要翻译：一组新化合物N-（全反式维甲酰基）-L-半胱氨酸，N-（13-顺 - 维甲酰基）-L-半胱氨酸，N-（全反式 - 维甲酰基）-L-半胱氨酸亚磺酸，N-（13-顺式 - 视黄酰基）-L-半胱氨酸亚磺酸，N-（全反式维甲酰基）-L-高半胱氨酸，N-（13-顺 - 维甲酰基）-L-高半胱氨酸和这些化合物，包括它们的酯和酰胺的钠盐，显示出本身具有治疗效果，哪些化合物与细胞毒性化合物如多西紫杉醇，紫杉醇，多柔比星和米托蒽醌组合显示出协同效应。这些化合物使得可以制备难溶性药物化合物的新制剂，并且本发明公开了制备这些化合物的水溶性制剂的方法，例如多西紫杉醇和紫杉醇，具有增强的药理活性，以及水溶性的制剂药物以多柔比星和米托蒽醌为例，具有改善的疗效。

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