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1. 发明授权

US10968246B2 Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists 有权
公开(公告)号：US10968246B2
公开(公告)日：2021-04-06
申请号：US16456661
申请日：2019-06-28
申请人： Ardelyx, Inc.
发明人： Jason G. Lewis , Michael Robert Leadbetter , Jeremy Caldwell , Dean Dragoli , Noah Bell , Jeffrey W. Jacobs , Patricia Finn , Rakesh Jain , Tao Chen , Matthew Siegel
IPC分类号： C07H15/26 , A61K31/4418 , C07D213/38 , A61K31/4427 , C07D405/12 , A61K31/443 , A61K31/444 , C07D213/30 , C07D405/04 , A61K31/4433 , A61K31/4439 , C07D413/12 , A61K31/553 , A61K31/496 , A61K31/706 , C07H15/04 , C07H15/18 , C07D401/12 , A61K31/5377 , C07H15/234 , A61K31/4436 , C07C409/12 , A61K31/4545 , A61K31/506 , A61K31/4425 , A61K31/551 , C07D471/04 , C07B59/00 , C07D213/81 , C07D213/80 , C07D487/08 , A61K45/06
摘要： The invention relates to non-systemic TGR5 agonist useful in the treatment of chemotherapy-induced diarrhea, diabetes, Type II diabetes, gestational diabetes, impaired fasting glucose, impaired glucose tolerance, insulin resistance, hyperglycemia, obesity, metabolic syndrome, ulcerative colitis, Crohn's disease, disorders associated with parenteral nutrition especially during short bowel syndrome, and irritable bowel syndrome (IBS), and other TGR5 associated diseases and disorders, having the Formula: where R1, R2, R2′, R3, R4, X1, X2, X3, X4, Q, and n are described herein.

2. 发明授权

US5847227A Method for producing aryl alkyl hydroperoxides 失效
标题翻译：芳基烷基氢过氧化物的制备方法
公开(公告)号：US5847227A
公开(公告)日：1998-12-08
申请号：US607496
申请日：1996-02-27
申请人： Terunori Fujita , Shigekazu Matsui , Toshihiro Takai , Hideto Matsuoka , Akifumi Kagayama , Hiroshi Kuroda , Masayasu Ishibashi , Hiroshi Iwasaki , Nobuya Hirokane
发明人： Terunori Fujita , Shigekazu Matsui , Toshihiro Takai , Hideto Matsuoka , Akifumi Kagayama , Hiroshi Kuroda , Masayasu Ishibashi , Hiroshi Iwasaki , Nobuya Hirokane
IPC分类号： C07F13/00 , C07C211/65 , C07C215/14 , C07C219/06 , C07C229/16 , C07C233/36 , C07C251/24 , C07C251/74 , C07C251/76 , C07C251/86 , C07C255/24 , C07C407/00 , C07C409/08 , C07C409/10 , C07C409/12 , C07D255/02 , C07D257/02 , C07D259/00 , C07F1/08 , C07F15/00 , C07C45/32 , C07C45/33
CPC分类号： C07C233/36 , C07C211/65 , C07C215/14 , C07C219/06 , C07C229/16 , C07C251/24 , C07C251/74 , C07C251/76 , C07C251/86 , C07C255/24 , C07C407/00 , C07C409/08 , C07C409/10 , C07C409/12 , C07D255/02 , C07D257/02 , C07D259/00
摘要： A method for producing aryl alkyl hydroperoxides which comprises selectively oxidizing an aryl alkyl hydrocarbon having the formula: ##STR1## wherein P and Q are hydrogen or an alkyl and may be the same or different from each other; x is an integer of 1-3; and Ar is an aromatic hydrocarbon group having a valence of x, with an oxygen-containing gas in the presence of a transition metal complex which contains, as a ligand, a cyclic polyfunctional amine compound having at least three nitrogen atoms in the ring forming molecular chain or an open chain polyfunctional amine compound having at least three nitrogen atoms in the main chain of the molecule.
摘要翻译：一种制备芳基烷基氢过氧化物的方法，其包括选择性氧化具有下式的芳基烷基烃：其中P和Q是氢或烷基并且可以彼此相同或不同; x是1-3的整数; 并且在具有含氧气体的过渡金属络合物存在下，Ar是具有x价的芳族烃基，其中所述过渡金属络合物在环形成分子中含有至少三个氮原子的环状多官能胺化合物链或在分子主链中具有至少三个氮原子的开链多官能胺化合物。

3. 发明授权

US4822943A Production of para-diisopropylbenzene 失效
标题翻译：生产对二异丙基苯
公开(公告)号：US4822943A
公开(公告)日：1989-04-18
申请号：US748883
申请日：1985-06-26
申请人： George T. Burress
发明人： George T. Burress
IPC分类号： C07C2/66 , C07C2/86 , C07C17/26 , C07C37/08 , C07C39/08 , C07C45/53 , C07C409/12 , C07C2/68
CPC分类号： C07C2/66 , C07C2/864 , C07C37/08 , C07C45/53 , C07C2529/70
摘要： A process is disclosed whereby cumene and/or benzene is brought into contact propylene in the presence of a ZSM-12 catalyst to selectively produce para-diisopropylbenzene.
摘要翻译：公开了一种方法，其中在ZSM-12催化剂存在下使异丙苯和/或苯与丙烯接触以选择性地产生对二异丙基苯。

4. 发明授权

US4288637A Process for preparation of aromatic hydroperoxides 失效
标题翻译：芳香族氢过氧化物的制备方法
公开(公告)号：US4288637A
公开(公告)日：1981-09-08
申请号：US143474
申请日：1980-04-24
申请人： Fujihisa Matsunaga , Yoshiyuki Shinohara , Isamu Okubo , Takayuki Nakamura , Seiichi Tanaka
发明人： Fujihisa Matsunaga , Yoshiyuki Shinohara , Isamu Okubo , Takayuki Nakamura , Seiichi Tanaka
IPC分类号： C07B61/00 , B01J27/00 , B01J31/00 , C07C39/02 , C07C67/00 , C07C407/00 , C07C409/08 , C07C409/10 , C07C409/12 , C07C179/035
CPC分类号： C07C39/02 , C07C407/00 , C07C409/08 , C07C409/10 , C07C409/12
摘要： Disclosed is a process for the preparation of aromatic hydroperoxides comprising contacting two liquid phases comprising an oily phase containing an aromatic compound having a secondary alkyl group and a basic aqueous phase under agitation with a molecular oxygen-containing gas in the presence of a copper compound catalyst such as an inorganic salt or organic acid salt of copper, thereby to oxidize the aromatic compound to a corresponding aromatic hydroperoxide, wherein the liquid phase catalytic oxidation is carried out while maintaining the catalyst concentration in the liquid phases at 0.005 to 10 ppm as the copper atom and the pH value of the basic aqueous phase at 7.6 to 10. According to this process, by adoption of the above-mentioned specific catalyst concentration and pH value in combination, the rate of oxidation of the aromatic compound is increased and the selectivity to the hydroperoxide is improved.
摘要翻译：公开了一种制备芳族氢过氧化物的方法，包括在铜化合物催化剂存在下，将含有含有仲烷基的芳族化合物的油相和搅拌下的碱性水相的两相液相与含分子氧的气体接触例如铜的无机盐或有机酸盐，从而将芳族化合物氧化成相应的芳香族氢过氧化物，其中进行液相催化氧化，同时将液相中的催化剂浓度保持在0.005〜10ppm，作为铜原子，碱性水相的pH值为7.6〜10。根据该方法，通过组合使用上述特定催化剂浓度和pH值，芳香族化合物的氧化速率提高，选择性氢过氧化物得到改善。

5. 发明授权

US4230890A Method of recovering dialkylbenzene dihydroperoxide 失效
标题翻译：回收二烷基苯二氢过氧化物的方法
公开(公告)号：US4230890A
公开(公告)日：1980-10-28
申请号：US926139
申请日：1978-07-19
申请人： Ward J. Burkholder
发明人： Ward J. Burkholder
IPC分类号： C07C409/12
CPC分类号： C07C409/12 , C07C407/00 , C07C407/003
摘要： Separation of diisopropylbenzene dihydroperoxide from a diisopropylbenzene oxidation reaction mixture by treating the reaction mixture with concentrated alkali metal hydroxide and recovering the alkali metal salt of diisopropylbenzene dihydroperoxide in high purity and good yield, and subsequently converting the salt to diisopropylbenzene dihydroperoxide.
摘要翻译：通过用浓碱金属氢氧化物处理反应混合物并以高纯度和高收率回收二异丙苯二氢过氧化物的碱金属盐，然后将盐转化为二异丙苯二氢过氧化物，从二异丙基苯氧化反应混合物中分离出二异丙苯二氢过氧化物。

6. 发明授权

US4200763A Benzoic acid ester derivative 失效
标题翻译：苯甲酸酯衍生物
公开(公告)号：US4200763A
公开(公告)日：1980-04-29
申请号：US38257
申请日：1979-05-11
申请人： Sheng-Hong A. Dai
发明人： Sheng-Hong A. Dai
IPC分类号： C07C409/08 , C07C409/12 , C07C69/78
CPC分类号： C07C409/08 , C07C407/00 , C07C409/12
摘要： Isopropylphenyl esters are converted to di- or tri-hydric phenols via a novel autoxidation of the esters at high conversion rates to the corresponding hydroperoxyisopropylphenyl esters in the presence of a catalyst combination comprising at least two members selected from the group consisting of (i) a metal phthalocyanine; (ii) a di-tertiary alkyl peroxide; and (iii) a tertiary alkyl hydroperoxide.Rearrangement of the hydroperoxyisopropylphenyl esters to the corresponding hydroxyphenyl esters and the hydrolysis of the latter compounds provides the phenols in overall yields (from the starting esters) heretofore not obtainable. Novel bis(hydroperoxyisopropylphenyl)carbonates are described which are attractive intermediates for the intermediate bisphenol carbonate or the final hydroquinone hydrolysis product.
摘要翻译：在包含至少两种选自以下的成员的催化剂组合的存在下，通过将酯以高转化率的新型自氧化转化为相应的氢过氧化异丙基苯基酯将异丙基苯基酯转化为二 - 或三 - 金属酞菁（ii）二叔烷基过氧化物; 和（iii）叔烷基氢过氧化物。氢过氧化异丙基苯基酯与相应的羟基苯基酯的重排和后者化合物的水解提供了迄今为止不可获得的总产率的苯酚（来自起始酯）。描述了新型双（氢过氧化异丙基苯基）碳酸酯，其是中间体双酚碳酸酯或最终氢醌水解产物的有吸引力的中间体。

7. 发明授权

US4136123A Use of water soluble metallo phthalocyanines as oxidation catalysts 失效
标题翻译：使用水溶性金属醇酞酸酯作为氧化催化剂
公开(公告)号：US4136123A
公开(公告)日：1979-01-23
申请号：US490424
申请日：1974-07-22
申请人： David A. Hutchings
发明人： David A. Hutchings
IPC分类号： C07C409/08 , C07C409/10 , C07C409/12 , C07C409/14 , C09B47/04 , C07C179/04
CPC分类号： C09B47/045 , C07C407/00 , C07C409/08 , C07C409/10 , C07C409/12 , C07C409/14 , C07C2101/14
摘要： Metallo phthalocyanines which have been rendered water soluble by substituting an alkali metal or alkaline earth metal sulfate or carboxylate salt onto the phthalocyanine structure have been found to be effective catalysts for the oxidation of aromatic compounds having benzylic carbon atoms to form the corresponding hydroperoxides.

8. 发明授权

US3160668A Hydroperoxide formation 失效
标题翻译：氢过氧化物形成
公开(公告)号：US3160668A
公开(公告)日：1964-12-08
申请号：US11783261
申请日：1961-06-19
申请人： PITTSBURGH CHEMICAL COMPANY
发明人： DAVIE WILLIAM R , SCHULT JOACHIM C E
IPC分类号： C07C409/08 , C07C409/10 , C07C409/12 , C07C409/14
CPC分类号： C07C409/10 , C07C407/00 , C07C409/08 , C07C409/12 , C07C409/14 , C07C2601/14

9. 发明授权

US2915557A Process for recovering di-isopropylbenzene-di-hydroperoxide from di-isopropylbenzene oxidation products 失效
标题翻译：从二异丙苯氧化产物中回收二异丙基苯 - 二氢过氧化物的方法
公开(公告)号：US2915557A
公开(公告)日：1959-12-01
申请号：US66300057
申请日：1957-06-03
申请人： SHELL DEV
发明人： KREPS ROBERT W F , DE WIT WILLEM F , GERRIT SCHUUR
IPC分类号： C07C409/12
CPC分类号： C07C409/12 , C07C407/003

10. 发明授权

US2856432A Aromatic dihydroperoxide production 失效
标题翻译：芳香族二氢过氧化物生产
公开(公告)号：US2856432A
公开(公告)日：1958-10-14
申请号：US37868953
申请日：1953-09-04
申请人： HERCULES POWDER CO LTD
发明人： CONNER JR JOSHUA C , VINCENT VERPLANCK
IPC分类号： C07C409/12
CPC分类号： C07C409/12 , C07C407/00 , C07C407/003

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