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1. 发明申请

US20210122695A1 METHOD FOR LINKAGE RECOVERY OF ORGANIC ACID IN AQUEOUS ORGANIC ACID SOLUTION 有权
公开(公告)号：US20210122695A1
公开(公告)日：2021-04-29
申请号：US17257375
申请日：2019-09-26
申请人： GUANGZHOU YINNOVATOR BIOTECH CO., LTD.
发明人： Ruizhe ZHANG , Yunsi LIU
IPC分类号： C07C51/48 , C07C49/303 , C07F9/113
摘要： Disclosed is a method for linkage recovery of an organic acid in an aqueous organic acid solution. The method comprises: mixing a solution with an organic acid concentration lower than 20 wt % with a specific extractant and then subjecting same to counter-current extraction so as to obtain an extract phase and a raffinate phase; and subjecting the extract phase together with a solution with an acid concentration higher than 70 wt % to an azeotropic rectification so as to recover an organic acid. When the concentration of the aqueous organic acid solution is 20 wt %-70 wt %, the aqueous organic acid solution is extracted and concentrated to make the concentration of the aqueous organic acid solution higher than 70 wt %. The method is simple, and has a low energy consumption and a good recovery effect with respect to the single recovery of a low concentration aqueous organic acid solution; and the method does not need to newly add an azeotrope agent and saves on costs with respect to the single recovery of a high concentration aqueous organic acid solution. In such a cooperating manner, a reagent during recovery can be fully utilized, energy consumption is reduced, and a process is simplified.

2. 发明申请

US20110084230A1 Process for Synthesizing Organoelemental Compounds 审中-公开
标题翻译：合成有机化合物的方法
公开(公告)号：US20110084230A1
公开(公告)日：2011-04-14
申请号：US12225647
申请日：2007-04-03
申请人： Paul Knochel , Andrei Gavryushin , Vladimir Malakhov , Arkady Krasovskiy
发明人： Paul Knochel , Andrei Gavryushin , Vladimir Malakhov , Arkady Krasovskiy
IPC分类号： C07F3/06 , C07C69/76 , C07C255/50 , C07C49/303 , C07C251/00 , C07C15/02 , C07D307/02 , C07D307/34 , C07C1/32 , C09K3/00
CPC分类号： C07F3/06 , C07F13/00
摘要： The present application discloses a process for preparing a compound of the general formula R1-M1-Ad.zLiX (I) by reacting a compound R1-A (III) with an element M1 in the presence of lithium salts. The application also discloses a process for preparing a compound of the general formula R1m-M3-Tm.zLiX (II) by reacting a compound R1-A (III) with an M3-containing compound in the presence of lithium salts and in the presence of an elemental metal M2. The metal M3 may be selected from Al, Mn, Cu, Zn, Sn, Ti, In, La, Ce, Nd, Y, Li, Sm, Bi, Mg, B, Si and S.
摘要翻译：本申请公开了通过在锂盐存在下使化合物R1-A（III）与元素M1反应来制备通式为R 1 -M1-Ad.zLiX（I）的化合物的方法。本申请还公开了在锂盐存在下使化合物R1-A（III）与含M3化合物反应制备通式为R1m-M3-Tm.zLiX（II）的化合物的方法，的元素金属M2。金属M3可以选自Al，Mn，Cu，Zn，Sn，Ti，In，La，Ce，Nd，Y，Li，Sm，Bi，Mg，B，Si和S.

3. 发明授权

US07834216B2 Desmosdumotins, the method for preparing the same and use as anti-tumor or anti-AIDS agents 有权
标题翻译：去糖丝氨酸蛋白酶，其制备方法和用作抗肿瘤或抗艾滋病药物
公开(公告)号：US07834216B2
公开(公告)日：2010-11-16
申请号：US11794422
申请日：2005-12-28
申请人： Jiuhong Wu , Kyoko Nakagawa-Goto , Xihong Wang , Ning Shi
发明人： Jiuhong Wu , Kyoko Nakagawa-Goto , Xihong Wang , Ning Shi
IPC分类号： C07C49/303 , C07D311/00 , A61K31/12 , A61K31/25
CPC分类号： C07D307/46 , C07C45/46 , C07C45/512 , C07C45/673 , C07C45/71 , C07C45/74 , C07C49/713 , C07C49/753 , C07C2601/14 , C07D277/24 , C07D311/74 , C07D333/22 , C07C49/825
摘要： This invention discloses the method for preparing desmosdumotin C, the series of desmosdumotin C derivatives and their manufactures, and the total synthesis of desmosdumotin B. The invention also discloses uses of the derivatives and pharmaceutical compositions containing the same in preparation of medicines for treatment of tumor or AIDS.
摘要翻译：本发明公开了脱氨基霉素C的制备方法，脱氨基霉素C衍生物及其制备方法，以及脱氨基霉素B的全合成方法。本发明还公开了含有该衍生物和药物组合物的制备用于治疗肿瘤药物的用途或艾滋病。

4. 发明授权

US07795258B2 Pyridazine compound and use thereof 有权
标题翻译：哒嗪化合物及其用途
公开(公告)号：US07795258B2
公开(公告)日：2010-09-14
申请号：US11630345
申请日：2005-06-02
申请人： Hiroshi Morishita , Akio Manabe
发明人： Hiroshi Morishita , Akio Manabe
IPC分类号： C07D237/08 , A61K31/50 , A61P31/10 , C07C205/06 , C07C49/303
CPC分类号： C07D237/08 , A01N43/58 , C07C49/233
摘要： A pyridazine compound represented by formula (1): wherein R1 and R2 are same or different and represent a C1-C4 alkyl group; R3 represents a halogen atom, a nitro group, a cyano group, a C1-C4 alkyl group optionally substituted by at least one halogen atom, a C1-C4 alkoxy group optionally substituted by at least one halogen atom or a C1-C4 alkylthio group optionally substituted by at least one halogen atom; R4 and R5 each represents a halogen atom, a nitro group, a cyano group, a C1-C4 alkyl group optionally substituted by at least one halogen atom or a C1-C4 alkoxy group optionally substituted by at least one halogen atom; and m and n each represents an integer.
摘要翻译：由式（1）表示的哒嗪化合物：其中R1和R2相同或不同，表示C1-C4烷基; R3表示卤素原子，硝基，氰基，任选被至少一个卤素原子取代的C1-C4烷基，可被至少一个卤素原子取代的C1-C4烷氧基或C1-C4烷硫基任选被至少一个卤素原子取代; R 4和R 5各自表示卤素原子，硝基，氰基，任选被至少一个卤素原子取代的C 1 -C 4烷基或任选被至少一个卤素原子取代的C 1 -C 4烷氧基; m和n各自表示整数。

5. 发明申请

US20100197713A1 BUTONE DERIVATIVES USEFUL AS COOLING AGENTS 有权
标题翻译：丁酮衍生物有用作冷却剂
公开(公告)号：US20100197713A1
公开(公告)日：2010-08-05
申请号：US12599122
申请日：2008-05-14
申请人： Stefan Michael Furrer , David Max Dastrup , Thomas Scott McCluskey
发明人： Stefan Michael Furrer , David Max Dastrup , Thomas Scott McCluskey
IPC分类号： C07D213/46 , C07C49/213 , C07C49/303 , C07C49/563 , A61K31/435 , A61K31/12
CPC分类号： C07C49/303 , A61K8/35 , A61K8/4926 , A61K2800/244 , A61Q11/00 , C07C45/292 , C07C49/213 , C07C49/225 , C07C49/35 , C07D213/50
摘要： Cooling compounds of formula (I) wherein R1 is selected from the group consisting of hydrogen, methyl, C1-C3 alkoxy, phenyl, C1-C3 alkylphenyl, C1-C3 alkoxyphenyl, thienyl, pyridyl, furyl, and indoyl; R2 is selected from the group consisting of hydrogen and hydroxyl, or R2 forms together with the carbon atom to which it is attached a carbonyl group; and R3 is selected from the group consisting of 2,4-dimethylpent-3-yl, 2,3,4-trimethylpent-3-yl, adamantly and 2-isopropyl-5-methyl-cycloheκyl-1-yI; and, product compositions comprising them.
摘要翻译：式（I）的冷却化合物，其中R 1选自氢，甲基，C 1 -C 3烷氧基，苯基，C 1 -C 3烷基苯基，C 1 -C 3烷氧基苯基，噻吩基，吡啶基，呋喃基和茚基; R2选自氢和羟基，或R2与与其连接的碳原子一起形成羰基; 并且R 3选自2,4-二甲基戊-3-基，2,3,4-三甲基戊-3-基，金刚烷基和2-异丙基-5-甲基 - 环庚烷-1-基; 以及包含它们的产品组合物。

6. 发明授权

US07678946B2 2,4,6,-trisubstituted having anesthetic properties 失效
标题翻译：具有麻醉性质的2,4,6-三取代酚
公开(公告)号：US07678946B2
公开(公告)日：2010-03-16
申请号：US11879018
申请日：2007-07-13
申请人： Max T. Baker
发明人： Max T. Baker
IPC分类号： C07C45/00 , C07C49/303 , C07C39/00 , A61K31/125 , A61K31/05
CPC分类号： C07C39/24
摘要： Trisubstituted phenol compounds and methods of using the compounds, e.g., for anesthetizing a subject, are disclosed.
摘要翻译：公开了三取代的酚化合物和使用化合物的方法，例如麻醉受试者。

7. 发明申请

US20090233998A1 Desmosdumotins, the Method for Preparing the Same and Use as Anti-Tumor or Anti-AIDS Agents 有权
标题翻译：去糖丝氨酸蛋白酶，其制备方法和用作抗肿瘤或抗艾滋病药物
公开(公告)号：US20090233998A1
公开(公告)日：2009-09-17
申请号：US11794422
申请日：2005-12-28
申请人： Jiuhong Wu , Kyoko Nakagawa-Goto , Xihong Wang , Ning Shi
发明人： Jiuhong Wu , Kyoko Nakagawa-Goto , Xihong Wang , Ning Shi
IPC分类号： A61K31/35 , C07C49/303 , A61K31/12 , C07D311/00
CPC分类号： C07D307/46 , C07C45/46 , C07C45/512 , C07C45/673 , C07C45/71 , C07C45/74 , C07C49/713 , C07C49/753 , C07C2601/14 , C07D277/24 , C07D311/74 , C07D333/22 , C07C49/825
摘要： This invention discloses the method for preparing desmosdumotin C, the series of desmosdumotin C derivatives and their manufactures, and the total synthesis of desmosdumotin B. The invention also discloses uses of the derivatives and pharmaceutical compositions containing the same in preparation of medicines for treatment of tumor or AIDS.
摘要翻译：本发明公开了脱氨基霉素C的制备方法，脱氨基霉素C衍生物及其制备方法，以及脱氨基霉素B的全合成方法。本发明还公开了含有该衍生物和药物组合物的制备用于治疗肿瘤药物的用途或艾滋病。

8. 发明申请

US20090221715A1 NOVEL POLYMORPH OF ATOVAQUONE 审中-公开
标题翻译：大潮的新世界
公开(公告)号：US20090221715A1
公开(公告)日：2009-09-03
申请号：US12394419
申请日：2009-02-27
申请人： Ashok Kumar , Suneel Yeshwant Dike , Pramilkumar Mathur , Nellithanath Thankachen Byju , Brajesh Sharma , Swapnil Shreekant Kore , Vitthal Suryabhan Buchude , Dharmendra Singh
发明人： Ashok Kumar , Suneel Yeshwant Dike , Pramilkumar Mathur , Nellithanath Thankachen Byju , Brajesh Sharma , Swapnil Shreekant Kore , Vitthal Suryabhan Buchude , Dharmendra Singh
IPC分类号： A61K31/122 , C07C49/303
CPC分类号： C07C50/32
摘要： The present invention relates to a novel polymorphic form of atovaquone. More particularly, it relates to a novel crystalline form, that has improved solubility and other bulk characteristics suitable for pharmaceutical application. The present invention also relates to processes for preparing a new polymorphic form of atovaquone and its use in industry.
摘要翻译：本发明涉及一种新的多形酮多形态。更具体地说，本发明涉及一种新颖的结晶形式，其具有改善的适用于药物应用的溶解度和其它体积特征。本发明还涉及制备新戊酰多新异构体形式及其在工业中的应用的方法。

9. 发明申请

US20090080074A1 POLYMER FILM, POLARIZING PLATE PROTECTIVE FILM, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY DEVICE 有权
标题翻译：聚合物膜，偏光板保护膜，极化板和液晶显示装置
公开(公告)号：US20090080074A1
公开(公告)日：2009-03-26
申请号：US12204438
申请日：2008-09-04
申请人： Nobutaka Fukagawa , Masaki Noro , Teruki Niori
发明人： Nobutaka Fukagawa , Masaki Noro , Teruki Niori
IPC分类号： F21V9/00 , C07C313/04 , C07C49/303 , C07D239/04 , C07D265/30 , G02B5/30 , C07D207/04 , C07D241/04 , C07C229/30 , C07D211/14
CPC分类号： G02B5/3083 , C07C311/34 , C07C317/48
摘要： A polymer film includes: a wavelength dispersion regulator represented by formula (I): wherein R1 and R2 each independently represents a hydrogen atom, an alkyl group or an aryl group, provided that both R1 and R2 are not hydrogen atoms at the same time; and R3 and R4 each independently represents an electron-withdrawing substituent, and R1 and R2, or R3 and R4 may be bonded together to form a ring, and wherein the polymer film has a retardation value that satisfies the following formulae (1) and (2): 70 nm≦Rth(548)≦300 nm Formula (1) Rth(628)
摘要翻译：聚合物膜包括：由式（I）表示的波长色散调节剂：其中R 1和R 2各自独立地表示氢原子，烷基或芳基，条件是R 1和R 2不同时为氢原子; R3和R4各自独立地表示吸电子取代基，R1和R2或R3和R4可以键合在一起形成环，其中聚合物膜具有满足下式（1）和（ 2）：<？in-line-formula description =“In-line formula”end =“lead”？> 70 nm <= Rth（548）<= 300 nm公式（1）<？in-line-formula description = “直线公式”end =“tail”？> <？in-line-formula description =“In-line Formulas”end =“lead”？> Rth（628）其中Rth（λ）表示在波长λnm处测量的膜厚度方向上以nm表示的延迟值。

10. 发明申请

US20080214433A1 Alpha-Decalones with Damascone-Woody Odor 有权
标题翻译：具有大马士革 - 木质气味的阿尔法 - 十角龙
公开(公告)号：US20080214433A1
公开(公告)日：2008-09-04
申请号：US11996924
申请日：2006-09-05
申请人： Robert Moretti , Olivier Etter
发明人： Robert Moretti , Olivier Etter
IPC分类号： A61K8/35 , C07C49/303
CPC分类号： C11B9/0053 , C07C45/62 , C07C45/69 , C07C49/447 , C07C49/637 , C07C2602/28
摘要： The present invention relates to a new class of compound, α-decalones with a 2,3,8a-trimethyl substitution, which are valuable perfuming ingredients of the woody type. The present invention also concerns the use of these compounds in the perfumery industry as well as the compositions or articles containing these compounds.
摘要翻译：本发明涉及一类具有2,3,8a-三甲基取代基的化合物α-癸醛，它们是木本型的有价值的加香成分。本发明还涉及这些化合物在香料工业中的用途以及含有这些化合物的组合物或制品。

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