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1. 发明授权

US11952338B2 Anticonvulsant compounds 有权
公开(公告)号：US11952338B2
公开(公告)日：2024-04-09
申请号：US17063019
申请日：2020-10-05
申请人： OWEN-BARRY PHARMACEUTICALS INC.
发明人： Michael Poulter , Tony Durst
IPC分类号： C07C69/78 , A61K31/122 , A61K31/166 , A61K31/192 , A61K31/216 , A61K31/4453 , A61P25/08 , C07C49/603 , C07C49/623 , C07C49/67 , C07C49/683 , C07C49/697 , C07C49/723 , C07C49/753 , C07C63/66 , C07C65/32 , C07C69/157 , C07C69/76 , C07C235/84 , C07C255/40 , C07C317/24 , C07C321/28 , C07D211/08 , C07D295/192
CPC分类号： C07C69/78 , A61K31/122 , A61K31/166 , A61K31/192 , A61K31/216 , A61K31/4453 , A61P25/08 , C07C49/603 , C07C49/623 , C07C49/67 , C07C49/683 , C07C49/697 , C07C49/723 , C07C49/753 , C07C63/66 , C07C65/32 , C07C69/157 , C07C69/76 , C07C235/84 , C07C255/40 , C07C317/24 , C07C321/28 , C07D211/08 , C07D295/192
摘要： The present application relates to compounds and methods for reducing the severity of convulsant activity or epileptic seizures, or for the treatment of chronic or acute pain.

2. 发明授权

US11345652B2 Anticonvulsant compounds 有权
公开(公告)号：US11345652B2
公开(公告)日：2022-05-31
申请号：US16723630
申请日：2019-12-20
申请人： OWEN-BARRY PHARMACEUTICALS INC.
发明人： Michael Poulter , Tony Durst
IPC分类号： C07C69/78 , C07C65/32 , C07C49/753 , C07C49/697 , C07C49/683 , A61P25/08 , C07C235/84 , C07C317/24 , C07C321/28 , C07C255/40 , C07D211/08 , C07C49/603 , C07C63/66 , C07C69/157 , C07C49/623 , C07C49/723 , C07C69/76 , C07D295/192 , C07C49/67 , A61K31/192 , A61K31/216 , A61K31/122 , A61K31/4453 , A61K31/166
摘要： The present application relates to compounds and methods for reducing the severity of convulsant activity or epileptic seizures, or for the treatment of chronic or acute pain.

3. 发明申请

US20190127292A1 METHODS FOR PRODUCING CYCLIC AND ACYCLIC KETONES 审中-公开
公开(公告)号：US20190127292A1
公开(公告)日：2019-05-02
申请号：US16224765
申请日：2018-12-18
申请人： The Regents of the University of California , BP Corporation North America Inc.
发明人： Sanil SREEKUMAR , F. Dean TOSTE , Amit A. GOKHALE , Gorkem GUNBAS , Balakrishnan MADHESAN , Alexis T. BELL , Eric SACIA , George E. ARAB
IPC分类号： C07C1/22 , C07D307/46 , C07C1/207 , C07C49/657 , C07C49/613 , C07C49/603 , C07C45/74 , C07C15/113 , C07C13/18 , C10L1/04 , C10G3/00 , C07C49/203
摘要： Provided herein are methods for producing cyclic and acyclic ketones from trimerization and dimerization of alkyl ketones, including for example methyl ketones. Such cyclic and acyclic ketones may be suitable for use as fuel and lubricant precursors, and may be hydrodeoxygenated to form their corresponding cycloalkanes and alkanes. Such cycloalkanes and alkanes may be suitable for use as fuels, including jet fuels, and lubricants.

4. 发明授权

US09388107B2 Process for the production of a mixture comprising cyclohexanone and cyclohexanol from phenol 有权
标题翻译：从苯酚生产包含环己酮和环己醇的混合物的方法
公开(公告)号：US09388107B2
公开(公告)日：2016-07-12
申请号：US14408614
申请日：2013-06-27
申请人： CAP III B.V.
发明人： Wilhelmus Rudolf Maria Martens , Robert Jan De Korte , Iris Verschuren , Corinne Daguenet , Johan Thomas Tinge , Roeland Wilhelmus Theodorus Maria Brands
IPC分类号： C07C45/00 , C07C29/00 , C07C51/00 , C07C29/20 , C07C35/08 , C07C49/603 , C07D223/10
CPC分类号： C07C45/006 , C07C29/20 , C07C35/08 , C07C49/603 , C07C51/00 , C07C2601/14 , C07D223/10 , C07C49/403
摘要： The present invention provides a process for continuously preparing a mixture of cyclohexanone and cyclohexanol comprising, a) hydrogenating phenol with gaseous hydrogen, in the presence of platinum or palladium, in a hydrogenation reactor, to produce a hydrogenation product stream comprising cyclohexanone, cyclohexanol, phenol and hydrogen; b) cooling the hydrogenation product stream to a temperature such that the fraction of phenol by mass in a first gas phase is lower than the fraction of phenol by mass in a first liquid phase; c) separating the first gas phase from the first liquid phase; d) returning at least part of the first gas phase to the hydrogenation reactor; e) heating the first liquid phase; f) purifying the first liquid phase by distillation; characterized in that heat is transferred from the hydrogenation product stream in step b) to another part of the process by means of in-process heat exchange; a mixture of cyclohexanone and cyclohexanol obtained by the process; and a chemical plant suitable for continuously preparing mixture of cyclohexanone and cyclohexanol according to the process.
摘要翻译：本发明提供一种连续制备环己酮和环己醇的混合物的方法，其包括：a）在氢化反应器中，在铂或钯存在下，用气态氢气氢化苯酚，生成包含环己酮，环己醇，苯酚和氢; b）将氢化产物流冷却至使第一气相中的质量分数低于第一液相中苯酚质量分数的温度; c）将第一气相与第一液相分离; d）将至少部分第一气相返回到氢化反应器; e）加热第一液相; f）通过蒸馏纯化第一液相; 其特征在于，通过在工艺中的热交换将热量从步骤b）中的氢化产物流转移到另一部分工艺; 通过该方法获得的环己酮和环己醇的混合物; 以及适用于连续制备环己酮和环己醇的混合物的化学植物。

5. 发明授权

US09169190B2 Methods for making retinoids and uses thereof 有权
标题翻译：维生素A的制备方法及用途
公开(公告)号：US09169190B2
公开(公告)日：2015-10-27
申请号：US13856631
申请日：2013-04-04
申请人： The UAB Research Foundation
发明人： Wayne J. Brouillette , Donald D. Muccio , Venkatram Reddy Atigadda , John M. Ruppert , Susan M. Lobo Ruppert
IPC分类号： C07C205/00 , C07C229/00 , C07C59/40 , C07C63/333 , C07C61/00 , A61K31/20 , A61K31/195 , C07C57/50 , C07C29/14 , C07C45/29 , C07C45/30 , C07C45/51 , C07C45/61 , C07C45/67 , C07C45/68 , C07C47/238 , C07C49/403 , C07C49/417 , C07C49/603 , C07C49/683 , C07C49/713 , C07C49/753 , C07C51/09 , C07C67/343 , C07C403/08 , C07C403/14 , C07C403/20 , C07D311/96 , C12C11/02 , C07C57/26
CPC分类号： A61K31/202 , A61K9/0014 , A61K45/06 , C07B2200/09 , C07C29/14 , C07C45/29 , C07C45/292 , C07C45/30 , C07C45/513 , C07C45/61 , C07C45/673 , C07C45/68 , C07C47/238 , C07C49/403 , C07C49/417 , C07C49/603 , C07C49/683 , C07C49/713 , C07C49/753 , C07C51/09 , C07C57/26 , C07C57/50 , C07C67/343 , C07C403/08 , C07C403/14 , C07C403/20 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07C2602/10 , C07C2602/28 , C07D311/96 , C12C11/02 , C07C33/16 , C07C69/618
摘要： Described herein are methods for making retinoids. Also described herein are retinoids and methods of use thereof.
摘要翻译：本文描述了制备类视黄醇的方法。本文还描述了类视黄醇及其使用方法。

6. 发明授权

US09090549B2 1,4-naphthoquinones derivatives and therapeutic use thereof 有权
标题翻译： 1,4-萘醌衍生物及其治疗用途
公开(公告)号：US09090549B2
公开(公告)日：2015-07-28
申请号：US12934382
申请日：2009-03-25
申请人： Elisabeth Davioud-Charvet , Tobias Muller , Holger Bauer , R. Heiner Schirmer
发明人： Elisabeth Davioud-Charvet , Tobias Muller , Holger Bauer , R. Heiner Schirmer
IPC分类号： A61K31/535 , A61K31/4965 , A61K31/47 , A61K31/122 , C07C49/603 , C07C50/14 , C07C46/00 , C07C46/02 , C07C50/10 , C07C50/24 , C07C50/32 , C07C50/38 , C07C69/95 , C07C205/46 , C07C225/24 , C07C255/29 , C07C255/56 , C07C271/28 , C07D295/096 , C07D295/116 , C07D265/30 , C07D241/04 , C07D215/16
CPC分类号： C07C50/14 , C07C46/00 , C07C46/02 , C07C50/10 , C07C50/24 , C07C50/32 , C07C50/38 , C07C69/95 , C07C205/46 , C07C225/24 , C07C255/29 , C07C255/56 , C07C271/28 , C07C2602/10 , C07D295/096 , C07D295/116
摘要： 1,4 naphthoquinones derivatives, of formula (I) wherein A is selected from the following rings: their preparation and their application as antimalarial agents
摘要翻译：式（I）的1,4-萘醌衍生物，其中A选自以下环：它们的制备及其作为抗疟剂的应用

7. 发明申请

US20140005438A1 USE OF BETA-ISOPHORONE AS SOLVENT 有权
标题翻译：以异烟肼为溶剂的使用
公开(公告)号：US20140005438A1
公开(公告)日：2014-01-02
申请号：US13704465
申请日：2011-06-07
申请人： Emmanouil Spyrou , Lars Hellkuhl , Marina Grammenos , Andrea Henschke
发明人： Emmanouil Spyrou , Lars Hellkuhl , Marina Grammenos , Andrea Henschke
IPC分类号： C07C49/603
CPC分类号： C07C49/603 , A01N25/02 , C09D7/20 , A01N37/22 , A01N47/22
摘要： The invention relates to the use of β-isophorone as solvent
摘要翻译：本发明涉及β-异佛尔酮作为溶剂的用途

8. 发明授权

US08367735B2 Pharmaceutical compositions 有权
标题翻译：药物组合物
公开(公告)号：US08367735B2
公开(公告)日：2013-02-05
申请号：US12375208
申请日：2007-07-26
申请人： Stanley M. Roberts , Gabriella M. Santoro
发明人： Stanley M. Roberts , Gabriella M. Santoro
IPC分类号： A61K31/015 , A61K31/12 , C07C49/603
CPC分类号： C07C49/753 , C07C45/74 , C07C323/59 , C07F7/1804
摘要： The present invention relates to compounds of formula I or II:—wherein R is an alkyl, alkenyl, alkynyl, aryl, aralkyl, aralkenyl, or aralkynyl group, that may be substituted or unsubstituted, and that optionally includes at least one heteroatom in its carbon skeleton; R1 is hydrogen, or an alkyl, substituted alkyl, alkenyl, alkynyl, aryl, substituted aryl, or aralkyl group; and R2 is an alkyl, alkenyl, alkynyl, aryl, aralkyl, aralkenyl, or aralkynyl group containing 4-12 carbon atoms, that may be substituted or unsubstituted, and that optionally includes at least one heteroatom in its carbon skeleton; provided that in a compound of formula I, when R1 is an iso-propyl or phenyl group, R2 is not an acetyl or tert-butyldimethylsilyl group; and their use in therapeutic, diagnostic and research methods.
摘要翻译：本发明涉及式I或II的化合物：其中R是烷基，烯基，炔基，芳基，芳烷基，芳烯基或芳炔基，其可以是取代或未取代的，并且其任选地在其中包含至少一个杂原子碳骨架 R1是氢或烷基，取代的烷基，烯基，炔基，芳基，取代的芳基或芳烷基; 并且R 2是可以被取代或未取代的含有4-12个碳原子的烷基，烯基，炔基，芳基，芳烷基，芳烯基或芳炔基，并且其任选地在其碳骨架中包含至少一个杂原子; 条件是在式I化合物中，当R 1是异丙基或苯基时，R 2不是乙酰基或叔丁基二甲基甲硅烷基; 及其在治疗，诊断和研究方法中的应用。

9. 发明申请

US20110059972A1 1,4-NAPHTHOQUINONES DERIVATIVES AND THERAPEUTIC USE THEREOF 有权
标题翻译： 1,4-萘醌衍生物及其治疗用途
公开(公告)号：US20110059972A1
公开(公告)日：2011-03-10
申请号：US12934382
申请日：2009-03-25
申请人： Elisabeth Davioud-Charvet , Tobias Muller , Holger Bauer , R. Heiner Schirmer
发明人： Elisabeth Davioud-Charvet , Tobias Muller , Holger Bauer , R. Heiner Schirmer
IPC分类号： A61K31/535 , A61K31/4965 , A61K31/47 , A61K31/122 , C07D265/30 , C07D241/04 , C07D215/16 , C07C49/603
CPC分类号： C07C50/14 , C07C46/00 , C07C46/02 , C07C50/10 , C07C50/24 , C07C50/32 , C07C50/38 , C07C69/95 , C07C205/46 , C07C225/24 , C07C255/29 , C07C255/56 , C07C271/28 , C07C2602/10 , C07D295/096 , C07D295/116
摘要： 1,4 naphthoquinones derivatives, of formula (I) wherein A is selected from the following rings: their preparation and their application as antimalarial agents
摘要翻译：式（I）的1,4-萘醌衍生物，其中A选自以下环：它们的制备及其作为抗疟剂的应用

10. 发明申请

US20100173134A1 Film and Device Using Layer Based on Ribtan Material 审中-公开
标题翻译：基于Ribtan材料的薄膜和器件使用层
公开(公告)号：US20100173134A1
公开(公告)日：2010-07-08
申请号：US12492127
申请日：2009-06-25
申请人： Pavel Khokhlov , Pavel I. Lazarev
发明人： Pavel Khokhlov , Pavel I. Lazarev
IPC分类号： B32B1/00 , C07D471/22 , B32B9/04 , B32B15/04 , B32B17/06 , B32B27/06 , B05D5/06 , C07D471/06 , C07C49/603
CPC分类号： H01L51/442 , H01L51/0078 , Y02E10/549 , Y10T428/24628 , Y10T428/31 , Y10T428/31507 , Y10T428/31678 , Y10T428/31721 , Y10T428/31786
摘要： The present invention relates generally to the field of electronics. More specifically, the present invention relates to film and device using layer based on carbon-based ribtan material. According to present invention, the film comprises at least one optically transparent and electrically conductive layer based on a ribtan material.
摘要翻译：本发明一般涉及电子领域。更具体地，本发明涉及基于碳基肋条材料的膜和装置使用层。根据本发明，膜包含至少一种基于肋条材料的光学透明导电层。

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