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1. 发明申请

US20200255395A1 THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：US20200255395A1
公开(公告)日：2020-08-13
申请号：US16747327
申请日：2020-01-20
申请人： KUALITY HERBCEUTICS LLC
发明人： Chengguo Xing
IPC分类号： C07D309/32 , C07C49/683 , C07C49/753 , C07D405/06 , C07C49/657 , A61P35/00 , C07D317/54 , C07D407/06
摘要： The invention provides compounds that are useful for treating or preventing cancer.

2. 发明申请

US20190127292A1 METHODS FOR PRODUCING CYCLIC AND ACYCLIC KETONES 审中-公开
公开(公告)号：US20190127292A1
公开(公告)日：2019-05-02
申请号：US16224765
申请日：2018-12-18
申请人： The Regents of the University of California , BP Corporation North America Inc.
发明人： Sanil SREEKUMAR , F. Dean TOSTE , Amit A. GOKHALE , Gorkem GUNBAS , Balakrishnan MADHESAN , Alexis T. BELL , Eric SACIA , George E. ARAB
IPC分类号： C07C1/22 , C07D307/46 , C07C1/207 , C07C49/657 , C07C49/613 , C07C49/603 , C07C45/74 , C07C15/113 , C07C13/18 , C10L1/04 , C10G3/00 , C07C49/203
摘要： Provided herein are methods for producing cyclic and acyclic ketones from trimerization and dimerization of alkyl ketones, including for example methyl ketones. Such cyclic and acyclic ketones may be suitable for use as fuel and lubricant precursors, and may be hydrodeoxygenated to form their corresponding cycloalkanes and alkanes. Such cycloalkanes and alkanes may be suitable for use as fuels, including jet fuels, and lubricants.

3. 发明申请

US20180134679A1 THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：US20180134679A1
公开(公告)日：2018-05-17
申请号：US15572439
申请日：2016-05-09
申请人： KUALITY HERBCEUTICS LLC
发明人： Chengguo Xing
IPC分类号： C07D309/32 , A61P35/00 , C07D317/54 , C07C49/657 , C07D407/06
CPC分类号： C07D309/32 , A61P35/00 , C07C49/657 , C07C49/683 , C07C49/753 , C07C2601/14 , C07C2601/16 , C07C2602/08 , C07D317/54 , C07D405/06 , C07D407/06
摘要： The invention provides compounds that are useful for treating or preventing cancer.

4. 发明申请

US20130096175A1 Compounds and Methods for Altering Lifespan of Eukaryotic Organisms 有权
标题翻译：改变真核生物使用寿命的化合物和方法
公开(公告)号：US20130096175A1
公开(公告)日：2013-04-18
申请号：US13510166
申请日：2010-11-17
申请人： David S. Goldfarb , Joseph A. Maddry , Lynn Rasmussen , Ellie Lucile White , Krister Wennerberg
发明人： David S. Goldfarb , Joseph A. Maddry , Lynn Rasmussen , Ellie Lucile White , Krister Wennerberg
IPC分类号： C07C49/657 , C07C49/403 , C07C49/613 , C07D333/22 , C07D209/12 , C07D307/46 , C07C49/792 , C07C49/753 , C07C235/82 , C07D307/54 , C07C49/417 , C07C225/22
CPC分类号： C07C49/657 , C07C49/403 , C07C49/417 , C07C49/543 , C07C49/553 , C07C49/567 , C07C49/573 , C07C49/577 , C07C49/613 , C07C49/753 , C07C49/792 , C07C69/743 , C07C69/757 , C07C225/22 , C07C235/82 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D209/12 , C07D307/46 , C07D307/54 , C07D317/54 , C07D319/18 , C07D333/22
摘要： Provided are compounds which generally have a triketone structure. Examples of the compounds include derivatives of 1,3-cyclohexanedione, such as: 1,3-cyclohexanedione, 2-propanoyl-5-cyclohexyl-; 1,3-cyclohexanedione, 2-propanoyl-5-[4-fluorophenyl]-; 1,3-cyclohexanedione, 2-acetyl-5-[thien-2-yl]-; 1,3-cyclohexanedione, 2-acetyl-5-butyl-; and 1,3-cyclohexanedione, 2-propanoyl-5-[bicyclo[2.2.1]hept-2-en-5-yl]-. The compounds can be used to alter the lifespan of eukaryotic organisms and treat inflammation.
摘要翻译：提供通常具有三酮结构的化合物。化合物的实例包括1,3-环己二酮的衍生物，例如：1,3-环己二酮，2-丙酰基-5-环己基 - 2-丙酰基-5- [4-氟苯基] - ; 1,3-环己二酮，2-乙酰基-5-〔噻吩-2-基] - 1,3-环己二酮，2-乙酰基-5-丁基 - 和1,3-环己二酮，2-丙酰基-5- [双环[2.2.1]庚-2-烯-5-基] - 。这些化合物可用于改变真核生物的寿命并治疗炎症。

5. 发明授权

US5670465A Preparation of p-fuchsones and synthesis of p-dihydroxylated aromatic compounds therefrom 失效
标题翻译： β-胡椒碱的制备及其由对二羟基化芳族化合物的合成
公开(公告)号：US5670465A
公开(公告)日：1997-09-23
申请号：US464311
申请日：1995-06-05
申请人： Michel Costantini , Daniel Manaut , Daniel Michelet
发明人： Michel Costantini , Daniel Manaut , Daniel Michelet
IPC分类号： B01J27/02 , B01J27/08 , B01J31/02 , C07B61/00 , C07C37/07 , C07C37/20 , C07C37/60 , C07C37/88 , C07C39/08 , C07C39/11 , C07C39/12 , C07C45/29 , C07C45/45 , C07C45/51 , C07C49/603 , C07C49/657 , C07C49/683 , C07C49/747 , C07C49/753
CPC分类号： C07C37/07 , C07C37/60 , C07C45/512 , C07C45/513 , C07C49/683 , C07C49/747 , C07C49/753
摘要： p-Dihydroxylated aromatic compounds are prepared via the oxidation of p-fuchsones, the latter advantageously being synthesized by reacting a phenolic compound having at least one hydrogen atom in the para-position to the hydroxyl function with a non-enolizable ketonic compound, in the presence of a catalytically effective amount of an acid catalyst and, optionally, a cocatalytically effective amount of an ionizable sulfur-containing compound.
摘要翻译：对 - 二羟基化的芳族化合物是通过p-胡蜂酮的氧化制备的，后者有利地通过使对位中具有至少一个氢原子的酚化合物与羟基官能团与非烯醇化酮化合物反应来合成，存在催化有效量的酸催化剂和任选的助催化有效量的可电离的含硫化合物。

6. 发明授权

US5480913A Anti-androgen compounds 失效
标题翻译：抗雄激素化合物
公开(公告)号：US5480913A
公开(公告)日：1996-01-02
申请号：US56523
申请日：1993-05-03
申请人： Shutsung Liao , John Pataki , Ronald G. Harvey
发明人： Shutsung Liao , John Pataki , Ronald G. Harvey
IPC分类号： A61K31/045 , A61K31/05 , A61K31/12 , A61K31/22 , C07C39/17 , C07C45/51 , C07C49/657 , C07C49/665 , C07C49/747 , C07C49/753 , C07C49/792 , C07J1/00 , C07J63/00 , C07C39/12 , C07C49/115
CPC分类号： C07J63/008 , A61K31/045 , A61K31/05 , A61K31/12 , A61K31/22 , C07C39/17 , C07C45/513 , C07C45/516 , C07C49/657 , C07C49/665 , C07C49/747 , C07C49/753 , C07C49/792 , C07J1/0055 , C07J1/0059 , C07J1/007 , C07J1/0088 , C07C2103/26
摘要： Disclosed are novel classes of anti-androgens including dihydrophenanthrene derivatives, their method of synthesis and their use in treating disorders associated with excessive androgenic activities.
摘要翻译：公开了新型抗雄激素，包括二氢菲衍生物，其合成方法及其在治疗与过度雄激素活性相关的疾病中的用途。

7. 发明授权

US5200535A Cyclohexanone derivatives 失效
标题翻译：环己酮衍生物
公开(公告)号：US5200535A
公开(公告)日：1993-04-06
申请号：US746977
申请日：1991-08-19
申请人： Paul H. Briner
发明人： Paul H. Briner
IPC分类号： C07C45/29 , C07C45/58 , C07C49/657 , C07C49/697 , C07C49/747 , C07C49/753 , C07C49/784 , C07C65/36 , C07C69/76 , C07C205/45 , C07C225/22 , C07C233/33 , C07C255/56 , C07C317/24 , C07C323/22 , C07D249/08 , C07D303/32 , C07D521/00
CPC分类号： C07D231/12 , C07C205/45 , C07C45/292 , C07C45/58 , C07C49/697 , C07C49/747 , C07C49/753 , C07D233/56 , C07D249/08
摘要： The invention provides cyclohexanone derivatives of the general formula ##STR1## in which n represents an integer from 0 to 5; each R represents a halogen atom, nitro, cyano, hydroxyl, alkyl, haloalkyl, alkoxy, haloalkoxy, amino, alkylamino, dialkylamino, alkoxycarbonyl, carboxyl, alkanoyl, alkylthio, alkylsulphinyl, alkylsulphonyl, carbamoyl, alkylamido, cycloalkyl or phenyl group; R.sup.1, R.sup.2 and R.sup.3 independently represent a hydrogen atom or an alkyl group; R.sup.6 and R.sup.7 together represent a single carbon-carbon bond or an epoxy group; and R.sup.8 represents a hydrogen atom or a hydroxyl group; with the proviso that when R.sup.6 and R.sup.7 together represent an epoxy group then R.sup.8 represents a hydrogen atom; and a process for their preparation. Compounds of formula I are useful as intermediates in the preparation of certain fungicidally active cyclopentane derivatives.

8. 发明授权

US4983208A Fungicidal and plant growth-regulating hydroxyalkylazolyl derivatives 失效
标题翻译：杀真菌和植物生长调节羟烷基唑衍生物
公开(公告)号：US4983208A
公开(公告)日：1991-01-08
申请号：US406996
申请日：1989-09-14
申请人： Klaus Stroech , Monika Frie , Thomas Himmler , Wilhelm Brandes , Stefan Dutzmann , Gerd Hanssler
发明人： Klaus Stroech , Monika Frie , Thomas Himmler , Wilhelm Brandes , Stefan Dutzmann , Gerd Hanssler
IPC分类号： A01N31/04 , A01N31/14 , A01N43/32 , A01N43/50 , A01N43/653 , C07C33/50 , C07C45/62 , C07C45/74 , C07C49/163 , C07C49/225 , C07C49/237 , C07C49/293 , C07C49/327 , C07C49/457 , C07C49/467 , C07C49/533 , C07C49/563 , C07C49/567 , C07C49/657 , C07C49/687 , C07C49/693 , C07C49/753 , C07C317/24 , C07C323/22 , C07D20060101 , C07D233/60 , C07D233/61 , C07D249/08 , C07D303/08 , C07D303/22 , C07D303/34 , C07D319/16 , C07D319/18 , C07D319/20 , C07D405/06 , C07D407/06 , C07D521/00
CPC分类号： C07D303/22 , A01N43/653 , C07C321/00 , C07C33/50 , C07C45/62 , C07C45/74 , C07C49/457 , C07C49/467 , C07C49/567 , C07C49/657 , C07C49/687 , C07C49/693 , C07C49/753 , C07D231/12 , C07D233/56 , C07D249/08 , C07D303/08 , C07D303/34 , C07D407/06
摘要： Fungicidal and plant growth-regulating hydroxyalkylazolyl derivatives of the formula ##STR1## in which R represents hydrogen, alkyl or acyl,R.sup.1 represents halogen, optionally substituted phenyl or the grouping --Z--R.sup.3, whereinZ represents oxygen, sulphur, SO or SO.sub.2 andR.sup.3 represents optionally substituted alkyl, optionally substituted phenyl or optionally substituted phenylalkyl,R.sup.2 represents optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted naphthyl or the radical of the formula ##STR2## m represents the numbers, 0, 1, 2 or 3, or R.sup.2 represents the radical or the formula ##STR3## X represents nitrogen or a CH group and Y represents the groupings --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --C.tbd.C--, ##STR4## and their addition products with acids and metal salts. Intermediates of the formulas ##STR5## are also new.

9. 发明授权

US4845129A Diaryl substituted cyclopentane and cyclopentene derivatives 失效
标题翻译：二芳基取代的环戊烷和环戊烯衍生物
公开(公告)号：US4845129A
公开(公告)日：1989-07-04
申请号：US167766
申请日：1988-03-14
申请人： Robert C. Anderson , William J. Houlihan , Howard C. Smith , Edwin B. Villhauer
发明人： Robert C. Anderson , William J. Houlihan , Howard C. Smith , Edwin B. Villhauer
IPC分类号： C07C43/21 , C07C43/215 , C07C43/23 , C07C45/30 , C07C45/56 , C07C45/62 , C07C45/66 , C07C45/68 , C07C49/657 , C07C49/683 , C07C49/753 , C07C205/45 , C07C217/74 , C07C251/44
CPC分类号： C07C251/44 , C07C205/45 , C07C217/74 , C07C43/21 , C07C43/215 , C07C43/23 , C07C45/30 , C07C45/567 , C07C45/62 , C07C45/66 , C07C45/68 , C07C49/657 , C07C49/683 , C07C49/753 , C07C2101/08 , C07C2101/10
摘要： The invention discloses certain diaryl substituted cyclopentane and cyclopentene derivatives useful as PAF inhibitors, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method of using such compositions for inhibiting PAF-induced blood platelet aggregation, PAF-mediated broncho-constriction and extravasation, PAF-induced hypotension, PAF-induced ischemic bowel disease and PAF-mediated, endotoxin induced lug injury.
摘要翻译：本发明公开了可用作PAF抑制剂的某些二芳基取代的环戊烷和环戊烯衍生物，含有所述化合物作为其活性成分的药物组合物和使用该组合物抑制PAF诱导的血小板聚集，PAF介导的支气管收缩和外渗的方法， PAF引起的低血压，PAF诱导的缺血性肠病和PAF介导的内毒素引起的耳损伤。

10. 发明授权

US4816059A Method of controlling undesirable vegetation with certain 2-phenylacetyl-1,3,5-cyclohexanetriones 失效
标题翻译：用某些2-苯乙酰基-1,3,5-环己酮来控制不希望的植被的方法
公开(公告)号：US4816059A
公开(公告)日：1989-03-28
申请号：US97978
申请日：1987-09-17
申请人： Charles G. Carter
发明人： Charles G. Carter
IPC分类号： A01N35/02 , A01N35/06 , A01N43/30 , C07C45/45 , C07C45/54 , C07C49/657 , C07C49/697 , C07C49/747 , C07C49/753 , C07D317/54 , A01N43/24 , A01N43/32
CPC分类号： C07D317/54 , A01N35/06 , A01N43/30 , C07C205/45 , C07C45/455 , C07C45/54 , C07C49/657 , C07C49/697 , C07C49/747 , C07C49/753
摘要： Compounds of the formula ##STR1## wherein R is hydrogen; halogen; C.sub.1 -C.sub.2 alkyl; C.sub.1 -C.sub.2 alkoxy; nitro; cyano; C.sub.1 -C.sub.2 haloalkyl; or R.sup.a SO.sub.m -- wherein m is 0 or 2 and R.sup.a is C.sub.1 -C.sub.2 alkyl;R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are methyl or ethyl;R.sup.5 and R.sup.6 independently are (1) hydrogen; (2) halogen; (3) C.sub.1 -C.sub.4 alkyl; (4) C.sub.1 -C.sub.4 alkoxy; (5) trifluoromethoxy; (6) cyano; (7) nitro; (8) C.sub.1 -C.sub.4 haloalkyl; (9) R.sup.b SO.sub.n -- wherein n is the integer 0, 1 or 2; and R.sup.b is (a) C.sub.1 -C.sub.4 alkyl; (b) C.sub.1 -C.sub.4 alkyl substituted with halogen or cyano; (c) phenyl; or (d) benzyl; (10) --NR.sup.c R.sup.d wherein R.sup.c and R.sup.d independently are hydrogen or C.sub.1 -C.sub.4 alkyl; (11) R.sup.e C(O)-- wherein R.sup.e is C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy; or (12) --SO.sub.2 NR.sup.c R.sup.d wherein R.sup.c and R.sup.d are defined; and (13) --N(R.sup.c)C(O)R.sup.d wherein R.sup.c and R.sup.d are as defined or R.sup.5 and R.sup.6 together are attached to adjacent carbon atoms and are methylenedioxy or ethylenedioxy and their salts.
摘要翻译：式（Ⅰ）化合物，其中R是氢; 卤素; C1-C2烷基; C1-C2烷氧基; 硝基氰基; C 1 -C 2卤代烷基; 或RaSOm-，其中m为0或2，Ra为C1-C2烷基; R1，R2，R3和R4是甲基或乙基; R5和R6独立地是（1）氢; （2）卤素; （3）C 1 -C 4烷基; （4）C1-C4烷氧基; （5）三氟甲氧基; （6）氰基; （7）硝基; （8）C 1 -C 4卤代烷基; （9）RbSO n-，其中n是整数0,1或2; 并且R b是（a）C 1 -C 4烷基; （b）被卤素或氰基取代的C 1 -C 4烷基; （c）苯基; 或（d）苄基; （10）-NRcRd其中Rc和Rd独立地是氢或C1-C4烷基; （11）ReC（O） - 其中Re为C1-C4烷基或C1-C4烷氧基; 或（12）-SO 2 NR c R d其中定义R c和R d; 和（13）-N（Rc）C（O）R d，其中R c和R d如所定义，或R 5和R 6一起连接到相邻的碳原子上，并且是亚甲二氧基或亚乙二氧基及其盐。

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