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1. 发明授权

US08624059B2 Processes for producing monoammonium succinate from fermentation broths containing diammonium succinate, monoammonium succinate and/or succinic acid, and conversion of monoammonium succinate to succinic acid 有权
标题翻译：从含有琥珀酸二铵，琥珀酸铵和/或琥珀酸的发酵液中生产琥珀酸一铵的方法，将琥珀酸一铵转化为琥珀酸
公开(公告)号：US08624059B2
公开(公告)日：2014-01-07
申请号：US13051302
申请日：2011-03-18
申请人： Olan S. Fruchey , Brian T. Keen , Brooke A. Albin , Nye A. Clinton , Dilum Dunuwila , Bernard D. Dombek
发明人： Olan S. Fruchey , Brian T. Keen , Brooke A. Albin , Nye A. Clinton , Dilum Dunuwila , Bernard D. Dombek
IPC分类号： C07C55/00 , C07C51/42
CPC分类号： C07C51/445 , C07C51/02 , C07C51/412 , C07C51/46 , C07C55/10
摘要： Processes for making monoammonium succinate (MAS) and/or succinic acid (SA) from either a clarified diammonium succinate (DAS)-containing fermentation broth or a clarified MAS-containing fermentation broth include (a) distilling the broth to form an overhead that includes water and optionally ammonia and a liquid bottoms that includes MAS or SA; (b) cooling and/or evaporating the bottoms and optionally adding an antisolvent to the bottoms to attain a temperature and composition sufficient to cause the bottoms to produce a solid portion that contains MAS or SA in contact with a liquid portion; (c) separating the solid portion from the liquid portion; and (d) recovering the solid portion.
摘要翻译：从澄清的含琥珀酸二铵（DAS）的发酵液或澄清的含有MAS的发酵液中制备琥珀酸一铵（MAS）和/或琥珀酸（SA）的方法包括（a）蒸馏肉汤以形成包含水和任选的氨和包括MAS或SA的液体底部; （b）冷却和/或蒸发塔底物，并任选地向塔底物中加入抗溶剂以达到足以使底部产生含有与液体部分接触的MAS或SA的固体部分的温度和组成; （c）从液体部分分离固体部分; 和（d）回收固体部分。

2. 发明申请

US20110123695A1 CRYSTAL GROWTH INHIBITOR FOR FATS AND OILS 有权
标题翻译：脂肪和油的晶体生长抑制剂
公开(公告)号：US20110123695A1
公开(公告)日：2011-05-26
申请号：US13055150
申请日：2009-07-24
申请人： Hiroyuki Kato , Yuuji Sakamoto , Yoshihiko Takase
发明人： Hiroyuki Kato , Yuuji Sakamoto , Yoshihiko Takase
IPC分类号： A23D7/06 , C07C57/02 , C07C55/00
CPC分类号： A23D9/013
摘要： An inhibitor for crystal growth of fats and oils, containing a polyglycerol fatty acid ester, which is an esterified product formed between a polyglycerol and a fatty acid, the polyglycerol having a hydroxyl value of 850 mg KOH/g or less and a ratio of primary hydroxyl groups to all the hydroxyl groups of the polyglycerol of 50% or more, wherein the polyglycerol fatty acid ester has a hydroxyl value of 100 mg KOH/g or less. Since the inhibitor for crystal growth of fats and oils of the present invention can inhibit crystal growth of fats and oils by adding the inhibitor to fats and oils, storage property of the fats and oils in a refrigerator, cold climates, or the like, so that the inhibitor can be suitably used in liquid fats and oils such as salad oil for which transparency is important.
摘要翻译：一种脂肪和油的晶体生长抑制剂，其含有聚甘油脂肪酸酯，其是在聚甘油和脂肪酸之间形成的酯化产物，羟基值为850mg KOH / g以下的聚甘油和初级聚甘油的全部羟基的羟基为50％以上，其中聚甘油脂肪酸酯的羟基值为100mgKOH / g以下。由于本发明的脂肪和油的结晶生长用抑制剂可以通过在脂肪和油中添加抑制剂，将油脂在冰箱中的保存性，寒冷气候等等来抑制脂肪和油的晶体生长，因此该抑制剂可以适用于液体脂肪和油，例如透明度重要的色拉油。

3. 发明申请

US20110040113A1 Pure PEG-lipid conjugates 审中-公开
标题翻译：纯PEG-脂质缀合物
公开(公告)号：US20110040113A1
公开(公告)日：2011-02-17
申请号：US12802197
申请日：2010-06-01
申请人： Nian Wu , Brian Charles Keller
发明人： Nian Wu , Brian Charles Keller
IPC分类号： C07C55/00 , C07C41/00
CPC分类号： C08G65/329 , A61K47/60 , A61K47/6911 , C08L2203/02
摘要： Syntheses of polyethyleneglycol (PEG)-lipid conjugates are disclosed. Such syntheses involve stepwise addition of small PEG oligomers to a glycerol backbone until the desired chain size is attained. Polymers resulting from the syntheses are highly monodisperse. The present invention provides several advantages such as simplified synthesis, high product yield and low cost for starting materials. The present synthesis method is suitable for preparing a wide range of conjugates.In another aspect, the invention comprises PEG lipid conjugates having a glycerol backbone covalently attached to one or two monodisperse PEG chains and one or two lipids. These conjugates are especially useful for pharmaceutical formulations.
摘要翻译：公开了聚乙二醇（PEG）脂质缀合物的合成。这种合成包括将小PEG低聚物逐步加入到甘油骨架中，直到达到所需的链尺寸。由合成产生的聚合物是高度单分散的。本发明提供了诸如简化合成，高产品收率和起始材料成本低等优点。本合成方法适用于制备宽范围的共轭物。在另一方面，本发明包括具有共价连接到一个或两个单分散PEG链和一个或两个脂质的甘油主链的PEG脂质缀合物。这些缀合物对于药物制剂特别有用。

4. 发明申请

US20110040094A1 1,3,4-TRISUBSTITUTED BENZENES 审中-公开
标题翻译： 1,3,4-三苯并噻吩
公开(公告)号：US20110040094A1
公开(公告)日：2011-02-17
申请号：US12678175
申请日：2008-09-15
申请人： Gideon Shapiro , Richard Chesworth
发明人： Gideon Shapiro , Richard Chesworth
IPC分类号： C07D471/02 , C07C313/04 , C07C55/00 , C07C59/13 , C07C229/00 , C07D213/55 , C07D231/12 , C07D213/62 , C07D271/12 , C07D285/14
CPC分类号： C07C229/34 , C07C59/64 , C07C59/68 , C07C59/72 , C07C69/734 , C07C205/37 , C07C205/56 , C07C255/57 , C07C317/44 , C07C317/46 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07D213/30 , C07D213/55 , C07D213/64 , C07D217/22 , C07D231/12 , C07D271/08 , C07D285/10 , C07D471/04
摘要： Compounds that are 1,3,4-trisubstituted benzenes which modulate (e.g., inhibit) the activity of γ-secretase. The compounds are expected to reduce the level of Aβ42 in patients and be useful in the treatment of diseases (e.g., Alzheimer's disease) characterized by elevated levels of Aβ42 and/or the formation of Aβ plaques.
摘要翻译：作为调节（例如抑制）γ-分泌酶活性的1,3,4-三取代苯的化合物。这些化合物预期会降低患者的A＆BGR 42水平，可用于治疗以升高的水平和/或形成A＆bgr为特征的疾病（如阿尔茨海默病）。斑块

5. 发明授权

US07834211B2 Method for producing tetracarboxylic acids 有权
标题翻译：生产四羧酸的方法
公开(公告)号：US07834211B2
公开(公告)日：2010-11-16
申请号：US11911686
申请日：2006-04-27
申请人： Kai Gumlich , Joaquim Henrique Teles
发明人： Kai Gumlich , Joaquim Henrique Teles
IPC分类号： C07C55/00
CPC分类号： C07C51/31 , C07C51/316 , C07C55/24
摘要： A process for preparing tetracarboxylic acids of the general formula I or salts thereof, wherein at least one compound of the general formula II a or II b (a) is first reacted with at least one epoxidation reagent and (b) then oxidized with nitric acid or at least one nitrogen oxide, where the variables are defined as follows: R1, R2 are the same or different and are selected from hydrogen, phenyl and C1-C10-alkyl.
摘要翻译：一种制备通式I的四羧酸或其盐的方法，其中至少一种通式II a或II b（a）的化合物首先与至少一种环氧化试剂反应，然后（b）然后用硝酸氧化或至少一种氮氧化物，其中变量定义如下：R 1，R 2相同或不同，并且选自氢，苯基和C 1 -C 10 - 烷基。

6. 发明申请

US20100183533A1 DETERGENT COMPOSITION 有权
标题翻译：洗涤剂组合物
公开(公告)号：US20100183533A1
公开(公告)日：2010-07-22
申请号：US12664714
申请日：2008-07-21
申请人： Matthew Robert Giles , Nicholas John Dixon
发明人： Matthew Robert Giles , Nicholas John Dixon
IPC分类号： C11D3/395 , C07C55/00 , C02F5/10 , A61K8/22 , D21C3/22
CPC分类号： C07C229/24 , C11D3/33 , D21C9/1042 , D21C9/163
摘要： The present invention provides a salt of ethylenediamine disuccinic acid comprising at least 1.6 mole of alkaline earth metal per mole of ethylenediamine disuccinic acid. Salts of the invention have been found to be useful in providing compositions comprising hydrogen peroxide having improved stability.
摘要翻译：本发明提供了每摩尔乙二胺二琥珀酸至少含有1.6摩尔碱土金属的乙二胺二琥珀酸盐。已经发现本发明的盐可用于提供包含具有改善的稳定性的过氧化氢的组合物。

7. 发明申请

US20090326269A1 Templated Monolayer Polymerization and Replication 有权
标题翻译：模板单层聚合和复制
公开(公告)号：US20090326269A1
公开(公告)日：2009-12-31
申请号：US12505508
申请日：2009-07-19
申请人： Joseph M. Jacobson , David W. Mosley
发明人： Joseph M. Jacobson , David W. Mosley
IPC分类号： B05D1/38 , C07C55/00
CPC分类号： H01L21/02112 , B05D1/185 , B82Y30/00 , B82Y40/00 , G01N31/22 , G03F7/165 , H01L21/283 , Y10S977/882 , Y10S977/883
摘要： A self-replicating monolayer system employing polymerization of monomers or nanoparticle ensembles on a defined template provides a method for synthesis of two-dimensional single molecule polymers. Systems of self-replicating monolayers are used as templates for growth of inorganic colloids. A preferred embodiment employs SAM-based replication, wherein an initial monolayer is patterned and used as a template for self-assembly of a second monolayer by molecular recognition. The second monolayer is polymerized in place and the monolayers are separated to form a replicate. Both may then function as templates for monolayer assemblies. A generic self-replicating monomer unit comprises a polymerizable moiety attached by methylene repeats to a recognition element and an ending unit that will not interfere with the chosen recognition chemistry. The recognition element is self-complementary, unless a set of two replicating monomers with compatible cross-linking chemistry is employed. In a two-component replication system utilizing two different kinds of recognition chemistries, the initial template undergoes replication cycles, while maintaining two-dimensional segregation of the two types of monomers. During subsequent replications, the component domains experience little or no mixing, allowing the two-component, patterned assembly to be exponentially replicated. After replication, selective mineralization and/or electroless plating may produce a two-dimensional inorganic sheet having patterned domains within it.
摘要翻译：使用单体或纳米颗粒聚合体在定义的模板上进行聚合的自复制单层体系提供了合成二维单分子聚合物的方法。自复制单层系统用作无机胶体生长的模板。优选的实施方案采用基于SAM的复制，其中初始单层被图案化并用作通过分子识别自组装第二单层的模板。将第二单层聚合就位，并将单层分离形成复制物。然后两者都可以作为单层组件的模板。一般的自复制单体单元包括通过亚甲基重复序列连接到识别元件的可聚合部分和不会干扰所选择的识别化学物质的结束单元。识别元件是自互补的，除非使用具有相容的交联化学的两组复制单体。在使用两种不同类型的识别化学物质的双组分复制系统中，初始模板经历复制循环，同时保持两种类型的单体的二维分离。在随后的复制过程中，组件域经历很少或不混合，允许双组分图案化组件以指数方式复制。复制后，选择性矿化和/或化学镀可以产生其内具有图案区的二维无机片。

8. 发明授权

US06841709B2 Method of cutting polymer chains and method for producing chemical raw materials 失效
标题翻译：切割聚合物链的方法和生产化学原料的方法
公开(公告)号：US06841709B2
公开(公告)日：2005-01-11
申请号：US09984519
申请日：2001-10-30
申请人： Masaaki Yoshida
发明人： Masaaki Yoshida
IPC分类号： C07C51/27 , C10G1/10 , C07C4/00 , C07C55/00 , C10G1/00
CPC分类号： C10G1/10 , C07C51/27 , Y02P20/544 , C07C55/02
摘要： The present invention is to provide a technology to establish a new cycle-based organic chemical industry, which may be called a polymer cascade (polymer reflux industry) wherein the polymer substances shall not remain the final products, but still give birth to synthetic materials as raw materials for chemical industry and produce useful organic compounds.The present invention to destroy polymer substances by severing a part of molecular chains from the said polymer substances by means of allowing nitrogen dioxide and/or dinitrogen tetraoxide to do oxidative decomposition reaction in inert gas, or destroying polymer substances by severing a part or all of molecular chains from the said polymer substances by allowing nitrogen dioxide and/or dinitrogen tetraoxide to do oxidative decomposition reaction in supercritical carbon dioxide, or to treat polymer substances that are at least one of what are selected from polymer substances of addition polymerization type, polyaddition type, polycondensation type or addition condensation type, or waste polymers thereof, or petroleum fraction of high boiling point.
摘要翻译：本发明是提供一种建立新的循环有机化学工业的技术，其可以被称为聚合物级联（聚合物回流工业），其中聚合物物质不应该保留在最终产品中，但仍然产生合成材料作为本发明通过使二氧化氮和/或四氧化二氮在惰性气体中进行氧化分解反应而从所述聚合物物质中切断一部分分子链而破坏聚合物物质，或通过使二氧化氮和/或四氧化二氮在超临界二氧化碳中进行氧化分解反应而切断所述聚合物物质的一部分或全部分子链，或者处理至少一种以上的聚合物物质来破坏聚合物物质选自加成聚合型聚合物，加聚型，聚合物还原型或加成缩合型，或其废聚合物，或高沸点的石油馏分。

9. 发明授权

US6137005A Method for manufacture of products containing disalts of formic acid 失效
标题翻译：制造含有甲酸的产品的方法
公开(公告)号：US6137005A
公开(公告)日：2000-10-24
申请号：US952009
申请日：1998-02-26
申请人： Leif Hj.o slashed.rnevik
发明人： Leif Hj.o slashed.rnevik
IPC分类号： A23K1/16 , C07C51/41 , C07C53/06 , C07C55/00
CPC分类号： C07C51/412
摘要： A method for manufacture of products containing disalts of formic acid. Potassium hydroxide, carbonate, bicarbonate or formate, sodium hydroxide, carbonate, bicarbonate for formate, cesium hydroxide, carbonate, bicarbonate or formate or ammonium formate or ammonia is mixed with formic acid at 40-100.degree. C., the mixture is cooled and centrifuged. The filtrate containing acid salt is collected. The filter cake is transported to a drier/mixer where other disalts, calcium formate and/or a desiccant can be added.
摘要翻译： PCT No.PCT / NO96 / 00115 Sec。 371日期1998年2月26日 102（e）日期1998年2月26日PCT提交1996年5月10日PCT公布。公开号WO96 / 35657 日期：1996年11月14日制造含有甲酸的产品的方法。将氢氧化钾，碳酸盐，碳酸氢盐或甲酸盐，氢氧化钠，碳酸盐，碳酸氢盐，甲酸铯，氢氧化铯，碳酸盐，碳酸氢盐或甲酸铵或甲酸铵或氨与40-100℃的甲酸混合，将混合物冷却并离心。收集含有酸盐的滤液。将滤饼运送到干燥器/混合器中，其中可以加入其它的盐，甲酸钙和/或干燥剂。

10. 发明授权

US5847202A Racemization process for optically active carboxylic acids or salts or esters thereof 失效
标题翻译：光学活性羧酸或其盐或酯的外消旋化方法
公开(公告)号：US5847202A
公开(公告)日：1998-12-08
申请号：US955543
申请日：1997-10-22
申请人： Robert E. Young , Hao V. Phan , Thanikavelu Manimaran , Ronald C. Zumstein
发明人： Robert E. Young , Hao V. Phan , Thanikavelu Manimaran , Ronald C. Zumstein
IPC分类号： C07B55/00 , C07C51/487 , C07C55/00 , C07C59/68 , C07C67/333
CPC分类号： C07C67/333 , C07C51/487 , C07C55/00
摘要： Optically active carboxylic acids, salts or esters, such as the profen-type compounds, are racemized in the presence by nitrogenous bases such as methylbenzylamine by heating an aqueous solution of such optically active compounds in the presence of a suitable excess of an alkali metal hydroxide relative to the amount optically active carboxylic compound present in the solution. The process not only enables conversion of inactive or undesirable enantiomers of compounds such as naproxen or ibuprofen into a usable, desirable enantiomers in an efficient and economical manner, but avoids conversion of the nitrogenous base into amide. Thus the deleterious consequences of amide formation are avoided.
摘要翻译：光化学活性的羧酸，盐或酯如丙烯酸类化合物在氮碱如甲基苄胺存在下，在合适的过量的碱金属氢氧化物存在下，加热这种光学活性化合物的水溶液，进行外消旋化相对于溶液中存在的光学活性羧酸化合物的量。该方法不仅能够以有效和经济的方式将化合物（例如萘普生或布洛芬）的无活性或不需要的对映异构体转化成可用的期望的对映异构体，而且避免将含氮碱转化为酰胺。因此，避免了酰胺形成的有害后果。

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