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1. 发明申请

US20220363657A1 FLAVONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE 有权
公开(公告)号：US20220363657A1
公开(公告)日：2022-11-17
申请号：US17275502
申请日：2019-09-11
申请人： Hoffmann-La Roche Inc.
发明人： Song FENG , Chungen LIANG , Yongfu LIU , Hong SHEN , Xuefei TAN , Jun WU , Dongdong CHEN , Chao LI , Li WANG
IPC分类号： C07D311/30 , A61P31/20 , C07D405/04 , C07D335/06
摘要： The present invention provides flavone derivatives having the general formula (I) which are useful for the treatment of Hepatitis B Virus infection (HBV). The compounds act as cccDNA (covalently closed circular DMA) inhibitors.

2. 发明授权

US11111226B2 Hydrophilic compounds for optically active devices 有权
公开(公告)号：US11111226B2
公开(公告)日：2021-09-07
申请号：US16868607
申请日：2020-05-07
申请人： Merck Patent GmbH
发明人： Lars Dobelmann-Mara , Stefan Riedmueller , Martin Schraub
IPC分类号： C07D311/16 , C07D215/227 , C07D311/42 , A61L27/50 , C07D335/06
摘要： The present invention relates to novel compounds, particularly to hydrophilic compounds, comprising a photoactive unit, said novel compounds being particularly suitable for ophthalmic devices. The present application also relates to ophthalmic devices comprising such compounds.

3. 发明授权

US11078177B2 Compounds for optically active devices 有权
公开(公告)号：US11078177B2
公开(公告)日：2021-08-03
申请号：US16560265
申请日：2019-09-04
申请人： Merck Patent GmbH
发明人： Lars Dobelmann-Mara , Stefan Riedmueller , Martin Schraub
IPC分类号： A61L27/16 , A61L27/50 , C08F20/30 , C08F20/38 , C08F20/40 , G02B1/04 , C07D311/16 , C07D335/06
摘要： The present invention relates to novel compounds, particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for ophthalmic devices as well as to ophthalmic devices comprising such compounds.

4. 发明授权

US10461263B2 Condensed cyclic compound and organic light-emitting device including the same 有权
公开(公告)号：US10461263B2
公开(公告)日：2019-10-29
申请号：US15703759
申请日：2017-09-13
申请人： Samsung Display Co., Ltd.
发明人： Jungsub Lee
IPC分类号： C07D335/06 , H01L51/00 , C07D333/66 , C07D221/18 , C07F9/6561
摘要： A condensed cyclic compound having the following structure and an organic light-emitting device including the same are provided: wherein A1 is one of the following:

5. 发明申请

US20190092744A1 RETINOID COMPOUND, PREPARATION METHOD THEREFOR, INTERMEDIATES THEREOF AND APPLICATION THEREOF 审中-公开
公开(公告)号：US20190092744A1
公开(公告)日：2019-03-28
申请号：US16083879
申请日：2017-01-20
申请人： SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES , HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
发明人： Xin CAO , Biao YU , Ning WANG , Junwei CHEN
IPC分类号： C07D335/06 , A61P35/04 , C07D409/10 , C07C69/84 , C07C69/78 , C07C63/70 , C07D239/28 , C07C229/56 , C07D213/84 , C07D213/79 , A61P35/00
CPC分类号： C07D335/06 , A61P35/00 , A61P35/02 , A61P35/04 , C07C63/70 , C07C67/343 , C07C69/76 , C07C69/78 , C07C69/84 , C07C229/56 , C07C233/54 , C07C2602/10 , C07D213/79 , C07D213/84 , C07D213/85 , C07D239/28 , C07D241/24 , C07D409/06 , C07D409/10
摘要： Disclosed are a retinoid compound, a preparation method therefor, intermediates thereof and an application thereof. The retinoid compound I of the present invention has a good tumor growth inhibition rate.

6. 发明申请

US20180362494A1 CONFIGURATIONAL STEREOISOMER OF DIFETHIALONE, COMPOSITION AND RODENTICIDAL BAIT COMPRISING SAME, AND PROCESS FOR CONTROLLING TARGET RODENT PESTS 审中-公开
公开(公告)号：US20180362494A1
公开(公告)日：2018-12-20
申请号：US16061084
申请日：2016-12-06
申请人： LIPHATECH , INSTITUT ENSEIGNEMENT SUPERIEUR ET RECHERCHE EN ALIMENTATION SANTE ANIMALE SCIENCES AGRNOMIQUES ET
发明人： Hervé CARUEL , Etienne BENOIT , Isabelle FOUREL , Virginie LATTARD
IPC分类号： C07D335/06 , A01N43/18 , A01N25/00
摘要： Disclosed is to a laevorotatory enantiomer of the configurational stereoisomer of difethialone, named hetero-stereoisomer, the formula of which is 3-(4′-bromobiphenyl-4-yl)-1-(4-hydroxythiocoumarin-3-yl)-1,2,3,4-tetrahydronaphthalene, in which carbons 1 and 3 of the 1,2,3,4-tetrahydronaphthalene group have different absolute configurations.

7. 发明申请

US20180237409A1 COMPOUNDS FOR OPTICALLY ACTIVE DEVICES 审中-公开
公开(公告)号：US20180237409A1
公开(公告)日：2018-08-23
申请号：US15753192
申请日：2016-08-03
申请人： Merck Patent GmbH
发明人： Lars DOBELMANN-MARA , Stefan RIEDMUELLER , Martin SCHRAUB
IPC分类号： C07D311/16 , C08F20/30 , C07D335/06 , G02B1/04 , C08F20/38 , C08F20/40 , A61L27/16 , A61L27/50
CPC分类号： C07D311/16 , A61L27/16 , A61L27/50 , C07D335/06 , C08F20/30 , C08F20/38 , C08F20/40 , G02B1/041
摘要： The present invention relates to novel compounds, particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for ophthalmic devices as well as to ophthalmic devices comprising such compounds.

8. 发明授权

US09951087B2 Fused ring analogues of anti-fibrotic agents 有权
公开(公告)号：US09951087B2
公开(公告)日：2018-04-24
申请号：US14730753
申请日：2015-06-04
申请人： Fibrotech Therapeutics PTY LTD
发明人： Spencer John Williams , Steven Zammit , Darren James Kelly
IPC分类号： C07D498/04 , C07C235/40 , C07C235/56 , C07D235/12 , C07D239/91 , C07D241/44 , C07D263/56 , C07D265/22 , C07D277/64 , C07D471/04 , C07D495/04 , C07D513/04 , C07D403/12 , C07D311/16 , C07D233/64 , C07D333/62 , C07D333/70 , C07D335/06 , C07D401/12 , C07D235/24 , C07D405/12 , C07D493/04 , C07D307/85 , C07D209/08 , C07D235/26 , C07D265/36 , C07D285/24
CPC分类号： C07D498/04 , C07C235/40 , C07C235/56 , C07C2602/08 , C07C2602/10 , C07D209/08 , C07D233/64 , C07D235/12 , C07D235/24 , C07D235/26 , C07D239/91 , C07D241/44 , C07D263/56 , C07D265/22 , C07D265/36 , C07D277/64 , C07D285/24 , C07D307/85 , C07D311/16 , C07D333/62 , C07D333/70 , C07D335/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D471/04 , C07D493/04 , C07D495/04 , C07D513/04
摘要： The present invention relates to arylcarbonyl and heteroarylcarbonyl anthranilate compounds that may be useful as anti-fibrotic agents. The present invention also relates to methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment disorders.

9. 发明申请

US20180076396A1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME 审中-公开
公开(公告)号：US20180076396A1
公开(公告)日：2018-03-15
申请号：US15703759
申请日：2017-09-13
申请人： Samsung Display Co., Ltd.
发明人： Jungsub LEE
IPC分类号： H01L51/00 , C07D335/06 , C07D333/66 , C07D221/18 , C07F9/6561
CPC分类号： H01L51/0072 , C07D221/18 , C07D333/66 , C07D335/06 , C07F9/5325 , C07F9/655354 , C07F9/65611 , C07F9/65685 , C07F9/6571 , H01L51/0062 , H01L51/0071 , H01L51/0074 , H01L51/5012
摘要： A condensed cyclic compound having the following structure and an organic light-emitting device including the same are provided: wherein A1 is one of the following:

10. 发明申请

US20160130246A1 THIOUREA COMPOUNDS AND THEIR USE AS INHIBITORS OF SIRT2 OR SIRT5 审中-公开
标题翻译：硫脲化合物及其作为SIRT2或SIRT5的抑制剂
公开(公告)号：US20160130246A1
公开(公告)日：2016-05-12
申请号：US14896057
申请日：2014-06-06
申请人： CORNELL UNIVERSITY
发明人： Hening LIN
IPC分类号： C07D335/06 , C07C335/08
CPC分类号： C07D335/06 , C07C335/08 , Y02P20/55
摘要： A compound useful as a Sirt2 or Sirt5 inhibitor having the formula (1) wherein: R1 is a hydrocarbon group having at least two carbon atoms connected by carbon-carbon bonds, wherein said hydrocarbon group is optionally endcapped by a neutral or anionic oxygen-containing group; R2a, R2b, and R2c are independently selected from hydrogen atom and hydrocarbon groups; X0, X1, X2, and X3 are independently selected from —(CH2)n—, —NR5—, —O—, —S—, and a bond, wherein n represents 1, 2, or 3, provided that at least one of X0-X3 is —(CH2)n—; and R3 and R4 are independently selected from the group consisting of hydrogen atom, hydrocarbon groups, biological groups, and protecting groups. Also described are pharmaceutical compositions of the inhibiting compounds, and methods of treatment by administration of the inhibiting compounds.
摘要翻译：可用作具有式（1）的Sirt2或Sirt5抑制剂的化合物，其中：R1是具有通过碳 - 碳键连接的至少两个碳原子的烃基，其中所述烃基任选地被中性或阴离子含氧的组; R2a，R2b和R2c独立地选自氢原子和烃基; X 0，X 1，X 2和X 3独立地选自 - （CH 2）n - ，-NR 5 - ， - O - ， - S-和键，其中n表示1,2或3，条件是至少一个的X0-X3是 - （CH2）n-; 并且R 3和R 4独立地选自氢原子，烃基，生物基团和保护基团。还描述了抑制化合物的药物组合物和通过施用抑制化合物治疗的方法。

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