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1. 发明授权

US10403824B2 Electronic device and compound 有权
公开(公告)号：US10403824B2
公开(公告)日：2019-09-03
申请号：US15323905
申请日：2015-07-03
申请人： Novaled GmbH
发明人： Sascha Dorok , Ina Steudtner , Ulrich Heggemann , Steffen Runge , Manuela Klose
IPC分类号： H01L51/00 , C07D235/30 , C07D295/125 , C07C279/18 , C08G73/02 , C07C211/53 , C07D233/50 , C07D295/13 , H01L51/42 , H01L51/44
摘要： The invention relates to an electronic device comprising a compound having Formula (1): ABx (1), wherein A is a structural moiety that consists of at least two atoms and comprises a conjugated system of delocalized electrons, each B is independently selected from an imine functional group (1a), wherein R1, R2, R3, R4 are independently selected from C1-C30 alkyl, C2-C30 alkenyl, C2-C3 alkinyl, C3-C30 cycloalkyl, C6-C30 aryl, C2-C30 heteroaryl, C7-C30 arylalkyl, C3-C30 heteroarylalkyl, the wave line represents a covalent bond to the imine nitrogen atom, G is in each group (1a) independently selected from a quarternary carbon atom and from a cyclopropenylidene structural moiety, x is an integer equal one or higher, preferably equal two or higher, and the lone electron pair of the imine nitrogen atom and/or the pi-electrons of the imine double bond of at least one group B is conjugated with the conjugated system of delocalized electrons comprised in the structural moiety A, with the proviso that two or more of the substituents R1, R2, R3, R4 may be connected to form a ring that may contain also unsaturation and, if any of the substituents R1, R2, R3, R4 comprises two or more carbon atoms, up to one third of the overall count of the carbon atoms in the substituent or in any ring formed by two connected substituents can be replaced with heteroatoms independently selected from O, S, N and B as well as to an electrically semiconducting material and a compound for use in the electronic device.

2. 发明授权

US10100070B2 Borate-based base generator, and base-reactive composition comprising such base generator 有权
公开(公告)号：US10100070B2
公开(公告)日：2018-10-16
申请号：US15114048
申请日：2015-01-22
申请人： FUJIFILM Wako Pure Chemical Corporation
发明人： Nobuhiko Sakai , Kosuke Yanaba
IPC分类号： G03F7/004 , C07C279/02 , C07C279/04 , C07C279/16 , C07C279/18 , C07F5/02 , C07F9/22 , C07C229/26 , C07F9/53 , C07F9/572 , C07F9/6584 , C07F9/06 , C07C279/26 , C07D233/50 , C07D487/04
摘要： A compound capable of providing a composition having high storage stability without reacting with a base-reactive compound, even when stored in a mixed state with the base-reactive compound, as well as capable of generating a strong base by irradiation of light (active energy rays) or heating. A base generator comprises the compound and a base-reactive composition comprises the base generator and the base-reactive compound. The compound is represented by the general formula (A).

3. 发明授权

US09062006B2 High molecular weight polylactic acid synthesized via polycondensation catalyzed by bionic creatinine guanidinium chloride 有权
标题翻译：通过由仿生肌酐氯化胍催化的缩聚合成的高分子量聚乳酸
公开(公告)号：US09062006B2
公开(公告)日：2015-06-23
申请号：US14129323
申请日：2011-11-02
申请人： Hong Li , Quanxing Zhang , Wei Huang , Wei Jiang , Xupeng Zong , Bingcai Pan
发明人： Hong Li , Quanxing Zhang , Wei Huang , Wei Jiang , Xupeng Zong , Bingcai Pan
IPC分类号： C08G63/87 , C07D233/50 , A61L27/18 , A61L31/06 , A61K47/34 , A61L17/12 , C07D233/32 , C08G63/06
CPC分类号： C07D233/50 , A61K47/34 , A61L17/12 , A61L27/18 , A61L31/06 , C07D233/32 , C07D233/46 , C07D233/88 , C08G63/06 , C08G63/87
摘要： Disclosed is a high molecular weight polylactic acid synthesized by using a method for synthesizing and catalytically-polycondensing bionic creatinine-guanidinium chloride. Creatinine is used as the material in a reaction with aqueous hydrochloric acid to synthesize a bionic creatinine-guanidinium salt catalyst, creatinine-guanidinium chloride (CR.Cl). The creatinine-guanidinium chloride synthesized is used as a catalyst, an industrial grade lactic acid (LA, 85% to 90%, aqueous solution) is used as a monomer, a solvent-free two-step polycondensation method is used to synthesize and afford metal-free and toxic residue-free polylactic acid featuring high biological safety and high molecular weight.
摘要翻译：本发明公开了一种通过使用合成和催化缩聚仿生肌酐 - 氯化胍的方法合成的高分子量聚乳酸。使用肌酸酐作为与盐酸水溶液反应的材料，以合成肌酸酐 - 胍盐催化剂，肌酸酐 - 氯化胍（CR.Cl）。使用合成的肌酸胍 - 氯化胍作为催化剂，使用工业级乳酸（LA，85％〜90％，水溶液）作为单体，使用无溶剂的两步缩聚法合成并提供无金属和无毒无残留的聚乳酸，具有高生物安全性和高分子量。

4. 发明授权

US08815923B2 Therapeutic compounds 有权
标题翻译：治疗化合物
公开(公告)号：US08815923B2
公开(公告)日：2014-08-26
申请号：US13853160
申请日：2013-03-29
申请人： Allergan, Inc.
发明人： Santosh C. Sinha , Smita S. Bhat , Todd M. Heidelbaugh , Daniel W. Gil , Ken Chow , Michael E. Garst
IPC分类号： A61K31/421 , A61K31/426 , A61K31/4168 , C07D233/02 , C07D263/04 , C07D277/04 , C07D277/18 , C07D263/28 , C07D233/44 , C07D233/50
CPC分类号： C07D233/44 , C07D233/50 , C07D263/28 , C07D277/18
摘要： Disclosed herein is a compound having a structure compositions, methods, and medicaments related thereto are also disclosed.
摘要翻译：本文公开了具有与其有关的结构组成，方法和药物的化合物也被公开。

5. 发明申请

US20110178144A1 THERAPEUTIC COMPOUNDS 失效
公开(公告)号：US20110178144A1
公开(公告)日：2011-07-21
申请号：US12673351
申请日：2008-08-14
申请人： Santosh C. Sinha , Smit S. Bhat , Todd M. Heidelbaugh , Daniel W. Gil , Ken Chow , Michael E. Garst
发明人： Santosh C. Sinha , Smit S. Bhat , Todd M. Heidelbaugh , Daniel W. Gil , Ken Chow , Michael E. Garst
IPC分类号： A61K31/4168 , C07D233/50 , A61P29/00 , A61P27/02
CPC分类号： C07D233/44 , C07D233/50 , C07D263/28 , C07D277/18
摘要： Disclosed herein is a compound having a structure compositions, methods, and medicaments related thereto are also disclosed.

6. 发明授权

US07560483B2 Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof 有权
标题翻译：从1-酰基 - 烷基衍生物合成前药的方法及其组合物
公开(公告)号：US07560483B2
公开(公告)日：2009-07-14
申请号：US11158405
申请日：2005-06-21
申请人： Mark A. Gallop , Jia-Ning Xiang , Fenmei Yao , Laxminarayan Bhat , Cindy X. Zhou
发明人： Mark A. Gallop , Jia-Ning Xiang , Fenmei Yao , Laxminarayan Bhat , Cindy X. Zhou
IPC分类号： C07C271/22 , A61K31/27 , C07D403/04 , A61K31/497 , C07C235/50 , A61K31/166 , C07C271/06 , C07C271/08 , C07C271/10 , C07C271/12 , C07C271/14 , C07C271/16 , C07C271/18 , C07C271/20 , C07C271/24 , C07C271/26 , C07C271/28 , C07C271/30 , C07D401/04 , C07D475/08 , A61K31/5355 , A61K31/4985 , C07D401/08 , C07D241/04 , C07H15/234 , A61K31/7036 , C07H15/236 , A61K31/704 , C07H15/24 , C07D235/28 , A61K31/4168 , A61K31/427 , C07D277/82 , A61K31/428 , C07D235/22 , C07D263/28 , A61K31/421 , C07D209/32 , A61K31/4045 , C07D209/08 , A61K31/4192 , C07D233/42 , A61K31/4178 , C07D235/32 , C07D403/12 , A61K31/4164 , C07D233/50 , A61K31/341 , C07D307/36 , C07D233/06 , C07D277/42 , C07D277/38 , A61K31/426 , C07D209/52 , A61K31/4025 , A61K31/4375 , C07D211/82 , A61K31/4418 , C07D213/65 , A61K31/4412 , C07D211/14 , A61K31/4458 , C07D211/42 , A61K31/45 , A61K31/4704 , C07D215/26 , C07D401/06 , A61K31/4462 , C07D487/04 , A61K31/519
CPC分类号： C07C269/06 , C07C271/12 , C07C271/22 , C07C2601/14 , C07F9/4087
摘要： The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amendable to scale-up. The current invention also provides 1-acyl-alkyl derivatives of known drug components and methods for synthesizing these 1-acyl-alkyl derivatives.
摘要翻译：本发明提供了从1-酰基 - 烷基衍生物合成1-（酰氧基） - 烷基衍生物的方法，其通常以高产率立体选择性地进行，不需要使用活化的中间体和/或有毒化合物，并且易于修饰放大。本发明还提供已知药物成分的1-酰基 - 烷基衍生物和合成这些1-酰基 - 烷基衍生物的方法。

7. 发明申请

US20050038087A1 Derivatives of heterocycles with 5 members, their preparation and their use as medicaments 失效
标题翻译：具有5个成员的杂环衍生物，其制备及其作为药物的用途
公开(公告)号：US20050038087A1
公开(公告)日：2005-02-17
申请号：US10915001
申请日：2004-08-10
申请人： Pierre-Etienne Chabrier De Lassauniere , Jermiah Harnett , Dennis Bigg , Ann-Marie Liberatore , Jacques Pommier , Jacques Lannoy , Christophe Thurieau , Zheng Xin Dong
发明人： Pierre-Etienne Chabrier De Lassauniere , Jermiah Harnett , Dennis Bigg , Ann-Marie Liberatore , Jacques Pommier , Jacques Lannoy , Christophe Thurieau , Zheng Xin Dong
IPC分类号： A61K31/417 , A61K31/4178 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/496 , A61P25/08 , A61P25/28 , A61P29/00 , C07D233/50 , C07D233/54 , C07D261/04 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/34 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/14 , A61K31/425 , A61K31/4164
CPC分类号： C07D233/64 , A61K31/417 , A61K31/4178 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/496 , C07D233/50 , C07D261/04 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/34 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/14
摘要： The invention relates to thiazole, oxazole, imidazole, isoxazole and isoxazoline derivatives of general formula (I) wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is notably selected from various optionally substituted aromatic radicals, B is notably hydrogen, alkyl or phenyl, R1 and R2 are notably independently hydrogen, alkyl or cycloalkyl or R1 and R2, taken together with the carbon atom which carries them, form a carbocycle with 3 to 7 members and Ω is —NR46R47 or —OR48, R46 and R47 are notably independently hydrogen, alkyl, cycloalkyl or —(CH2)k—COOR51, R51 is notably alkyl or haloalkyl and R48 is notably hydrogen or alkyl. These compounds have advantageous pharmacological properties which allow their use in therapeutics, notably for treating neurodegenerative disorders or pain.
摘要翻译：本发明涉及噻唑，恶唑，咪唑，异恶唑和其中Het为噻唑，恶唑，咪唑，异恶唑或异恶唑啉的通式（I）的异恶唑啉衍生物，n为0至6的整数，A特别选自各种任选取代的芳基，B特别是氢，烷基或苯基，R 1和R 2独特地独立地表示氢，烷基或环烷基或R 1和R 2与携带它们的碳原子一起，形成具有3至7个成员的碳环，并且ω是-NR 46 R 47或-OR 48，R 46和R 47独立地是氢，烷基，环烷基或 - （CH 2）k -COOR 51，R 51特别是烷基或卤代烷基，R 48特别是氢或烷基。这些化合物具有有利的药理学性质，其允许其用于治疗学，特别是用于治疗神经变性疾病或疼痛。

8. 发明申请

US20050020505A1 R-isomer of beta amino acid compounds as integrin receptor antagonists derivatives 审中-公开
标题翻译： β-氨基酸化合物的R-异构体作为整合素受体拮抗剂衍生物
公开(公告)号：US20050020505A1
公开(公告)日：2005-01-27
申请号：US10741768
申请日：2003-12-19
申请人： Thomas Rogers , Peter Ruminski , Srinivasan Nagarajan , Balekudru Devadas , James Malecha , Lawrence Miller , Joseph Rico , Hwang-Fun Lu , Laura Marrufo , Joe Collins
发明人： Thomas Rogers , Peter Ruminski , Srinivasan Nagarajan , Balekudru Devadas , James Malecha , Lawrence Miller , Joseph Rico , Hwang-Fun Lu , Laura Marrufo , Joe Collins
IPC分类号： A61P35/00 , C07D223/12 , C07D233/50 , C07D239/14 , C07D243/04 , C07D401/12 , A61K38/04 , C07D267/02 , C07D281/02 , C07K5/04
CPC分类号： C07D401/12 , C07D223/12 , C07D233/50 , C07D239/14 , C07D243/04
摘要： The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αvβ3 and/or the αvβ5 integrin without significantly inhibiting the αvβ6 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物，以及选择性抑制或拮抗阿尔法博乙和/或阿尔法肽5整联蛋白的方法，而不显着抑制alphavbeta6 整合素

9. 发明授权

US6150389A Comformationally rigid bicyclic and adamantane derivatives useful as .alpha..sub.2 -adrenergic blocking agents 失效
标题翻译：用作α2肾上腺素能阻断剂的组合刚性双环和金刚烷衍生物
公开(公告)号：US6150389A
公开(公告)日：2000-11-21
申请号：US3902
申请日：1998-01-07
申请人： Stephen A. Munk , Michael E. Garst , James A. Burke
发明人： Stephen A. Munk , Michael E. Garst , James A. Burke
IPC分类号： A61P3/04 , A61P3/10 , A61P15/10 , A61P25/24 , A61P27/02 , C07D233/50 , C07D233/54 , C07D263/28 , C07D277/18 , C07D413/12 , A61K31/421 , C07D263/08
CPC分类号： C07D413/12 , C07D233/50 , C07D263/28 , C07D277/18
摘要： A compound of formula I in which: ring A is one of the five alternative multi-cyclic rings as shown wherein a dotted line adjacent to a bond indicates that a single bond or a double bond may be present at that position; X is nitrogen, oxygen or sulfur; R is hydrogen, lower straight or branched chain alkyl of 1 to 6 carbon atoms, or lower straight or branched chain alkenyl of 2 to 6 carbon atoms, a cycloaliphatic ring of 3 to 6 carbon atoms, phenyl optionally mono- or di-substituted with hydroxy, halogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 2 carbon atoms, or methylenedioxyphenyl; or a stereoisomer, or a pharmaceutically acceptable salt thereof.These compounds have .alpha..sub.2 receptor blocking activity and hence find use in the treatment or palliation of elevated intraocular pressure, non insulin-dependent diabetes, male impotence and obesity.
摘要翻译：式I化合物，其中：环A是所示的五种替代多环之一，其中与键相邻的虚线表示在该位置可能存在单键或双键; X是氮，氧或硫; R为氢，1至6个碳原子的较低直链或支链烷基，或2至6个碳原子的较低直链或支链烯基，3至6个碳原子的脂环族环，任选被一个或二个取代羟基，卤素，1至3个碳原子的烷基或1至2个碳原子的烷氧基，或亚甲二氧基苯基; 或立体异构体或其药学上可接受的盐。这些化合物具有α2受体阻断活性，因此可用于治疗或缓解眼内压升高，非胰岛素依赖性糖尿病，男性阳ence和肥胖症。

10. 发明授权

US6107345A Benzocyclobutane compounds 失效
标题翻译：苯并环丁烷化合物
公开(公告)号：US6107345A
公开(公告)日：2000-08-22
申请号：US261803
申请日：1999-03-03
申请人： Jean-Louis Peglion , Aimee Dessinges , Jean-Christophe Harmange , Mark Millan , Adrian Newman-Tancredi , Mauricette Brocco
发明人： Jean-Louis Peglion , Aimee Dessinges , Jean-Christophe Harmange , Mark Millan , Adrian Newman-Tancredi , Mauricette Brocco
IPC分类号： C07D233/50 , A61K31/00 , A61K31/135 , A61K31/33 , A61K31/35 , A61K31/351 , A61K31/38 , A61K31/382 , A61K31/415 , A61K31/4164 , A61K31/4168 , A61K31/445 , A61K31/4465 , A61K31/451 , A61P1/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/30 , A61P43/00 , C07C215/42 , C07C217/58 , C07C217/74 , C07D211/44 , C07D233/48 , C07D263/28 , C07D309/10 , C07D335/02 , C07D345/00 , A61K31/133
CPC分类号： C07D309/10 , C07C215/42 , C07C217/74 , C07D233/48 , C07D263/28 , C07D335/02
摘要： A compound of formula (I): ##STR1## wherein: Z.sub.1, Z.sub.2, Z.sub.3, Z.sub.4, which may be identical or different, represent a group as defined in the description,X represents oxygen, S(O).sub.p, --(CH.sub.2).sub.n -- or --CH.sub.2 --Y--CH.sub.2 -- wherein p, n and Y are as defined in the description,A represents ##STR2## wherein m, R.sub.1, R.sub.2 and G are as defined in the description, their isomers and addition salts thereof with a pharmaceutically-acceptable acid, and medicinal products containing the same are useful in the treatment of diseases like depression, panic attacks, obsessive compulsive disorders, phobias, impulsive disorders, drug abuse or anxiety.
摘要翻译：式（I）的化合物：其中：可以相同或不同的Z 1，Z 2，Z 3，Z 4表示如说明书中所定义的基团，X表示氧，S（O）p， - （CH 2）n - 或-CH 2 -Y-CH 2 - ，其中p，n和Y如说明书中所定义，A表示其中m，R 1，R 2和G如说明书中所定义，其异构体和加成盐与药学上可接受的酸和含有它们的药用产品可用于治疗抑郁症，恐慌发作，强迫症，恐惧症，冲动性疾病，药物滥用或焦虑症等疾病。

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