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1. 发明授权

US10383960B2 Small molecule imaging of fungi by positron emission tomography scanning 有权
公开(公告)号：US10383960B2
公开(公告)日：2019-08-20
申请号：US15961554
申请日：2018-04-24
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , The Reearch Foundation of the State University of New York
发明人： Peter R. Williamson , Dale O. Kiesewetter , John Panepinto , Jin Qiu
IPC分类号： C07D251/68 , A61K31/53 , A61K51/04 , C07B59/00
摘要： Disclosed herein are isotopically labeled calcofluor derivatives and uses of such to detect fungi, such as filamentous fungi, including Aspergillus species, such as by positron emission tomography (PET) scanning. In some examples, the disclosed compounds have a formula of wherein R1 is an amine, a hydroxyl group, a sulfide, a carboxylic acid, an amide, an alkyl, or aryl; R2 is —NHC(O)—R3-L or —C(O)NH—R3-L, wherein R3 is an aryl or an aliphatic group (such as alkyl); each R4 independently may be selected from halogen, aliphatic (such as alkyl), aryl, amine, hydroxyl, haloalkyl, carboxylic acid, amide, aralkyl, cyano, ester, thiol, thioether, or alkoxy; each R5 independently may be selected from hydrogen, aralkyl, alkyl, or aryl, with any one of the aralkyl, alkyl, or aryl groups optionally being substituted with any one of the substituents provided for R4; each n independently is 1, 2, 3, 4, or 5; and L is 18F or a chelator capable of chelating a radiolabel (such as chelators for [18F]AlF, 64Cu, 68Ga), 1,4,7,10-tetraazacyclododecane-tetraacetic acid (DOTA) or 1,4,7-triazacyclononane-triacetic acid (NOTA).

2. 发明授权

US09629945B2 Stilbene-based reactive compounds, polymeric matrices formed therefrom, and articles visualizable by fluorescence 有权
公开(公告)号：US09629945B2
公开(公告)日：2017-04-25
申请号：US14104208
申请日：2013-12-12
申请人： SurModics, Inc.
发明人： Aleksey V. Kurdyumov , Dale G. Swan , Nathan A. Lockwood , Bruce M. Jelle
IPC分类号： C07C233/81 , C07C271/58 , C07C309/51 , A61L31/14 , A61L31/10 , C07D251/68 , C07C235/84 , C07C309/46 , A61B1/005 , C07D251/54 , A61B1/00
CPC分类号： A61L31/14 , A61B1/00135 , A61B1/005 , A61L31/10 , C07C235/84 , C07C309/46 , C07D251/54 , C07D251/68 , Y10T428/31942
摘要： The invention is directed to latent reactive and polymerizable derivatives of fluorescent stilbene-based compounds. The compounds can be used to provide articles with a fluorescence property, such as medical devices (e.g., catheters). The fluorescent compounds can be used in association with polymers, or can be incorporated into polymers, and the polymers used in a coating composition on the article surface. The compounds allow for visual or machine inspection of coating properties such as uniformity of coverage.

3. 发明授权

US06929667B2 Method for the fluorescent whitening of cotton 有权
公开(公告)号：US06929667B2
公开(公告)日：2005-08-16
申请号：US10333258
申请日：2001-07-12
申请人： Fabienne Cuesta , Dieter Reinehr , Hans Kramer , Georges Metzger , Bernd Wockenfuss
发明人： Fabienne Cuesta , Dieter Reinehr , Hans Kramer , Georges Metzger , Bernd Wockenfuss
IPC分类号： C07D251/68 , D06L3/12 , D06M13/358 , D06P5/06
CPC分类号： D06P5/06 , C07D251/68 , D06L4/621 , D06M13/358 , D06M2101/06 , Y10S8/918
摘要： A method for the fluorescent whitening of cotton in a discontinuous process comprising contacting the cotton, I an aqueous bath having a pH value of 6 or less, with one or more compounds of the Formula (I) wherein R1 represents an —SO2R3, —SOR3, CO2M, —CO2R3, —CONR3R4, —CN or —NO2 substituent, R2 is —NH2, —NH(C1-C4alkyl), —N(C1-C4alkyl)2, —NH(C2-C4hydroxyalkyl), —N(C2-C4hydroxyalkyl)2, —NH(C1-C4alkoxy)(C1-C4alkyl), —N[(C1-C4alkoxy)(C1-C4alkyl)]2, NHC2—C4alkylsulphonic acid, morpholineo, piperidino pyrrolidino, an amino acid or amino acid amide residue from which a hydrogen atom on the amino group has been removed, —OC1-C4alkyl or —OC1-C4hydroxyalkyl, R3 and R4 each, independently, represent hydrogen, C1-C4alkyl, C2-C4hydroxyalkyl or C1-C4alkoxyC1-C4alkyl and M is H, Na, Li, K, Ca, Mg, ammonium, or ammonium that is mono-, di-, tri- or tetrasubsituted by C1-C4alkyl, C2-C4hydroxyalkyl or a mixture thereof, some of which are new

4. 发明申请

US20050106114A1 Process for improving the sun protection factor of cellulosic fibre material 失效
标题翻译：改善纤维素纤维材料防晒系数的方法
公开(公告)号：US20050106114A1
公开(公告)日：2005-05-19
申请号：US10504945
申请日：2003-02-11
申请人： Georges Metzger , Jean-Jacques Donze , Hans Kramer , Serge Hauger , Volker Papendick , Michael Milde , Ted Deisenroth , Rainer Traber , Ullrich Menge , Hauke Rohwer
发明人： Georges Metzger , Jean-Jacques Donze , Hans Kramer , Serge Hauger , Volker Papendick , Michael Milde , Ted Deisenroth , Rainer Traber , Ullrich Menge , Hauke Rohwer
IPC分类号： C09B57/00 , C07D251/68 , C11D3/28 , D06L3/12 , D06M13/355 , D06M13/358 , D06M101/04 , D06P1/00 , D06M13/322 , A61K7/42
CPC分类号： D06M13/358 , C07D251/68 , D06M2200/25
摘要： A process for improving the sun protection factor (SPF) of cellulosic fibre materials and blends thereof, which comprises contacting said materials with at least one compound of the formula (1) according to claim 1.
摘要翻译：一种用于改善纤维素纤维材料及其共混物的防晒因子（SPF）的方法，其包括使所述材料与至少一种根据权利要求1的式（1）化合物接触。

5. 发明授权

US6121444A Process for preparing substituted 4,4'-diaminostilbene-2,2'-disulphonic acid salts 失效
标题翻译：制备取代的4,4'-二氨基芪-2,2'-二磺酸盐的方法
公开(公告)号：US6121444A
公开(公告)日：2000-09-19
申请号：US230108
申请日：1999-01-24
申请人： Ulrich Feldhues , Udo Eckstein , Uwe Vogt , Rolf Brockmann
发明人： Ulrich Feldhues , Udo Eckstein , Uwe Vogt , Rolf Brockmann
IPC分类号： C07D251/68 , D06L3/12
CPC分类号： C07D251/68 , D06L3/1214
摘要： In the preparation of substituted 4,4'-diaminostilbene-2,2'-disulfonic acid salts a clear increase in the reaction rate may be achieved by carrying out the reaction of the tetrachlorine derivative (III) with the aniline (IV) in the presence of the amine (VI) as acid-absorber.
摘要翻译： PCT No.PCT / EP96 / 03357 Sec。 371日期1999年1月22日 102（e）1999年1月22日PCT PCT 1996年7月31日PCT公布。第WO98 / 05653号公报日期1998年2月12日在制备取代的4,4'-二氨基芪-2,2'-二磺酸盐中，通过进行四氯化锑衍生物（III）与苯胺的反应可以实现反应速率的明显增加（Ⅳ）在作为酸吸收剂的胺（Ⅵ）存在下进行。

6. 发明授权

US5656760A Fluorescent whitening agents 失效
标题翻译：荧光增白剂
公开(公告)号：US5656760A
公开(公告)日：1997-08-12
申请号：US530975
申请日：1995-09-20
申请人： Jean-Pierre Bacher , Claude Eckhardt , Dieter Reinehr
发明人： Jean-Pierre Bacher , Claude Eckhardt , Dieter Reinehr
IPC分类号： C07D251/52 , C07D251/68 , C07D251/70 , C11D3/395 , D06L3/12 , D06M13/07 , C07D251/48 , C07D251/54 , C07D403/02
CPC分类号： D06L3/1214 , C07D251/68 , D06L3/1257 , D06M13/07 , D06M2101/06
摘要： The present invention provides a compound having the formula: ##STR1## in which M is hydrogen, sodium, potassium, calcium, magnesium, ammonium, mono-, di-, tri- or tetra-C.sub.1 -C.sub.4 alkylammonium, mono-, di- or tri-C.sub.1 -C.sub.4 hydroxyalkylammonium or ammonium that is di- or tri-substituted by a mixture of C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 hydroxyalkyl groups; R.sub.1 is a group having the formula: ##STR2## in which M has its previous significance and n is 1 or 2; and R.sub.2 is O--C.sub.1 -C.sub.12 alkyl or N(R.sub.3)(R.sub.4) in which R.sub.3 and R.sub.4, independently, are hydrogen, C.sub.1 -C.sub.12 alkyl or C.sub.1 -C.sub.4 hydroxyalkyl, or R.sub.3 and R.sub.4, together with the nitrogen atom, are the atoms required to form a pyrrolidine, piperidine or morpholine group.The compounds of formula (1) are particularly useful as fluorescent whitening agents for cotton in discontinuous processes, in the course of which an acidic treatment, especially a finishing treatment using a polymer resin, occurs.
摘要翻译：本发明提供具有下式的化合物：其中M是氢，钠，钾，钙，镁，铵，一，二，三或四-C 1 -C 4烷基铵，被C1-C4烷基和C1-C4羟烷基的混合物二或三取代的单，二或三-C 1 -C 4羟烷基铵或铵; R1是具有下式的组：其中M具有其先前的含义，n是1或2; 并且R 2为O-C 1 -C 12烷基或N（R 3）（R 4），其中R 3和R 4独立地为氢，C 1 -C 12烷基或C 1 -C 4羟烷基，或者R 3和R 4与氮原子一起为所需原子以形成吡咯烷，哌啶或吗啉基团。式（1）的化合物特别可用作不连续工艺中用于棉花的荧光增白剂，其中酸性处理，特别是使用聚合物树脂的整理处理发生。

7. 发明授权

US4112226A Process for removing non-fluorescent triazine derivative impurities from fluorescent agents 失效
标题翻译：从荧光剂除去非荧光三嗪衍生物杂质的方法
公开(公告)号：US4112226A
公开(公告)日：1978-09-05
申请号：US734686
申请日：1976-10-22
申请人： Philip Richard Norman Eymond
发明人： Philip Richard Norman Eymond
IPC分类号： G01N31/00 , C07D251/68 , C09B67/54 , D06L3/12 , C07D251/08
CPC分类号： D06L3/1264 , C07D251/68
摘要： A method for removing non-fluorescent triazine derivative impurities having the structural formula: ##STR1## wherein R.sub.1 is a hydroxy group or a halogen atom,R.sub.2 is a hydroxy group or the group --NR.sub.4 R.sub.5, each ofR.sub.4 and R.sub.5 being a hydrogen atom, alkyl, substituted alkyl, aryl or substituted aryl group, or R.sub.4 or R.sub.5 being combined in a heterocyclic ring, andR.sub.3 is an alkyl, substituted alkyl, aryl or substituted aryl group,From fluorescent agents belonging to the class of compounds of 4,4'-di(sym-triazinylamino) stilbene-2,2'- disulphonic acids and salts thereof, by washing said fluorescent agent with a dilute aqueous solution of an alkali metal hydroxide under atmospheric pressure and at a temperature not exceeding 75.degree. C.
摘要翻译：一种除去具有以下结构式的非荧光三嗪衍生物杂质的方法：其中R1是羟基或卤素原子，R2是羟基或-NR4R5基，R4和R5各自是氢原子，烷基，取代的烷基，芳基或取代的芳基，或R4或R5组合在杂环中，R3是烷基，取代的烷基，芳基或取代的芳基，来自与化合物类别相关的荧光剂通过用大气压力下的碱金属氢氧化物的稀释水溶液和在不超过75℃的温度下洗涤含有荧光的溶液，将'-DI（SYM-三亚氨基）苯并-2'-2' - 二磺酸及其盐

8. 发明授权

US3951960A Novel crystalline forms of optical brighteners 失效
标题翻译：荧光增白剂的新型结晶形式
公开(公告)号：US3951960A
公开(公告)日：1976-04-20
申请号：US834560
申请日：1969-06-18
申请人： James C. Heath , Raymond E. Werner , John W. Delaney , Nathan N. Crounse
发明人： James C. Heath , Raymond E. Werner , John W. Delaney , Nathan N. Crounse
IPC分类号： C07D251/68 , D06L3/12 , C07D251/54
CPC分类号： C07D251/68 , D06L3/1264
摘要： Novel crystalline needle forms of the fluorescent compounds disodium 4,4'-bis(4-anilino-6-morpholino-s-triazin-2-ylamino)-2,2'-stilbenedisulfonate and disodium 4,4'-bis(4,6-dianilino-s-triazin-2-ylamino)-2,2'-stilbenedisulfonate, useful as optical brightening agents, particularly when incorporated into detergent compositions. The novel crystalline forms are prepared by heating the compound in an aqueous alkaline medium containing excess amine reactant.
摘要翻译：新型结晶针形式的4,4'-双（4-苯胺基-6-吗啉代-s-三嗪-2-基氨基）-2,2'-芪二磺酸二钠和4,4'-双（4 ，6-二苯胺基-s-三嗪-2-基氨基）-2,2'-二苯乙烯二磺酸盐，可用作荧光增白剂，特别是当掺入洗涤剂组合物中时。通过在含有过量胺反应物的含水碱性介质中加热化合物来制备新的结晶形式。

9. 发明授权

US3808202A Metalized s-triazinyloxy-and amino-salicylic acid biocides 失效
标题翻译：金属化的三亚磷酸和氨基磺酸生物
公开(公告)号：US3808202A
公开(公告)日：1974-04-30
申请号：US18855071
申请日：1971-10-12
申请人： GAF CORP
发明人： STROBEL A
IPC分类号： C07D251/46 , C07D251/52 , C07D251/68 , C07D413/04 , C07D55/20 , C07D55/22
CPC分类号： C07D413/04 , C07D251/46 , C07D251/52 , C07D251/68
摘要： THERE ARE DISCLOSED BIOCIDAL COMPOUNDS OF THE FORMULA:

((4-((V,Z-S-TRIAZINYL)-NH-),X-PHENYL)-W-)2-

W IS A MONOVALENT BOND OR -CH=CH-; X IS BYDROGEN, COOR, SO3R, COOME/2 OR SO3ME/2;

V IS (3-HO,4-(ME/2-OOC-)PHENYL)-O- OR

(3-(ME/2-OOC-),4-HO-PHENYL)-NH-;

Z IS R1-N(-R2)-, (3-HO,4-(ME/2-OOC-)PHENYL)-O-, OR

(3-HO,4-(ME/2-OOC-)PHENYL)-NH-

WHEREIN R IS AN ALKALI METAL SUCH AS K OR NA: R1 IS HYDROGEN, LOWER ALKYL OR HYDROXYL LOWER ALKYL; R2 IS HYDROGEN, LOWER ALKYL, HYDROXY LOWER ALKYL, ALKYLENECOOR, ALKYLENE-SO3R, ALKYLENE-COOME/2 OR ALKYLENESO3ME/2; ME IS A METAL SUCH AS CU++ OR ZN++; AND AT LEAST ONE OF X AND Z HAS A FREE WATER SOLUBLIZING SULFONIC OR CARBOXYLIC ACID GROUP. THE COMPOUNDS ARE PARTICULARLY USEFIL AS FINGICIDES AND BACTERICIDES.

10. 发明授权

US3532692A Brightening agents of the bistriazinylaminostilbene series 失效
标题翻译：双嘧丝氨基苯乙烯系列的加强剂
公开(公告)号：US3532692A
公开(公告)日：1970-10-06
申请号：US3532692D
申请日：1967-05-02
申请人： BAYER AG
发明人： GOLD HEINRICH , KLEINHEIDT ERNST-AUGUST
IPC分类号： C07D251/68 , C07D413/14 , C07D55/22
CPC分类号： C07D413/14 , C07D251/68

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