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1. 发明授权

US09249090B2 N-substituted carbamic acid ester production method and isocyanate production method using the N-substituted carbamic acid ester 有权
标题翻译： N-取代氨基甲酸酯的制造方法和使用N-取代氨基甲酸酯的异氰酸酯制造方法
公开(公告)号：US09249090B2
公开(公告)日：2016-02-02
申请号：US14490027
申请日：2014-09-18
申请人： Asahi Kasei Chemicals Corporation
发明人： Nobuhisa Miyake , Masaaki Shinohata , Atsushi Okubo
IPC分类号： C07C261/00 , C07C275/40 , C07C263/04 , C07C269/00 , C07C269/04 , C07C271/54 , C07C271/56 , C07C271/58
CPC分类号： C07C275/40 , C07C263/04 , C07C269/00 , C07C269/04 , C07C271/54 , C07C271/56 , C07C271/58 , C07C2601/14 , C07C265/14 , C07C271/52
摘要： The present invention provides a method for producing N-substituted carbamic acid-O-aryl ester derived from a compound having an ureido group, the method comprising the step of carrying out esterification or esterification and transesterification from the compound having the ureido group and a hydroxy composition containing one type or a plurality of types of hydroxy compounds.
摘要翻译：本发明提供一种由具有脲基的化合物衍生的N-取代氨基甲酸-O-芳基酯的方法，该方法包括从具有脲基的化合物和羟基进行酯化或酯化和酯交换的步骤含有一种或多种类型的羟基化合物的组合物。

2. 发明授权

US09145358B2 N-substituted carbamic acid ester production method, isocyanate production method using such N-substituted carbamic acid ester, and composition for transfer and storage of N-substituted carbamic acid ester comprising N-substituted carbamic acid ester and aromatic hydroxy compound 有权
公开(公告)号：US09145358B2
公开(公告)日：2015-09-29
申请号：US14151213
申请日：2014-01-09
申请人： Asahi Kasei Chemicals Corporation
发明人： Masaaki Shinohata , Nobuhisa Miyake
IPC分类号： C07C271/06 , C07C275/40 , C07C263/04 , C07C269/00 , C07C269/04 , C07C271/54 , C07C271/56 , C07C271/58
CPC分类号： C07C275/40 , C07C263/04 , C07C269/00 , C07C269/04 , C07C271/54 , C07C271/56 , C07C271/58 , C07C2601/14 , C07C265/14 , C07C271/52
摘要： The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compounds, wherein the organic amine, the carbonic acid derivative and the hydroxy composition are reacted using a urethane production reaction vessel provided with a condenser, a gas containing the hydroxy composition, the compound having the carbonyl group derived from the carbonic acid derivative, and an ammonia formed as a by-product in the reaction, is introduced into the condenser provided in the urethane production reaction vessel, and the hydroxy composition and the compound having the carbonyl group derived from the carbonic acid derivative are condensed, and wherein a stoichiometric ratio of a hydroxy compound contained in the condensed hydroxy composition to the condensed compound having the carbonyl group derived from the carbonic acid derivative is 1 or more, and a ratio of number of carbonyl groups (—C(═O)—) contained in the compound having the carbonyl group derived from the carbonic acid derivative and number of ammonia molecules contained in the ammonia recovered as a gas from the condenser is 1 or less.

3. 发明授权

US09145357B2 N-substituted carbamic acid ester production method, isocyanate production method using such N-substituted carbamic acid ester, and composition for transfer and storage of N-substituted carbamic acid ester comprising N-substituted carbamic acid ester and aromatic hydroxy compound 有权
标题翻译： N-取代氨基甲酸酯的制造方法，使用这种N-取代氨基甲酸酯的异氰酸酯的制造方法以及N-取代氨基甲酸酯和芳香族羟基化合物的N-取代氨基甲酸酯的转移和储存组合物
公开(公告)号：US09145357B2
公开(公告)日：2015-09-29
申请号：US14151178
申请日：2014-01-09
申请人： Asahi Kasei Chemicals Corporation
发明人： Masaaki Shinohata , Nobuhisa Miyake
IPC分类号： C07C263/00 , C07C263/04 , C07C275/40 , C07C269/00 , C07C269/04 , C07C271/54 , C07C271/56 , C07C271/58
CPC分类号： C07C275/40 , C07C263/04 , C07C269/00 , C07C269/04 , C07C271/54 , C07C271/56 , C07C271/58 , C07C2601/14 , C07C265/14 , C07C271/52
摘要： The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compounds, wherein the organic amine, the carbonic acid derivative and the hydroxy composition are reacted using a urethane production reaction vessel provided with a condenser, a gas containing the hydroxy composition, the compound having the carbonyl group derived from the carbonic acid derivative, and an ammonia formed as a by-product in the reaction, is introduced into the condenser provided in the urethane production reaction vessel, and the hydroxy composition and the compound having the carbonyl group derived from the carbonic acid derivative are condensed, and wherein a stoichiometric ratio of a hydroxy compound contained in the condensed hydroxy composition to the condensed compound having the carbonyl group derived from the carbonic acid derivative is 1 or more, and a ratio of number of carbonyl groups (—C(═O)—) contained in the compound having the carbonyl group derived from the carbonic acid derivative and number of ammonia molecules contained in the ammonia recovered as a gas from the condenser is 1 or less.
摘要翻译：本发明是从有机胺，碳酸衍生物和含有一种以上羟基化合物的羟基组合物生产由有机胺衍生的N-取代氨基甲酸酯的方法，其中有机胺，碳酸衍生物和羟基组合物使用设置有冷凝器，含有羟基组合物的气体，具有衍生自碳酸衍生物的羰基的化合物和在反应中作为副产物形成的氨的氨基甲酸酯制备反应容器进行反应被引入聚氨酯生产反应容器中的冷凝器中，羟基组合物和衍生自碳酸衍生物的具有羰基的化合物被缩合，其中在缩合羟基组合物中包含的羟基化合物的化学计量比与具有衍生自碳酸衍生物的羰基的缩合化合物为1以上，由碳酸衍生物衍生的具有羰基的化合物中所含的羰基数（-C（= O） - ））与作为气体回收的氨中氨分子数的比例冷凝器为1或更小。

4. 发明授权

US08859620B2 Phthalanilate compounds and methods of use 有权
标题翻译：邻苯二甲酸酯化合物和使用方法
公开(公告)号：US08859620B2
公开(公告)日：2014-10-14
申请号：US13393436
申请日：2010-08-31
申请人： Shahriar Mobashery , Dusan Hesek , Mayland Chang
发明人： Shahriar Mobashery , Dusan Hesek , Mayland Chang
IPC分类号： A61K31/195 , A01N37/12 , A01N37/44 , C07C233/66 , C07D295/108 , C07C233/26 , C07C235/16 , C07D339/08 , C07D295/135 , C07C233/59 , C07D213/75 , C07C233/75 , C07D495/04 , C07C271/58 , C07C233/60 , C07C333/08 , C07D209/46 , C07C233/15 , C07C233/73 , C07C233/81 , C07D501/34 , C07C327/48
CPC分类号： C07D513/04 , C07C233/15 , C07C233/26 , C07C233/59 , C07C233/60 , C07C233/66 , C07C233/69 , C07C233/73 , C07C233/75 , C07C233/81 , C07C235/16 , C07C235/74 , C07C235/84 , C07C271/58 , C07C327/48 , C07C333/08 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D209/46 , C07D213/75 , C07D215/40 , C07D295/108 , C07D295/135 , C07D295/155 , C07D295/192 , C07D307/52 , C07D319/16 , C07D339/08 , C07D495/04 , C07D501/34
摘要： The invention provides antimicrobial compounds and compositions, and methods of using them. The compounds and compositions include, for example, a compound of any one of Formulas I-X. The invention further provides methods of preparing the compounds, and useful intermediates for their preparation. The compounds can possess highly specific and selective activity, such as antibacterial activity and/or enzymatic inhibitory activity. Accordingly, the compounds and compositions can be used to treat bacterial infections, or to inhibit or kill bacteria, either in vitro or in vivo.
摘要翻译：本发明提供了抗微生物化合物和组合物，以及使用它们的方法。化合物和组合物包括例如式I-X中任一项的化合物。本发明还提供了制备该化合物的方法及其制备用途的中间体。该化合物可以具有高度特异性和选择性的活性，例如抗菌活性和/或酶促抑制活性。因此，化合物和组合物可用于治疗细菌感染，或在体外或体内抑制或杀死细菌。

5. 发明申请

US20110190267A1 PRODRUGS OF OPIOIDS AND USES THEREOF 审中-公开
标题翻译： OPIOIDS的产品及其用途
公开(公告)号：US20110190267A1
公开(公告)日：2011-08-04
申请号：US12978210
申请日：2010-12-23
申请人： Richard Franklin , Karl Swift , Bernard T. Golding , Robert G. Tyson
发明人： Richard Franklin , Karl Swift , Bernard T. Golding , Robert G. Tyson
IPC分类号： A61K31/55 , C07D223/04 , C07D401/12 , C07D489/02 , A61K31/439 , C07C271/58 , A61K31/27 , C07D221/28 , C07D211/34 , A61K31/451 , A61P25/04
CPC分类号： A61K31/55 , A61K31/485
摘要： The present invention concerns prodrugs of opioid analgesics and pharmaceutical compositions containing such prodrugs. Methods for providing more consistent pain relief by increasing the bioavailability of the opioid analgesic with the aforementioned prodrugs are provided. The invention also provides for decreasing the adverse GI side effects of opioid analgesics.
摘要翻译：本发明涉及阿片类镇痛药的前药和含有这些前药的药物组合物。提供了通过用前述药物提高阿片类镇痛剂的生物利用度来提供更一致的疼痛缓解的方法。本发明还提供降低阿片样镇痛药的不良GI副作用。

6. 发明授权

US07652166B2 Biuret compounds, their preparation and use, and intermediates in their preparation 有权
标题翻译：缩二脲化合物，其制备和用途以及其制备中的中间体
公开(公告)号：US07652166B2
公开(公告)日：2010-01-26
申请号：US11400721
申请日：2006-04-07
申请人： Karlheinz Haubennestel , Stefan Moessmer , Ulrich Orth , Daniela Betcke
发明人： Karlheinz Haubennestel , Stefan Moessmer , Ulrich Orth , Daniela Betcke
IPC分类号： C07C271/58 , C07C271/52 , C07C271/34 , C07C271/36 , C07C271/38 , C07C271/24 , C07C271/28 , C07C271/20 , C07C275/40 , C07C275/18 , C07C275/14 , C07C269/06
CPC分类号： C08G18/798 , C07C275/62 , C07D229/00 , C08G18/2825 , C08G18/283 , C08G18/2865 , C08G18/3228 , C08G18/324 , C08G18/5024 , C08K5/21 , C09D5/04 , C09D7/63
摘要： The present invention relates to biuret compounds of the general formula in which R1 is C2-C18 alkylene, cycloalkylene, arylene or aralkylene, Y is —O— and/or —NH—, R2 is C4-C22 alkyl, C3-C18 alkenyl, cycloalkyl, aralkyl, CmH2m+1(O—CnH2n)x—(O—CH(C6H5)—CH2)u-, CmH2m+1(OOC—CvH2v)x-, X—C6H4—(O—CnH2n)x—(O—CH(C6H5)—CH2)u-, where m=1-22, n=2-4, x=0-15, u=0-15, v=4-5, X is C1-C12 alkyl, —(C6H5)1-4 and R3, R4 and R5 are C2-C18 alkylene, cycloalkylene, arylene or aralkylene, it being possible for R3, R4 and R5 to be identical or different, Z is —COO—, NHCO—, NHCOO—, NHCONH— and/or mixtures thereof and a is 1-20. The invention also relates to a process for preparing biuret compounds and to their use as rheology control agents. The invention further relates to urethane- and/or urea-containing uretdiones which are useful intermediates for preparing the biuret compounds.
摘要翻译：本发明涉及通式的缩二脲化合物，其中R 1是C 2 -C 18亚烷基，亚环烷基，亚芳基或亚芳烷基，Y是-O-和/或-NH-，R 2是C 4 -C 22烷基，C 3 -C 18烯基，环烷基，芳烷基，CmH2m + 1（O-CnH2n）x-（O-CH（C6H5）-CH2）u-，CmH2m + 1（OOC-CvH2v）x-，X-C6H4-（O-CnH2n）x-（ O-CH（C 6 H 5）-CH 2）u - ，其中m = 1-22，n = 2-4，x = 0-15，u = 0-15，v = 4-5，X是C 1 -C 12烷基， - （C6H5）1-4，R3，R4和R5是C2-C18亚烷基，亚环烷基，亚芳基或亚芳基，R3，R4和R5可以相同或不同，Z是-COO-，NHCO-，NHCOO - ，NHCONH-和/或其混合物，和a为1-20。本发明还涉及一种制备缩二脲化合物的方法及其作为流变控制剂的用途。本发明还涉及用于制备缩二脲化合物的有用的中间体的氨基甲酸酯和/或尿素脲基。

7. 发明申请

US20050222450A1 Process for preparing carbamates 审中-公开
标题翻译：制备氨基甲酸酯的方法
公开(公告)号：US20050222450A1
公开(公告)日：2005-10-06
申请号：US10816586
申请日：2004-03-31
申请人： Sunil Gupte , Raghunath Chaudhari , Anandkumar Shivarkar , Shafeek Mulla
发明人： Sunil Gupte , Raghunath Chaudhari , Anandkumar Shivarkar , Shafeek Mulla
IPC分类号： C07C269/04 , C07C271/12 , C07C271/24 , C07C271/28 , C07C271/58
CPC分类号： C07C269/04 , C07C271/12 , C07C271/24 , C07C271/28 , C07C271/58
摘要： A process for the preparation of carbamates from organic urea and organic carbonate in presence of a solid base catalyst is disclosed. The process works at the milder reaction conditions and utilizes inexpensive catalysts that can be recycled several times.
摘要翻译：公开了一种在固体碱催化剂存在下由有机脲和有机碳酸酯制备氨基甲酸酯的方法。该工艺在较温和的反应条件下工作，并且可以使用可再循环数次的廉价催化剂。

8. 发明申请

US20050131032A1 (Oxime)carbamoyl fatty acid amide hydrolase inhibitors 审中-公开
公开(公告)号：US20050131032A1
公开(公告)日：2005-06-16
申请号：US11039516
申请日：2005-01-19
申请人： Sing-Yuen Sit , Kai Xie , Hongfeng Deng
发明人： Sing-Yuen Sit , Kai Xie , Hongfeng Deng
IPC分类号： C07D295/08 , A61K31/27 , A61K31/343 , A61K31/404 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/47 , A61K31/472 , A61K31/5375 , A61P1/08 , A61P1/14 , A61P3/04 , A61P9/00 , A61P25/02 , A61P25/04 , A61P25/14 , A61P25/22 , A61P25/28 , A61P27/06 , A61P29/02 , A61P43/00 , C07C271/26 , C07C271/28 , C07C271/48 , C07C271/58 , C07C271/60 , C07D209/08 , C07D209/40 , C07D213/53 , C07D213/64 , C07D213/643 , C07D213/65 , C07D213/68 , C07D215/20 , C07D215/22 , C07D217/02 , C07D295/092 , C07D307/91 , C07D401/12 , C07D405/12 , A61K31/325 , C07D213/72
CPC分类号： C07D213/53 , C07C271/28 , C07C271/48 , C07C271/58 , C07C271/60 , C07D209/40 , C07D213/643 , C07D213/65 , C07D215/22 , C07D217/02 , C07D295/088 , C07D307/91 , C07D405/12
摘要： The present invention relates to novel oxime carbamyl derivatives and pharmaceutical compositions comprising said derivatives which inhibit fatty acid amide hydrolase. These pharmaceutical compositions are useful for the treatment of conditions which can be effected by inhibiting fatty acid amide hydrolase including, but not limited to, neuropathic pain, emesis, anxiety, altering feeding behaviors, movement disorders, glaucoma, brain injury, and cardiovascular disease.

9. 发明授权

US6057269A Benzylhydroxylamines and intermediates used to prepare them 失效
公开(公告)号：US6057269A
公开(公告)日：2000-05-02
申请号：US973780
申请日：1998-01-05
申请人： Ralf Klintz , Gerhard Hamprecht , Elisabeth Heistracher , Peter Schafer , Cyrill Zagar , Karl-Otto Westphalen , Helmut Walter , Ulf Misslitz , Olaf Menke , Markus Menges
发明人： Ralf Klintz , Gerhard Hamprecht , Elisabeth Heistracher , Peter Schafer , Cyrill Zagar , Karl-Otto Westphalen , Helmut Walter , Ulf Misslitz , Olaf Menke , Markus Menges
IPC分类号： A01N43/54 , A01N47/12 , A01N47/24 , A01N47/30 , A01N53/00 , C07C239/08 , C07C239/10 , C07C239/16 , C07C239/20 , C07C265/12 , C07C271/22 , C07C271/28 , C07C271/54 , C07C271/58 , C07C275/32 , C07C275/40 , C07D239/54 , C07D405/12
CPC分类号： C07D239/54 , A01N43/54 , A01N47/12 , A01N47/24 , A01N47/30 , A01N53/00 , C07C239/08 , C07C239/10 , C07C265/12 , C07C271/22 , C07C271/28 , C07C271/54 , C07C271/58 , C07C275/40
摘要： Benzylhydroxylamines I ##STR1## (X=--N(R.sup.7)--O--; Y=O, S; R.sup.1 =halogen, CN, NO.sub.2, CF.sub.3 ; R.sup.2 =H, halogen; R.sup.3 =H, NH.sub.2, CH.sub.3 ;R.sup.4 =H, halogen, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -haloalkyl, C.sub.1 -C.sub.6 -alkylthio, C.sub.1 -C.sub.6 -alkylsulfinyl or C.sub.1 -C.sub.6 -alkylsulfonyl;R.sup.5 =H, halogen, C.sub.1 -C.sub.6 -alkyl;R.sup.6 =H, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -haloalkyl, C.sub.3 -C.sub.6 -cycloalkyl, C.sub.2 -C.sub.6 -alkenyl;R.sup.7 =H, C.sub.1 -C.sub.6 -alkyl, C.sub.3 -C.sub.8 -cycloalkyl, C.sub.1 -C.sub.6 -haloalkyl, C.sub.3 -C.sub.6 -alkenyl, C.sub.3 -C.sub.6 -alkynyl, C.sub.1 -C.sub.6 -alkylcarbonyl, C.sub.3 -C.sub.6 -alkenylcarbonyl, C.sub.3 -C.sub.6 -alkynylcarbonyl, C.sub.1 -C.sub.6 -alkoxycarbonyl, C.sub.2 -C.sub.8 -alkenyloxycarbonyl, C.sub.2 -C.sub.6 -alkynyloxycarbonyl, C.sub.1 -C.sub.6 -alkylthiocarbonyl, C.sub.1 -C.sub.6 -alkylsulfonyl, C.sub.1 -C.sub.6 -alkylcarbamoyl, it being possible for the 14 last-mentioned radicals to have attached to them 1-3 substituents:NO.sub.2, CN, halogen, C.sub.3 -C.sub.8 -cycloalkyl, OH, C.sub.1 -C.sub.6 -alkoxy, C.sub.3 -C.sub.8 -cycloalkoxy, C.sub.3 -C.sub.6 -alkenyloxy, C.sub.3 -C.sub.6 -alkynyloxy, C.sub.1 -C.sub.6 -alkoxy-C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -alkylthio, C.sub.1 -C.sub.6 -alkylcarbonyl, C.sub.1 -C.sub.6 -alkylcarbonyloxy, C.sub.1 -C.sub.6 -alkylsulfinyl, C.sub.1 -C.sub.6 -alkylsulfonyl, C.sub.1 -C.sub.6 -alkylideneaminoxy, C.sub.1 -C.sub.6 -alkylcarbamoyl,unsubstituted or substituted phenyl, phenoxy or phenylsulfonyl,a 3- to 7-membered heterocyclyl or heterocyclyloxy group having 1-3 hetero atoms, it being possible for this group to be saturated, unsaturated or aromatic and to have attached to it 1-3 substituents,--CO--Z.sup.1 R.sup.9, --OCO--Z.sup.1 R.sup.9, --N(R.sup.9)R.sup.10 orR.sup.7 =unsubstituted or substituted cycloalkylcarbonyl, phenylcarbonyl, phenylsulfonyl, phenylcarbamoyl;R.sup.8 =H, C.sub.1 -C.sub.6 -alkyl, C.sub.3 -C.sub.8 -cycloalkyl, C.sub.1 -C.sub.6 -haloalkyl, C.sub.3 -C.sub.6 -alkenyl or C.sub.3 -C.sub.6 -alkynyl, it being possible for each of the 5 last-mentioned radicals to have attached to it 1-3 substituents:NO.sub.2, CN, halogen, C.sub.3 -C.sub.8 -cycloalkyl, OH, C.sub.1 -C.sub.6 -alkoxy, C.sub.3 -C.sub.8 -cycloalkoxy, C.sub.3 -C.sub.6 -alkenyloxy, C.sub.3 -C.sub.6 -alkynyloxy, C.sub.1 -C.sub.6 -alkoxy-C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -alkylthio, C.sub.1 -C.sub.6 -alkylsulfinyl, C.sub.1 -C.sub.6 -alkylsulfonyl, C.sub.1 -C.sub.6 -alkylideneaminoxy,unsubstituted or substituted phenyl- [sic], phenoxy-[sic] or phenylsulfonyl,a 3- to 7-membered heterocyclyl or heterocyclyloxy group having 1-3 hetero atoms, it being possible for this group to be saturated, unsaturated or aromatic and to have attached to it 1-3 substituents,--CO--Z.sup.2 R.sup.11, --OCO--Z.sup.2 R.sup.11, --N(R.sup.11)R.sup.12 ;Z.sup.1 a chemical bond, oxygen, sulfur or --N(R.sup.10)--;Z.sup.2 =a chemical bond, oxygen, sulfur or --N(R.sup.12)--;R.sup.9, R.sup.11 =H, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -haloalkyl, C.sub.3 -C.sub.8 -cycloalkyl, C.sub.3 -C.sub.6 -alkenyl, C.sub.3 -C.sub.6 -alkynyl, C.sub.1 -C.sub.6 -alkoxy-C.sub.1 -C.sub.6 -alkyl, (C.sub.1 -C.sub.6 -alkoxy)carbonyl-C.sub.1 -C.sub.6 -alkyl, unsubstituted or substituted phenyl or phenyl-C.sub.1 -C.sub.6 -alkyl,orZ.sup.1 and R.sup.9 and/or Z.sup.2 and R.sup.11 together=a 3- to 7-membered heterocycle having 1-3 hetero atoms and bonded via nitrogen, it being possible for this heterocycle to be saturated, unsaturated or aromatic and, if desired, to have attached to it one to three substituents,R.sup.10, R.sup.12 =H, OH, C.sub.1 -C.sub.6 -alkyl, C.sub.3 -C.sub.8 -cycloalkyl, C.sub.1 -C.sub.6 -alkoxy)and the salts of I where R.sup.3, R.sup.7 and/or R.sup.8 =hydrogenare used as herbicides and for the desiccation/defoliation of plants.

10. 发明授权

US5861427A Substituted 4-biarylbutyric acid derivatives as matrix metalloprotease inhibitors 失效
标题翻译：取代的4-联芳基丁酸衍生物作为基质金属蛋白酶抑制剂
公开(公告)号：US5861427A
公开(公告)日：1999-01-19
申请号：US866679
申请日：1997-05-30
申请人： Harold Clinton Eugene Kluender , Guenter Hans Herbert Heinz Benz , David Ross Brittelli , Brian Richard Dixon , Michael Christopher VanZandt , Scott McClelland Wilhelm , Donald John Wolanin
发明人： Harold Clinton Eugene Kluender , Guenter Hans Herbert Heinz Benz , David Ross Brittelli , Brian Richard Dixon , Michael Christopher VanZandt , Scott McClelland Wilhelm , Donald John Wolanin
IPC分类号： A61K31/19 , A61K31/215 , A61K31/275 , A61K31/4035 , A61K31/47 , A61P35/00 , A61P43/00 , C07C17/12 , C07C17/16 , C07C17/20 , C07C22/04 , C07C25/18 , C07C45/28 , C07C45/46 , C07C45/56 , C07C45/72 , C07C47/228 , C07C47/277 , C07C49/813 , C07C55/02 , C07C57/38 , C07C59/48 , C07C59/56 , C07C59/68 , C07C59/84 , C07C59/88 , C07C59/90 , C07C59/92 , C07C61/04 , C07C61/06 , C07C62/22 , C07C62/38 , C07C63/72 , C07C65/24 , C07C65/34 , C07C69/145 , C07C69/616 , C07C69/63 , C07C69/712 , C07C69/738 , C07C69/757 , C07C205/34 , C07C205/56 , C07C229/34 , C07C229/40 , C07C233/54 , C07C235/18 , C07C235/84 , C07C255/21 , C07C255/57 , C07C271/22 , C07C271/26 , C07C271/28 , C07C271/58 , C07C317/44 , C07C323/52 , C07C323/61 , C07C323/62 , C07C327/32 , C07D207/08 , C07D207/16 , C07D207/40 , C07D207/404 , C07D209/48 , C07D209/68 , C07D213/00 , C07D213/30 , C07D213/50 , C07D213/70 , C07D215/36 , C07D221/14 , C07D257/04 , C07D263/32 , C07D277/30 , C07D277/74 , C07D295/192 , C07D307/28 , C07D307/32 , C07D307/33 , C07D307/54 , C07D307/68 , C07D307/93 , C07D307/935 , C07D311/96 , C07D317/30 , C07D317/60 , C07D333/00 , C07D333/22 , C07D333/28 , C07D333/34 , C07D405/06 , C07D409/12 , C07D413/06 , C07D471/04 , C07D491/04 , C07D498/04 , C07F9/141 , C07F9/40 , A61K31/40 , A61K31/535 , C07D241/00 , C07D265/30
CPC分类号： C07D207/08 , A61K31/4035 , A61K31/47 , C07C17/12 , C07C17/16 , C07C17/208 , C07C205/34 , C07C205/56 , C07C22/04 , C07C229/34 , C07C229/40 , C07C233/54 , C07C235/84 , C07C25/18 , C07C255/21 , C07C255/57 , C07C271/22 , C07C271/26 , C07C271/28 , C07C271/58 , C07C317/44 , C07C323/52 , C07C323/61 , C07C323/62 , C07C327/32 , C07C45/28 , C07C45/46 , C07C45/56 , C07C45/72 , C07C47/228 , C07C47/277 , C07C49/813 , C07C55/02 , C07C59/56 , C07C59/84 , C07C59/88 , C07C59/90 , C07C59/92 , C07C61/04 , C07C61/06 , C07C62/22 , C07C62/38 , C07C63/72 , C07C65/24 , C07C65/34 , C07C69/616 , C07C69/712 , C07C69/738 , C07C69/757 , C07D207/16 , C07D207/404 , C07D209/48 , C07D209/68 , C07D213/30 , C07D213/50 , C07D213/70 , C07D215/36 , C07D221/14 , C07D257/04 , C07D263/32 , C07D277/30 , C07D277/74 , C07D295/192 , C07D307/28 , C07D307/32 , C07D307/33 , C07D307/54 , C07D307/68 , C07D307/93 , C07D307/935 , C07D311/96 , C07D317/30 , C07D317/60 , C07D333/22 , C07D333/28 , C07D333/34 , C07D405/06 , C07D409/12 , C07D413/06 , C07D471/04 , C07D491/04 , C07F9/1415 , C07F9/4059 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要： Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein each T is a substituent group; x is 0, 1, or 2; the group D represents ##STR2## the group R6 represents a variety of possible substituent groups on the carbon chain between D and G, and the group G represents M, ##STR3## in which M represents --CO.sub.2 H, --CON(R.sup.11).sub.2, or --CO.sub.2 R.sup.12 ; and R.sup.13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids.
摘要翻译：基质金属蛋白酶抑制剂，含有它们的药物组合物和使用它们的方法可以处理各种生理条件。本发明的化合物具有通用化合物“IMAGE”，其中每个T是取代基; x为0,1或2; 基团D表示基团R6表示D和G之间的碳链上的各种可能的取代基，基团G表示M，其中M表示-CO 2 H，-CON（R 11）2，或-CO 2 R 12; R13表示19个非环状天然氨基酸的任一侧链。

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