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1. 发明申请

US20230097256A1 ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS 有权
公开(公告)号：US20230097256A1
公开(公告)日：2023-03-30
申请号：US17877538
申请日：2022-07-29
申请人： Avilar Therapeutics, Inc.
发明人： Mark George Saulnier , Jesse Jingyang Chen , Srinivasa Karra , Kevin Tyler Sprott , Jason Allan Wiles , Soumya Ray
IPC分类号： A61K47/54 , A61K47/62 , C07H5/06 , C07H17/00 , C07H17/02 , C07H15/203 , C07H7/02 , C07H9/02 , C07H19/044 , C07H19/02
摘要： Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

2. 发明授权

US11267840B1 Compound or salt thereof 有权
公开(公告)号：US11267840B1
公开(公告)日：2022-03-08
申请号：US17464810
申请日：2021-09-02
申请人： M.T.3, Inc. , NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY
发明人： Masahiko Oshige , Ichiro Matsuo , Hiroaki Horiuchi , Shinji Katsura , Fumio Sugawara , Kengo Sakaguchi
IPC分类号： C07H15/04 , C07H7/02
摘要： There is provided with a compound. The compound is represented by formula or a salt thereof. R1 is an aliphatic hydrocarbon group having 10 to 26 carbon atoms.

3. 发明授权

US10238611B2 Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid 有权
公开(公告)号：US10238611B2
公开(公告)日：2019-03-26
申请号：US15293965
申请日：2016-10-14
申请人： BHI Limited Partnership
发明人： Xianqi Kong , Mohamed Atfani , Benoit Bachand , Abderrahim Bouzide , Stephane Ciblat , Sophie Levesque , David Migneault , Isabelle Valade , Xinfu Wu , Daniel Delorme
IPC分类号： A61K31/145 , A61K47/54 , C07C309/18 , C07C309/19 , C07C309/24 , C07D333/24 , C07D317/40 , A61K47/64 , C07J9/00 , C07D285/38 , C07H7/02 , C07D323/02 , C07H15/12 , C12P13/00 , C07D285/36 , C07D291/02 , C07K5/062 , C12P11/00 , C07D233/64 , C07D217/24 , C07D209/20 , C07D207/16 , C07C309/15 , C07K5/083 , C07K5/068
摘要： The invention relates to methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid (3APS) in a subject, preferably a human subject. The invention encompasses compound that will yield or generate 3APS, either in vitro or in vivo. Preferred compounds include amino acid prodrugs of 3APS for use, including but not limited to the prevention and treatment of Alzheimer's disease.

4. 发明申请

US20180133137A1 PROCESS FOR TREATING KERATIN MATERIALS USING AMIDE, ACID OR ESTER C-GLYCOSIDE DERIVATIVES, AND COSMETIC COMPOSITION CONTAINING SAME 审中-公开
公开(公告)号：US20180133137A1
公开(公告)日：2018-05-17
申请号：US15571951
申请日：2016-05-09
申请人： L'OREAL
发明人： Maria DALKO , Marie-Céline FRANTZ , Emélie GUEGUINIAT , Jinzhu XU , Lisheng MAO
IPC分类号： A61K8/60 , A61K8/365 , A61Q19/08 , C07H7/02
CPC分类号： A61K8/602 , A61K8/365 , A61Q19/08 , C07H7/02
摘要： The present invention relates to a process for cosmetic treatment of the skin, comprising the application to the skin of a composition comprising a compound (I) with R, R′ and X as defined in the description and S* a monosaccharide or polysaccharide.

5. 发明申请

US20160303259A1 PROBES AND METHODS OF IMAGING A BACTERIAL INFECTION 审中-公开
标题翻译：影像感染的探索与方法
公开(公告)号：US20160303259A1
公开(公告)日：2016-10-20
申请号：US15096308
申请日：2016-04-12
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： Mohammad Namavari , Gayatri Gowrishankar , Sanjiv S. Gambhir , Ananth Srinivasan
IPC分类号： A61K51/04 , C07H7/02 , C07B59/00 , C07H15/04
CPC分类号： A61K51/0491 , A61K51/06 , C07B59/005 , C07B2200/05 , C07H7/02 , C07H15/04
摘要： Embodiments of the present disclosure provide for labeled probes such as labeled maltoside probes and labeled maltotriose probes, methods of making labeled probes, pharmaceutical compositions including labeled probes, methods of using labeled probes, methods of diagnosing, localizing, monitoring, and/or assessing bacterial infections, using labeled probes, kits for diagnosing, localizing, monitoring, and/or assessing bacterial infections, using labeled probes, and the like.
摘要翻译：本公开的实施方案提供了标记的探针，例如标记的麦芽四糖探针和标记的麦芽三糖探针，制备标记探针的方法，包括标记探针的药物组合物，使用标记探针的方法，诊断，定位，监测和/或评估细菌的方法感染，使用标记的探针，用于诊断，定位，监测和/或评估细菌感染的试剂盒，使用标记的探针等。

6. 发明授权

US09096630B2 Amphiphilic compositions and methods for preparing and using same 有权
标题翻译：两亲组合物及其制备和使用方法
公开(公告)号：US09096630B2
公开(公告)日：2015-08-04
申请号：US13505953
申请日：2010-11-08
申请人： Patrick Foley , Paul Anastas , Toby Sommer
发明人： Patrick Foley , Paul Anastas , Toby Sommer
IPC分类号： C07H7/04 , C07H1/00 , C07H7/02 , C07D309/04 , C07D309/10 , C11D3/22
CPC分类号： C07H7/02 , C07D309/04 , C07D309/10 , C07H7/04 , C11D3/221
摘要： The invention relates to amphiphilic C-glycoside derivatives, to methods of using them and to processes for synthesizing them. Specifically, the invention relates to novel cyclic and linear enone-glycolipids and cyclic ketone-glycolipids.
摘要翻译：本发明涉及两亲性C-糖苷衍生物，其使用方法和合成方法。具体地说，本发明涉及新的环状和线型乙二糖和环状酮糖脂。

7. 发明授权

US09085597B2 Method for producing diester of polyhydric alcohol and fatty acid 有权
标题翻译：多元醇和脂肪酸二酯的制备方法
公开(公告)号：US09085597B2
公开(公告)日：2015-07-21
申请号：US14006313
申请日：2012-03-21
申请人： Kazunobu Konishi , Mayumi Sato , Makoto Okamoto
发明人： Kazunobu Konishi , Mayumi Sato , Makoto Okamoto
IPC分类号： C07H7/02 , C07H13/06 , C07C67/03 , C07H1/00
CPC分类号： C07H7/02 , C07C67/03 , C07C2601/14 , C07H1/00 , C07H13/06 , C07C69/33
摘要： A method for producing a diester of polyhydric alcohol and fatty acid, comprising a step of reacting a monoester of polyhydric alcohol and fatty acid in the presence of a catalyst containing a hydrotalcite compound to obtain a diester of polyhydric alcohol and fatty acid.
摘要翻译：一种生产多元醇和脂肪酸二酯的方法，包括在含有水滑石化合物的催化剂存在下使多元醇和脂肪酸的单酯反应得到多元醇和脂肪酸的二酯的步骤。

8. 发明授权

US08647670B2 Biocompatible rapid-gelating hydrogel and associated preparation method of spray 有权
标题翻译：生物相容性快速胶凝水凝胶及其相关制备方法
公开(公告)号：US08647670B2
公开(公告)日：2014-02-11
申请号：US12452441
申请日：2008-06-10
申请人： Xiaozheng Shu
发明人： Xiaozheng Shu
IPC分类号： A61K9/14 , A61K31/74 , C07H7/02
CPC分类号： A61L27/52 , C08G75/04 , C08G75/045
摘要： This invention discloses a preparation method for biocompatible rapid-gelating hydrogel. Wherein, hydrogel is formed by rapid chemical-crosslinking using the mixing and chemical-crosslinking reaction under specified conditions between several active compound components. The preparation method comprises the following steps: (1) The solution containing biocompatible thiolated macromolecular derivatives (component A) and biocompatible thiol reactive crosslinking agents (component B) mutually mix to form reactive mixture with specified crosslinking conditions; (2) the reactive mixture forms the hydrogel. The invention also discloses a preparation method for novel rapid-gelating hydrogel spray and an application in medical field. This invention has the advantages of good biocompatibility, no by-products, good stability, convenient use, small amount of raw materials used, suitable for many medical application, etc.
摘要翻译：本发明公开了一种生物相容性快速胶凝水凝胶的制备方法。其中，水凝胶通过在几种活性化合物组分之间的特定条件下的混合和化学交联反应的快速化学交联形成。制备方法包括以下步骤：（1）含有生物相容性硫醇化大分子衍生物（A组分）和生物相容性硫醇反应性交联剂（B组分）的溶液相互混合，形成具有规定交联条件的反应性混合物; （2）反应混合物形成水凝胶。本发明还公开了一种新型快速凝胶化水凝胶喷雾的制备方法及其在医学领域的应用。本发明具有生物相容性好，无副产物，稳定性好，使用方便，使用少量原料，适用于多种医疗用途等优点。

9. 发明申请

US20130122094A1 SIALIC ACID ANALOGS 有权
公开(公告)号：US20130122094A1
公开(公告)日：2013-05-16
申请号：US13659550
申请日：2012-10-24
申请人： ULTRAGENYX PHARMACEUTICAL, INC.
发明人： Emil Kakkis , Steven Jungles
IPC分类号： C07H7/02 , C07D493/08
CPC分类号： C07H7/02 , C07D493/08 , C07H7/027 , C07H13/04 , C07H13/10
摘要： The present invention provides sialic acid analogs and their compositions useful for the treatment of sialic acid deficiencies.

10. 发明申请

US20110144281A1 AMPHIPHILIC POLYMERS HAVING A CHOLANE CORE 审中-公开
标题翻译：具有蜡烛芯的聚合物聚合物
公开(公告)号：US20110144281A1
公开(公告)日：2011-06-16
申请号：US12746479
申请日：2008-12-05
申请人： Xiao-Xia Zhu , Juntao Luo , Guillaume Giguere
发明人： Xiao-Xia Zhu , Juntao Luo , Guillaume Giguere
IPC分类号： C08F8/06 , C07J9/00 , C07J41/00 , C07K16/00 , C07K14/505 , C07K14/485 , C07K14/62 , C07H7/02 , C07D475/04
CPC分类号： C08G65/2612 , A61K9/1075 , C08G65/2648 , C08G65/30 , C08G65/3322 , C08G65/33306 , C08G65/33327 , C08G65/3342 , C08L2203/02
摘要： The present invention relates to a polymer comprising a cholane core having at least one derivatizable group covalently bonded thereto and a hydrophilic polymer chain covalently bonded to derivatizable group(s) and a process for producing it The present invention also relates to micellar aggregate formed from the polymer of the present.
摘要翻译：本发明涉及一种聚合物，其包含具有至少一个共价键合的可衍生基团的胆碱核心和共价键合至可衍生基团的亲水性聚合物链及其制备方法本发明还涉及由本发明的聚合物。

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