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1. 发明申请

US20140342037A1 NOVEL PREBIOTICS 审中-公开
标题翻译：新的预兆
公开(公告)号：US20140342037A1
公开(公告)日：2014-11-20
申请号：US14317295
申请日：2014-06-27
申请人： DSM IP ASSETS B.V.
发明人： Albertus Alard VAN DIJK , Yulia M. EFIMOVA , Margot Elisabeth Francoise SCHOONEVELD-BERGMANS
IPC分类号： A23L1/30
CPC分类号： A23L31/00 , A23C9/1216 , A23C9/15 , A23C21/02 , A23K20/121 , A23K20/163 , A23L5/00 , A23L29/30 , A23L33/10 , A23L33/125 , A23L33/21 , A23V2002/00 , C07H7/027 , C12P19/04 , C12P19/26
摘要： The present invention relates to a composition which comprises: an oligosaccharide which is free of sialyloligosaccharide, and free sialic acid.
摘要翻译：本发明涉及一种组合物，其包含：不含唾液酸寡糖的寡糖和游离唾液酸。

2. 发明授权

US08840926B2 Sialic acid analogs 有权
标题翻译：唾液酸类似物
公开(公告)号：US08840926B2
公开(公告)日：2014-09-23
申请号：US13659550
申请日：2012-10-24
申请人： Ultragenyx Pharmaceutical, Inc.
发明人： Emil Kaskkis , Steven Jungles , He Zhao
IPC分类号： C07H7/02 , C07D493/08 , C07H13/10 , C07H13/04 , C07H7/027
CPC分类号： C07H7/02 , C07D493/08 , C07H7/027 , C07H13/04 , C07H13/10
摘要： The present invention provides sialic acid analogs and their compositions useful for the treatment of sialic acid deficiencies.
摘要翻译：本发明提供唾液酸类似物及其用于治疗唾液酸缺乏症的组合物。

3. 发明授权

US08492350B2 Therapeutic agent for pain disease 有权
标题翻译：疼痛病治疗剂
公开(公告)号：US08492350B2
公开(公告)日：2013-07-23
申请号：US12449152
申请日：2008-02-06
申请人： Yoshitaka Nakazawa
发明人： Yoshitaka Nakazawa
IPC分类号： A61K31/70 , C07H5/04 , C07H5/06 , C08B37/00 , A01N43/04
CPC分类号： A61K31/7012 , C07H7/027
摘要： A method for treating neuropathic pain by administering a pharmaceutical preparation containing N-acetylneuraminic acid or a pharmaceutically acceptable salt thereof to a person in need of treatment of neuropathic pain. Examples of neuropathic pain include trigeminal neuralgia, postherpetic neuralgia, strangulated neuropathy, complex regional pain syndrome (CRPS), diabetic neuropathy, neuropathy caused by trauma, phantom limb pain, central pain, and neuropathic pain caused by drug therapy or radiation therapy.
摘要翻译：一种通过向需要治疗神经性疼痛的人施用含有N-乙酰神经氨酸或其药学上可接受的盐的药物制剂来治疗神经性疼痛的方法。神经性疼痛的例子包括三叉神经痛，带状疱疹后神经痛，窒息性神经病变，复杂区域性疼痛综合征（CRPS），糖尿病性神经病变，由创伤引起的神经病变，幻肢疼痛，中枢性疼痛和药物治疗或放射治疗引起的神经性疼痛。

4. 发明申请

US20110206734A1 HYBRID SCFA-HYDROXYL-DERIVATIZED MONOSACCHARIDES, METHODS OF SYNTHESIS, AND METHODS OF TREATING DISORDERS 有权
标题翻译： HYBRID SCFA-羟基衍生的单糖，合成方法和治疗疾病的方法
公开(公告)号：US20110206734A1
公开(公告)日：2011-08-25
申请号：US12671994
申请日：2008-08-07
申请人： Kevin J. Yarema , Udayanath Aich , Christopher Thomas Campbell , Srinivasa-Gopalan Sampathkumar , Sean S. Choi , Michael Adam Meledeo , Christopher Weier
发明人： Kevin J. Yarema , Udayanath Aich , Christopher Thomas Campbell , Srinivasa-Gopalan Sampathkumar , Sean S. Choi , Michael Adam Meledeo , Christopher Weier
IPC分类号： A61K39/00 , C07H15/04 , A61K31/7028 , C07H13/04 , A61K31/7024 , A61P35/00 , C12N5/071
CPC分类号： A61K31/7008 , A61K31/7012 , A61K31/7028 , A61K45/06 , C07H5/06 , C07H7/027 , C07H13/04 , C07H15/04 , G01N33/5091
摘要： Described herein are fatty acid carbohydrate-hydroxyl-hybrid compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.
摘要翻译：本文描述的是脂肪酸碳水化合物 - 羟基 - 杂合化合物及其衍生物，以及使用该化合物及其组合物治疗或预防疾病和疾病症状的方法。

5. 发明申请

US20100217017A1 NOVEL REACTION WITH A GOLD CATALYST 有权
标题翻译：与金催化剂的新反应
公开(公告)号：US20100217017A1
公开(公告)日：2010-08-26
申请号：US12600859
申请日：2008-06-05
申请人： Werner Bonrath , Jocelyn Fischesser
发明人： Werner Bonrath , Jocelyn Fischesser
IPC分类号： C07D307/62
CPC分类号： C07H3/02 , C07B2200/07 , C07C51/235 , C07H7/027 , C07H9/04 , C07C57/03 , C07C63/06
摘要： The invention relates to a process for the catalytic conversion of a carbohydrate, an alcohol, an aldehyde or a poly-hydroxy compound in the presence of a catalyst containing gold in a solvent.
摘要翻译：本发明涉及在溶剂中含有金的催化剂存在下，碳水化合物，醇，醛或多羟基化合物的催化转化方法。

6. 发明申请

US20100121040A1 THERAPEUTIC AGENT FOR PAIN DISEASE 有权
标题翻译：用于治疗疼痛的治疗剂
公开(公告)号：US20100121040A1
公开(公告)日：2010-05-13
申请号：US12449152
申请日：2008-02-06
申请人： Yoshitaka Nakazawa
发明人： Yoshitaka Nakazawa
IPC分类号： C07H7/027
CPC分类号： A61K31/7012 , C07H7/027
摘要： Disclosed is an analgesic agent for a non-inflammatory pain disease, which comprises a sialic acid or a pharmaceutically acceptable salt thereof as an active ingredient. The sialic acid which is an active ingredient for the agent has an analgesic effect on a disease model animal of neurogenic pain which is a non-inflammatory pain. Therefore, the analgesic agent is useful as a pharmaceutical agent for the treatment of a non-inflammatory pain disease such as a neurogenic pain disease, e.g. trigeminal neuralgia, postherpetic neuralgia, entrapment neuropathy, complex regional pain syndrome, diabetic neuropathy, traumatic neuropathy, phantom limb pain, central pain after spinal cord injury or stroke, and neuropathy caused by pharmacotherapy or radiation therapy, or the like.
摘要翻译：公开了一种非炎症性疼痛疾病的止痛剂，其包含唾液酸或其药学上可接受的盐作为活性成分。作为药剂的活性成分的唾液酸对作为非炎症性疼痛的神经源性疼痛的疾病模型动物具有镇痛作用。因此，止痛剂可用作治疗非炎性疼痛疾病如神经性疼痛疾病的药剂，例如神经性疼痛疾病。三叉神经痛，带状疱疹后神经痛，包埋神经病，复杂的局部疼痛综合征，糖尿病性神经病，外伤性神经病，幻肢疼痛，脊髓损伤或中风后的中枢疼痛，以及由药物治疗或放射治疗引起的神经病变等。

7. 发明申请

US20100062991A1 NOVEL 1,4-BENZOTHIEPIN-1,1-DIOXIDE DERIVATIVES WHICH ARE SUBSTITUTED WITH FLUORINE, METHOD FOR PRODUCING THE SAME, DRUGS CONTAINING SAID COMPOUNDS AND USE THEREOF 有权
标题翻译：与氟化物取代的新的1,4-苯并二氢吡喃-1,1-二氧化物衍生物，其制备方法，含有化合物的药物及其用途
公开(公告)号：US20100062991A1
公开(公告)日：2010-03-11
申请号：US12465928
申请日：2009-05-14
申请人： Heiner Glombik , Wendelin Frick , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
发明人： Heiner Glombik , Wendelin Frick , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
IPC分类号： A61K31/7028 , C07H5/06 , A61P3/10 , A61P25/28 , A61P25/18 , A61P3/06
CPC分类号： C07H7/02 , A61K31/38 , A61K31/7028 , A61K45/06 , C07D409/12 , C07H5/04 , C07H5/06 , C07H7/027 , C07H13/12 , C07H15/26 , A61K2300/00
摘要： This invention relates to Novel 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with fluorine, method for producing the same, drugs containing said compounds and use thereof.
摘要翻译：本发明涉及被氟取代的新的1,4-苯并硫代-1,1-二氧化物衍生物，其制备方法，含有所述化合物的药物及其用途。

8. 发明授权

US07091375B2 Method for the production of 2=-keto-l-gulonic acid C4C10 alkyl esters 失效
标题翻译：制备2 =酮-1-古洛糖酸C 4 C 10烷基酯的方法
公开(公告)号：US07091375B2
公开(公告)日：2006-08-15
申请号：US10534334
申请日：2003-11-07
申请人： Thomas Domschke , Martin Merger , Georg Grossmann , Tillmann Faust
发明人： Thomas Domschke , Martin Merger , Georg Grossmann , Tillmann Faust
IPC分类号： C07D305/12
CPC分类号： C07H7/027 , Y02P20/127
摘要： The invention relates to a method for producing 2-keto-L-gulonic acid-C4–C10 alkyl ester by esterifying 2-keto-L-gulonic acid (KGS) with an unsaturated, branched or unbranched C4–C10 alcohol. The inventive method is characterized by the fact that an aqueous KGS solution is reacted with a C4–C10 alcohol up to an esterification degree of 20 to 70 percent in a pre-esterification process carried out under acidic catalysis conditions; and the obtained product is dehydrogenated with an unsaturated, branched or unbranched C4–C10 alcohol in a continuous rectification device, whereby the esterification reaction continues, n-butanol preferably being used as the alkyl alcohol. In a preferred embodiment, the aqueous KGS solution is concentrated up to or beyond the limit of solubility prior to the esterification process, preferably by catalyzing a homogeneous or heterogeneous catalyst, especially sulfonic acid, at temperatures of 50 to 120° C. In another embodiment, the produced KGS ester is reacted in one or several additional steps so as to obtain L-ascorbic acid.
摘要翻译：本发明涉及通过酯化2-酮-L-古洛糖酸（KGS）制备2-酮-L-古洛糖酸-C 4 -C 10烷基酯的方法）与不饱和，支链或非支链C 4 -C 10醇。本发明的方法的特征在于，将KGS水溶液与C 4 -C 10 - 醇反应，直到酯化程度为20至70％在酸性催化条件下进行酯化过程; 并将得到的产物用连续精馏装置中的不饱和支链或非支链C 4 -C 10醇脱氢，由此继续进行酯化反应，正丁醇优选为用作烷基醇。在优选的实施方案中，在酯化过程之前，优选通过在50至120℃的温度下催化均相或多相催化剂，特别是磺酸，将KGS水溶液浓缩至或超过溶解度的极限。在另一个实施方案中，所制备的KGS酯在一个或几个附加步骤中反应，以获得L-抗坏血酸。

9. 发明申请

US20040181054A1 Process for producing sugar chain asparagine derivative 有权
标题翻译：制备糖链天冬酰胺衍生物的方法
公开(公告)号：US20040181054A1
公开(公告)日：2004-09-16
申请号：US10481246
申请日：2003-12-18
发明人： Yasuhiro Kajihara , Ken Sasaki
IPC分类号： C13K005/00
CPC分类号： C07H13/10 , C07H5/06 , C07H7/027 , C07H15/12 , C12P13/04 , C12P19/04 , C12P19/28 , Y02P20/55
摘要： The present invention provides a process for preparing a sugar chain asparagine derivative. According to the process, various isolated sugar chain asparagine derivatives useful in the field of the development of pharmaceuticals and the like can be conveniently obtained in a large amount as compared to that of the prior art. The present invention also provides a process for preparing a sugar chain asparagine and a process for preparing a sugar chain via a step for preparing a sugar chain asparagine derivative. The present invention further provides a novel sugar chain asparagine derivative, a sugar chain asparagine and a sugar chain.
摘要翻译：本发明提供了制备糖链天冬酰胺衍生物的方法。根据该方法，与现有技术相比，可以方便地获得与药物开发领域有用的各种分离的糖链天冬酰胺衍生物。本发明还提供了制备糖链天冬酰胺的方法和通过制备糖链天冬酰胺衍生物的步骤制备糖链的方法。本发明还提供了一种新型的糖链天冬酰胺衍生物，糖链天冬酰胺和糖链。

10. 发明授权

US06512100B1 Chromogenic substrates of sialidase and methods of making and using the same 有权
标题翻译：唾液酸酶的显色底物及其制备和使用方法
公开(公告)号：US06512100B1
公开(公告)日：2003-01-28
申请号：US09651622
申请日：2000-08-30
申请人： Stephen C Johnson , Ashraf Saeed , Ming Luo
发明人： Stephen C Johnson , Ashraf Saeed , Ming Luo
IPC分类号： C07H1504
CPC分类号： C07H15/203 , C07H7/027 , C07H15/24 , C07H17/02 , C07H17/075
摘要： The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. In particular, this invention provides a novel class of effective compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.
摘要翻译：本发明公开了用于细菌，病毒，原生动物和脊椎动物（包括人）起源的唾液酸酶的显色底物化合物的设计，合成和生物化学评估的材料和方法。特别地，本发明提供了一种新型的有效化合物作为这些唾液酸酶的显色底物，其在由唾液酸酶催化的反应发生后产生显色产物。还提供了使用这些底物化合物制备这些底物化合物的方法，唾液酸酶相关疾病的诊断和预后的方法。

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