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    • 5. 发明授权
    • Acid-functionalized saccharides as polyvalent anti-infectives
    • 酸官能化糖作为多价抗感染药
    • US5700458A
    • 1997-12-23
    • US717264
    • 1996-09-20
    • W. Harry Mandeville, IIIVenkata R. Garigapati
    • W. Harry Mandeville, IIIVenkata R. Garigapati
    • C07H15/04A61K31/785C08F12/14C08F16/26C08F20/26C08F20/28C08F20/38C08F20/58C08F26/02C08F220/56A61K31/765
    • A61K31/785C08F20/28C08F20/38C08F20/58
    • The present invention includes polymerizable monomers comprising an acid-functionalized glycoside moiety. In one embodiment, the monomer has a polymerizable functional group, such as an olefinic bond, to which the acid-functionalized glycoside moiety is attached by a spacer group, for example, an alkylene group, or an alkylene group wherein one or more carbon atoms are substituted by heteroatoms, such as oxygen, nitrogen or sulfur atoms. The present invention also includes polymers comprising one or more acid-functionalized glycoside moieties, such as pendant acid-functionalized glycoside moieties, which can inhibit or prevent rotavirus infection in a mammal. Such a polymer can comprise, for example, a monomer of the present invention. The polymer can be a homopolymer or a copolymer, and can have, for example, a polyacrylamide, polyacrylate or polystyrene backbone. In another embodiment, the present invention comprises a method for treating a rotaviral infection in a mammal, for example, a human, by administering to the mammal a therapeutically effective amount of a polymer comprising one or more glycoside moieties, such as pendant glycoside moieties. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer which comprises an acid-functionalized glycoside-bearing monomer and acrylamide.
    • 本发明包括包含酸官能化的糖苷部分的可聚合单体。 在一个实施方案中,单体具有可聚合官能团,例如烯键,酸官能化糖苷部分通过间隔基团连接到其上,例如亚烷基或其中一个或多个碳原子 被杂原子,如氧,氮或硫原子所取代。 本发明还包括可以抑制或预防哺乳动物轮状病毒感染的一种或多种酸官能化糖苷部分的聚合物,例如侧酸官能化糖苷部分。 这样的聚合物可以包括例如本发明的单体。 聚合物可以是均聚物或共聚物,并且可以具有例如聚丙烯酰胺,聚丙烯酸酯或聚苯乙烯主链。 在另一个实施方案中,本发明包括通过向哺乳动物施用治疗有效量的包含一个或多个糖苷部分的聚合物,例如侧链糖苷部分,来治疗哺乳动物例如人类的轮状病毒感染的方法。 聚合物可以是均聚物或共聚物。 在一个实施方案中,聚合物是包含酸官能化的含糖单体和丙烯酰胺的共聚物。