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1. 发明申请

US20230125454A1 CONJUGATE OF PHTHALOCYANINE DYE AND ANTIBODY OR PEPTIDE 有权
公开(公告)号：US20230125454A1
公开(公告)日：2023-04-27
申请号：US17795719
申请日：2021-02-04
申请人： THE UNIVERSITY OF TOKYO , SAVID THERAPEUTICS INC.
发明人： Motomu KANAI , Kenzo YAMATSUGU , Toshifumi TATSUMI , Kazuki TAKAHASHI , Tatsuhiko KODAMA , Akira SUGIYAMA , Masanobu TSUKAGOSHI , Yuzo TODA
IPC分类号： A61K47/68 , A61K47/55 , C09B47/30
摘要： Objects of the present invention are to provide a novel phthalocyanine dye for use in photoimmunotherapy, and a method for producing the same, and to provide a conjugate of the above-described phthalocyanine dye and an antibody or a peptide. According to the present invention, a compound represented by the following formula (1) or a salt thereof is provided: wherein X represents a substituent having a hydrophilic group at the terminus thereof; L3, L4, L5, and L6 each independently represent a divalent linking group; Y represents a group capable of binding to an antibody or a peptide; R3 represents a substituent, such as an alkyl group containing 1 to 6 carbon atoms, an alkoxy group containing 1 to 6 carbon atoms, a halogen atom, —SR11, —SOR12, an aryl group containing 6 to 10 carbon atoms, —N(R13)(R14), or —NO2, wherein when a plurality of R3s are present, the plurality of R3s may be identical to or different from one another; and s represents an integer of 0 to 4.

2. 发明申请

US20150125792A1 PHTHALOCYANINE PIGMENT AND PIGMENT DISPERSION, INK AND COLOR FILTER RESIST COMPOSITION CONTAINING SAME 审中-公开
标题翻译：色氨酸颜料和色素分散剂，含有其的油墨和颜料过滤剂组合物
公开(公告)号：US20150125792A1
公开(公告)日：2015-05-07
申请号：US14407646
申请日：2013-08-21
申请人： CANON KABUSHIKI KAISHA
发明人： Ryuji Higashi , Akiko Kitao , Taichi Shintou , Takeshi Miyazaki
IPC分类号： C09B47/04 , G03F7/00 , C09B47/30
CPC分类号： C09B47/04 , C09B47/08 , C09B47/30 , C09B69/108 , C09D11/037 , C09D11/322 , G02B5/223 , G03F7/0007
摘要： The present invention provides a phthalocyanine pigment having superior color development property, and a pigment dispersion, an ink and a color filter resist composition containing the phthalocyanine pigment, in which the phthalocyanine pigment having a structure represented by general formula (1), and the pigment dispersion, the ink and the color filter resist composition containing the phthalocyanine pigment.
摘要翻译：本发明提供具有优异显色性的酞菁颜料和含有酞菁颜料的颜料分散体，油墨和滤色器抗蚀剂组合物，其中具有由通式（1）表示的结构的酞菁颜料和颜料分散体，油墨和含有酞菁颜料的滤色器抗蚀剂组合物。

3. 发明申请

US20120308826A1 STOBER METHOD FOR PREPARING SILICA PARTICLES CONTAINING A PHTHALOCYANINE DERIVATIVE, SAID PARTICLES AND THE USES THEREOF 审中-公开
标题翻译：制备含有羟基苯甲酸衍生物的硅胶颗粒的STOBER方法，所述颗粒及其用途
公开(公告)号：US20120308826A1
公开(公告)日：2012-12-06
申请号：US13578554
申请日：2011-02-10
申请人： Aurélien Auger
发明人： Aurélien Auger
IPC分类号： C09B47/30
CPC分类号： C09C1/3063 , C01P2004/03 , C01P2004/62 , C09B69/008 , C09B69/108 , C09C1/3081 , C09C1/309 , Y10T428/2982
摘要： The present invention concerns a method for preparing a silica particle incorporating at least one phthalocyanine derivative, said particle being prepared from at least one silicon phthalocyanine derivative by hydrolysis of said derivative in an alcohol solution. The present invention also concerns the silica particles thus prepared and the uses thereof.
摘要翻译：本发明涉及一种制备掺入至少一种酞菁衍生物的二氧化硅颗粒的方法，所述颗粒由至少一种硅酞菁衍生物通过在醇溶液中水解所述衍生物而制备。本发明还涉及如此制备的二氧化硅颗粒及其用途。

4. 发明授权

US5932723A Phase-directed preparation of metal-free phthalocyanine 失效
标题翻译：无相金属酞菁的相向制备
公开(公告)号：US5932723A
公开(公告)日：1999-08-03
申请号：US991780
申请日：1997-12-16
申请人： Andrea Birgit Schutze , Frank Scherhag , Ingo Klopp , Anette Hartmann
发明人： Andrea Birgit Schutze , Frank Scherhag , Ingo Klopp , Anette Hartmann
IPC分类号： C09B47/067 , C09B47/22 , C09B47/24 , C09B47/26 , C09B47/30 , C09B67/50 , C09D11/02 , C09B47/04
CPC分类号： C09B67/0026 , C09B47/30
摘要： A process for preparing metal-free phthalocyanine by reductive cyclization of phthalonitrile in the presence of an aliphatic alcohol, of a redox catalyst and of an inorganic base comprises effecting the cyclization in the presence of one or more phthalocyanine derivatives selected from the group consisting of phthalocyanine-sulfonic acids and -carboxylic acids and their alkali metal, ammonium and alkylarnozium salts, the amino-substituted and aminomethylated phthalocyanines and their reaction products with alkylating agents, sulfonic acids, sulfonyl chlorides and carbonyl chlorides, the imidomethylene- and amidomethylene-substituted phthalocyanines, the alkyl-, aryl- and cyano-substituted phthalocyanines, the hydroxyl- and alkoxy-substituted phthalocyanines and their reaction products with tetraalkyl- and tetraalkoxy-silanes and the halogenated phthalocyanines.
摘要翻译：通过在脂族醇，氧化还原催化剂和无机碱的存在下还原环化邻苯二甲腈制备无金属酞菁的方法包括在一种或多种选自酞菁的酞菁衍生物的存在下进行环化磺酸和羧酸及其碱金属，铵和烷基锍盐，氨基取代的和氨甲基化的酞菁及其与烷基化剂，磺酸，磺酰氯和羰基氯的反应产物，亚氨基亚甲基和亚氨基亚甲基取代的酞菁，烷基，芳基和氰基取代的酞菁，羟基和烷氧基取代的酞菁及其与四烷基 - 和四烷氧基硅烷和卤代酞菁的反应产物。

5. 发明授权

US5872248A Methods for inserting silicon into phthalocyanines and naphthalocyanines 失效
标题翻译：将硅插入酞菁和萘酞菁的方法
公开(公告)号：US5872248A
公开(公告)日：1999-02-16
申请号：US829527
申请日：1997-03-28
申请人： Gongzhen Cheng , Guolun Hao , Hongqiao Wu , Ying-Syi Li , Malcolm E. Kenney
发明人： Gongzhen Cheng , Guolun Hao , Hongqiao Wu , Ying-Syi Li , Malcolm E. Kenney
IPC分类号： C09B47/08 , C09B47/30 , C09B47/04
CPC分类号： C09B47/30 , C09B47/08
摘要： A simple, flexible, convenient method for making silicon phthalocyanines and naphthalocyanines by inserting silicon into metal-free phthalocyanines and metal-free naphthalocyanines is provided. The method comprises: providing a metal-free phthalocyanine or metal-free naphthalocyanine; reacting the metal-free phthalocyanine or metal-free naphthalocyanine with HSiCl.sub.3 to provide a reaction product; then reacting the reaction product with water; and extracting a silicon phthalocyanine or a silicon naphthalocyanine. The invention also relates to novel phthalocyanines and naphthalocyanines. The phthalocyanines and naphthalocyanines are useful as photosensitizers and as dyes.
摘要翻译：提供了一种通过将硅插入无金属酞菁和无金属萘酞菁来制造硅酞菁和萘酞菁的简单，灵活，方便的方法。该方法包括：提供无金属酞菁或无金属酞菁; 使无金属酞菁或无金属萘酞菁与HSiCl 3反应以提供反应产物; 然后使反应产物与水反应; 并提取硅酞菁或硅萘酞菁。本发明还涉及新型酞菁和萘酞菁。酞菁和萘酞菁可用作光敏剂和染料。

6. 发明授权

US5763602A Methods of syntheses of phthalocyanine compounds 失效
标题翻译：酞菁化合物合成方法
公开(公告)号：US5763602A
公开(公告)日：1998-06-09
申请号：US724347
申请日：1996-10-01
申请人： Ying-Syi Li , Malcolm E. Kenney
发明人： Ying-Syi Li , Malcolm E. Kenney
IPC分类号： C07D487/04 , A61K41/00 , C07D487/22 , C09B47/08 , C09B47/30 , C09B47/04 , C07F7/18
CPC分类号： C07D487/22 , A61K41/0071 , C09B47/08
摘要： The present invention provides improved methods for synthesizing phthalocyanines, particularly HOSiPcOSi(CH.sub.3).sub.2 (CH.sub.2).sub.3 N(CH.sub.3).sub.2, which do not involve photolysis, and which produces purity of at least about 95%, and in the preferred embodiment of the first method of synthesis provide a yield of greater than about 70% and typically greater than 80%. The first method involves a method for synthesizing a phthalocyanine compound comprising the following steps: providing a phthalocyanine precursor having a central silicon; adding a first aminosiloxy ligand to the central silicon of the phthalocyanine precursor; adding a second aminosiloxy ligand to the central silicon of the phthalocyanine precursor; displacing the second aminosiloxy ligand by an organic acid ligand, preferably Cl.sub.3 CCOO ligand; then displacing the Cl.sub.3 CCOO ligand with an HO ligand. The second method for making Pc4 is a method for synthesizing a phthalocyanine compound comprising the following steps: providing a phthalocyanine precursor having a central silicon; providing a siloxy ligand with an iodo group; adding a first and second siloxyiodo ligand to the central silicon of the phthalocyanine precursor; displacing the second siloxyiodo ligand by an organic acid, preferably a Cl.sub.3 CCOO ligand; then displacing the a Cl.sub.3 CCOO ligand with an HO ligand; and then displacing the iodo group with a dimethylamino group.
摘要翻译：本发明提供了用于合成酞菁，特别是不涉及光解的HOSiPcOSi（CH3）2（CH2）3N（CH3）2）并且产生至少约95％的纯度的改进方法，并且在第一合成方法提供大于约70％且通常大于80％的产率。第一种方法涉及一种合成酞菁化合物的方法，包括以下步骤：提供具有中心硅的酞菁前体; 将第一氨基硅氧基配体加入到酞菁前体的中心硅中; 向所述酞菁前体的中心硅中加入第二氨基硅氧基配体; 通过有机酸配体，优选Cl 3 COOO配体置换第二氨基甲硅烷氧基配体; 然后用HO配体置换Cl3CCOO配体。制备Pc4的第二种方法是合成酞菁化合物的方法，包括以下步骤：提供具有中心硅的酞菁前体; 提供具有碘基团的甲硅烷氧基配体; 向所述酞菁前体的中心硅添加第一和第二硅氧烷碘配体; 通过有机酸，优选Cl 3 COOO配体置换第二硅氧烷碘配体; 然后用HO配体取代Cl 3 COOO配体; 然后用二甲基氨基取代碘代基团。

7. 发明授权

US5591555A Electrophotographic photoconductor including a metal-free phthalocyanine 失效
标题翻译：包括无金属酞菁的电子照相感光体
公开(公告)号：US5591555A
公开(公告)日：1997-01-07
申请号：US370384
申请日：1995-01-10
申请人： Shinichi Tamura , Seishi Terasaki , Tadashi Mimura , Teruaki Kobayashi , Youichi Tei
发明人： Shinichi Tamura , Seishi Terasaki , Tadashi Mimura , Teruaki Kobayashi , Youichi Tei
IPC分类号： C07D487/22 , C09B47/30 , C09B67/50 , G03G5/06
CPC分类号： C09B67/0026 , C09B47/30 , G03G5/0696
摘要： An electrophotographic photoconductor, includes metal-free phthalocyanine as a charge-generating substance, wherein the X-ray diffraction spectrum of said metal-free phthalocyanine as measured using CuK.alpha. as a radiation source includes intense diffraction peaks at Bragg angles (2.theta..+-.0.2.degree.) of 7.5.degree., 9.0.degree., 16.6.degree., 17.2.degree., 21.5.degree., 22.2.degree., 23.8.degree., and 28.5.degree., and wherein the infrared absorption spectrum of said metal-free phthalocyanine includes four absorption bands with the maximum absorption intensity at a wavenumber of 716 cm.sup.-1 between a wavenumber of 700 cm.sup.-1 and a wavenumber of 760 cm.sup.-1 and a characteristic absorption band at a wavenumber of 3,291.+-.2 cm.sup.-1.
摘要翻译：电子照相感光体包括无金属酞菁作为电荷产生物质，其中使用CuKα作为辐射源测量的所述无金属酞菁的X射线衍射光谱包括在布拉格角（2θ/ -0.2°）为7.5°，9.0°，16.6°，17.2°，21.5°，22.2°，23.8°和28.5°，其中所述无金属酞菁的红外吸收光谱包括具有最大吸收的四个吸收带波数为700cm -1，波数为760cm -1的波数716cm -1处的波数和波数为3,291 +/- 2cm -1的特征吸收带。

8. 发明授权

US5432277A Metal-free phthalocyanine of the .gamma.-form 失效
标题翻译：无伽马型无金属酞菁
公开(公告)号：US5432277A
公开(公告)日：1995-07-11
申请号：US136287
申请日：1993-10-15
申请人： Peter Boettcher , Peter Erk , Joachim Jesse
发明人： Peter Boettcher , Peter Erk , Joachim Jesse
IPC分类号： C09B47/30 , C09B67/16 , C09B67/50
CPC分类号： C09B67/0026 , C09B67/0019
摘要： Metal-free phthalocyanine of the .gamma.-form is suitable inter alia for coloring printing inks, plastics and coatings and is characterized by the X-ray powder diagram (Cu.sub.K.alpha.) having the essential glancing angles 2 theta [.degree.]6.8, 7.4, 13.6, 14.9, 15.9, 16.9, 20.5, 22.4, 24.7, 26.2 and 27.8, possibly in mixture with other crystal forms, in which case the glancing angles may be shifted by .+-.0.2.degree. (FIG. 1).
摘要翻译： γ型的无金属酞菁特别适用于着色印刷油墨，塑料和涂料，其特征在于具有基本瞥见角2θ[°] 6.8,7.4,13.6的X射线粉末图（CuKα），14.9,15.9,16.9,20.5,22.4,24.7,26.2和27.8，可能与其他晶体形式混合，在这种情况下，扫掠角可能偏移+/- 0.2°（图1）。

9. 发明授权

US5403928A Fluorescent marker components and fluorescent probes 失效
标题翻译：荧光标记组分和荧光探针
公开(公告)号：US5403928A
公开(公告)日：1995-04-04
申请号：US701449
申请日：1991-05-15
申请人： Peter O. G. Arrhenuis
发明人： Peter O. G. Arrhenuis
IPC分类号： A61K31/695 , A61K41/00 , A61K47/48 , A61K49/00 , A61P35/00 , C07D487/22 , C07F7/10 , C07H15/26 , C07H17/00 , C07H23/00 , C07J43/00 , C07J51/00 , C09B47/00 , C09B47/073 , C09B47/08 , C09B47/24 , C09K11/06 , G01N33/533 , G01N33/58 , C09B47/30
CPC分类号： A61K49/0036 , A61K41/0071 , A61K47/48215 , A61K49/0015 , A61K49/0054 , C07J43/003 , C07J51/00 , C09B47/00 , C09B47/073 , C09B47/08 , C09B47/24 , G01N33/533 , G01N33/582 , G01N2333/19
摘要： Marker components are provided which are compatible with aqueous solutions, exhibit favorable fluorescence properties and exhibit decreased non-specific binding to macromolecules in solution. These marker components are useful in applications such as fluorescence immunoassays, in vivo imaging and in vivo tumor therapy.
摘要翻译：提供与水溶液相容的标记组分，显示出有利的荧光性质，并且在溶液中表现出降低的非特异性结合大分子。这些标记组分可用于荧光免疫测定，体内成像和体内肿瘤治疗等应用。

10. 发明授权

US4824948A Substituted phthalocyanine 失效
标题翻译：取代酞菁
公开(公告)号：US4824948A
公开(公告)日：1989-04-25
申请号：US162513
申请日：1988-03-01
申请人： William Stark , Nigel Hughes , Donald M. Gunn
发明人： William Stark , Nigel Hughes , Donald M. Gunn
IPC分类号： G03G9/08 , C07D487/22 , C09B47/04 , C09B47/20 , C09B47/24 , C09D11/02 , G03G9/09 , C09B47/30
CPC分类号： C09D11/037 , C09B47/045 , C09B47/20 , C09B47/24 , G03G9/0918
摘要： A phthalocyanine compound of the formula:(R--X--).sub.m Pc (--Y--R.sup.1 --Z--).sub.n (--SO.sub.3 M).sub.p IwhereinPc is a phthalocyanine nucleus (Pc);eachR independently is a monovalent aromatic radical linked to a peripheral carbon atom of the Pc nucleus through X;X selected from S, Se and Te;m is 4 to 16;eachR.sup.1 independently is a divalent aromatic radical linked to two adjacent peripheral carbon atoms of the Pc nucleus through Y and Z;Y is selected from S, NT, Se and Te;Z is selected from S, Se, Te, NT and O;T is selected from H, alkyl and aryl;n is 0 to 7;M is H, a metal or optionally-substituted ammonium;andP is from 1 to 16.The compounds have a significant absorption band in the near infra red and depending on the number of sulphonic acids groups and the nature of the counter ion are soluble in aqueous and polar organic media. The compounds are useful in many applications where absorption of infra-red radiation is desirable, such as in OCR readable inks, rapid-drying inks, security printing and reprographic toners.

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