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1. 发明授权

US11175294B2 Protein composition and methods for analysing microbiota 有权
公开(公告)号：US11175294B2
公开(公告)日：2021-11-16
申请号：US16305461
申请日：2017-06-01
申请人： UNIVERSITY OF OTTAWA
发明人： Joseph Michel Daniel Figeys , Alain Christophe Stintzi , David R. Mack , Xu Zhang , Zhibin Ning
IPC分类号： G01N33/68 , G16H50/30 , G16H50/70 , G16H50/20 , G16B30/10 , G16B40/10 , G16B40/20 , A61B5/00 , C12Q1/16 , G01N33/50
摘要： A method of isotope-labelling a microbiota sample. It involves providing a first microbiota sample that was obtained from a given source; exposing the first microbiota sample to an isotope enriched medium; and culturing the exposed first microbiota sample in the isotope enriched medium to obtain an isotope-labelled microbiota sample, wherein the isotope labelled metaproteome of the isotope-labelled microbiota sample is taxon specific for taxa present in the first microbiota sample when initially obtained from the given source.

2. 发明申请

US20190331693A1 PROTEIN COMPOSITION AND METHODS FOR ANALYSING MICROBIOTA 审中-公开
公开(公告)号：US20190331693A1
公开(公告)日：2019-10-31
申请号：US16305461
申请日：2017-06-01
申请人： UNIVERSITY OF OTTAWA , CHILDREN'S HOSPITAL OF EASTERN ONTARIO RESEARCH INSTITUTE
发明人： Joseph Michel Daniel FIGEYS , Alain Christophe STINTZI , David R. MACK , Xu ZHANG , Zhibin NING
IPC分类号： G01N33/68 , C12Q1/16 , A61B5/00 , G16B30/10 , G16H50/20 , G16H50/70 , G16H50/30 , G01N33/50 , G16B40/10 , G16B40/20
摘要： A method of isotope-labelling a microbiota sample. It involves providing a first microbiota sample that was obtained from a given source; exposing the first microbiota sample to an isotope enriched medium; and culturing the exposed first microbiota sample in the isotope enriched medium to obtain an isotope-labelled microbiota sample, wherein the isotope labelled metaproteome of the isotope-labelled microbiota sample is taxon specific for taxa present in the first microbiota sample when initially obtained from the given source.

3. 发明授权

US08906610B2 Using phylogenetic probes for quantification of stable isotope labeling and microbial community analysis 有权
标题翻译：使用系统发育探针来定量稳定同位素标记和微生物群落分析
公开(公告)号：US08906610B2
公开(公告)日：2014-12-09
申请号：US13023538
申请日：2011-02-08
申请人： Eoin L. Brodie , Todd Z. DeSantis , Ulas Karaoz , Gary L. Andersen
发明人： Eoin L. Brodie , Todd Z. DeSantis , Ulas Karaoz , Gary L. Andersen
IPC分类号： C12Q1/68 , C12Q1/04 , C12Q1/16 , G01N33/68
CPC分类号： G01N33/6848 , C12Q1/6837 , C12Q2565/627 , C12Q2545/114
摘要： Herein is described methods for a high-sensitivity means to measure the incorporation of stable isotope labeled substrates into RNA following stable isotope probing experiments (SIP). RNA is hybridized to a set of probes such as phylogenetic microarrays and isotope incorporation is quantified such as by secondary ion mass spectrometer imaging (NanoSIMS).
摘要翻译：本文描述了用于在稳定同位素探测实验（SIP）之后测量稳定同位素标记的底物掺入RNA中的高灵敏度手段的方法。 RNA与一系列探针杂交，如系统发育微阵列，同位素结合如通过二次离子质谱仪成像（NanoSIMS）进行定量。

4. 发明申请

US20130034496A1 POSITRON EMISSION TOMOGRAPHY TRACER 审中-公开
标题翻译： POSITRON排放TOMOGRAPHY追踪器
公开(公告)号：US20130034496A1
公开(公告)日：2013-02-07
申请号：US13565599
申请日：2012-08-02
申请人： Amnon Kohen
发明人： Amnon Kohen
IPC分类号： A61K51/04 , C12Q1/16 , C07D475/04
CPC分类号： C07D475/12 , A61K51/0459
摘要： The present invention relates to positron emission tomography tracers and methods of using these tracers.
摘要翻译：本发明涉及正电子发射断层摄影示踪剂和使用这些示踪剂的方法。

5. 发明授权

US07435555B2 Asparagine hydroxylation of the CAD domain of a HIF protein 失效
标题翻译： HIF蛋白的CAD结构域的天冬酰胺羟化作用
公开(公告)号：US07435555B2
公开(公告)日：2008-10-14
申请号：US10490085
申请日：2002-09-18
申请人： Murray L Whitelaw , David Lando , Daniel J Peet , Jeffrey J Gorman , Sarah Linke
发明人： Murray L Whitelaw , David Lando , Daniel J Peet , Jeffrey J Gorman , Sarah Linke
IPC分类号： C12Q1/00 , C12Q1/16 , C12Q1/68
CPC分类号： G01N33/6875 , C07K14/4702 , C12Q1/26 , G01N2500/00
摘要： A target asparagine residue of HIF 1 alpha and 2 alpha is hydroxylated at high oxygen tension to render HIF as a weak transcription factor. An asparagine hydroxylase hydroxylation motif and binding motif is proposed. A method of screening for agonists or antagonists of an asparagine hydroxylase is also proposed and involves mixing peptides or proteins having the hydroxylation and or the binding motif with asparagine hydroxylase and a candidate agonist or antagonist. The extent of inhibition or enhancement of binding; level of asparagine hydroxylation or transactivation may be measured depending on the nature of the protein or peptide. Additionally altered proteins resistant to hydroxylation are described as are nucleic acids encoding such proteins.
摘要翻译： HIF1α和2α的目标天冬酰胺残基在高氧压下被羟基化，使HIF作为弱转录因子。提出了天冬酰胺羟化酶羟化基序和结合基序。还提出了筛选天冬酰胺羟化酶的激动剂或拮抗剂的方法，并且涉及将具有羟基化和/或结合基序的肽或蛋白质与天冬酰胺羟化酶和候选激动剂或拮抗剂混合。抑制或增强结合的程度; 天冬酰胺羟化或反式激活的水平可以根据蛋白质或肽的性质来测量。另外，抗羟化反应的改变的蛋白质被描述为编码这种蛋白质的核酸。

6. 发明申请

US20070172908A1 Enteropathogenic E. Coli is a separate genus pathogenic bacteria 审中-公开
标题翻译：肠道致病性大肠杆菌是一种单独的病原菌
公开(公告)号：US20070172908A1
公开(公告)日：2007-07-26
申请号：US11635390
申请日：2006-12-06
申请人： Yakov Brilman
发明人： Yakov Brilman
IPC分类号： C12Q1/26 , C12Q1/16
CPC分类号： C12Q1/10 , C12Q1/32 , G01N2333/245
摘要： An assay is provided which recognizes the absence of dehydrogenase in all pathogenic bacteria and its presence in nonpathogenic (conditionally pathogenic) bacteria creating the opportunity to separate and establish enteropathogenic Escherichia (EPE) in a pathogenic genus bacteria; genus Brilmanella. A method for diagnosing maladies of the bowel based on the existence of the Brilmanella is also provided.
摘要翻译：提供了一种识别所有致病细菌中脱氢酶不存在及其在非病原性（有条件致病性）细菌中的存在的分析，其产生在致病性属细菌中分离和建立致病性埃希氏杆菌（EPE）的机会; Brilmanella属。还提供了一种基于Brilmanella的存在来诊断肠道疾病的方法。

7. 发明申请

US20050112718A1 Culture medium for detecting enterococcus 审中-公开
标题翻译：用于检测肠球菌的培养基
公开(公告)号：US20050112718A1
公开(公告)日：2005-05-26
申请号：US10976065
申请日：2004-10-28
申请人： Tomota Nakano , Ryoichi Kubo
发明人： Tomota Nakano , Ryoichi Kubo
IPC分类号： C12Q1/08 , C12N1/20 , C12Q1/04 , C12Q1/34 , C12Q1/16
CPC分类号： C12N1/20 , C12Q1/045 , C12Q1/34 , C12Q2334/50 , G01N2333/315
摘要： A culture medium is provided that includes a reducing chromogenic reagent that does not give a coloration with Enterococcus faecium. There is also provided a method for differentiating Enterococcus faecium from Enterococcus faecalis in a sample, the method including a step of inoculating the above culture medium with the sample; and a step of differentiating between the two bacterial strains by observing the colony color during culture or after culturing.
摘要翻译：提供了一种培养基，其包括不会使屎肠球菌产生着色的还原显色试剂。还提供了一种在样品中分离粪肠球菌的粪肠球菌的方法，所述方法包括用样品接种上述培养基的步骤; 以及通过在培养期间或培养后观察菌落颜色来区分两种细菌菌株的步骤。

8. 发明授权

US6127154A Methods for direct synthesis of compounds having complementary structure to a desired molecular entity and use thereof 有权
公开(公告)号：US6127154A
公开(公告)日：2000-10-03
申请号：US303656
申请日：1999-05-03
申请人： Klaus Mosbach , Peter A. G. Cormack , Olof Ramstrom , Karsten Haupt
发明人： Klaus Mosbach , Peter A. G. Cormack , Olof Ramstrom , Karsten Haupt
IPC分类号： C08J5/00 , C08J9/26 , C08J9/28 , C12N13/00 , C12Q1/16
CPC分类号： B82Y5/00 , B82Y30/00
摘要： Compounds which possess a complementary structure to a desired molecule, such as a biomolecule, in particular polymeric or oligomeric compounds, which are useful as in vivo or in vitro diagnostic and therapeutic agents are provided. Also, various methods for producing such compounds are provided. These polymeric or oligomeric compounds are useful in particular as antimicrobial agents, receptor, hormone or enzyme agonists and antagonists.

9. 发明授权

US5348861A Device and method for the detection of microorganisms which produce low-molecular-weight metabolites 失效
标题翻译：用于检测产生低分子量代谢物的微生物的装置和方法
公开(公告)号：US5348861A
公开(公告)日：1994-09-20
申请号：US781023
申请日：1991-10-18
申请人： Hans Kulla
发明人： Hans Kulla
IPC分类号： C12M1/12 , C12M1/34 , C12Q1/16 , C12M1/00 , C12N11/00 , C12Q1/02
CPC分类号： C12Q1/16 , C12M41/36 , Y10S435/807
摘要： Selective detection of microorganisms is achieved by a screening technique in which radioactively labeled, low-molecular-weight metabolites produced by microorganisms to be detected reach an adsorption medium through a semipermeable medium which passes the labeled metabolites but blocks the labeled incubation medium. The adsorption medium is then subject to analysis, such as antoradiography, to detect the presence of the labeled metabolites. An analytical assembly for such detection includes a filter membrane support for growing microorganisms in discrete colonies and for holding a radioactively labeled incubating medium applied thereon, a semipermeable filter medium covering the support having the grown microorganisms and the incubating medium for passing low-molecular-weight, labeled metabolites produced by microorganisms of interest while blocking the incubating medium, and a cohesive layer of an adsorption medium conformably disposed with the filter membrane support and the semipermeable medium and being capable of adsorbing the labeled metabolites which have traversed the semipermeable medium during incubation of the assembly. Following incubation of the assembly, the adsorption medium layer is transferable for analysis, e.g., by autoradiography, to detect the presence of labeled metabolites produced by microorganisms of interest and to identify specific colonies of the microorganisms producing the radioactively labeled metabolite.
摘要翻译：通过筛选技术实现微生物的选择性检测，其中由被检测的微生物产生的放射性标记的低分子量代谢物通过通过标记的代谢物但阻断标记的培养基的半透性培养基达到吸附介质。然后对吸附介质进行分析，例如抗晕蚀，以检测标记的代谢物的存在。用于这种检测的分析组件包括用于在离散集落中生长微生物并用于保持施加于其上的放射性标记的孵育培养基的过滤膜支持物，覆盖具有生长的微生物的支持物的半透性过滤介质和用于通过低分子量的培养基，在阻断培养基的同时标记的感兴趣的微生物标记的代谢物，以及与过滤膜支持物和半透性培养基顺应地配置的吸附介质的内聚层，并且能够吸附已经穿过半透性培养基的标记的代谢物，大会。在组装温育之后，例如通过放射自显影可以将吸附介质层转移以进行分析，以检测由感兴趣的微生物产生的标记的代谢物的存在，并鉴定产生放射性标记的代谢物的微生物的特定菌落。

10. 发明授权

US4753878A Microorganism identification technique 失效
标题翻译：微生物识别技术
公开(公告)号：US4753878A
公开(公告)日：1988-06-28
申请号：US729792
申请日：1985-05-02
申请人： Robert E. Silman
发明人： Robert E. Silman
IPC分类号： C12Q1/04 , C12Q1/16
CPC分类号： C12Q1/16 , C12Q1/04
摘要： A technique for identifying an unknown microorganism, in which technique a specimen of the unknown microorganism is prepared to which a radioactive emissive agent has been added that is actively incorporated into the products of metabolism of the microorganism to produce a mix of radioactive peptide or protein emissive products in a manner that depends on the metabolic mechanism of the microorganism. The peptide or protein emissive products in the mix resulting from the preparation of the specimen are then separated. The separated emissive products are detected by sensing the emission from the products to provide an electrical signal whose wave pattern is indicative of the identity of the microorganism. This wave pattern is compared in a computer with patterns stored therein representing a collection of known microorganisms.
摘要翻译：一种用于鉴定未知微生物的技术，其中制备了已经添加了放射性发射剂的未知微生物的标本，其被积极地并入微生物代谢产物中以产生放射性肽或蛋白质发射的混合物产品的方式取决于微生物的代谢机制。然后分离由制备样品得到的混合物中的肽或蛋白质发射产物。通过感测来自产品的发射来检测分离的发射产物，以提供其波形指示微生物的身份的电信号。在计算机中比较这种波形，其中存储的图案表示已知微生物的集合。

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